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公开(公告)号：US11149242B2
公开(公告)日：2021-10-19
申请号：US16827609
申请日：2020-03-23
摘要： Systems, methods, and apparatuses of controlling fluid flow are disclosed. An apparatus includes a first microplate having a first open portion and defining one or more first wells therein, a second microplate having a second open portion and defining one or more second wells therein, and a pneumatic lid constructed of styrene ethylene butylene styrene (SEBS). The pneumatic lid extends over the first open portion and the second open portion and includes one or more microfluidic channels that fluidly couple the one or more first wells to the one or more second wells. The pneumatic lid provides an airtight seal over the first microplate and the second microplate.
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2.发明授权公开(公告)号：US11958048B2
公开(公告)日：2024-04-16
申请号：US17681802
申请日：2022-02-27
发明人： Ryan Denomme , Lidija Malic , Daniel Brassard , Keith Morton , Teodor Veres
IPC分类号： B01L3/00 , G01N21/552 , G01N33/543
CPC分类号： B01L3/502715 , B01L3/502746 , B01L3/502784 , B01L3/502792 , G01N21/554 , G01N33/54386 , B01L2300/0645 , B01L2300/0663 , G01N2201/023 , G01N2201/061
摘要： A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.
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公开(公告)号：US11753485B2
公开(公告)日：2023-09-12
申请号：US16651067
申请日：2018-09-25
发明人： Lidija Malic , Xuefeng Zhang , Keith Morton , Teodor Veres
IPC分类号： C08F2/01 , C08F222/10 , C08F2/44 , C08F2/48 , C08K3/08 , C08K5/053 , C12Q1/686 , B82Y30/00 , B82Y40/00
CPC分类号： C08F2/01 , C08F2/44 , C08F2/48 , C08F222/102 , C08K3/08 , C08K5/053 , C12Q1/686 , B82Y30/00 , B82Y40/00 , C08K2003/0831 , C08K2201/011
摘要： The present application relates to polymer microparticle-metal nanoparticle composites, to methods of preparing polymer microparticle-metal nanoparticle composites and to uses of such composites. The methods comprise introducing into a microfluidic device, a composition comprising: a cationic metal nanoparticle precursor; a polymer microparticle precursor that comprises a plurality of photopolymerizable groups; and a photoreducer-photoinitiator; then irradiating the composition under conditions to simultaneously reduce the cationic metal and polymerize the photopolymerizable groups to obtain the composite.
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4.发明授权公开(公告)号：US11278890B2
公开(公告)日：2022-03-22
申请号：US17265162
申请日：2019-08-06
发明人： Ryan Denomme , Lidija Malic , Daniel Brassard , Keith Morton , Teodor Veres
IPC分类号： B01L3/00 , G01N21/552 , G01N33/543
摘要： A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.
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公开(公告)号：US11071985B2
公开(公告)日：2021-07-27
申请号：US15313961
申请日：2015-05-26
发明人： Liviu Clime , Teodor Veres , Keith Morton
摘要： A centrifugal microfluidic chip mounting, kit and method include a swivel joint permitting a chip to rotate about an axis of the chip in a plane swept by a centrifuge, and a force applicator for controlling an angle of the swivel and for applying a force in proportion to a rotational rate of the centrifuge. The mounting includes: a blade part (18) that couples to, or defines, a blade (10) of a centrifuge at a radial distance from a centrifuge axis (12); a chip part (20) that holds the chip at an orientation having a normal not perpendicular to the axis; a one degree of freedom (DoF) joint (16) between the blade part and the chip part; and a force applicator (28) which bears on the chip part at a fixed set of one or more points, which do not surround, and are not surrounded by, the joint.
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公开(公告)号：US20200223999A1
公开(公告)日：2020-07-16
申请号：US16651018
申请日：2018-09-25
发明人： Lidija Malic , Xuefeng Zhang , Keith Morton , Teodor Veres
摘要： The present application relates to polymer film-metal composites, to methods of preparing polymer film-metal composites and to uses of such composites. The metal can be in the form of a nanoparticle or a film. The methods comprise depositing on a surface, a composition comprising: a cationic metal precursor; a polymer film precursor that comprises a plurality of photopolymerizable groups; and a photoreducer-photoinitiator; then irradiating the composition under conditions to simultaneously reduce the cationic metal and polymerize the photopolymerizable groups to obtain the composite on the surface.
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7.发明申请公开(公告)号：US20200223948A1
公开(公告)日：2020-07-16
申请号：US16651067
申请日：2018-09-25
发明人： Lidija Malic , Xuefeng Zhang , Keith Morton , Teodor Veres
摘要： The present application relates to polymer microparticle-metal nanoparticle composites, to methods of preparing polymer microparticle-metal nanoparticle composites and to uses of such composites. The methods comprise introducing into a microfluidic device, a composition comprising: a cationic metal nanoparticle precursor; a polymer microparticle precursor that comprises a plurality of photopolymerizable groups; and a photoreducer-photoinitiator; then irradiating the composition under conditions to simultaneously reduce the cationic metal and polymerize the photopolymerizable groups to obtain the composite.
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8.发明公开公开(公告)号：US20240342708A1
公开(公告)日：2024-10-17
申请号：US18610057
申请日：2024-03-19
发明人： Ryan Denomme , Lidija Malic , Daniel Brassard , Keith Morton , Teodor Veres
IPC分类号： B01L3/00 , G01N21/552 , G01N33/543
CPC分类号： B01L3/502715 , B01L3/502746 , B01L3/502784 , B01L3/502792 , G01N21/554 , G01N33/54386 , B01L2300/0645 , B01L2300/0663 , G01N2201/023 , G01N2201/061
摘要： A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.
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公开(公告)号：US11867320B2
公开(公告)日：2024-01-09
申请号：US16970520
申请日：2019-03-04
发明人： Kebin Li , Keith Morton , Teodor Veres
CPC分类号： F16K99/0025 , F16K99/0015 , B01L3/502738 , B01L2200/12 , B01L2300/123 , B01L2400/0487 , B01L2400/0655 , F16K99/0059 , F16K2099/0074 , F16K2099/0084
摘要： In a polymeric microfluidic valve, an adhesion control surface with discrete micro- or nano-scale structured surfaces are separated by fluid filled voids at an interface between an elastomeric membrane seals against a substrate layer. The structured surfaces reduce adhesion between the membrane layer and the substrate layer and prevent permanent bonding, while at the same time providing a good balance of adhesion at the valve seat to provide a sealing engagement. Microstructured adhesion control surfaces on and around valve bodies permit opening the valve, by reducing contact surface area.
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公开(公告)号：US11661469B2
公开(公告)日：2023-05-30
申请号：US16651018
申请日：2018-09-25
发明人： Lidija Malic , Xuefeng Zhang , Keith Morton , Teodor Veres
IPC分类号： C08F290/06 , C08F222/10 , C08J7/18 , C08K3/08 , G03F7/004 , G03F7/027 , G03F7/028 , C08J7/044 , B82Y30/00 , B82Y40/00 , G03F7/00
CPC分类号： C08F290/062 , C08F222/102 , C08J7/044 , C08J7/18 , C08K3/08 , G03F7/0043 , G03F7/028 , G03F7/0275 , B82Y30/00 , B82Y40/00 , C08J2333/08 , C08K2003/0831 , C08K2201/011 , G03F7/0037
摘要： Disclosed is a method of preparing polymer film-metal composites and uses of such composites. The metal can be in the form of a nanoparticle or a film. The methods comprise depositing on a surface, a composition comprising: a cationic metal precursor; a polymer film precursor that comprises a plurality of photopolymerizable groups; and a photoreducer-photoinitiator; then irradiating the composition under conditions to simultaneously reduce the cationic metal and polymerize the photopolymerizable groups to obtain the composite on the surface.
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