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    Micro-Machined Frit and Flow Distributor Devices for Liquid Chromatography
    1.
    发明申请
    Micro-Machined Frit and Flow Distributor Devices for Liquid Chromatography 审中-公开
    用于液相色谱的微加工玻璃料和流量分配器

    公开(公告)号：US20130001145A1

    公开(公告)日：2013-01-03

    申请号：US13172034

    申请日：2011-06-29

    申请人： Hongfeng Yin ,  Qing Bai ,  Reid A. Brennen

    发明人： Hongfeng Yin ,  Qing Bai ,  Reid A. Brennen

    IPC分类号： B01D15/08 ,  B32B17/00 ,  B01D15/18 ,  B32B3/10

    CPC分类号： G01N30/603 ,  B01D15/22 ,  G01N30/6017 ,  G01N30/6095 ,  G01N2030/027 ,  Y10T428/24273 ,  Y10T428/24314 ,  Y10T428/24322

    摘要： A micro-machined frit is provided for use in a chromatography column, having a substrate with a thickness, and holes extending through the thickness and providing fluid communication through the substrate. A micro-machined flow distributor is provided for use in a chromatography column having a substrate, holes extending through the substrate, and channels in fluid communication with the holes. A micro-machined integrated frit and flow distributor device is also provided having a substrate with a thickness, holes extending through the thickness and providing fluid communication therethrough, and channels in fluid communication with at least one of the holes. A chromatography column is provided having a tube, an extraction medium contained therein, and a micro-machined frit positioned proximate an end of the tube. The column can include a micro-machined flow distributor positioned between the frit and the end of the tube.

    摘要翻译： 提供微加工玻璃料用于色谱柱，其具有厚度的基材和延伸穿过该厚度并提供通过基材的流体连通的孔。 提供微加工流量分配器用于具有基板，延伸穿过基板的孔和与孔流体连通的通道的色谱柱。 还提供了一种微加工的集成玻璃料和流量分配器装置，其具有厚度的衬底，延伸穿过该厚度的孔，并且提供流体连通，以及与至少一个孔流体连通的通道。 提供了一种色谱柱，其具有管，其中包含的萃取介质和靠近管的端部定位的微加工玻璃料。 该柱可以包括位于玻璃料和管的端部之间的微加工流量分配器。

    TANDEM IONIZER ION SOURCE FOR MASS SPECTROMETER AND METHOD OF USE
    4.
    发明申请
    TANDEM IONIZER ION SOURCE FOR MASS SPECTROMETER AND METHOD OF USE 有权
    用于质谱仪的串联离子源和使用方法

    公开(公告)号：US20100193702A1

    公开(公告)日：2010-08-05

    申请号：US12363685

    申请日：2009-01-30

    申请人： Gangqiang Li ,  Hongfeng Yin

    发明人： Gangqiang Li ,  Hongfeng Yin

    IPC分类号： H01J27/02 ,  H01J49/04 ,  H01J49/10 ,  H01J49/14 ,  H01J27/20

    CPC分类号： H01J49/107 ,  H01J49/165

    摘要： An ion source a first ionizer comprising: an electrospray needle comprising a tip; and a conduit disposed annularly about the needle and configured to pass an inert gas in proximity of the tip to nebulize a fluid emerging from the tip, the nebulized fluid comprising analytes and a mobile phase. The ion source comprises a capillary in tandem with the first ionizer and configured to receive the droplets; a heater configured to heat the capillary to a temperature at which mobile phase vaporizes; and a second ionizer in tandem with the capillary and configured to receive the vaporized mobile phase and the analytes. A method is also described.

    摘要翻译： 离子源，第一离子发生器，包括：电喷针，包括尖端; 以及围绕所述针环设置的导管，其被配置成使所述尖端附近的惰性气体通过，以使从所述尖端出来的流体雾化，所述雾化流体包含分析物和流动相。 离子源包括与第一离子发生器串联的毛细管并且构造成接收液滴; 加热器，被配置为将毛细管加热至流动相蒸发的温度; 以及第二离子发生器，其与所述毛细管串联并且被配置为接收蒸发的流动相和所述分析物。 还描述了一种方法。

    Incremental update of long-term and short-term user profile scores in a behavioral targeting system
    5.
    发明申请
    Incremental update of long-term and short-term user profile scores in a behavioral targeting system 有权
    在行为定位系统中增加长期和短期用户配置文件分数

    公开(公告)号：US20070260624A1

    公开(公告)日：2007-11-08

    申请号：US11394358

    申请日：2006-03-29

    申请人： Christina Chung ,  Abhinav Gupta ,  Joshua Koran ,  Long-Ji Lin ,  Hongfeng Yin

    发明人： Christina Chung ,  Abhinav Gupta ,  Joshua Koran ,  Long-Ji Lin ,  Hongfeng Yin

    IPC分类号： G06F7/00

    CPC分类号： G06Q30/02

    摘要： A behavioral targeting system determines user profiles from online activity. The system includes a plurality of models that define parameters for determining a user profile score. Event information, which comprises on-line activity of the user, is received at an entity. To generate a user profile score, a model is selected. The model comprises recency, intensity and frequency dimension parameters. The behavioral targeting system generates a user profile score for a target objective, such as brand advertising or direct response advertising. The parameters from the model are applied to generate the user profile score in a category. The behavioral targeting system has application for use in ad serving to on-line users.

    摘要翻译： 行为定位系统从在线活动确定用户个人资料。 该系统包括多个模型，其定义用于确定用户简档分数的参数。 事件信息，包括用户的在线活动，在一个实体被接收。 要生成用户配置文件分数，选择一个模型。 该模型包括近似度，强度和频率尺寸参数。 行为定位系统为目标目标生成用户简档分数，例如品牌广告或直接回应广告。 应用来自模型的参数以在类别中生成用户简档分数。 行为定位系统具有在在线用户的广告投放中使用的应用。

    Behavioral targeting system that generates user profiles for target objectives
    6.
    发明申请
    Behavioral targeting system that generates user profiles for target objectives 有权
    为目标目标生成用户配置文件的行为定位系统

    公开(公告)号：US20070239535A1

    公开(公告)日：2007-10-11

    申请号：US11394332

    申请日：2006-03-29

    申请人： Joshua Koran ,  Christina Chung ,  Long-Ji Lin ,  Hongfeng Yin

    发明人： Joshua Koran ,  Christina Chung ,  Long-Ji Lin ,  Hongfeng Yin

    IPC分类号： G06Q30/00

    CPC分类号： G06F17/30528 ,  G06F17/30294 ,  G06F17/30587 ,  G06F17/30876 ,  G06Q30/02 ,  G06Q30/0224 ,  G06Q30/0251

    摘要： A behavioral targeting system determines user profiles from online activity. The system includes a plurality of models that define parameters for determining a user profile score. Event information, which comprises on-line activity of the user, is received at an entity. To generate a user profile score, a model is selected. The model comprises recency, intensity and frequency dimension parameters. The behavioral targeting system generates a user profile score for a target objective, such as brand advertising or direct response advertising. The parameters from the model are applied to generate the user profile score in a category. The behavioral targeting system has application for use in ad serving to on-line users.

    摘要翻译： 行为定位系统从在线活动确定用户个人资料。 该系统包括多个模型，其定义用于确定用户简档分数的参数。 事件信息，包括用户的在线活动，在一个实体被接收。 要生成用户配置文件分数，选择一个模型。 该模型包括近似度，强度和频率尺寸参数。 行为定位系统为目标目标生成用户简档分数，例如品牌广告或直接回应广告。 应用来自模型的参数以在类别中生成用户简档分数。 行为定位系统具有在在线用户的广告投放中使用的应用。

    Fluidic separation devices and methods with reduced sample broadening
    8.
    发明申请
    Fluidic separation devices and methods with reduced sample broadening 审中-公开
    流体分离装置和减少样品扩增的方法

    公开(公告)号：US20070140918A1

    公开(公告)日：2007-06-21

    申请号：US11311960

    申请日：2005-12-19

    申请人： Hongfeng Yin ,  Kevin Killeen ,  Reid Brennen

    发明人： Hongfeng Yin ,  Kevin Killeen ,  Reid Brennen

    IPC分类号： B01L11/00

    CPC分类号： G01N30/20 ,  G01N30/02 ,  G01N30/6095 ,  G01N30/7266 ,  G01N2030/202 ,  Y10T436/25 ,  B01D15/14

    摘要： Fluidic separation devices and methods with reduced sample broadening are provided. A column is located downstream from a holding chamber, and a flow providing means provides fluid flow effective to convey a sample along a flow path that extends from the holding chamber into the separation column. The sample is typically focused in the flow path upstream from the separation column. Optionally, the invention may be employed with electrospray mass spectrometry and in microfluidic applications.

    摘要翻译： 提供了流体分离装置和减少样品加宽的方法。 柱位于保持室的下游，并且流动提供装置提供有效地沿着沿着从保持室延伸到分离柱的流动路径输送样品的流体流。 样品通常聚焦在分离柱上游的流路中。 任选地，本发明可以与电喷雾质谱法和微流体应用一起使用。

    Electrospray devices for mass spectrometry
    10.
    发明授权
    Electrospray devices for mass spectrometry 有权
    用于质谱的电喷雾装置

    公开(公告)号：US07060975B2

    公开(公告)日：2006-06-13

    申请号：US10982189

    申请日：2004-11-05

    申请人： Karen L. Seaward ,  Hongfeng Yin ,  Kevin P. Killeen ,  Daniel Sobek ,  Daniel Roitman

    发明人： Karen L. Seaward ,  Hongfeng Yin ,  Kevin P. Killeen ,  Daniel Sobek ,  Daniel Roitman

    IPC分类号： H01J49/10

    CPC分类号： H01J49/165

    摘要： An electrospray device for a mass spectrometry system is described. The electrospray device comprises a body portion and a tip portion extending from the body portion. The tip portion comprises a polymeric material. The electrospray device also comprises a hydrophobic coating substantially selectively covering the tip portion. The hydrophobic coating is electrically nonconductive.

    摘要翻译： 描述了用于质谱系统的电喷雾装置。 电喷雾装置包括主体部分和从主体部分延伸的尖端部分。 尖端部分包括聚合材料。 电喷雾装置还包括基本上选择性地覆盖尖端部分的疏水涂层。 疏水涂层是不导电的。