Pharmaceutical coating materials soluble or swellable in gastric juice
and pharmaceutical dosage forms coated therewith
    5.
    发明授权
    Pharmaceutical coating materials soluble or swellable in gastric juice and pharmaceutical dosage forms coated therewith 失效
    在胃液中可溶或溶胀的药物包衣材料和用其涂覆的药物剂型

    公开(公告)号:US4452862A

    公开(公告)日:1984-06-05

    申请号:US345478

    申请日:1982-02-03

    CPC分类号: A61K9/2846 Y10T428/2998

    摘要: Coating materials for pharmaceutical dosage forms contain, besides the conventional liquid or solid additives for pharmaceutical coatings, a binder comprising a synthetic polymer, prepared by emulsion polymerization, having 5 to 100% by weight of units derived from monomers of the formula ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl group, R.sub.2 is an alkylene or aralkylene group having at least 3 carbon atoms in the chain between the amino nitrogen and the ester oxygen atom of which at least one is tertiary or quaternary, and R.sub.3 and R.sub.4 are lower alkyl radicals or together with the amino-nitrogen atom form a heteroaliphatic ring, and, optionally, additional comonomer units.

    摘要翻译: 用于药物剂型的涂层材料除了用于药物涂层的常规液体或固体添加剂外,还包含通过乳液聚合制备的包含合成聚合物的粘合剂,其具有5至100重量%的衍生自下式的单体的单元:其中 R1是氢原子或低级烷基,R2是在氨基氮和酯氧原子之间的链中具有至少3个碳原子的亚烷基或亚芳基,其至少一个是叔或四价,R3和R4 是低级烷基或与氨基 - 氮原子一起形成杂脂族环,和任选的另外的共聚单体单元。

    Aqueous artificial resin dispersions free of emulsifying agents
    7.
    发明授权
    Aqueous artificial resin dispersions free of emulsifying agents 失效
    水性人造树脂分散体不含乳化剂

    公开(公告)号:US4373056A

    公开(公告)日:1983-02-08

    申请号:US295544

    申请日:1981-08-24

    CPC分类号: C08F246/00 C08F220/58

    摘要: An aqueous artificial resin dispersion, comprising an aqueous phase and a water-insoluble disperse phase formed from particles containing a copolymer formed in substantial part from a water insoluble or slightly soluble first monomer, wherein the copolymer additionally is formed from a second monomer of the formula ##STR1## wherein R represents hydrogen or methyl, R' represents hydrogen or an alkyl radical with 1 to 12 C-atoms, R" represents an alkyl radical with 7 to 20 C-atoms, and M represents a proton, an alkali metal ion, or an ammonium ion, with the proviso that the aqueous phase is free of low molecular weight, ionic emulsifying agents. Such dispersions are particularly well suited for continuous emulsion polymerization because of the highly stable monomer emulsions formed by mixtures produced according to the invention.

    摘要翻译: 一种水性人造树脂分散体,其包含水相和由非水溶性或微溶性第一单体形成的含有共聚物的颗粒形成的水不溶性分散相,其中所述共聚物另外由式 其中R表示氢或甲基,R'表示氢或具有1至12个C原子的烷基,R“表示具有7至20个碳原子的烷基,M表示质子,碱金属 离子或铵离子,条件是水相不含低分子量离子乳化剂。 由于由根据本发明制备的混合物形成的高度稳定的单体乳液,这种分散体特别适用于连续乳液聚合。