公开(公告)号：US20240245602A1

公开(公告)日：2024-07-25

申请号：US18023566

申请日：2021-08-27

Applicant: President and Fellows of Harvard College ,  Massachusetts Eye and Eye Infirmary

Inventor： Ida PAVLICHENKO ,  Joanna AIZENBERG ,  Haritosh PATEL ,  Michael AIZENBERG ,  Cathy ZHANG ,  Aaron Kyle REMENSCHNEIDER ,  Elliot D. KOZIN

IPC: A61K9/00 ,  A61F11/00 ,  A61P27/16

CPC classification number: A61K9/0046 ,  A61F11/00 ,  A61P27/16

Abstract: A kit for delivering a drug formulation to treat disorders, e.g. car disorders, is disclosed. The kit includes two components: a drug formulation and a conduit for delivering the drug formulation. The kit may contain a tailored drug formulation that includes one or more of a therapeutic agent, a priming agent, an activating agent, and a reversal agent. In certain embodiments, the conduit may be provided with additional therapeutic formulations preloaded into the conduit. In some embodiments, a plug can be provided over the inner surface of the conduit where the plug contains a plug formulation.

公开(公告)号：US20180327608A1

公开(公告)日：2018-11-15

申请号：US15973193

申请日：2018-05-07

Applicant: President and Fellows of Harvard College

Inventor： Joanna AIZENBERG ,  Michael AIZENBERG ,  Jiaxi CUI ,  Stuart DUNN ,  Benjamin HATTON ,  Caitlin HOWELL ,  Philseok KIM ,  Tak Sing WONG ,  Xi YAO

IPC: C09D5/16 ,  C09D201/00 ,  A61L29/08 ,  C10M171/00 ,  C10M105/76 ,  B08B17/06 ,  B08B17/02 ,  B01D65/08

CPC classification number: C09D5/1637 ,  A61L29/085 ,  A61L29/14 ,  A61L31/04 ,  A61L31/049 ,  A61L31/06 ,  A61L31/14 ,  A61L2400/10 ,  B01D65/08 ,  B01D2321/00 ,  B05D5/08 ,  B08B17/025 ,  B08B17/065 ,  C08J2300/00 ,  C09D5/1675 ,  C09D5/1693 ,  C09D201/005 ,  C10M105/76 ,  C10M171/00 ,  C10M2203/1006 ,  C10M2229/025 ,  C10M2229/0515 ,  C10N2250/18 ,  C10N2270/00 ,  C08L83/04

Abstract: The present disclosure describes a strategy to create self-healing, slippery self-lubricating polymers. Lubricating liquids with affinities to polymers can be utilized to get absorbed within the polymer and form a lubricant layer (of the lubricating liquid) on the polymer. The lubricant layer can repel a wide range of materials, including simple and complex fluids (water, hydrocarbons, crude oil and bodily fluids), restore liquid-repellency after physical damage, and resist ice, microorganisms and insects adhesion. Some exemplary applications where self-lubricating polymers will be useful include energy-efficient, friction-reduction fluid handling and transportation, medical devices, anti-icing, optical sensing, and as self-cleaning, and anti-fouling materials operating in extreme environments.

公开(公告)号：US20160209642A1

公开(公告)日：2016-07-21

申请号：US14974734

申请日：2015-12-18

Applicant: President and Fellows of Harvard College

Inventor： Joanna AIZENBERG ,  Michael AIZENBERG ,  Philseok KIM

IPC: G02B26/08 ,  B81B3/00

CPC classification number: G02B26/0833 ,  B29D11/0074 ,  B81B3/0032 ,  B81B2201/038 ,  B81B2207/053 ,  G02B26/00 ,  G02B26/0808 ,  G02B26/0866 ,  Y10T156/109

Abstract: Microstructured hybrid actuator assemblies in which microactuators carrying designed surface properties to be revealed upon actuation are embedded in a layer of responsive materials. The microactuators in a microactuator array reversibly change their configuration in response to a change in the environment without requiring an external power source to switch their optical properties.

Abstract translation: 微结构化混合致动器组件，其中携带设计表面特性的微致动器在致动时被显示，嵌入在一层响应材料中。 微致动器阵列中的微致动器响应于环境的变化而可逆地改变其配置，而不需要外部电源来切换其光学特性。

公开(公告)号：US20140290731A1

公开(公告)日：2014-10-02

申请号：US14140374

申请日：2013-12-24

Applicant: President and Fellows of Harvard College

Inventor： Joanna AIZENBERG ,  Michael AIZENBERG ,  Sung Hoon KANG ,  Tak Sing WONG ,  Philseok KIM

IPC: F01D25/18 ,  H01L31/0236 ,  F28F13/18 ,  B05D3/00

CPC classification number: C09D5/00 ,  A61L15/24 ,  A61L15/34 ,  A61L15/42 ,  A61L15/46 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  A61L33/0094 ,  A61L33/064 ,  A61L2400/12 ,  B01D69/02 ,  B01D2325/06 ,  B01L3/5027 ,  B01L2300/16 ,  B05D3/002 ,  B05D5/00 ,  B05D5/083 ,  B63B59/04 ,  B64D15/00 ,  B65D25/14 ,  C02F1/44 ,  C09D5/16 ,  C09D5/1656 ,  C09D5/1681 ,  C09D5/1693 ,  C10M105/54 ,  C10M105/56 ,  D06M13/00 ,  E04B1/92 ,  F01D25/02 ,  F01D25/18 ,  F15D1/02 ,  F15D1/10 ,  F16L57/00 ,  F28F13/185 ,  F28F19/02 ,  F28F2245/04 ,  G02B1/14 ,  H01L31/02167 ,  H01L31/0236 ,  Y10T428/24355 ,  Y10T428/24364 ,  C08L27/12

Abstract: The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces (SLIPS). Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of materials, referred to herein as Object A (Solid A or Liquid A). SLIPS outperforms other conventional surfaces in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low-contact-angle hysteresis (

公开(公告)号：US20190136070A1

公开(公告)日：2019-05-09

申请号：US16096220

申请日：2017-04-27

Applicant: President and Fellows of Harvard College ,  Beth Israel Deaconess Medical Center, Inc.

Inventor： Joanna AIZENBERG ,  Steffi SUNNY ,  Nicolas VOGEL ,  Adnan MAJID ,  George CHENG ,  Michael AIZENBERG

IPC: C09D5/00 ,  A61B1/00 ,  A61B1/07 ,  A61B1/018 ,  A61B1/012 ,  A61B1/05 ,  G02B27/00

Abstract: A transparent repellent, liquid-infused coating applied onto the distal end of an endoscope that prevents vision loss and reduces fouling is described. Also described is a disposable endoscope window that is coated in a transparent, repellant, liquid-infused coating for attachment to the distal end or distal window of an endoscope to obviate vision loss. Also described is an endoscope comprising a miniature camera coated in a transparent, repellent, liquid-infused coating.

公开(公告)号：US20140328999A1

公开(公告)日：2014-11-06

申请号：US14268171

申请日：2014-05-02

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Joanna AIZENBERG ,  Benjamin HATTON ,  Xi YAO ,  Michael AIZENBERG ,  Wendong WANG

IPC: C10M171/00 ,  B05D3/00 ,  A61F2/28 ,  B05D3/14 ,  B05D3/12 ,  B05D3/02 ,  F17D1/08 ,  B05D3/06

CPC classification number: C10M171/001 ,  A61F2/28 ,  A61F2240/001 ,  A61L15/425 ,  A61L15/50 ,  A61L27/50 ,  A61L27/56 ,  A61L29/14 ,  A61L29/146 ,  A61L2400/10 ,  A61L2400/16 ,  A61L2400/18 ,  A61M31/00 ,  B05D3/007 ,  B05D3/0254 ,  B05D3/06 ,  B05D3/12 ,  B05D3/14 ,  B05D3/207 ,  F17D1/08 ,  Y10T137/0324 ,  Y10T428/139 ,  Y10T428/24355

Abstract: The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces (SLIPS) that can be modified as desired. Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of objects, referred to herein as Object A (Solid A or Liquid A). Use of an external stimuli or degradation of the Liquid B can be utilized to change the characteristics of SLIPS structures reversibly or irreversibly that may be desired in a number of different applications. Numerous characteristics, such as adhesion, optical, mechanical, and the like, can be dynamically changed.

Abstract translation: 本公开描述了创建可以根据需要进行修改的自愈，滑滑液体注入的多孔表面（SLIPS）的策略。 粗化（例如，多孔）表面可以用于将本文称为液体B的润滑流体锁定在一起，以排斥在本文中称为对象A（固体A或液体A）的宽范围的物体。 可以利用外部刺激或液体B的降解来改变在许多不同应用中可能需要的可逆或不可逆的SLIPS结构的特征。 可以动态地改变许多特征，例如粘附，光学，机械等。

公开(公告)号：US20140290732A1

公开(公告)日：2014-10-02

申请号：US14140391

申请日：2013-12-24

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Joanna AIZENBERG ,  Michael AIZENBERG ,  Sung Hoon KANG ,  Tak Sing WONG ,  Philseok KIM

IPC: H01L31/0236 ,  F01D25/18 ,  F28F13/18 ,  B05D3/00

CPC classification number: C09D5/00 ,  A61L15/24 ,  A61L15/34 ,  A61L15/42 ,  A61L15/46 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  A61L33/0094 ,  A61L33/064 ,  A61L2400/12 ,  B01D69/02 ,  B01D2325/06 ,  B01L3/5027 ,  B01L2300/16 ,  B05D3/002 ,  B05D5/00 ,  B05D5/083 ,  B63B59/04 ,  B64D15/00 ,  B65D25/14 ,  C02F1/44 ,  C09D5/16 ,  C09D5/1656 ,  C09D5/1681 ,  C09D5/1693 ,  C10M105/54 ,  C10M105/56 ,  D06M13/00 ,  E04B1/92 ,  F01D25/02 ,  F01D25/18 ,  F15D1/02 ,  F15D1/10 ,  F16L57/00 ,  F28F13/185 ,  F28F19/02 ,  F28F2245/04 ,  G02B1/14 ,  H01L31/02167 ,  H01L31/0236 ,  Y10T428/24355 ,  Y10T428/24364 ,  C08L27/12

Abstract: The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces (SLIPS). Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of materials, referred to herein as Object A (Solid A or Liquid A). SLIPS outperforms other conventional surfaces in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low-contact-angle hysteresis (

公开(公告)号：US20200254432A1

公开(公告)日：2020-08-13

申请号：US16651951

申请日：2018-10-01

Applicant: President and Fellows of Harvard College

Inventor： Elijah SHIRMAN ,  Tanya SHIRMAN ,  Joanna AIZENBERG ,  Michael AIZENBERG

IPC: B01J35/00 ,  B01J23/89

Abstract: Aspects of the present application provides for enhanced catalytic materials, which can feature multiple functional and/or catalytic species, and methods of their formation. The materials can include catalytic nanoparticles (NPs) partially embedded within a supporting matrix. Treatment of the material, e.g., thermal, optical, microwave, plasma, and/or chemical treatment, can lead to the formation of functionally, e.g., catalytic or co-catalytic, relevant chemical and structural/morphological species or features at the NP-matrix, NP-pore, and matrix-pore interfaces. The treated material is characterized by enhanced properties, e.g., greater mechanical stability.

公开(公告)号：US20200023346A1

公开(公告)日：2020-01-23

申请号：US16391053

申请日：2019-04-22

Applicant: President and Fellows of Harvard College

Inventor： Joanna AIZENBERG ,  Tanya SHIRMAN ,  Nicolas VOGEL ,  Mathias KOLLE ,  Michael AIZENBERG

IPC: B01J35/10 ,  C04B38/00 ,  B01J23/52 ,  B01J37/00

Abstract: Methods for forming an interconnected network of solid material and pores, with metal residing only at the air/solid interface of the interconnected network structure are described. In certain embodiments, nanoparticle decorated sacrificial particles can be used as sacrificial templates for the formation of a porous structure having an interconnected network of solid material and interconnected network of pores. The nanoparticles reside predominantly at the air/solid interface and allow further growth and accessibility of the nanoparticles at defined positions of the interconnected structure. SEM and TEM measurements reveal the formation of 3D interconnected porous structures with nanoparticles residing predominantly at the air/solid interface of the interconnected structure.

公开(公告)号：US20180362875A1

公开(公告)日：2018-12-20

申请号：US16025589

申请日：2018-07-02

Applicant: President and Fellows of Harvard College

Inventor： Joanna AIZENBERG ,  Michael AIZENBERG ,  Philseok KIM

IPC: C10M105/76 ,  B05D3/10 ,  C23C18/12 ,  C09D7/61 ,  C10M177/00 ,  B08B17/06 ,  C09D5/16 ,  C23C18/04 ,  C03C17/00 ,  B05D5/08 ,  B65D25/14

Abstract: A method of preparing an article having a slippery surface includes providing a metal-containing surface, chemically modifying the metal-containing surface to roughen the metal-containing surface, and disposing a lubricating layer on the roughened metal-containing surface, wherein the lubricating layer is substantially stabilized on the roughened metal-containing surface.