公开(公告)号：US20130053711A1

公开(公告)日：2013-02-28

申请号：US13503954

申请日：2010-09-27

申请人： Rama Krishna Kotlanka ,  Pradeep Basappa Khannur ,  Kok Lim Chan ,  Soo Yeng Benjamin Chua ,  Xiaojun Yuan ,  Minkyu Je ,  Vaidyanathan Kripesh ,  Daquan Yu ,  Pavel Neuzil ,  Lichun Shao ,  Woo Tae Park

发明人： Rama Krishna Kotlanka ,  Pradeep Basappa Khannur ,  Kok Lim Chan ,  Soo Yeng Benjamin Chua ,  Xiaojun Yuan ,  Minkyu Je ,  Vaidyanathan Kripesh ,  Daquan Yu ,  Pavel Neuzil ,  Lichun Shao ,  Woo Tae Park

IPC分类号： A61B5/0265

CPC分类号： A61B5/026 ,  A61B5/02007 ,  A61B5/02028 ,  A61B5/686 ,  A61B2560/0219 ,  G01F1/28 ,  G01F1/34 ,  G01F15/063

摘要： According to embodiments of the present invention, an implantable device for detecting variation in fluid flow rate is provided. The implantable device includes: a substrate having an active element arrangement; a sensor arrangement having a first portion that is mechanically secured and a second portion that is freely deflectable, the sensor arrangement in electrical communication with the active element arrangement, wherein the active element arrangement is configured to detect changes in deformation of the sensor arrangement and produce an output in response to the detected changes; and at least one inductive element mechanically coupled to the substrate and in electrical communication with the active element arrangement, wherein the inductive element is adapted to power the active element arrangement through inductive coupling to an excitation source, and wherein the inductive element is adapted to transmit the output associated with the detected changes in the sensor.

摘要翻译： 根据本发明的实施例，提供了一种用于检测流体流量变化的可植入装置。 该可植入装置包括：具有有源元件装置的衬底; 传感器装置，其具有机械固定的第一部分和可自由偏转的第二部分，所述传感器装置与所述有源元件装置电连通，其中所述有源元件布置被配置为检测所述传感器装置的变形的变化并产生 响应于检测到的变化的输出; 以及至少一个电感元件，其机械耦合到所述衬底并与所述有源元件布置电连通，其中所述电感元件适于通过与激励源的感应耦合为所述有源元件布置供电，并且其中所述电感元件适于传输 输出与传感器中检测到的变化相关联。

公开(公告)号：US20130053730A1

公开(公告)日：2013-02-28

申请号：US13504455

申请日：2010-08-27

申请人： Rama Krishna Kotlanka ,  Vaidyanathan Kripesh ,  Daquan Yu ,  Kok Lim Chan ,  Soo Yeng Benjamin Chua ,  Pavel Neuzil

发明人： Rama Krishna Kotlanka ,  Vaidyanathan Kripesh ,  Daquan Yu ,  Kok Lim Chan ,  Soo Yeng Benjamin Chua ,  Pavel Neuzil

IPC分类号： A61M25/09

CPC分类号： A61M25/0068 ,  A61B5/6851 ,  A61B5/6852 ,  A61B2090/064 ,  A61B2090/065 ,  A61M25/0082 ,  A61M25/01 ,  A61M25/09 ,  A61M2025/09183

摘要： According to embodiments of the present invention, a micro-sensory tip for use in blood vessels is provided. The micro-sensory tip includes: a force transmission element; at least three force detecting sensors coupled to the force transmission element, each of the at least three force detecting sensors responsive to force applied on the force transmission element, wherein each of the at least three force detecting sensors produces an output representing at least one force component of a three-dimensional Cartesian co-ordinate system, of the force experienced by the force transmission element, such that the outputs of the at least three force detecting sensors can cover the space of the three-dimensional Cartesian co-ordinate system; and an active element arrangement coupled to the at least three force detecting sensors, the active element arrangement configured to process the output from the at least three force detecting sensors.

摘要翻译： 根据本发明的实施例，提供了一种用于血管的微感觉尖端。 微感觉尖端包括：力传递元件; 耦合到所述力传递元件的至少三个力检测传感器，所述至少三个力检测传感器中的每一个响应于施加在所述力传递元件上的力，其中所述至少三个力检测传感器中的每一个产生表示至少一个力 三维笛卡尔坐标系的分量，由力传递元件所经受的力，使得至少三个力检测传感器的输出可以覆盖三维笛卡尔坐标系的空间; 以及耦合到所述至少三个力检测传感器的有源元件布置，所述有源元件布置被配置为处理来自所述至少三个力检测传感器的输出。

公开(公告)号：US20100116682A1

公开(公告)日：2010-05-13

申请号：US12310957

申请日：2007-09-13

申请人： Pavel Neuzil ,  Hsiao-Hua Yu ,  Jackie Y. Ying

发明人： Pavel Neuzil ,  Hsiao-Hua Yu ,  Jackie Y. Ying

IPC分类号： G01N27/26 ,  C25B3/00 ,  G01N27/403

CPC分类号： H01L51/0006 ,  G01N27/403 ,  H01L51/0035 ,  H01L51/0036

摘要： The present invention generally relates to electronic devices and methods. In some cases, the invention provides a sensor device comprising a pair of interdigitated microelectrodes (60), coated with an electrically conducting polymer material (70). The microelectrodes (60) may be surrounded by a first electrode (22), a second electrode (40), and a hydrophobic wall (50).

摘要翻译： 本发明一般涉及电子设备和方法。 在一些情况下，本发明提供一种传感器装置，其包括涂覆有导电聚合物材料（70）的一对叉指式微电极（60）。 微电极（60）可以被第一电极（22），第二电极（40）和疏水壁（50）围绕。

公开(公告)号：US08216855B2

公开(公告)日：2012-07-10

申请号：US12279308

申请日：2006-02-13

申请人： Juergen Pipper ,  Tseng-Ming Hsieh ,  Pavel Neuzil

发明人： Juergen Pipper ,  Tseng-Ming Hsieh ,  Pavel Neuzil

IPC分类号： G01N33/553

CPC分类号： C07K1/22 ,  B01D15/3804 ,  B01J20/28009 ,  B01J2220/54 ,  B03C1/01 ,  C12M25/01 ,  G01N33/5432 ,  G01N33/5436 ,  G01N2446/00

摘要： The invention provides a method of processing a biological and/or chemical sample. The method includes providing a fluid droplet, which includes an inner phase and an outer phase. The outer phase is immiscible with the inner phase, and the outer phase is surrounding the inner phase. The inner phase includes the biological and/or chemical sample. The fluid droplet furthermore comprises magnetically attractable matter. The method also includes providing at least one surface, which is of such a texture and such a wettability for the fluid of the inner phase of the fluid droplet, that the fluid droplet remains intact upon being contacted therewith. The method further includes disposing the fluid droplet onto the at least one surface. The method also includes performing a process on the biological and/or chemical sample in the fluid droplet.

摘要翻译： 本发明提供了一种处理生物和/或化学样品的方法。 该方法包括提供包括内相和外相的流体液滴。 外相与内相不混溶，外相围绕内相。 内相包括生物和/或化学样品。 流体液滴还包括磁吸引物质。 该方法还包括提供至少一个表面，其具有这样的质地和对流体液滴的内相的流体的润湿性，使得流体液滴在与其接触时保持完整。 该方法还包括将流体液滴设置在至少一个表面上。 该方法还包括对流体液滴中的生物和/或化学样品进行处理。

公开(公告)号：US20100227386A1

公开(公告)日：2010-09-09

申请号：US12438725

申请日：2007-08-24

申请人： Pavel Neuzil ,  Juergen Pipper ,  Lukas Novak

发明人： Pavel Neuzil ,  Juergen Pipper ,  Lukas Novak

IPC分类号： C12M1/34 ,  G01J1/58

CPC分类号： G01N21/645 ,  B01L3/5088 ,  B01L7/52 ,  B01L2200/147 ,  B01L2300/1827 ,  G01N21/0332 ,  G01N21/6428 ,  G01N21/76 ,  G01N21/763 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/0221 ,  G01N2201/0625 ,  G01N2201/0627 ,  G01N2201/0693

摘要： A detection system is provided, the detection system comprising a light source that generates excitation light having a wavelength sufficient to excite a fluorophore in a sample; an excitation filter positioned along a first line along a path of the excitation light, the excitation filter transmitting the excitation light from the light source; a beam splitter positioned along the first line, the beam splitter reflecting the excitation light transmitted by the excitation filter along a second line toward a mirror positioned on one side of the beam splitter, and passing emitted light reflected along the second line; the mirror, positioned to reflect the excitation light from the beam splitter to the fluorophore in the sample along a third line, normal to both the first and second lines, wherein the mirror further reflects emitted light emitted along the third line, along the second line toward the beam splitter; an emission filter positioned along the second line, on a second side of the beam splitter; and a detector that detects the emitted light transmitted by the emission filter.

摘要翻译： 提供一种检测系统，所述检测系统包括产生具有足以激发样品中的荧光团的波长的激发光的光源; 激励滤光器，其沿着激励光的路径沿着第一线定位，所述激发滤光器透射来自所述光源的激发光; 分束器，沿着第一线定位，分束器将由激励滤光器透射的激发光沿着第二线反射到位于分束器一侧的反射镜，并且使沿着第二线反射的发射光反射; 所述反射镜被定位成将来自分束器的激发光沿着与第一和第二线垂直的第三线反射到样品中的荧光团，其中反射镜还沿着第二条线反射沿着第三条线发射的发射光 朝向分束器; 沿着所述第二线定位在所述分束器的第二侧上的发射滤光器; 以及检测由发射滤波器发射的发射光的检测器。

公开(公告)号：US20090263870A1

公开(公告)日：2009-10-22

申请号：US12428901

申请日：2009-04-23

申请人： Juergen Pipper ,  Pavel Neuzil ,  Yi Zhang ,  Muhammad Khidhir Khairudin ,  Tseng-Ming Hsieh

发明人： Juergen Pipper ,  Pavel Neuzil ,  Yi Zhang ,  Muhammad Khidhir Khairudin ,  Tseng-Ming Hsieh

IPC分类号： C12P19/34 ,  C12M1/00

CPC分类号： C12P19/34 ,  C12Q1/686 ,  C12Q2527/125 ,  C12Q2563/137

摘要： There is provided a method and/or system which allow on-chip preconditioning of complex real-world samples and/or handling of limited amounts of target material, and/or on-chip nucleic acid amplification process, using a free droplet containing magnetic attractable material. The nucleic acid amplification process comprises controlling the position of the magnetic attractable material and performing the nucleic acid amplification in a thermocycling droplet located onto at least one temperature zone. The low thermal masses of the herein described heaters/temperature sensors come along with fast temperature transitions within the corresponding temperature zones allowing impressing temperature gradients in at least one temperature zone between subsequent or within the same thermocycle(s). Additionally, the variable residence times of the droplet in a given temperature zone permit to customize the denaturation, annealing and/or extension times within the same or between different PCR runs. Additionally, the herein described method and/or system allow amplification of one or more nucleic acid molecules. Additionally, the herein described method and/or system allow real-time monitoring with or without the presence of magnetic attractable material bound to said nucleic acid molecule.

摘要翻译： 提供了一种方法和/或系统，其允许使用包含磁性可吸引的自由液滴来对复杂的现实世界样品进行片上预处理和/或处理有限量的靶材料和/或片上核酸扩增过程 材料。 核酸扩增方法包括控制磁性可吸引材料的位置并在位于至少一个温度区域上的热循环液滴中进行核酸扩增。 本文描述的加热器/温度传感器的低热质量伴随着相应温度区域内的快速温度转变，允许在相同或相同的热循环之间的至少一个温度区域内施加温度梯度。 此外，液滴在给定温度区域的可变停留时间允许在相同或不同PCR运行之间定制变性，退火和/或延伸时间。 另外，本文所述的方法和/或系统允许扩增一个或多个核酸分子。 另外，本文描述的方法和/或系统允许使用或不存在与所述核酸分子结合的可磁性吸引材料的实时监测。

公开(公告)号：US20120244605A1

公开(公告)日：2012-09-27

申请号：US13346418

申请日：2012-01-09

申请人： Pavel Neuzil ,  Tseng-Ming Hsieh ,  Juergen Pipper

发明人： Pavel Neuzil ,  Tseng-Ming Hsieh ,  Juergen Pipper

IPC分类号： C12M1/38 ,  G01N1/28

CPC分类号： B01L3/5088 ,  B01J2219/00495 ,  B01L3/5027 ,  B01L3/50851 ,  B01L7/52 ,  B01L2200/147 ,  B01L2300/0819 ,  B01L2300/1822 ,  B01L2300/1827 ,  G01N21/0332 ,  G01N25/18

摘要： The invention provides an apparatus for regulating the temperature of a chemical and/or biological sample and a method of using the same. The apparatus includes at least one temperature control module. The temperature control module includes a heater, a conductor of caloric, and a temperature sensor. The heater of the temperature control module is adapted to thermally communicate with a removable substrate, on which said chemical and/or biological sample is placed, via the conductor of caloric. The temperature sensor of the temperature control module is adapted to detect and control the temperature of the substrate via the conductor of caloric. The apparatus is designed such that the substrate is situated above said temperature control module to entirely cover said temperature control module.

摘要翻译： 本发明提供了一种用于调节化学和/或生物样品的温度的装置及其使用方法。 该装置包括至少一个温度控制模块。 温度控制模块包括加热器，热量导体和温度传感器。 温度控制模块的加热器适于通过热量导体与其上放置所述化学和/或生物样品的可移除基板热连通。 温度控制模块的温度传感器适于通过热量导体检测和控制基板的温度。 设备被设计成使得基板位于所述温度控制模块上方以完全覆盖所述温度控制模块。

公开(公告)号：US06075639A

公开(公告)日：2000-06-13

申请号：US141501

申请日：1998-08-28

申请人： Gordon S. Kino ,  Pavel Neuzil

发明人： Gordon S. Kino ,  Pavel Neuzil

IPC分类号： G02B7/182 ,  G02B26/08 ,  G02B27/00

CPC分类号： G02B26/0841 ,  G02B7/1821 ,  Y10S359/90

摘要： A silicon nitride scanning torsion mirror supported within a layer of silicon nitride by integral silicon nitride hinges. The layer is supported by a substrate which has a well beneath said mirror. A method of forming a silicon nitride scanning torsion mirror which includes depositing a silicon nitride layer on a support substrate etching the silicon nitride layer to form a mirror supported within the layer by integral torsion hinges and then selectively etching the substrate under the mirror to form a well.

摘要翻译： 氮化硅扫描扭转镜，通过整体氮化硅铰链支撑在氮化硅层内。 该层由衬底支撑，该衬底在所述反射镜下方具有良好的孔。 一种形成氮化硅扫描扭转镜的方法，其包括在支撑衬底上沉积氮化硅层，蚀刻氮化硅层以形成通过整体扭转铰链支撑在该层内的反射镜，然后在镜下选择性地蚀刻衬底，以形成 好。

公开(公告)号：US5969345A

公开(公告)日：1999-10-19

申请号：US847166

申请日：1997-04-30

申请人： Clayton C Williams ,  Robert C Davis ,  Pavel Neuzil

发明人： Clayton C Williams ,  Robert C Davis ,  Pavel Neuzil

IPC分类号： G01Q70/12 ,  G01Q60/22 ,  G01Q70/14 ,  G01R31/28 ,  H01J37/26

CPC分类号： G01Q60/22 ,  B82Y20/00 ,  B82Y35/00 ,  Y10S977/875

摘要： A submicrometer photodiode probe with a sub-50 nanometer tip radius is used for optical surface characterization on a nanometer scale. The nanoprobe detects subwavelength optical intensity variations in the near field of an illuminated surface. The probe comprises a metal-semiconductor Schottky diode that is constructed at the end of a micromachined tip of a semiconductor wafer. A process is disclosed for micromachining the tip of the semiconductor wafer and then of creating a photodiode at the tip, with the photodiode having an optical aperture of a size less than 1000 nanometers.

摘要翻译： 具有亚50纳米尖端半径的亚微米光电二极管探针用于纳米尺度的光学表面表征。 纳米探针检测被照射表面的近场中的亚波长光强度变化。 探针包括金属半导体肖特基二极管，其构造在半导体晶片的微加工尖端的末端。 公开了一种用于微加工半导体晶片的尖端然后在尖端产生光电二极管的工艺，其中光电二极管具有尺寸小于1000纳米的光学孔径。

公开(公告)号：US20090289213A1

公开(公告)日：2009-11-26

申请号：US12279308

申请日：2006-02-13

申请人： Juergen Pipper ,  Tseng-Ming Hsieh ,  Pavel Neuzil

发明人： Juergen Pipper ,  Tseng-Ming Hsieh ,  Pavel Neuzil

IPC分类号： H01F1/00

CPC分类号： C07K1/22 ,  B01D15/3804 ,  B01J20/28009 ,  B01J2220/54 ,  B03C1/01 ,  C12M25/01 ,  G01N33/5432 ,  G01N33/5436 ,  G01N2446/00

摘要： The invention provides a method of processing a biological and/or chemical sample. The method includes providing a fluid droplet, which includes an inner phase and an outer phase. The outer phase is immiscible with the inner phase, and the outer phase is surrounding the inner phase. The inner phase includes the biological and/or chemical sample. The fluid droplet furthermore comprises magnetically attractable matter. The method also includes providing at least one surface, which is of such a texture and such a wettability for the fluid of the inner phase of the fluid droplet, that the fluid droplet remains intact upon being contacted therewith. The method further includes disposing the fluid droplet onto the at least one surface. The method also includes performing a process on the biological and/or chemical sample in the fluid droplet.

摘要翻译： 本发明提供了一种处理生物和/或化学样品的方法。 该方法包括提供包括内相和外相的流体液滴。 外相与内相不混溶，外相围绕内相。 内相包括生物和/或化学样品。 流体液滴还包括磁吸引物质。 该方法还包括提供至少一个表面，其具有这样的质地和对流体液滴的内相的流体的润湿性，使得流体液滴在与其接触时保持完整。 该方法还包括将流体液滴设置在至少一个表面上。 该方法还包括对流体液滴中的生物和/或化学样品进行处理。