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公开(公告)号：US20190201898A1
公开(公告)日：2019-07-04
申请号：US16224626
申请日：2018-12-18
Applicant: STMICROELECTRONICS S.R.L.
Inventor： Davide CUCCHI , Marco Angelo BIANCHESSI , Alessandro COCCI , Lillo RAIA , Lorenzo BRUNO , Nadia SERINA , Marco CEREDA , Danilo PIROLA , Pietro FERRARI , Francesco FERRARA , Alessandro Paolo BRAMANTI
IPC: B01L3/00 , C12Q1/6806
CPC classification number: B01L3/502715 , B01L3/502738 , B01L2200/026 , B01L2200/0621 , B01L2200/0668 , B01L2200/10 , B01L2300/022 , B01L2300/044 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2400/043 , B01L2400/0487 , B01L2400/049 , B01L2400/0677 , C12Q1/6806 , G01N1/34 , C12Q2531/113 , C12Q2561/113 , C12Q2563/143 , C12Q2563/149 , C12Q2565/501
Abstract: A sample treatment and molecule analysis cartridge is configured to be mounted in a treatment machine vertically. The cartridge has a sample inlet opening, a fluidic inlet, and a fluidic outlet. The cartridge houses an extraction chamber extending vertically from the sample inlet opening and connected to the fluidic inlet; a waste chamber extending vertically, alongside the extraction chamber; and a collector extending along the extraction chamber and the waste chamber and having a smaller height than the extraction chamber and the waste chamber. A fluidic circuit connects together the extraction chamber, the waste chamber, the collector, the fluidic inlet, and the fluidic outlet, and is configured to connect the fluidic outlet to vent openings of the extraction chamber, the waste chamber, and the collector, and to connect the bottom end of the extraction chamber to the fluidic inlet, the waste chamber, and the collector.
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公开(公告)号：US20230160024A1
公开(公告)日：2023-05-25
申请号：US17531313
申请日：2021-11-19
Applicant: STMICROELECTRONICS S.r.l.
Inventor： Massimiliano PESATURO , Lillo RAIA , Salvatore PETRALIA , Domenico GIUSTI , Marco FERRERA
CPC classification number: C12Q1/701 , C12Q1/686 , C12Q1/6806 , B01L3/527 , B01L7/52 , B41M5/0023 , B01L2200/0647 , B01L2200/0689 , B01L2200/12 , B01L2200/16 , B01L2300/0819 , B01L2300/16
Abstract: A substrate has a plurality of microdots positioned thereon. Each microdot contains one or more primers for gene amplification for a particular target gene. The microdots are placed on the substrate and the substrate is positioned in a housing. The housing has a sample fluid to be tested introduced therein covering the microdot array. While the sample fluid is overlying the substrate, the amplification of the target gene is carried out if it is present within the sample. If the target gene that matches the primers is not present, then amplification will not take place. The fluid also contains fluorophores which will be fixed into the gene as it increases in size as it clearly detects if gene amplification has occurred by detecting the amount of light detected for a particular microdot. In a preferred embodiment, the sample fluid is placed on top of a sealing layer that is less dense then water, such as wax or mineral oil. During a heating of the sample fluid and sealing layer, the sample fluid will sink to the bottom of the sealing layer so that it is fully encased and protected.
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3.发明申请公开(公告)号：US20190201897A1
公开(公告)日：2019-07-04
申请号：US16221152
申请日：2018-12-14
Applicant: STMICROELECTRONICS S.R.L.
Inventor： Marco CEREDA , Lillo RAIA , Danilo PIROLA
CPC classification number: B01L3/5082 , A61B5/15003 , A61B5/150221 , A61B5/150351 , A61B5/150389 , A61B5/150503 , A61B5/150732 , A61B5/154 , B01F13/0059 , B01F13/0255 , B01F13/0818 , B01L3/5023 , B01L3/502707 , B01L3/502715 , B01L3/502738 , B01L3/5029 , B01L3/508 , B01L3/50825 , B01L3/52 , B01L3/523 , B01L3/527 , B01L9/527 , B01L2200/025 , B01L2200/026 , B01L2200/0621 , B01L2200/0642 , B01L2200/0668 , B01L2200/0673 , B01L2200/0689 , B01L2200/10 , B01L2200/141 , B01L2200/16 , B01L2300/022 , B01L2300/023 , B01L2300/044 , B01L2300/0609 , B01L2300/0681 , B01L2300/08 , B01L2300/0816 , B01L2300/0819 , B01L2300/0829 , B01L2300/0848 , B01L2300/0851 , B01L2300/0858 , B01L2300/0864 , B01L2300/087 , B01L2300/12 , B01L2300/16 , B01L2300/1827 , B01L2400/04 , B01L2400/0406 , B01L2400/043 , B01L2400/0487 , B01L2400/049 , B01L2400/0677 , C12Q1/6806 , C12Q1/6844 , C12Q2565/629
Abstract: An analysis unit formed by an analysis body housing an analysis chamber and having a sample inlet and a supply channel configured to fluidically connect the sample inlet to the analysis chamber. Dried assay reagents are arranged in the analysis chamber and are contained in an alveolar mass. For instance, the alveolar mass is a lyophilized mass formed by excipients and by assay-specific reagents.
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公开(公告)号：US20220161259A1
公开(公告)日：2022-05-26
申请号：US17671382
申请日：2022-02-14
Applicant: STMICROELECTRONICS S.r.l.
Inventor： Davide CUCCHI , Marco Angelo BIANCHESSI , Alessandro COCCI , Lillo RAIA , Lorenzo BRUNO , Nadia SERINA , Marco CEREDA , Danilo PIROLA , Pietro FERRARI , Francesco FERRARA , Alessandro Paolo BRAMANTI
IPC: B01L3/00 , C12Q1/6806
Abstract: A sample treatment and molecule analysis cartridge is configured to be mounted in a treatment machine vertically. The cartridge has a sample inlet opening, a fluidic inlet, and a fluidic outlet. The cartridge houses an extraction chamber extending vertically from the sample inlet opening and connected to the fluidic inlet; a waste chamber extending vertically, alongside the extraction chamber; and a collector extending along the extraction chamber and the waste chamber and having a smaller height than the extraction chamber and the waste chamber. A fluidic circuit connects together the extraction chamber, the waste chamber, the collector, the fluidic inlet, and the fluidic outlet, and is configured to connect the fluidic outlet to vent openings of the extraction chamber, the waste chamber, and the collector, and to connect the bottom end of the extraction chamber to the fluidic inlet, the waste chamber, and the collector.
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公开(公告)号：US20190201905A1
公开(公告)日：2019-07-04
申请号：US16231272
申请日：2018-12-21
Applicant: STMICROELECTRONICS S.R.L.
Inventor： Marco Angelo BIANCHESSI , Lillo RAIA
CPC classification number: B01L3/502715 , B01L3/502738 , B01L2200/026 , B01L2200/0621 , B01L2200/0668 , B01L2200/10 , B01L2300/022 , B01L2300/044 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2400/043 , B01L2400/0487 , B01L2400/049 , B01L2400/0677 , G01N35/00029 , G01N35/1095 , G01N2035/00158
Abstract: A microfluidic group includes a female connector and a male needle connector. The female connector has a connector chamber in a containment body; a duct extending in the containment body to a duct opening on a first face of the connector chamber; a needle entry hole extending from a lateral face of the containment body to a second face, not facing the first face of the connector chamber; and a gasket arranged in the connector chamber. The gasket has a side wall internally delimiting a cavity and extending in part adjacent to the second face of the connector chamber. The cavity of the gasket faces the first face of the connector chamber.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20230130810A1
公开(公告)日：2023-04-27
申请号：US17967245
申请日：2022-10-17
Applicant: STMICROELECTRONICS S.r.l.
Inventor： Lillo RAIA , Alessandro FREGUGLIA , Massimiliano PESATURO
Abstract: A chip for biochemical reactions comprising: a first body including a plurality of first through openings arranged according to an arrangement pattern; a second body, having a hydrophilic surface, coupled to the first body on the hydrophilic surface; and an intermediate layer, which extends over the hydrophilic surface and forms a coupling interface between the first and the second bodies. The intermediate layer is of hydrophobic material, extends continuously over the hydrophilic surface, and has a plurality of second through openings through which respective regions of the hydrophilic surface are exposed. The hydrophilic regions may be functionalized for carrying out a PCR.
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公开(公告)号：US20210394181A1
公开(公告)日：2021-12-23
申请号：US17465732
申请日：2021-09-02
Applicant: STMICROELECTRONICS S.R.L.
Inventor： Marco CEREDA , Lillo RAIA , Danilo PIROLA
Abstract: An analysis unit formed by an analysis body housing an analysis chamber and having a sample inlet and a supply channel configured to fluidically connect the sample inlet to the analysis chamber. Dried assay reagents are arranged in the analysis chamber and are contained in an alveolar mass. For instance, the alveolar mass is a lyophilized mass formed by excipients and by assay-specific reagents.
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公开(公告)号：US20190201899A1
公开(公告)日：2019-07-04
申请号：US16226590
申请日：2018-12-19
Applicant: STMICROELECTRONICS S.R.L.
Inventor： Marco CEREDA , Lillo RAIA , Alessandro Paolo BRAMANTI
CPC classification number: B01L9/527 , B01L3/5023 , B01L3/502707 , B01L3/502715 , B01L3/502738 , B01L3/5029 , B01L3/508 , B01L3/5082 , B01L3/50825 , B01L3/52 , B01L3/523 , B01L3/527 , B01L2200/025 , B01L2200/026 , B01L2200/0621 , B01L2200/0642 , B01L2200/0668 , B01L2200/0673 , B01L2200/0689 , B01L2200/10 , B01L2200/141 , B01L2200/16 , B01L2300/022 , B01L2300/023 , B01L2300/044 , B01L2300/0609 , B01L2300/0681 , B01L2300/08 , B01L2300/0816 , B01L2300/0819 , B01L2300/0829 , B01L2300/0848 , B01L2300/0851 , B01L2300/0858 , B01L2300/0864 , B01L2300/087 , B01L2300/12 , B01L2300/16 , B01L2300/1827 , B01L2400/04 , B01L2400/0406 , B01L2400/043 , B01L2400/0487 , B01L2400/049 , B01L2400/0677 , B29C43/021 , B29C43/14 , B29C43/18 , B29L2031/753
Abstract: A solid reagent containment unit is formed by a support; a frame body fixed to the support and delimiting internally, together with the support, an analysis volume; a reagent-adhesion structure within the analysis volume; and at least one reagent cavity, which extends within the reagent-adhesion structure. The reagent-adhesion structure is of an adhesion material embossable at temperatures lower by 6-8° C. than its own melting point and has a melting point such as not to interfere with the analysis. The reagent cavity forms a retention wall, laterally surrounding the reagent cavity, and houses dried reagents. The adhesion material is chosen among wax, such as paraffin, a polymer, such as polycaprolactone, a solid fat, such as cocoa butter, and a gel, such as hydrogel or organogel.
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9.发明公开公开(公告)号：US20240307876A1
公开(公告)日：2024-09-19
申请号：US18674548
申请日：2024-05-24
Applicant: STMICROELECTRONICS S.r.l.
Inventor： Marco CEREDA , Lillo RAIA , Danilo PIROLA
IPC: B01L3/00 , A61B5/15 , A61B5/154 , B01F33/30 , B01F33/40 , B01F33/452 , B01L9/00 , C12M3/06 , C12Q1/6806 , C12Q1/6844
CPC classification number: B01L3/502753 , A61B5/15003 , A61B5/150221 , A61B5/150351 , A61B5/154 , B01F33/30 , B01F33/406 , B01F33/452 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/5029 , B01L3/508 , B01L3/5082 , B01L3/52 , B01L3/527 , B01L9/527 , C12M23/16 , A61B5/150389 , A61B5/150503 , A61B5/150732 , B01L3/5023 , B01L3/502707 , B01L3/50825 , B01L3/523 , B01L2200/025 , B01L2200/026 , B01L2200/0621 , B01L2200/0642 , B01L2200/0668 , B01L2200/0673 , B01L2200/0689 , B01L2200/10 , B01L2200/141 , B01L2200/16 , B01L2300/022 , B01L2300/023 , B01L2300/044 , B01L2300/0609 , B01L2300/0681 , B01L2300/08 , B01L2300/0816 , B01L2300/0819 , B01L2300/0829 , B01L2300/0848 , B01L2300/0851 , B01L2300/0858 , B01L2300/0864 , B01L2300/087 , B01L2300/12 , B01L2300/16 , B01L2300/1827 , B01L2400/04 , B01L2400/0406 , B01L2400/043 , B01L2400/0487 , B01L2400/049 , B01L2400/0677 , C12Q1/6806 , C12Q1/6844
Abstract: An analysis unit formed by an analysis body housing an analysis chamber and having a sample inlet and a supply channel configured to fluidically connect the sample inlet to the analysis chamber. Dried assay reagents are arranged in the analysis chamber and are contained in an alveolar mass. For instance, the alveolar mass is a lyophilized mass formed by excipients and by assay-specific reagents.
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公开(公告)号：US20230058091A1
公开(公告)日：2023-02-23
申请号：US17981299
申请日：2022-11-04
Applicant: STMICROELECTRONICS S.r.l.
Inventor： Marco CEREDA , Lillo RAIA , Alessandro Paolo BRAMANTI
Abstract: A solid reagent containment unit is formed by a support; a frame body fixed to the support and delimiting internally, together with the support, an analysis volume; a reagent-adhesion structure within the analysis volume; and at least one reagent cavity, which extends within the reagent-adhesion structure. The reagent-adhesion structure is of an adhesion material embossable at temperatures lower by 6-8° C. than its own melting point and has a melting point such as not to interfere with the analysis. The reagent cavity forms a retention wall, laterally surrounding the reagent cavity, and houses dried reagents. The adhesion material is chosen among wax, such as paraffin, a polymer, such as polycaprolactone, a solid fat, such as cocoa butter, and a gel, such as hydrogel or organogel.
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