公开(公告)号：US20050075632A1

公开(公告)日：2005-04-07

申请号：US10679158

申请日：2003-10-03

申请人： Thomas Russell ,  Lauralan Terrill-Grisoni ,  Patrick Culley ,  Therise Ruffin ,  Kevin Raburn

发明人： Thomas Russell ,  Lauralan Terrill-Grisoni ,  Patrick Culley ,  Therise Ruffin ,  Kevin Raburn

IPC分类号： A61B19/00 ,  A61B17/58

CPC分类号： A61B90/50 ,  A61B34/20 ,  A61B2034/2055 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/3983

摘要： Surgical positioners may include platforms, surgical item positioners and/or surgical references as well as methods for using stabilizer platforms, surgical item positioners and/or surgical references. Stabilizer platforms may include low profile platforms rigidly mounted to portions of an individual's anatomy. Various items may be secured and/or stabilized by the stabilizer platform, including support platforms as well as surgical references. Support platforms may stabilize and assist surgeons in using, navigating, aligning and positioning surgical items. Surgical references may include modular fiducial systems that may be secured to stabilizer platforms, support platforms, surgical items and/or directly to portions of an individual's anatomy.

摘要翻译： 手术定位器可以包括平台，外科物品定位器和/或手术参考以及使用稳定器平台，手术物品定位器和/或手术参考的方法。 稳定器平台可以包括刚性地安装到个体解剖结构的部分的低轮廓平台。 各种物品可以通过稳定剂平台来固定和/或稳定，包括支撑平台以及手术参考。 支撑平台可以稳定和辅助外科医生使用，导航，对准和定位手术物品。 手术参考可以包括可以固定到稳定器平台，支撑平台，手术物品和/或直接到个体解剖结构的部分的模块化基准系统。

公开(公告)号：US20050149024A1

公开(公告)日：2005-07-07

申请号：US10936996

申请日：2004-09-08

申请人： Joseph Ferrante ,  Angie Mines ,  Anthony James ,  Thomas Russell ,  Roy Sanders

发明人： Joseph Ferrante ,  Angie Mines ,  Anthony James ,  Thomas Russell ,  Roy Sanders

IPC分类号： A61B17/16 ,  A61B17/72 ,  A61B17/74 ,  A61B17/78 ,  A61B17/80 ,  A61B17/56

CPC分类号： A61B17/744 ,  A61B17/1604 ,  A61B17/1615 ,  A61B17/1633 ,  A61B17/164 ,  A61B17/1668 ,  A61B17/1684 ,  A61B17/1728 ,  A61B17/72 ,  A61B17/7233 ,  A61B17/725 ,  A61B17/7258 ,  A61B17/7283 ,  A61B17/746 ,  A61B17/8061

摘要： Systems, devices and methods are disclosed for treating fractures. The systems, devices and methods may include one or both of an implant, such as an intramedullary nail, and a fastening assembly, such as a lag screw and compression screw assembly. The implant in some embodiments has a proximal section with a transverse aperture and a cross-section that may be shaped to more accurately conform to the anatomical shape of cortical bone and to provide additional strength and robustness in its lateral portions, preferably without requiring significant additional material. The fastening assembly may be received to slide, in a controlled way, in the transverse aperture of the implant. In some embodiments, the engaging member and the compression device are configured so that the compression device interacts with a portion of the implant and a portion of the engaging member to enable controlled movement between the first and second bone fragments. This configuration is useful for, among other things, compressing a fracture.

摘要翻译： 公开了用于治疗骨折的系统，装置和方法。 系统，装置和方法可以包括植入物（例如髓内钉）和紧固组件中的一个或两个，例如拉力螺钉和压缩螺钉组件。 在一些实施例中，植入物具有近端部分，其具有横向孔和横截面，该截面可以被成形为更精确地符合皮质骨的解剖形状并且在其侧向部分中提供额外的强度和鲁棒性，优选地不需要显着的附加 材料。 紧固组件可被接收以可控的方式在植入物的横向孔中滑动。 在一些实施例中，接合构件和压缩装置被构造成使得压缩装置与植入物的一部分和接合构件的一部分相互作用以实现第一和第二骨碎片之间的受控运动。 这种配置对于压缩骨折尤为重要。

公开(公告)号：US5554505A

公开(公告)日：1996-09-10

申请号：US160986

申请日：1993-12-01

申请人： Constance M. Hajek ,  Thomas Russell

发明人： Constance M. Hajek ,  Thomas Russell

IPC分类号： G01N1/28 ,  G01N1/30 ,  G01N1/31 ,  G01N15/06 ,  G01N15/14 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G01N33/574 ,  G01N21/00 ,  G01N33/80

CPC分类号： G01N33/574 ,  G01N1/312 ,  G01N15/147 ,  G01N15/0625 ,  G01N15/1475 ,  G01N2015/1472

摘要： An optical screening method and apparatus for identifying both the morphology and selected characteristics or properties expressed by cells, such as cancer cells. The cells are combined with one or more different sets of microspheres, each set having a reactant bond thereto which will bind to a specific molecule which can exist on one or more types of cancer cells. The cells and microspheres are formed as a smear on a slide, stained with a histological type stain and optically viewed to identify the type of cells to which the different sets of microspheres do or do not bind. The different sets of microspheres are optically differentiated by having different optical characteristics, such as size, shape, color or combinations thereof. A fast cancer cell screening method or panel is provided by adding different sets of microspheres having different reactants bound thereto to different sample portions and optically screening the different sample smears. The microspheres also can be removed from a sample portion with any cells bound thereto and compared to another non-modified sample portion to ascertain if the cancer cells of interest have been removed from the sample portion.

摘要翻译： 一种光学筛选方法和装置，其用于鉴别由诸如癌细胞的细胞表达的形态和所选特征或特性。 细胞与一个或多个不同组的微球组合，每组具有与其结合的反应物键，其将结合可存在于一种或多种类型的癌细胞上的特定分子。 细胞和微球体在载玻片上形成为涂片，用组织学染色染色，并以光学方式观察以鉴定不同组的微球体与其结合的细胞类型。 通过具有不同的光学特性，例如尺寸，形状，颜色或其组合，不同组的微球被光学分化。 通过将不同的具有不同反应物的微球体组合到不同的样品部分并对不同的样品涂片进行光学筛选来提供快速的癌细胞筛选方法或小组。 也可以从具有结合于其上的任何细胞的样品部分中除去微球体，并与另一个未修饰的样品部分进行比较，以确定目的癌细胞是否已经从样品部分去除。

公开(公告)号：US20130034893A1

公开(公告)日：2013-02-07

申请号：US13566003

申请日：2012-08-03

申请人： Zhiyu Li ,  Thomas Russell ,  Jun Gao

发明人： Zhiyu Li ,  Thomas Russell ,  Jun Gao

IPC分类号： C07K1/107 ,  C07K17/02 ,  C07K14/00 ,  C12N11/14 ,  C07K14/765

CPC分类号： C07K1/1077 ,  B01J20/28009 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3217 ,  B01J20/3229 ,  B01J20/3274 ,  B01J20/3282 ,  B01J39/26 ,  B01J41/20 ,  C07K1/22 ,  C07K17/14 ,  G01N33/532

摘要： Functionalized magnetic particles are emerging as a reliable and convenient technique in the purification of biomacromolecules (proteins and nucleic acids). We disclose a novel coupling procedure that can be used to create stable ferromagnetic nickel particles coated with Protein A for the affinity purification of antibody. The protein purification procedure is gentle, scalable, automatable, efficient and economical. By modifying the functional groups of amino acids in the protein coating, nickel particles can be used not only for affinity purification but for other sample preparation and chromatographic applications as well including nucleic acid isolations. The method can be easily modified for small and medium scale antibody purification in lab and pre-clinical research.

摘要翻译： 功能化磁性颗粒正在成为生物大分子（蛋白质和核酸）纯化中的可靠和方便的技术。 我们公开了一种新的偶联方法，可用于产生用蛋白A包被的稳定的铁磁性镍颗粒进行抗体亲和纯化。 蛋白质纯化程序温和，可扩展，可自动化，高效和经济。 通过改变蛋白质包衣中氨基酸的官能团，镍颗粒不仅可用于亲和纯化，还可用于其他样品制备和色谱应用，包括核酸分离。 该方法可以容易地修改用于实验室和临床前研究中的中小规模抗体纯化。

公开(公告)号：US20060149265A1

公开(公告)日：2006-07-06

申请号：US11219850

申请日：2005-09-07

申请人： Anthony James ,  Joseph Ferrante ,  Paul Tornetta ,  Thomas Russell

发明人： Anthony James ,  Joseph Ferrante ,  Paul Tornetta ,  Thomas Russell

IPC分类号： A61B17/58

CPC分类号： A61B17/8057 ,  A61B17/863

摘要： A locking fastener for use with a bone plate. The fastener has threads on its shank to engage bone and threads on its head to engage the internal threads of the bone plate. The threads in the head may have a constant major diameter and a tapered minor diameter that creates a radial interference fit. The threads in the head may also have a variable pitch that creates an axial interference fit. The head may have a low profile to reduce soft tissue irritation.

摘要翻译： 一种与骨板一起使用的锁定紧固件。 紧固件在其柄上具有螺纹以将骨头和螺纹接合在其头部上以接合骨板的内螺纹。 头部中的螺纹可以具有恒定的大直径和形成径向干涉配合的锥形小直径。 头部中的螺纹还可具有产生轴向过盈配合的可变间距。 头部可能具有较低的轮廓以减少软组织刺激。

公开(公告)号：US20050232248A1

公开(公告)日：2005-10-20

申请号：US11153827

申请日：2005-06-15

申请人： John Norris ,  Thomas Russell

发明人： John Norris ,  Thomas Russell

IPC分类号： H04M3/54 ,  H04L12/28 ,  H04L12/66 ,  H04M3/00 ,  H04M3/42 ,  H04M3/428 ,  H04M7/00 ,  H04M7/12 ,  H04M11/00 ,  H04Q3/72

CPC分类号： H04M3/4281 ,  H04L12/66 ,  H04M3/42 ,  H04M3/42042 ,  H04M3/42102 ,  H04M3/428 ,  H04M7/006 ,  H04M7/12 ,  H04M2203/156 ,  H04M2203/2011 ,  H04M2242/22 ,  H04Q3/72

摘要： Conventional Internet access service and new computer programs are added to a conventional telephone central office. This system is able to alert a subscriber whose telephone line is connected to the Internet of a waiting call via the Internet access connection. Specifically, in response to a call that is waiting for a subscriber, the system establishes a new communication with the subscriber using the Internet access connection and new programs in the subscriber's data terminal. The system then notifies the subscriber of the waiting call via the Internet access connection. The system may then forward the telephone call to the subscriber via the Internet access connection responsive to a subscriber's request to do so without terminating the subscriber's Internet connection, or the subscriber may choose to answer the call in a conventional manner, or may select another option in response to the call notification.

公开(公告)号：US06453281B1

公开(公告)日：2002-09-17

申请号：US08688299

申请日：1996-07-30

申请人： Timothy L. Walters ,  Anil K. Agarwal ,  Thomas Russell

发明人： Timothy L. Walters ,  Anil K. Agarwal ,  Thomas Russell

IPC分类号： G06F300

CPC分类号： G06F17/30755 ,  G06F3/0481 ,  G06F17/30749 ,  G06F17/30775

摘要： A method and apparatus for storing and retrieving information to and from a memory of a hand-held audio database device. The audio database device includes a graphics display provided on a hand-held housing for displaying graphical information. A microphone and a speaker are provided on the housing to receive and broadcast audio information from and to a user, respectively. The audio database device includes a memory configured to store graphical icons and to support a hierarchical memory structure comprising categories, wherein the icons graphically represent the categories. A user-actuated navigation control is provided on the housing and permits a user to navigate the categories in the hierarchical memory structure and to select a desired category. A processor is coupled to the memory, the display, and the navigation control and effects displaying of one of the icons on the display when the user is navigating a corresponding one of the categories, and storing of the audio information in the desired category of the memory.

摘要翻译： 一种用于存储和从手持音频数据库设备的存储器检索信息的方法和装置。 音频数据库装置包括设置在用于显示图形信息的手持外壳上的图形显示器。 麦克风和扬声器分别设置在外壳上以从用户接收和广播音频信息。 音频数据库设备包括被配置为存储图形图标并且支持包括类别的分层存储器结构的存储器，其中图标以图形方式表示类别。 在壳体上提供用户致动的导航控制，并且允许用户在分层存储器结构中导航类别并选择期望的类别。 处理器耦合到存储器，显示器和导航控制，并且当用户正在浏览相应的一个类别时将显示器上的图标之一显示出来，并将音频信息存储在期望的类别中 记忆。

公开(公告)号：US5468616A

公开(公告)日：1995-11-21

申请号：US58692

申请日：1993-04-29

申请人： Wallace H. Coulter ,  John D. Hollinger ,  Kenneth H. Kortright ,  Thomas Russell ,  Carlos Rodriguez ,  Ronald Paul

发明人： Wallace H. Coulter ,  John D. Hollinger ,  Kenneth H. Kortright ,  Thomas Russell ,  Carlos Rodriguez ,  Ronald Paul

IPC分类号： G01N33/50 ,  G01N33/569 ,  C12Q1/24 ,  G01N33/543

CPC分类号： G01N33/5005 ,  G01N33/56966 ,  G01N33/56972 ,  Y10S436/808

摘要： A method and apparatus for accelerating at least one definitive biological reaction including increasing the accuracy of determinations made therefrom. The reaction involves selected viable biological cells which are prepared in a small sample volume and rapidly mixed with microspheres having antibody specific at least to specific ones of the cells bound thereto. The microspheres can be magnetic and the bound cells can be magnetically removed to analyze the remaining blood cell populations. The microspheres can be introduced sequentially or simultaneously.

摘要翻译： 一种用于加速至少一种确定性生物反应的方法和装置，包括增加由其制备的测定精度。 该反应涉及选择的活体生物细胞，它们以小的样品体积制备，并且与具有抗体特异性至少与结合于其上的特定细胞的微球快速混合。 微球可以是磁性的，并且结合的细胞可以被磁性去除以分析剩余的血细胞群体。 微球可以顺序或同时引入。

公开(公告)号：US5348859A

公开(公告)日：1994-09-20

申请号：US703163

申请日：1991-05-20

申请人： Robert F. Brunhouse ,  Constance M. Hajek ,  Thomas Russell ,  Wallace H. Coulter

发明人： Robert F. Brunhouse ,  Constance M. Hajek ,  Thomas Russell ,  Wallace H. Coulter

IPC分类号： G01N15/14 ,  G01N1/31 ,  G01N15/00 ,  G01N15/06 ,  G01N33/49 ,  G01N33/543 ,  G01N33/569 ,  G01N33/574 ,  G01N33/53 ,  G01N33/48 ,  G06M11/02

CPC分类号： G01N1/312 ,  G01N15/147 ,  G01N33/54313 ,  G01N33/56972 ,  G01N33/574 ,  G01N15/0625 ,  G01N15/1475 ,  G01N2015/008 ,  G01N2015/1472 ,  G01N2015/1486

摘要： An optical screening method and apparatus for identifying and counting cells expressing selected characteristics or properties. The cells are combined with one or more different sets of microspheres, each set having a reactant bound thereto which will bind to a specific molecule which can exist on one or more types of the cells. The cells and microspheres are formed in a known volume on a slide and optically viewed to identify and count the type of cells to which the different sets of microspheres do or do not bind. The cell count then is related to the known volume to provide an absolute cell count. A plurality of different sample portions can be utilized with different reactants to obtain a multipart WBC differential/absolute count. The different sets of microspheres are optically differentiated by having different optical characteristics, such as size, shape, color or combinations thereof.

摘要翻译： 用于鉴定和计数表达所选特征或性质的细胞的光学筛选方法和装置。 细胞与一个或多个不同组的微球组合，每组具有与其结合的反应物，其结合可存在于一种或多种类型细胞上的特定分子。 细胞和微球体在载玻片上的已知体积中形成，并且在光学上被观察以鉴定和计数不同组的微球体与其结合的细胞的类型。 然后，细胞计数与已知体积相关，以提供绝对细胞计数。 可以将多个不同的样品部分用于不同的反应物以获得多部分WBC差异/绝对计数。 通过具有不同的光学特性，例如尺寸，形状，颜色或其组合，不同组的微球被光学分化。

公开(公告)号：US5231005A

公开(公告)日：1993-07-27

申请号：US849481

申请日：1992-03-10

申请人： Thomas Russell ,  Kenneth H. Kortright ,  Wallace H. Coulter ,  Carlos M. Rodriguez ,  Ronald Paul ,  Constance M. Hajek ,  James C. Hudson

发明人： Thomas Russell ,  Kenneth H. Kortright ,  Wallace H. Coulter ,  Carlos M. Rodriguez ,  Ronald Paul ,  Constance M. Hajek ,  James C. Hudson

IPC分类号： G01N15/00 ,  G01N15/10 ,  G01N15/12 ,  G01N15/14 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  G01N35/00

CPC分类号： G01N15/12 ,  G01N33/5002 ,  G01N33/5094 ,  G01N33/5302 ,  G01N33/54326 ,  G01N33/56972 ,  G01N15/14 ,  G01N2015/008 ,  G01N2015/1037 ,  G01N2015/1062 ,  G01N2015/1081 ,  G01N35/0098 ,  Y10T436/101666 ,  Y10T436/117497 ,  Y10T436/24

摘要： A method and apparatus for automatically and rapidly, retrieving, counting and/or analyzing at least one selected population of cells or formed bodies, such as a white blood cell population and at least one subset thereof of a whole blood sample or portion thereof. A volume of a biological medium containing the white blood cells is prepared and at least one reactant specific or preferential at least to some selected biological cells is introduced thereto and rapidly mixed for a short period of time. The opacity and/or volume parameter of the cells can be modified and the mixture is then counted and analyzed in one or more steps to obtain the desired white blood cell population and subset analysis. The biological sample can be a whole blood sample and the reactant can include or be a lyse or a monoclonal antibody bound to microspheres, which will bind to specific ones of the cells or a combination of lyse and microspheres with antibody bound thereto. The microspheres can be magnetic and the bound cells can be magnetically removed for retrieving and analyzing the remaining blood cell population.

摘要翻译： 一种用于自动并快速地检索，计数和/或分析全血样本或其部分的至少一个选定细胞群体或形成体，例如白细胞群体及其至少一个子集的方法和装置。 制备含有白细胞的体积的生物培养基，并将至少一种至少一种选择的生物细胞特异性或优先选择的反应物引入其中并在短时间内快速混合。 可以修改细胞的不透明度和/或体积参数，然后在一个或多个步骤中对混合物进行计数和分析，以获得所需的白细胞群体和子集分析。 生物样品可以是全血样品，并且反应物可以包括结合微球的裂解液或单克隆抗体，其将与特定细胞结合，或与结合抗体的溶血和微球体的组合。 微球可以是磁性的，并且结合的细胞可被磁性去除，用于检索和分析剩余的血细胞群体。