Novel penicillin derivatives
    2.
    发明授权
    Novel penicillin derivatives 失效
    新型青霉素衍生物

    公开(公告)号:US4190581A

    公开(公告)日:1980-02-26

    申请号:US929566

    申请日:1978-07-31

    摘要: Novel penicillin derivatives of the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R is hydrogen or hydroxy, are produced by acylating ampicillin, amoxicillin or a salt thereof with 4-hydroxy-pyrazino[2,3-f]quinoline-3-carboxylic acid or its functional derivative. They have high anti-pseudomonas activity and other antibacterial activity against gram-positive and gram-negative bacteria, and are of extremely low toxicity.

    摘要翻译: 通过用4-羟基 - 吡嗪并[2,3-f]将氨苄青霉素,阿莫西林或其盐酰化来制备其中R为氢或羟基的新颖的式 + TR 及其药学上可接受的盐的青霉素衍生物 ]喹啉-3-羧酸或其官能衍生物。 它们对革兰氏阳性和革兰氏阴性细菌具有很高的抗假单胞菌活性和其他抗菌活性,毒性极低。