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公开(公告)号：US20190249234A1
公开(公告)日：2019-08-15
申请号：US16393814
申请日：2019-04-24
发明人： Andrea Marziali , Milenko Despotovic , Joel Pel
IPC分类号： C12Q1/6832 , C12Q1/6825 , C12N15/10 , B03C5/02 , B01L3/00 , C12Q1/6837
CPC分类号： C12Q1/6832 , B01L3/502753 , B01L2200/0631 , B01L2300/1805 , B01L2400/0421 , B01L2400/0451 , B03C5/026 , B03C2201/18 , B03C2201/26 , C12N15/101 , C12Q1/6825 , C12Q1/6837 , C12Q2527/101 , C12Q2563/107 , C12Q2565/125
摘要： Methods and apparatus providing for the isolation of an unknown mutation from a sample comprising wild type nucleic acids and mutated nucleic acids through the application of time-varying driving fields and periodically varying mobility-altering fields to the sample within in an affinity matrix.
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公开(公告)号：US20170052147A1
公开(公告)日：2017-02-23
申请号：US15307221
申请日：2015-04-30
发明人： Therese HERLING , Thomas MUELLER , Tuomas KNOWLES
IPC分类号： G01N27/447 , B01L3/00
CPC分类号： G01N27/44795 , B01L3/502715 , B01L3/50273 , B01L3/502776 , B01L2200/0652 , B01L2300/0645 , B01L2300/0861 , B01L2300/0864 , B01L2300/0883 , B01L2400/0421 , B01L2400/0451 , B01L2400/0472 , G01N15/0266 , G01N27/44756 , G01N27/44769 , G01N27/44791
摘要： A method for analyzing a component is provided. The method includes the steps of: (iii) providing the electrophoretic or thermophoretic movement of the component into a second fluid flow; (iv) diverting a part of a first fluid flow, a part of the second fluid flow, or parts of the first fluid flow and the second fluid flow, wherein the diverted part is a third fluid flow which includes, the component; (v) contacting the third fluid flow with a fourth fluid flow, such as to form a laminar flow; (vi) providing the diffusion of the component into the fourth fluid flows.
摘要翻译： 提供了一种用于分析组件的方法。 该方法包括以下步骤：（iii）将组件的电泳或热泳运动提供到第二流体流中; （iv）使第一流体流的一部分，第二流体流的一部分或第一流体流和第二流体流的一部分转向，其中转向部分是包括该部件的第三流体流; （v）使第三流体流与第四流体流接触，以形成层流; （vi）提供组分向第四流体流中的扩散。
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公开(公告)号：US08853650B2
公开(公告)日：2014-10-07
申请号：US13871622
申请日：2013-04-26
发明人： Stefan Duhr , Phillip Baaske
IPC分类号： G01N21/64 , G01N21/63 , G01N21/62 , G01N21/17 , G01N15/14 , B01L3/00 , G01N15/00 , G01N15/02 , B01F13/00
CPC分类号： G01N33/6803 , B01F13/0079 , B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2400/0442 , B01L2400/0451 , B01L2400/0454 , C12Q1/68 , G01K11/12 , G01N15/0205 , G01N15/1434 , G01N15/1475 , G01N21/171 , G01N21/6408 , G01N21/6428 , G01N21/6458 , G01N21/6486 , G01N33/6845 , G01N2015/0065 , G01N2015/0092 , G01N2015/025 , G01N2021/6439 , G01N2201/02 , G01N2201/06113 , G01N2201/0638 , Y10T436/143333
摘要： The present invention relates to a method and an apparatus for a fast thermo-optical characterization of particles. In particular, the present invention relates to a method and a device to measure the stability of (bio)molecules, the interaction of molecules, in particular biomolecules, with, e.g. further (bio)molecules, particularly modified (bio)molecules, particles, beads, and/or the determination of the length/size (e.g. hydrodynamic radius) of individual (bio)molecules, particles, beads and/or the determination of length/size (e.g. hydrodynamic radius).
摘要翻译： 本发明涉及用于快速热光学表征颗粒的方法和装置。 特别地，本发明涉及测量（生物）分子的稳定性，特别是生物分子与分子的相互作用的方法和装置。 进一步（生物）分子，特别是改性（生物）分子，颗粒，珠粒和/或单个（生物）分子，颗粒，珠子的长度/尺寸（例如流体动力学半径）的确定和/或长度/ 尺寸（例如流体动力学半径）。
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公开(公告)号：US09995684B2
公开(公告)日：2018-06-12
申请号：US14533314
申请日：2014-11-05
发明人： Susanne Seidel , Dieter Braun , Stefan Duhr , Philipp Baaske
CPC分类号： G01N21/6486 , B01L3/0268 , B01L3/5027 , B01L3/50851 , B01L2200/0642 , B01L2200/0673 , B01L2300/0663 , B01L2300/0819 , B01L2300/0829 , B01L2300/0838 , B01L2300/1872 , B01L2400/0451 , G01N15/0205 , G01N21/645 , G01N21/6456 , G01N2201/06113
摘要： The present invention relates generally to a system and a method for thermo-optical measurements in a droplet of aqueous solution comprising particles of interest, the method comprising the following steps: providing the droplet of aqueous solution with a volume of less than 200 nl, wherein the aqueous solution is a first liquid and at least a part of the particles of interest are fluorescent particles; embedding the droplet of aqueous solution at least partly in a second liquid; irradiating a laser light beam into the droplet to obtain a spatial temperature distribution in the droplet around the irradiated laser light beam; exciting fluorescently said fluorescent particles and detecting fluorescence at least at one position or at around one position in the droplet or detecting the fluorescence distribution of said fluorescently excited particles, wherein said detection of fluorescence is performed at least once at a predetermined time after the start of the laser irradiation; and determining a characteristic of the particles of interest from the detected fluorescence intensity or fluorescence intensity distribution.
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公开(公告)号：US20170120248A1
公开(公告)日：2017-05-04
申请号：US15343784
申请日：2016-11-04
申请人： Lehigh University
发明人： Xuanhong Cheng , Chao Zhao , Alparslan Oztekin
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L3/502746 , B01L7/54 , B01L2300/1822 , B01L2300/185 , B01L2400/0451 , B01L2400/086 , B01L2400/088
摘要： Disclosed herein are apparatuses comprising, for example, a microfluidic channel device comprising a main body comprising a channel configured to provide for helical fluid motion of material within the channel; and a temperature control system that applies a temperature gradient to the channel. Methods of making and using the apparatus are also described.
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公开(公告)号：US20170030921A1
公开(公告)日：2017-02-02
申请号：US15254456
申请日：2016-09-01
发明人： Stefan DUHR , Philipp BAASKE
CPC分类号： G01N33/6803 , B01F13/0079 , B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2400/0442 , B01L2400/0451 , B01L2400/0454 , C12Q1/68 , G01K11/12 , G01N15/0205 , G01N15/1434 , G01N15/1475 , G01N21/171 , G01N21/6408 , G01N21/6428 , G01N21/6458 , G01N21/6486 , G01N33/6845 , G01N2015/0065 , G01N2015/0092 , G01N2015/025 , G01N2021/6439 , G01N2201/02 , G01N2201/06113 , G01N2201/0638 , Y10T436/143333
摘要： The present invention relates to a method and an apparatus for a fast thermo-optical characterisation of particles. In particular, the present invention relates to a method and a device to measure the stability of (bio)molecules, the interaction of molecules, in particular biomolecules, with, e.g. further (bio)molecules, particularly modified (bio)molecules, particles, beads, and/or the determination of the length/size (e.g. hydrodynamic radius) of individual (bio)molecules, particles, beads and/or the determination of length/size (e.g. hydrodynamic radius).
摘要翻译： 本发明涉及用于快速热光学表征颗粒的方法和装置。 特别地，本发明涉及测量（生物）分子的稳定性，特别是生物分子与分子的相互作用的方法和装置。 进一步（生物）分子，特别是改性（生物）分子，颗粒，珠粒和/或单个（生物）分子，颗粒，珠子的长度/尺寸（例如流体动力学半径）的确定和/或长度/ 尺寸（例如流体动力学半径）。
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公开(公告)号：US09459211B2
公开(公告)日：2016-10-04
申请号：US14504843
申请日：2014-10-02
发明人： Stefan Duhr , Philipp Baaske
IPC分类号： G01N21/64 , B01L3/00 , G01N15/02 , G01N15/14 , G01N21/17 , G01K11/12 , B01F13/00 , G01N15/00
CPC分类号： G01N33/6803 , B01F13/0079 , B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2400/0442 , B01L2400/0451 , B01L2400/0454 , C12Q1/68 , G01K11/12 , G01N15/0205 , G01N15/1434 , G01N15/1475 , G01N21/171 , G01N21/6408 , G01N21/6428 , G01N21/6458 , G01N21/6486 , G01N33/6845 , G01N2015/0065 , G01N2015/0092 , G01N2015/025 , G01N2021/6439 , G01N2201/02 , G01N2201/06113 , G01N2201/0638 , Y10T436/143333
摘要： The present invention relates to a method and an apparatus for a fast thermo-optical characterization of particles. In particular, the present invention relates to a method and a device to measure the stability of (bio)molecules, the interaction of molecules, in particular biomolecules, with, e.g. further (bio)molecules, particularly modified (bio)molecules, particles, beads, and/or the determination of the length/size (e.g. hydrodynamic radius) of individual (bio)molecules, particles, beads and/or the determination of length/size (e.g. hydrodynamic radius).
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公开(公告)号：US20070059510A1
公开(公告)日：2007-03-15
申请号：US11227663
申请日：2005-09-15
申请人： Thomas Krupenkin , Joseph Taylor
发明人： Thomas Krupenkin , Joseph Taylor
IPC分类号： B32B3/26
CPC分类号： B01L3/502792 , B01L2300/161 , B01L2400/0427 , B01L2400/0451 , Y10T428/249953
摘要： An apparatus comprising a plurality of closed-cells on a substrate surface. Each of the closed-cells comprise one or more internal walls that divide an interior of each of the closed-cells into a single first zone and a plurality of second zones. The first zone occupies a larger area of the closed-cell than any one of said second zones and the first and second zones are interconnected to form a common volume.
摘要翻译： 一种在衬底表面上包括多个闭孔的设备。 每个闭孔包括一个或多个将每个闭孔的内部分成单个第一区和多个第二区的内壁。 所述第一区占所述第二区中任何一个的所述闭孔的较大面积，并且所述第一和第二区被互连以形成公共体积。
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公开(公告)号：US20240294972A1
公开(公告)日：2024-09-05
申请号：US18473205
申请日：2023-09-22
发明人： Andrea Marziali , Milenko Despotovic , Joel Pel
IPC分类号： C12Q1/6832 , B01D29/05 , B01D35/027 , B01L3/00 , B01L7/00 , B03C5/00 , B03C5/02 , B62D5/06 , C12N15/10 , C12Q1/6813 , C12Q1/6825 , C12Q1/6837 , F15B1/26 , F15B21/041
CPC分类号： C12Q1/6832 , B01D29/05 , B01D35/027 , B01D35/0273 , B01L3/502753 , B03C5/005 , B03C5/026 , B62D5/062 , C12N15/101 , C12Q1/6825 , C12Q1/6837 , F15B1/26 , F15B21/041 , B01L7/52 , B01L2200/0631 , B01L2300/1805 , B01L2400/0421 , B01L2400/0451 , B03C2201/18 , B03C2201/26 , C12Q1/6813
摘要： Methods and apparatus providing for the isolation of an unknown mutation from a sample comprising wild type nucleic acids and mutated nucleic acids through the application of time-varying driving fields and periodically varying mobility-altering fields to the sample within in an affinity matrix.
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公开(公告)号：US20150125897A1
公开(公告)日：2015-05-07
申请号：US14504843
申请日：2014-10-02
发明人： Stefan DUHR , Philipp Baaske
CPC分类号： G01N33/6803 , B01F13/0079 , B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2400/0442 , B01L2400/0451 , B01L2400/0454 , C12Q1/68 , G01K11/12 , G01N15/0205 , G01N15/1434 , G01N15/1475 , G01N21/171 , G01N21/6408 , G01N21/6428 , G01N21/6458 , G01N21/6486 , G01N33/6845 , G01N2015/0065 , G01N2015/0092 , G01N2015/025 , G01N2021/6439 , G01N2201/02 , G01N2201/06113 , G01N2201/0638 , Y10T436/143333
摘要： The present invention relates to a method and an apparatus for a fast thermo-optical characterisation of particles. In particular, the present invention relates to a method and a device to measure the stability of (bio)molecules, the interaction of molecules, in particular biomolecules, with, e.g. further (bio)molecules, particularly modified (bio)molecules, particles, beads, and/or the determination of the length/size (e.g. hydrodynamic radius) ofindividual (bio)molecules, particles, beads and/or the determination of length/size (e.g. hydrodynamic radius).
摘要翻译： 本发明涉及用于快速热光学表征颗粒的方法和装置。 特别地，本发明涉及测量（生物）分子的稳定性，特别是生物分子与分子的相互作用的方法和装置。 进一步（生物）分子，特别是改性（生物）分子，颗粒，珠粒和/或个体（生物）分子，颗粒，珠子的长度/尺寸（例如流体动力学半径）的确定和/或长度/尺寸的确定 （例如流体动力学半径）。
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