公开(公告)号：US20240358888A1

公开(公告)日：2024-10-31

申请号：US18553461

申请日：2022-03-31

申请人： Vitrean Inc.

发明人： Ira H. SCHACHAR ,  Ronald A. Schachar

IPC分类号： A61L27/20 ,  A61L27/52 ,  A61L27/54 ,  C08J3/075

CPC分类号： A61L27/20 ,  A61L27/52 ,  A61L27/54 ,  C08J3/075 ,  A61L2400/06 ,  C08J2305/08

摘要： Methods for mixing highly concentrated hydrogels are provided herein. The methods can be performed aseptically. Hydrogels created by this process may include many types of polymers, which may include glycosaminoglycans such as hyaluronic acid. The hydrogels formed by the methods described herein may further include and/or incorporate other molecules having biological activity.

公开(公告)号：US20240351290A1

公开(公告)日：2024-10-24

申请号：US18444350

申请日：2024-02-16

申请人： Carnegie Mellon University

发明人： Andrew Hudson ,  Thomas Hinton ,  Adam Feinberg ,  Andrew Lee

IPC分类号： B29C64/40 ,  A61L27/20 ,  A61L27/22 ,  A61L27/24 ,  A61L27/52 ,  A61L27/56 ,  B29C64/106 ,  B29C64/165 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00

CPC分类号： B29C64/40 ,  A61L27/20 ,  A61L27/222 ,  A61L27/24 ,  A61L27/52 ,  A61L27/56 ,  B29C64/106 ,  B29C64/165 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00

摘要： This document describes systems and method of embedded printing for additive manufacturing. A print material is printed into a support material. The print material and the support material each have a fluid phase and a solid phase. The print material transitions from the fluid phase to the solid phase based on a fluid-fluid interaction with the support material. One or more parameters of the support material can be adjusted to cause a diffusion rate of the print material into the support material during the fluid-fluid interaction to be less than a threshold value. Multiple print materials can be printed into the support material simultaneously.

公开(公告)号：US20240335592A1

公开(公告)日：2024-10-10

申请号：US18743016

申请日：2024-06-13

申请人： Vanderbilt University

发明人： Scott A. Guelcher ,  Sichang Lu ,  Madison A.P. McGough ,  Katarzyna J. Zienkiewicz

IPC分类号： A61L27/48 ,  A61L27/10 ,  A61L27/18 ,  A61L27/20 ,  A61L27/26 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  C04B26/16 ,  C04B111/00 ,  C08G18/10 ,  C08G18/38 ,  C08G18/48 ,  C08G18/77 ,  C08G18/80

CPC分类号： A61L27/48 ,  A61L27/10 ,  A61L27/18 ,  A61L27/20 ,  A61L27/26 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  C04B26/16 ,  C08G18/10 ,  C08G18/3868 ,  C08G18/4833 ,  C08G18/771 ,  C08G18/8061 ,  A01K2207/20 ,  A61L2300/404 ,  A61L2300/412 ,  A61L2300/604 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/02 ,  C04B2111/00836

摘要： A hybrid composite and method for producing a polymer network are provided. The hybrid composite includes nanocrystalline hydroxyapatite (nHA) and polyurethane. The method for producing a polymer network includes reacting nanocrystalline hydroxyapatite (nHA) particles with lysine derived triisocyanate (LTI) to form a nHA/LTI hybrid prepolymer and reacting the prepolymer with a thioketal (TK) diol to form a nHA/poly(thioketal urethane) (PTKUR) hybrid polymer network.

公开(公告)号：US12102735B2

公开(公告)日：2024-10-01

申请号：US17298349

申请日：2019-12-02

申请人： NVD

发明人： Jean-Claude Giannotta ,  Charles Calleja

IPC分类号： A61L27/16 ,  A61L27/18 ,  A61L27/20 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  C08L33/26

CPC分类号： A61L27/52 ,  A61L27/18 ,  A61L27/20 ,  C08L33/26 ,  A61L2400/06

摘要： A biocompatible hydrogel has between 0.3% and 30% by weight of dry matter of a copolymer formed at least from acrylamide, chitosan and N,N′-methylenebisacrylamide, as well as a diffusing agent. The diffusing agent is advantageously selected from the group consisting of inert ingredients which have biomechanical properties and active ingredients. A method of manufacturing the hydrogel by copolymerizing, washing, and adding the diffusing agent is provided, as well as a mechanical visco-supplementation system adapted for external or internal use that includes the hydrogel, and an external or internal mechanical visco-supplementation kit including an acrylamide and chitosan copolymer crosslinked with N,N′-methylenebisacrylamide, and a diffusing agent in solid phase or in suspension, the copolymer and the diffusing agent having been previously mixed in the form of a hydrogel during manufacture or being adapted to be mixed extemporaneously to form a hydrogel.

公开(公告)号：US12097304B2

公开(公告)日：2024-09-24

申请号：US15591728

申请日：2017-05-10

申请人： BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS

发明人： Karrer M. Alghazali ,  Zeid A. Nima ,  Alexandru S. Biris

IPC分类号： A61L27/36 ,  A61L27/12 ,  A61L27/14 ,  A61L27/18 ,  A61L27/20 ,  A61L27/38 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61K9/14 ,  A61K31/4453 ,  A61K31/704 ,  C07C211/38 ,  C07C229/36 ,  C07D209/14 ,  C07D209/24 ,  C07D211/22 ,  C07D215/22 ,  C07D265/18 ,  C07D277/56 ,  C07D405/12 ,  C07D473/18 ,  C07D473/30 ,  C07D491/22 ,  C07D501/22 ,  C07H15/252 ,  C07H17/08

CPC分类号： A61L27/3695 ,  A61L27/12 ,  A61L27/14 ,  A61L27/18 ,  A61L27/20 ,  A61L27/3608 ,  A61L27/38 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/256 ,  A61L2300/258 ,  A61L2300/414 ,  A61L2400/08 ,  A61L2400/12 ,  A61L2430/02 ,  A61L27/18 ,  C08L67/04

摘要： A method for forming a biocompatible structure includes the steps of forming a layered structure having alternatively disposed first layers and second layers, where the first layers includes at least one polymer and first particles, and the second layers includes second particles; and treating the layered structure with a washing solvent to form the biocompatible structure, where the first particles are solvable in the washing solvent.

公开(公告)号：US20240299621A1

公开(公告)日：2024-09-12

申请号：US18423852

申请日：2024-01-26

申请人： Chitogel Limited

发明人： Peter-John WORMALD ,  Stephen Carl MORATTI ,  Lyall Robert HANTON ,  Simon ROBINSON ,  Alistair JUKES

IPC分类号： A61L27/20 ,  A61L27/36

CPC分类号： A61L27/20 ,  A61L27/3641

摘要： A haemostat agent in the form of a multi-layer patch comprising at least first and second layers, wherein said first layer comprises a composition comprising fibrous β-chitin (which may be sourced from a marine source such as squid pens) and one or more biocompatible polymer (for example, a polyethylene glycol (PEG) polymer or sodium polyphosphate (PolyP)), and said second layer comprises a film layer comprising fibrous β-chitin. In one particular application, the haemostat agent is used for treating carotid artery injury associated with endonasal surgery.

公开(公告)号：US12083245B2

公开(公告)日：2024-09-10

申请号：US15515049

申请日：2015-10-01

申请人： WAKE FOREST UNIVERSITY HEALTH SCIENCES

发明人： Sean V. Murphy ,  Aleksander Skardal ,  Anthony Atala

IPC分类号： A61L27/36 ,  A61K31/726 ,  A61K35/50 ,  A61K38/17 ,  A61K38/36 ,  A61K38/39 ,  A61L26/00 ,  A61L27/20 ,  A61L27/22 ,  A61L27/24 ,  A61L27/26 ,  A61L27/52 ,  A61L27/54 ,  A61L27/60

CPC分类号： A61L27/3604 ,  A61K31/726 ,  A61K35/50 ,  A61K38/177 ,  A61K38/36 ,  A61K38/39 ,  A61L26/0057 ,  A61L26/008 ,  A61L27/20 ,  A61L27/222 ,  A61L27/227 ,  A61L27/24 ,  A61L27/26 ,  A61L27/3641 ,  A61L27/3683 ,  A61L27/52 ,  A61L27/54 ,  A61L27/60 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2430/34

摘要： The present invention includes compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane powder. The compositions of the present invention comprise amniotic membrane powder and a scaffold. The methods of the present invention comprises applying a composition of the present invention to a subject to induce wound healing and tissue regeneration.

公开(公告)号：US20240285829A1

公开(公告)日：2024-08-29

申请号：US18650265

申请日：2024-04-30

申请人： Axogen Corporation

发明人： Jennifer FALERIS ,  Kasra TAJDARAN

IPC分类号： A61L27/38 ,  A61L27/20 ,  A61L27/22 ,  A61L27/24 ,  A61L27/52

CPC分类号： A61L27/3878 ,  A61L27/20 ,  A61L27/222 ,  A61L27/225 ,  A61L27/227 ,  A61L27/24 ,  A61L27/52 ,  A61L2430/32

摘要： The present disclosure provides fasciculated nerve grafts of customizable lengths and diameters, and methods of preparing the same. The grafts are made by digesting native extracellular matrix (ECM) around the nerve fascicles of a nerve tissue, and the epineurial sheath. One or more of the individual fascicles may then be entubulated in an entubulation material, embedded in or coated with a coating material, or both, to form a fasciculated nerve graft. The fasciculated nerve grafts are customizable and designed to bridge nerve gaps; the modularity of the fasciculated nerve graft allows for restoring continuity to nerve defects of virtually any length and allows for matching the diameter of the patient's recipient nerve.

公开(公告)号：US20240252715A1

公开(公告)日：2024-08-01

申请号：US18424626

申请日：2024-01-26

申请人： INSIGNIA PHARMACEUTICALS, LLC

发明人： David BAR-OR ,  Gregory THOMAS ,  Melissa HAUSBURG ,  Jason WILLIAMS ,  Raphael BAR-OR

IPC分类号： A61L27/20 ,  A61L27/52 ,  A61L27/54

CPC分类号： A61L27/20 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/222 ,  A61L2300/412 ,  A61L2430/06

摘要： The present disclosure provides methods and compositions comprising hyaluronic acid (HA) hydrogel in combination with a saturated fatty acid for treating osteoarthritis. In some embodiments, aspects of the disclosure relate to pharmaceutical compositions comprising HA hydrogel in combination with a steroid. In some embodiments, the pharmaceutical compositions may be administrable via local, topical, and injection. In some embodiments, the pharmaceutical composition may be administrable by intra-articular injection.

公开(公告)号：US20240216571A1

公开(公告)日：2024-07-04

申请号：US18415412

申请日：2024-01-17

申请人： Tricol Biomedical, Inc.

发明人： Brian Clare ,  Radim Dvorák ,  Simon McCarthy ,  Jirí Machát

IPC分类号： A61L15/28 ,  A61L15/42 ,  A61L24/00 ,  A61L24/08 ,  A61L27/20 ,  A61L27/50 ,  A61L27/56 ,  D01D1/02 ,  D01D5/08 ,  D01D5/084 ,  D01D5/18 ,  D01D10/02 ,  D01F1/02 ,  D01F9/00

CPC分类号： A61L15/28 ,  A61L15/425 ,  A61L24/0036 ,  A61L24/08 ,  A61L27/20 ,  A61L27/50 ,  A61L27/56 ,  D01D5/08 ,  D01D5/084 ,  D01D5/18 ,  D01F9/00 ,  A61L2400/04 ,  A61L2430/00 ,  D01D1/02 ,  D01D10/02 ,  D01F1/02

摘要： The present chitosan-based superfine fiber invention relates to compositions, formulations, and processes that result in numerous significant advantages for the production and use of superfine fiber bioactive matrices in biomedical applications. The present invention relates to superfine, chitosan-based fibers, wherein the chitosan-based fibers have a percentage chitosan content of at least about 20% w/w, and highly conformable and compliant matrices comprising such fibers, processes for their production, and related formulations. The superfine chitosan-based fibers of the invention preferably include microfibers with diameter less than or equal to about 10 microns and micron and submicron fibers that are about 2 microns and less.