摘要:
It has now been found that certain novel heterocyclic derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): R Preferred are those compounds of formula (I) where R and R3 taken together is =NCH(R )CH(R )N(R )-, =NC(R6)=C(R7)N(R8)-, or =CHN=C(R )N(R )-, and tautomers thereof, and where R and R taken together is -C(R11)=C(R12)C(R13)=C(R14) 1 12, -, where R,R,R 6 ,R 7 ,R8,R I1, R R 13 ,R 14 ,andX are described. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula (I), and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.
摘要:
The invention relates to a method that is suitable for producing useful products, which are usually retained in the interior of cells, in organisms and for obtaining the products from the latter, without destroying the productive organisms. The invention facilities an excess production and excretion into the surrounding medium. This method produces in particular high concentrations of the useful product in the product solution and obtains large quantities of the end products of metabolic pathways, which would normally be limited by feed-back inhibition of synthesis efficiency. The method is characterised in that transport systems produced naturally in the cell for accumulating/retaining said useful products are disabled, or their capacity for accumulating/retaining said useful products is impaired.
摘要:
Substituted heterocyclic compounds are disclosed. The compounds are useful for treating multidrug resistance. The compounds can be formulated in compositions with a carrier and, optionally, a therapeutic agent. One suitable substituted heterocyclic compound has formula (I).
摘要:
Substituted acyclic compounds are disclosed. The compounds are useful for treating multidrug resistance. The compounds can be formulated in compositions with a carrier and, optionally, a therapeutic agent. One suitable substituted acyclic compound has the formula: (1)
摘要:
MC4-R binding compounds of the formula (I): B-Z-E wherein B is an anchor moiety, Z is a central moiety, and E is an MC4-R interacting moiety are discussed. Methods of using the compounds to treat MC4-R associated disorders, such as disorders associated with weight loss, are also discussed.
摘要:
Described is an in vivo method of obtaining cell components, the cells concerned being suddenly changed from a first state, in which essentially constant conditions exist between the cell and the surrounding medium, to a second state, thus forcing the cells to react by discharging cell components into the surrounding medium in order to adapt to the conditions in the second state.
摘要:
The invention relates to compounds represented by general formula (I) (wherein R1, R3 and R4, which may be the same or different, each represents an optionally substituted heterocyclic methyl group, hydrogen, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, an optionally substituted phenyl group, α, β, γ, δ or ε (wherein R5, R6, R7, R8, R9 and R10, which may be the same or different, each represents an optionally substituted heterocyclic methyl group, hydrogen, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, or an optionally substituted phenyl group, and n represents 0, 1 or 2), R2 represents an optionally substituted heterocyclic methyl group, hydrogen, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, or an optionally substituted phenyl group, provided that the cases wherein R1 represents hydrogen, R2, R3 and R4 represent each a benzyl group and wherein R2 represents hydrogen and R1, R3 and R4 represent each a benzyl group are excluded), a process for preparing same, and insecticides containing same as active ingredients.
摘要:
Die vorliegende Erfindung beschreibt ein Amidin enthaltend mindestens eine Struktureinheit der Formel (I), sowie dessen Verwendung als Katalysator für die Vernetzung einer funktionellen Verbindung, insbesondere eines Silangruppen aufweisenden Polymers. Das beschriebene Amidin ist in einem einfachen Verfahren aus gut erhältlichen Grundstoffen herstellbar, bei Raumtemperatur weitgehend geruchlos und wenig toxisch. Es beschleunigt die Vernetzung von funktionellen Verbindungen überraschend gut und kann über den Rest, an welchen die Struktureinheit der Formel (I) gebunden ist, auf eine optimale Verträglichkeit mit unterschiedlichen Zusammensetzungen hin eingestellt werden, wodurch solche Zusammensetzungen nicht zu migrationsbedingten Fehlern wie Separation, Ausschwitzen oder Substratverschmutzung neigen.
摘要:
This disclosure provides compounds and compositions for use as analgesics and for the treatment of various conditions, such as pain, headaches, allodynia, and fibromyalgia. The disclosure also provides compounds that are ligands, and in some embodiments, modulators (e.g., agonists), for the imidazoline receptor type 1.