摘要:
There is disclosed the use of a compound of formula (I) wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of nitric oxide synthase activity is beneficial. Certain novel compounds of formula (Ia) and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof are disclosed; together with processes for their preparation, compositions containing them and their use in therapy. The compounds of formulae (I) and (Ia) are inhibitors of the enzyme nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease.
摘要:
There are provided novel compounds of formula (I), wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.
摘要:
There is disclosed the use of a compound of formula (I), wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of nitric oxide synthase activity is beneficial. Certain novel compounds of formula (Ia) and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof are disclosed; together with processes for their preparation, compositions containing them and their use in therapy. The compounds of formulae (I) and (Ia) are inhibitors of the enzyme nitric oxide synthase and are thereby particularly useful in the treatment or prohylaxis of inflammatory disease
摘要:
A fastener for fastening pipes or electrical conduit can be installed with the optional use of nails or screws. The fastener includes sharp teeth or spikes which can be hammered into an external surface, such as wood or masonry. The teeth or spikes are positioned, oriented, and otherwise configured to best suit the intended application. Installation can be accomplished using only the fastener itself and force exceeding a minimal threshold.
摘要:
In various embodiments, training objects are classified by human annotators, psychometric data characterizing the annotation of the training objects is acquired, a human-weighted loss function based at least in part on the classification data and the psychometric data is computationally derived, and one or more features of a query object are computationally classified based at least its part on the human-weighted loss function.
摘要:
Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic acid analysis. Nucleic acid analysis can be an integrated DNA amplification/DNA sequencing procedure.
摘要:
Systems and methods for reactively authorizing publication of information by a third party are coordinated through the use of a presence server. The presence server communicates with other communication nodes/devices to determine and relay publication information. Publication requests that are initially unauthorized, from the perspective of the presence server, are resolved.
摘要:
Locating devices and systems providing haptic tactile feedback are disclosed. In one embodiment, a locator includes a haptic handle configured to provide directional signals through an operator's sense of touch to aid in locating and tracing a buried conductor or other object such as a pipe or cable.
摘要:
The invention provides a 2-stroke internal combustion engine comprising two opposed cylinders, each cylinder housing two opposed pistons and having at least one exhaust port and at least one intake port, and a crankshaft having asymmetrically arranged journals and scotch-yoke mechanisms for driving the journals from the pistons. The pistons in each cylinder operate to open its exhaust port or ports before its intake port or ports and to close its exhaust port or ports before its intake port or ports.
摘要:
Embodiments of the present invention include a system and method for implementing a presence system. According to an embodiment of the present invention, responsive to receiving a request for presence information associated with a presentity from a watcher, the presence system receives instructions indicating that an authorization instance other than the presentity shall be given an opportunity to change or verify an authorization rule associated with the request for presence information. As a consequence, the presence system notifies the authorization instance of the request for presence information, thereby enabling the authorization instance to change or verify the authorization rule. The presence system also makes a final decision on the authorization rule on the basis of the instructions and a notification indicating a change or verification of the authorization rule.