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20 条记录 (耗时 0.036 秒)

    Method and structure for extracting molecular species
    3.
    发明授权
    Method and structure for extracting molecular species 有权
    提取分子种类的方法和结构

    公开(公告)号：US08101388B2

    公开(公告)日：2012-01-24

    申请号：US11904862

    申请日：2007-09-28

    申请人： Timothy E. McKnight ,  Anatoli V. Melechko ,  Michael L. Simpson

    发明人： Timothy E. McKnight ,  Anatoli V. Melechko ,  Michael L. Simpson

    IPC分类号： C12N13/00 ,  C12P1/00 ,  C12P21/00 ,  C12M1/00

    CPC分类号： C07K1/22

    摘要： The present invention in one embodiment provides a method for extracting molecular material including providing a probe comprising a penetration portion having a nanoscale surface for penetrating a biological compartment, a receptor present on the penetrating portion of the probe, wherein the receptor has an affinity for a target molecular material from the biological compartment; inserting the probe into the biological compartment, the receptor present on the penetrating portion of the probe engages the target molecular material; and extracting the probe and the target molecular material engaged to the inserting portion of the probe from the biological compartment.

    摘要翻译： 本发明在一个实施方案中提供了一种提取分子材料的方法，包括提供包含穿透部分的探针，所述探针具有用于穿透生物室的纳米级表面，存在于探针的穿透部分上的受体，其中所述受体对 来自生物室的靶分子物质; 将探针插入生物室中，存在于探针的穿透部分上的受体与目标分子材料接合; 以及从所述生物室提取与所述探针的插入部分接合的所述探针和所述靶分子材料。

    Implantable device for in-vivo intracranial and cerebrospinal fluid pressure monitoring
    6.
    发明授权
    Implantable device for in-vivo intracranial and cerebrospinal fluid pressure monitoring 失效
    用于体内颅内和脑脊液压监测的植入式装置

    公开(公告)号：US06533733B1

    公开(公告)日：2003-03-18

    申请号：US09406280

    申请日：1999-09-24

    申请人： Milton N. Ericson ,  Timothy E. McKnight ,  Stephen F. Smith ,  James O. Hylton

    发明人： Milton N. Ericson ,  Timothy E. McKnight ,  Stephen F. Smith ,  James O. Hylton

    IPC分类号： A61B500

    CPC分类号： A61B5/0031 ,  A61B5/031 ,  A61B2562/028 ,  A61M27/006 ,  Y10S128/903

    摘要： The present invention relates to a completely implantable intracranial pressure monitor, which can couple to existing fluid shunting systems as well as other internal monitoring probes. The implant sensor produces an analog data signal which is then converted electronically to a digital pulse by generation of a spreading code signal and then transmitted to a location outside the patient by a radio-frequency transmitter to an external receiver. The implanted device can receive power from an internal source as well as an inductive external source. Remote control of the implant is also provided by a control receiver which passes commands from an external source to the implant system logic. Alarm parameters can be programmed into the device which are capable of producing an audible or visual alarm signal. The utility of the monitor can be greatly expanded by using multiple pressure sensors simultaneously or by combining sensors of various physiological types.

    摘要翻译： 本发明涉及一种完全可植入的颅内压监测器，其可以耦合到现有的流体分流系统以及其它内部监测探针。 植入物传感器产生模拟数据信号，然后通过产生扩展码信号将其电子地转换为数字脉冲，然后通过射频发射器发送到患者外部位置到外部接收器。 植入的设备可以从内部源以及感应外部源接收电力。 植入物的远程控制也由控制接收器提供，控制接收器将命令从外部源传递到植入物系统逻辑。 可以将报警参数编程到能够产生声音或视觉报警信号的设备中。 可以通过同时使用多个压力传感器或通过组合各种生理类型的传感器来大大扩展显示器的效用。

    Method and apparatus for sustaining viability of biological cells on a substrate
    10.
    发明授权
    Method and apparatus for sustaining viability of biological cells on a substrate 有权
    维持生物细胞在基质上的生存力的方法和装置

    公开(公告)号：US08343766B2

    公开(公告)日：2013-01-01

    申请号：US13305134

    申请日：2011-11-28

    申请人： Timothy E. McKnight ,  Anatoli V. Melechko ,  Michael L. Simpson

    发明人： Timothy E. McKnight ,  Anatoli V. Melechko ,  Michael L. Simpson

    IPC分类号： C12N15/87

    CPC分类号： B01L3/02 ,  Y10S977/876

    摘要： A method for the transient transformation of a living biological cell having an intact cell membrane defining an intracellular domain, and an apparatus for the transient transformation of biological cells. The method and apparatus include introducing a compartmentalized extracellular component fixedly attached to a cellular penetrant structure to the intracellular domain of the cell, wherein the cell is fixed in a predetermined location and wherein the component is expressed within in the cell while being retained within the compartment and wherein the compartment restricts the mobility and interactions of the component within the cell and prevents transference of the component to the cell.

    摘要翻译： 用于瞬时转化具有限定细胞内结构域的完整细胞膜的活的生物细胞的方法和用于瞬时转化生物细胞的装置。 所述方法和装置包括将固定连接到细胞渗透结构的分隔的细胞外组分引入细胞的细胞内结构域，其中细胞被固定在预定位置，并且其中所述成分在细胞内表达，同时被保留在隔室内 并且其中所述隔室限制所述部件在所述电池内的移动性和相互作用并且防止所述部件移动到所述电池。