公开(公告)号：US20180074012A1

公开(公告)日：2018-03-15

申请号：US15818341

申请日：2017-11-20

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Jenn-Hann Larry Wang ,  Michael E. Miller ,  Raghavendhar Gautham ,  Yiwen Li ,  Rajiv Shah

IPC: G01N27/416 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1486 ,  G01N33/66 ,  G01N27/02 ,  A61M5/172 ,  A61M5/158 ,  A61B5/00 ,  A61B5/1495 ,  A61M5/142 ,  A61B5/053

CPC classification number: A61B5/1495 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20170184527A1

公开(公告)日：2017-06-29

申请号：US14980185

申请日：2015-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Jaeho Kim ,  Mike C. Liu ,  Andy Y. Tsai ,  Andrea Varsavsky ,  Fei Yu

IPC: G01N27/02 ,  G01N33/487 ,  G01N27/416 ,  G01N33/49

CPC classification number: G01N27/026 ,  G01N33/48707 ,  G01N33/49

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US20170055892A1

公开(公告)日：2017-03-02

申请号：US15272225

申请日：2016-09-21

Applicant: Medtronic MiniMed, Inc.

Inventor： Megan E. Little ,  Katherine T. Wolfe ,  Raghavendhar Gautham ,  Bradley Chi Liang ,  Rajiv Shah

IPC: A61B5/145 ,  G01N27/327 ,  A61B5/1486 ,  C12Q1/00

CPC classification number: A61B5/14532 ,  A61B5/14865 ,  A61B2562/125 ,  A61B2562/166 ,  A61B2562/222 ,  C12Q1/001 ,  C12Q1/006 ,  G01N27/3272 ,  Y10T29/49204

Abstract: The invention disclosed herein includes sensors having three dimensional configurations that allow expansive “360°” sensing (i.e. sensing analyte from multiple directions) in the environments in which such sensors are disposed. Embodiments of the invention provide analyte sensors having foldable substrates adapted to produce optimized configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

Abstract translation: 本文公开的本发明包括具有三维结构的传感器，其在这些传感器被布置的环境中允许宽广的“360°”感测（即感测来自多个方向的分析物）。 本发明的实施例提供了分析物传感器，其具有适于产生电极元件的优化配置的可折叠基底以及用于制造和使用这种传感器的方法。 本发明的典型实施方案包括用于治疗糖尿病的葡萄糖传感器。

公开(公告)号：US20160249840A1

公开(公告)日：2016-09-01

申请号：US14632731

申请日：2015-02-26

Applicant: Medtronic MiniMed, Inc.

Inventor： Daniel E. Pesantez ,  Jia Yao ,  Bradley C. Liang ,  Rajiv Shah

IPC: A61B5/1486 ,  C12Q1/00 ,  A61B5/145 ,  G01N27/327

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/14539 ,  C12Q1/005 ,  C12Q1/006 ,  G01N27/3272

Abstract: Embodiments of the invention provide amperometric analyte sensor systems comprising a plurality of electrodes including one or more electrodes designed to monitor pH in order to facilitate the sensing of analytes at different pH levels within a sensor environment. Typical embodiments of the invention include glucose oxidase based amperometric sensors used in the management of diabetes.

Abstract translation: 本发明的实施方案提供电流分析物传感器系统，其包括多个电极，包括设计成监测pH的一个或多个电极，以便于感测在传感器环境内的不同pH值下的分析物。 本发明的典型实施方案包括用于治疗糖尿病的基于葡萄糖氧化酶的电流传感器。

公开(公告)号：US20160054424A1

公开(公告)日：2016-02-25

申请号：US14933372

申请日：2015-11-05

Applicant: MEDTRONIC MINIMED, INC.

Inventor： NING YANG ,  Rajiv Shah

IPC: G01R35/00 ,  A61B5/145 ,  G01N27/02

CPC classification number: G01N27/4163 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20150122647A1

公开(公告)日：2015-05-07

申请号：US14532364

申请日：2014-11-04

Applicant: Medtronic MiniMed, Inc.

Inventor： Rajiv Shah ,  Qingling Yang ,  Robert C. Mucic ,  Jenn-Hann Larry Wang

IPC: G01N27/327 ,  C12Q1/00

CPC classification number: G01N27/3271 ,  C12Q1/002 ,  C12Q1/006

Abstract: The invention pertains to analyte sensors designed to include layered compositions that provide these sensors with enhanced functional and/or material properties including, for example, resistance to damage caused by ethylene oxide during sterilization processes. Embodiments of the invention include polyvinyl alcohol N-methyl-4(4′-formylstyryl)pyridinium (SbQ) polymer materials and methods for employing such materials during the ethylene oxide sterilization of glucose sensors.

Abstract translation: 本发明涉及分析物传感器，其被设计为包括分层组合物，其为这些传感器提供增强的功能和/或材料性能，包括例如在灭菌过程中由环氧乙烷引起的损伤的抗性。 本发明的实施方案包括聚乙烯醇N-甲基-4（4'-甲酰基苯乙烯基）吡啶鎓（SbQ）聚合物材料和在葡萄糖传感器的环氧乙烷灭菌期间使用这种材料的方法。

公开(公告)号：US20150122645A1

公开(公告)日：2015-05-07

申请号：US14074248

申请日：2013-11-07

Applicant: Medtronic MiniMed, Inc.

Inventor： Qingling Yang ,  Rajiv Shah ,  Robert C. Mucic ,  Mercedes M. Perez ,  Ting Huang

IPC: C12Q1/00 ,  A61B5/1486 ,  A61K49/00 ,  A61B5/145

CPC classification number: C12Q1/002 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/6849 ,  C12Q1/006

Abstract: Embodiments of the invention provide analyte sensors formed from layered materials that include polymeric enzyme compositions selected to provide advantageous material properties, as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

Abstract translation: 本发明的实施方案提供由分层材料形成的分析物传感器，其包括被选择用于提供有利的材料性质的聚合酶组合物，以及制备和使用这些传感器的方法。 本发明的典型实施方案包括用于治疗糖尿病的葡萄糖传感器。

公开(公告)号：US20140046154A1

公开(公告)日：2014-02-13

申请号：US14055155

申请日：2013-10-16

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rajiv Shah ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

IPC: G01N27/403 ,  A61B5/1473

CPC classification number: G01N27/403 ,  A61B5/14532 ,  A61B5/1473 ,  A61B2560/0223 ,  A61B2562/02 ,  C12Q1/006 ,  G01N27/327 ,  G01N27/416

Abstract: A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.

公开(公告)号：US20130102866A1

公开(公告)日：2013-04-25

申请号：US13657642

申请日：2012-10-22

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Xiaolong Li ,  Brian T. Kannard ,  Rajiv Shah

IPC: A61B5/145

CPC classification number: A61B5/14532 ,  A61B5/1451 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61M5/1723

Abstract: Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.

公开(公告)号：US20130079608A1

公开(公告)日：2013-03-28

申请号：US13622927

申请日：2012-09-19

Applicant: Medtronic MiniMed, Inc.

Inventor： Michael E Miller ,  Rajiv Shah

IPC: A61B5/00 ,  A61B5/1455 ,  A61B5/04 ,  A61M5/172 ,  A61B5/145

CPC classification number: A61B5/6847 ,  A61B5/0031 ,  A61B5/04 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14552 ,  A61B5/14865 ,  A61B5/6882 ,  A61B17/3468 ,  A61M1/1698 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2230/20 ,  A61M2230/201

Abstract: Systems and methods for non-vascular sensor implantation and for measuring physiological parameters in areas of a body where the physiological parameters are heterogeneous. An implant unit is implanted in an area of a body and a foreign body capsule is allowed to form around the implant unit area. A sensor may be directed into a body cavity such as, for example, the peritoneal space, subcutaneous tissues, the foreign body capsule, or other area. A subcutaneous area of the body may be tunneled for sensor placement. Spatially separated sensing elements may be used for detecting individual amounts of the physiological parameter. An overall amount of the physiological parameter may be determined by calculating a statistical measurement of the individual sensed amounts in the area. Another embodiment of the invention, a multi-analyte measuring device, may include a substrate having an electrode array on one side and an integrated circuit on another side.