公开(公告)号：US20180356562A1

公开(公告)日：2018-12-13

申请号：US16000930

申请日：2018-06-06

Applicant: Novartis AG

Inventor： Daqing Wu ,  Junhao Ge ,  Steve Yun Zhang ,  Richard Charles Breitkopf ,  Xinming Qian ,  Zach Munoz ,  Matthew D. Nelson ,  Augustine Twum Kumi ,  Weihong Lang ,  Ying Zheng ,  Feng Jing ,  Frank Chang

IPC: G02B1/04 ,  C08L83/04

CPC classification number: G02B1/043 ,  B29D11/00134 ,  C08F230/08 ,  C08L83/04

Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

公开(公告)号：US20180355112A1

公开(公告)日：2018-12-13

申请号：US16000933

申请日：2018-06-06

Applicant: Novartis AG

Inventor： Steve Yun Zhang ,  Daqing Wu ,  Junhao Ge ,  Richard Charles Breitkopf ,  Xinming Qian ,  Zach Munoz ,  Matthew D. Nelson ,  Augustine Twum Kumi ,  Weihong Lang ,  Ying Zheng ,  Feng Jing ,  Frank Chang

IPC: C08G77/442 ,  C08G77/20 ,  C08G77/388 ,  C08G77/392 ,  C08G77/14 ,  C08G77/12 ,  C08L83/10 ,  G02B1/04

CPC classification number: C08G77/442 ,  B29D11/00134 ,  C08G77/12 ,  C08G77/14 ,  C08G77/20 ,  C08G77/388 ,  C08G77/392 ,  C08G2210/00 ,  C08L83/10 ,  C08L2201/10 ,  G02B1/043 ,  G02B2207/109 ,  G02C7/04

Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

公开(公告)号：US10138316B2

公开(公告)日：2018-11-27

申请号：US15376707

申请日：2016-12-13

Applicant: Novartis AG

Inventor： Frank Chang ,  Jinyu Huang ,  Troy Vernon Holland

IPC: C08L101/14 ,  C08L83/04 ,  C08F290/06 ,  G02B1/04 ,  C08G77/20 ,  C08F283/12

Abstract: The invention provides a class of amphiphilic branched macromers and the uses thereof. An amphiphilic branched polydiorganosiloxane macromer of the invention is produced from an α,ω-dimethacryloyl-terminated polydiorganosiloxane vinylic crosslinker comprising one or more ATRP-containing siloxane units having one substituent having an ATRP initiator by ATRP polymerization of one or more hydrophilic vinylic monomers. It comprises at least two polydiorganosiloxane polymer chains each having at most two terminal methacryloxy groups, dangling hydrophilic polymer chains each having a polymerizable or non-polymerizable terminal group, and one or more hydrophilic polymer chains as linkages between two polydiorganosiloxane chains. The present invention is also related to a silicone hydrogel contact lens, which comprises units derived from a polydiorganosiloxane-containing amphiphilic branched macromer of the invention.

公开(公告)号：US10081697B2

公开(公告)日：2018-09-25

申请号：US15376700

申请日：2016-12-13

Applicant: Novartis AG

Inventor： Jinyu Huang ,  Frank Chang ,  Steve Yun Zhang ,  Feng Jing

IPC: C08L101/14 ,  C08L83/04 ,  C08F290/06 ,  G02B1/04 ,  C08G77/20 ,  C08G77/16 ,  C08G77/392 ,  C08G77/12

CPC classification number: C08F290/068 ,  C08G77/12 ,  C08G77/16 ,  C08G77/20 ,  C08G77/392 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14

Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

公开(公告)号：US09921340B2

公开(公告)日：2018-03-20

申请号：US14883142

申请日：2015-10-14

Applicant: Novartis AG

Inventor： Jinyu Huang ,  Frank Chang ,  Robert Scott ,  Arturo Norberto Medina ,  Venkat Shankar ,  Selma Kuyu ,  Dawn Alison Smith ,  Daqing Wu

IPC: G02C7/04 ,  G02B1/04 ,  C08G77/42 ,  C08G77/442 ,  C08L83/10 ,  C08J3/075 ,  C08G77/20

CPC classification number: G02B1/043 ,  C08G77/20 ,  C08G77/42 ,  C08G77/442 ,  C08J3/075 ,  C08J2343/04 ,  C08J2383/08 ,  C08L83/10 ,  C08L101/14 ,  C08L83/04

Abstract: The invention provide a class of water-processable polymerizable prepolymers which comprises (1) siloxane-containing monomeric units derived at least one siloxane containing monomer having one hydrophilic group or chain and/or polysiloxane-containing crosslinking units derived from at least one hydrophilized polysiloxane or chain-extended polysiloxane crosslinker; (2) hydrophilic monomeric units derived from one or more hydrophilic vinylic monomers; and (3) from about 0.05% to about 5% by weight of polymerizable units each having a pendant or terminal, ethylenically-unsaturated group and free of any polysiloxane segment. The prepolymer comprises from about 20% to about 50% by weight of silicone relative to the total weight of the prepolymer and has a high water solubility or dispersibility of at least about 5% by weight in water and suitable for making silicone hydrogel contact lenses.

公开(公告)号：US09720138B2

公开(公告)日：2017-08-01

申请号：US14833477

申请日：2015-08-24

Applicant: Novartis AG

Inventor： Frank Chang ,  Troy Vernon Holland

IPC: G02B1/10 ,  C07D205/04 ,  G02B1/04 ,  B29D11/00 ,  C09D179/02 ,  C08G73/02 ,  B05D5/00 ,  C08G73/06 ,  C09D179/04 ,  G02C7/04 ,  A61L27/14 ,  A61L27/50

CPC classification number: G02B1/043 ,  A61L27/14 ,  A61L27/50 ,  A61L2430/16 ,  B05D5/00 ,  B29D11/00048 ,  B29D11/00125 ,  B29D11/00865 ,  C07D205/04 ,  C08G73/022 ,  C08G73/0226 ,  C08G73/0233 ,  C08G73/06 ,  C08J3/247 ,  C08J2379/02 ,  C09D5/00 ,  C09D179/02 ,  C09D179/04 ,  G02B1/10 ,  G02C7/049 ,  G02C2202/16 ,  C08L101/14 ,  C08L33/08 ,  C08L83/04

Abstract: The invention is related to poly(2-oxazoline-co-ethyleneimine)-epichlorohydrin copolymers and chemically-modified derivatives thereof as well as their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.

公开(公告)号：US09684095B2

公开(公告)日：2017-06-20

申请号：US14694150

申请日：2015-04-23

Applicant: Novartis AG

Inventor： Jinyu Huang ,  Frank Chang

IPC: G02B1/04 ,  C07F7/18 ,  C07F9/09 ,  C08F230/08 ,  C08F283/12 ,  C08G77/38 ,  C08G77/388 ,  C08G77/392 ,  C08G77/395 ,  C08G77/50 ,  C08G77/20

CPC classification number: G02B1/043 ,  C07F7/1804 ,  C07F9/09 ,  C07F9/092 ,  C08F230/08 ,  C08F283/124 ,  C08G77/20 ,  C08G77/38 ,  C08G77/388 ,  C08G77/392 ,  C08G77/395 ,  C08G77/50 ,  C08L101/14 ,  C08L83/04 ,  C08L83/14 ,  C08L33/10

Abstract: The invention provides a hydrophilized carbosiloxane vinylic monomer which comprises (1) a poly(carbosiloxane) segment, (2) one sole ethylenically unsaturated group, and (3) at least one terminal or pendant group which is a hydrophilic group or hydrophilic polymer chain. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from a hydrophilized carbosiloxane vinylic monomer of the invention.

公开(公告)号：US09567352B2

公开(公告)日：2017-02-14

申请号：US15264624

申请日：2016-09-14

Applicant: Novartis AG ,  Shin-Etsu Chemical Company, Ltd.

Inventor： Frank Chang ,  Mamoru Hagiwara ,  Shoji Ichinohe

IPC: C08L101/14 ,  C07F7/08 ,  G02B1/04

CPC classification number: C07F7/0889 ,  C07F7/0834 ,  C07F7/0838 ,  C08F287/00 ,  G02B1/043 ,  C08L83/04 ,  C08L51/085 ,  C08L101/14 ,  C08L33/08

Abstract: The invention provides a TRIS-containing vinylic monomer which comprises one sole (meth)acryloyloxy group and a tris(trimethylsiloxy)silyl group covalently linked to the ethylenically-unsaturated group through a polyoxyethylene linker. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from a TRIS-containing vinylic monomer of the invention. In addition, the invention provides a method for making a TRIS-containing vinylic monomer of the invention.

Abstract translation: 本发明提供了一种含TRIS的乙烯基单体，其包含一个唯一的（甲基）丙烯酰氧基和通过聚氧乙烯接头与烯属不饱和基团共价连接的三（三甲基甲硅烷氧基）甲硅烷基。 本发明还涉及包含衍生自本发明的含TRIS的乙烯基单体的单体单元的聚合物，可光化交联的含硅氧烷的预聚物，硅氧烷水凝胶聚合物材料或硅氧水凝胶隐形眼镜。 此外，本发明提供了制备本发明的含TRIS的乙烯基单体的方法。

公开(公告)号：US09422447B2

公开(公告)日：2016-08-23

申请号：US13913734

申请日：2013-06-10

Applicant: Novartis AG

Inventor： Troy Vernon Holland ,  Frank Chang ,  Yongxing Qiu ,  John Dallas Pruitt ,  Chung-Yuan Chiang ,  Manivakkam J. Shankernarayanan ,  Robert Scott ,  Yash Kapoor

IPC: C09D139/04 ,  C08F20/00 ,  C08F26/00 ,  B29D11/00

CPC classification number: C09D133/24 ,  B29D11/00865 ,  C07D205/04 ,  C08F20/00 ,  C08F26/00 ,  C08F220/54 ,  C08F220/56 ,  C08F224/00 ,  C08F283/124 ,  C08F2500/26 ,  C09D133/26 ,  C09D137/00 ,  C09D139/04 ,  C09D151/085

Abstract: The invention is related to azetidinium-containing copolymers and vinylic monomers and their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.

Abstract translation: 本发明涉及含吖啶啶的共聚物和乙烯基单体及其在硅酮水凝胶隐形眼镜上形成非硅氧烷水凝胶涂层的用途。

公开(公告)号：US20160061995A1

公开(公告)日：2016-03-03

申请号：US14833477

申请日：2015-08-24

Applicant: Novartis AG

Inventor： Frank Chang ,  Troy Vernon Holland

IPC: G02B1/04 ,  G02C7/04 ,  C08G73/06 ,  C09D179/04 ,  B05D5/00 ,  C07D205/04

CPC classification number: G02B1/043 ,  A61L27/14 ,  A61L27/50 ,  A61L2430/16 ,  B05D5/00 ,  B29D11/00048 ,  B29D11/00125 ,  B29D11/00865 ,  C07D205/04 ,  C08G73/022 ,  C08G73/0226 ,  C08G73/0233 ,  C08G73/06 ,  C08J3/247 ,  C08J2379/02 ,  C09D5/00 ,  C09D179/02 ,  C09D179/04 ,  G02B1/10 ,  G02C7/049 ,  G02C2202/16 ,  C08L101/14 ,  C08L33/08 ,  C08L83/04

Abstract: The invention is related to poly(2-oxazoline-co-ethyleneimine)-epichlorohydrin copolymers and chemically-modified derivatives thereof as well as their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.

Abstract translation: 本发明涉及聚（2-恶唑啉 - 共 - 乙烯亚胺） - 表氯醇共聚物及其化学改性的衍生物，以及它们在硅酮水凝胶隐形眼镜上形成非硅氧烷水凝胶涂层的用途。