公开(公告)号：US3277084A

公开(公告)日：1966-10-04

申请号：US28748363

申请日：1963-06-13

Applicant: EASTMAN KODAK CO

Inventor： MARTIN JAMES C

IPC: C07D331/04 ,  C09B23/01 ,  C09B23/10

CPC classification number: C07D331/04 ,  C09B23/0075 ,  C09B23/10 ,  C09B23/105 ,  C09B23/107

公开(公告)号：US3247225A

公开(公告)日：1966-04-19

申请号：US30461163

申请日：1963-08-26

Applicant: EASTMAN KODAK CO

Inventor： FIELDS DONALD L ,  REYNOLDS DELBERT D

IPC: C07D331/02 ,  C07D331/04

CPC classification number: C07D331/04 ,  C07C329/00 ,  C07D331/02

公开(公告)号：US20230303509A1

公开(公告)日：2023-09-28

申请号：US18189380

申请日：2023-03-24

Applicant: NiKang Therapeutics, Inc.

Inventor： Yan LOU

IPC: C07D331/04 ,  A61P35/00

CPC classification number: C07D331/04 ,  A61P35/00

Abstract: The present disclosure provides certain sulfonamido derivatives that are Cyclin-dependent kinase 2 (CDK2) inhibitors of Formula (I):




for the treatment of diseases treatable by inhibition of CDK2. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

公开(公告)号：US20230180761A1

公开(公告)日：2023-06-15

申请号：US18166601

申请日：2023-02-09

Applicant: CORTEVA AGRISCIENCE LLC

Inventor： RONALD J. HEEMSTRA ,  RONALD ROSS, JR. ,  KYLE A. DEKORVER ,  KAITLYN GRAY ,  DANIEL I. KNUEPPEL ,  PETER VEDNOR ,  TIMOTHY P. MARTIN ,  JOSEPH D. ECKELBARGER ,  JOHN F. DAEUBLE, SR. ,  RICKY HUNTER ,  DAVID A. DEMETER ,  TONY K. TRULLINGER ,  ERICH W. BAUM ,  ZOLTAN L. BENKO ,  NAKYEN CHOY ,  GARY D. CROUSE ,  FANGZHENG LI ,  JEFFREY NISSEN ,  MONICA B. OLSON ,  MICHELLE RIENER ,  THOMAS C. SPARKS ,  FRANK J. WESSELS ,  MAURICE C. YAP

IPC: A01N53/00 ,  C07C255/46 ,  C07C255/57 ,  C07C255/60 ,  C07C259/10 ,  C07D213/84 ,  C07D213/89 ,  C07D215/227 ,  C07C271/28 ,  C07C271/66 ,  C07D215/38 ,  C07D231/56 ,  C07D233/36 ,  C07C311/08 ,  C07C311/46 ,  C07D235/30 ,  C07C317/28 ,  C07C317/40 ,  C07C317/50 ,  C07C323/41 ,  C07C323/42 ,  C07C323/59 ,  C07C331/12 ,  C07C381/10 ,  C07D205/04 ,  C07C237/42 ,  C07D207/452 ,  C07C255/29 ,  C07D209/49 ,  C07D213/75 ,  C07D213/81 ,  C07D309/14 ,  C07D231/12 ,  C07D331/04 ,  C07D333/36 ,  C07D249/08 ,  C07D207/10 ,  C07D285/06 ,  C07D295/32 ,  C07D305/08 ,  C07D207/273 ,  C07D233/80 ,  C07D261/12 ,  C07D263/26 ,  C07D277/36 ,  C07D307/33 ,  C07D333/48 ,  C07C237/22 ,  C07D213/56 ,  C07D277/30 ,  C07D307/52 ,  C07D333/60 ,  A01N37/22 ,  A01N37/34 ,  A01N41/10 ,  A01N43/40 ,  A01N43/60 ,  A01N43/653 ,  A01N43/707 ,  A01N43/82 ,  A01N43/90 ,  C07C233/63 ,  C07C233/65 ,  C07C317/14 ,  C07D241/20 ,  C07D253/07 ,  C07D487/04

CPC classification number: A01N53/00 ,  C07C255/46 ,  C07C255/57 ,  C07C255/60 ,  C07C259/10 ,  C07D213/84 ,  C07D213/89 ,  C07D215/227 ,  C07C271/28 ,  C07C271/66 ,  C07D215/38 ,  C07D231/56 ,  C07D233/36 ,  C07C311/08 ,  C07C311/46 ,  C07D235/30 ,  C07C317/28 ,  C07C317/40 ,  C07C317/50 ,  C07C323/41 ,  C07C323/42 ,  C07C323/59 ,  C07C331/12 ,  C07C381/10 ,  C07D205/04 ,  C07C237/42 ,  C07D207/452 ,  C07C255/29 ,  C07D209/49 ,  C07D213/75 ,  C07D213/81 ,  C07D309/14 ,  C07D231/12 ,  C07D331/04 ,  C07D333/36 ,  C07D249/08 ,  C07D207/10 ,  C07D285/06 ,  C07D295/32 ,  C07D305/08 ,  C07D207/273 ,  C07D233/80 ,  C07D261/12 ,  C07D263/26 ,  C07D277/36 ,  C07D307/33 ,  C07D333/48 ,  C07C237/22 ,  C07D213/56 ,  C07D277/30 ,  C07D307/52 ,  C07D333/60 ,  A01N37/22 ,  A01N37/34 ,  A01N41/10 ,  A01N43/40 ,  A01N43/60 ,  A01N43/653 ,  A01N43/707 ,  A01N43/82 ,  A01N43/90 ,  C07C233/63 ,  C07C233/65 ,  C07C317/14 ,  C07D241/20 ,  C07D253/07 ,  C07D487/04 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14

Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

公开(公告)号：US20230141913A2

公开(公告)日：2023-05-11

申请号：US17270652

申请日：2019-08-23

Applicant: XENIOPRO GmbH

Inventor： Viktoria REINMÜLLER ,  Roman MARTY ,  Olivier WAGNIÉRES ,  Jean-Baptiste GUALTIEROTTI ,  Verena KÜPPERS

IPC: A61K31/5375 ,  C07C43/275 ,  C07D213/647 ,  A61K31/09 ,  A61K31/44 ,  A61P35/02 ,  A61P35/00 ,  C07D295/096 ,  C07D453/02 ,  A61K31/351 ,  A61K31/451 ,  A61K31/495 ,  A61K31/439 ,  C07D305/06 ,  C07D331/04 ,  C07D205/04 ,  A61K31/337 ,  A61K31/38 ,  A61K31/397 ,  C07D407/12 ,  C07D411/12 ,  C07D405/12 ,  C07D409/12 ,  C07D401/12 ,  A61K31/5377 ,  A61K31/496 ,  C07D309/04 ,  A61K31/12 ,  A61K31/085 ,  C07C49/255 ,  C07C43/295 ,  C07C205/04 ,  C07C251/20 ,  C07C251/48 ,  A61K31/04 ,  A61K31/15 ,  A61K39/39

CPC classification number: A61K31/5375 ,  C07C43/275 ,  C07D213/647 ,  A61K31/09 ,  A61K31/44 ,  A61P35/02 ,  A61P35/00 ,  C07D295/096 ,  C07D453/02 ,  A61K31/351 ,  A61K31/451 ,  A61K31/495 ,  A61K31/439 ,  C07D305/06 ,  C07D331/04 ,  C07D205/04 ,  A61K31/337 ,  A61K31/38 ,  A61K31/397 ,  C07D407/12 ,  C07D411/12 ,  C07D405/12 ,  C07D409/12 ,  C07D401/12 ,  A61K31/5377 ,  A61K31/496 ,  C07D309/04 ,  A61K31/12 ,  A61K31/085 ,  C07C49/255 ,  C07C43/295 ,  C07C205/04 ,  C07C251/20 ,  C07C251/48 ,  A61K31/04 ,  A61K31/15 ,  A61K39/39

Abstract: The present invention comprises novel aromatic molecules, which can be used in the treatment of pathological conditions, such as cancer, skin diseases, muscle disorders, and immune system-related disorders such as disorders of the haematopoietic system including the haematologic system in human and veterinary medicine.

公开(公告)号：US20220265595A1

公开(公告)日：2022-08-25

申请号：US17606884

申请日：2020-04-30

Applicant: Sitryx Therapeutics Limited

Inventor： Michael Liam COOKE ,  David COUSIN ,  Matthew Colin Thor FYFE ,  Barry John TEOBALD ,  Stephen Malcolm THOM ,  Thomas Michael WAUGH

IPC: A61K31/225 ,  C07C255/14 ,  C07C317/18 ,  C07C69/593 ,  C07D305/08 ,  C07D207/27 ,  C07C233/05 ,  C07D207/273 ,  C07C311/03 ,  C07C219/08 ,  C07D307/20 ,  C07D309/12 ,  C07D211/96 ,  C07D295/08 ,  C07D331/04 ,  C07D205/04 ,  C07D295/088 ,  C07D207/277 ,  C07D257/04 ,  C07D519/00 ,  C07D451/10 ,  A61K31/275 ,  A61K31/337 ,  A61K31/4015 ,  A61K31/341 ,  A61K31/351 ,  A61K31/445 ,  A61K31/5375 ,  A61K31/38 ,  A61K31/397 ,  A61K31/495 ,  A61K31/54 ,  A61K31/41 ,  A61K31/46

Abstract: The invention relates to compounds of formula (IW-1) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: wherein RA, RB, RC and RD are as defined herein.

公开(公告)号：US20220249500A1

公开(公告)日：2022-08-11

申请号：US17270652

申请日：2019-08-23

Applicant: XENIOPRO GmbH

Inventor： Viktoria REINMÜLLER ,  Roman MARTY ,  Olivier WAGNIÈRES ,  Jean-Baptiste GUALTIEROTTI ,  Verena KÜPPERS

IPC: A61K31/5375 ,  C07C43/275 ,  C07D213/647 ,  A61K31/09 ,  A61K31/44 ,  A61P35/02 ,  A61P35/00 ,  C07D295/096 ,  C07D453/02 ,  A61K31/351 ,  A61K31/451 ,  A61K31/495 ,  A61K31/439 ,  C07D305/06 ,  C07D331/04 ,  C07D205/04 ,  A61K31/337 ,  A61K31/38 ,  A61K31/397 ,  C07D407/12 ,  C07D411/12 ,  C07D405/12 ,  C07D409/12 ,  C07D401/12 ,  A61K31/5377 ,  A61K31/496 ,  C07D309/04 ,  A61K31/12 ,  A61K31/085 ,  C07C49/255 ,  C07C43/295 ,  C07C205/04 ,  C07C251/20 ,  C07C251/48 ,  A61K31/04 ,  A61K31/15 ,  A61K39/39

Abstract: The present invention comprises novel aromatic molecules, which can be used in the treatment of pathological conditions, such as cancer, skin diseases, muscle disorders, and immune system-related disorders such as disorders of the haematopoietic system including the haematologic system in human and veterinary medicine.

公开(公告)号：US10219516B2

公开(公告)日：2019-03-05

申请号：US15679415

申请日：2017-08-17

Applicant: Dow AgroSciences LLC

Inventor： Ronald J. Heemstra ,  Ronald Ross, Jr. ,  Kyle A. DeKorver ,  Kaitlyn Gray ,  Daniel I. Knueppel ,  Peter Vednor ,  Timothy P. Martin ,  Joseph D. Eckelbarger ,  John F. Daeuble, Sr. ,  Ricky Hunter ,  David A. Demeter ,  Tony K. Trullinger ,  Erich W. Baum ,  Zoltan L. Benko ,  Nakyen Choy ,  Gary D. Crouse ,  Fangzheng Li ,  Jeffrey Nissen ,  Monica B. Olson ,  Michelle Riener ,  Thomas C. Sparks ,  Frank J. Wessels ,  Maurice C. Yap

IPC: A01N53/00 ,  C07D487/04 ,  C07D333/60 ,  C07D333/48 ,  C07D333/36 ,  C07D331/04 ,  C07D309/14 ,  C07D307/52 ,  C07D307/33 ,  C07C255/46 ,  C07C255/57 ,  C07C255/60 ,  C07C259/10 ,  C07D213/84 ,  C07D213/89 ,  C07D215/227 ,  C07C271/28 ,  C07C271/66 ,  C07D215/38 ,  C07D231/56 ,  C07D233/36 ,  C07C311/08 ,  C07C311/46 ,  C07D235/30 ,  C07C317/28 ,  C07C317/40 ,  C07C317/50 ,  C07C323/41 ,  C07C323/42 ,  C07C323/59 ,  C07C331/12 ,  C07C381/10 ,  C07D205/04 ,  C07C237/42 ,  C07D207/452 ,  C07C255/29 ,  C07D209/49 ,  C07D207/273 ,  C07D233/80 ,  C07D261/12 ,  C07D263/26 ,  C07D277/36 ,  C07C237/22 ,  C07D213/56 ,  C07D277/30 ,  C07C233/63 ,  C07C233/65 ,  C07C317/14 ,  C07D241/20 ,  C07D253/07

Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

公开(公告)号：US20180290966A1

公开(公告)日：2018-10-11

申请号：US16003385

申请日：2018-06-08

Applicant: Hoffmann-La Roche Inc.

Inventor： Olivier GAVELLE ,  Uwe GRETHER ,  Matthias NETTEKOVEN ,  Stephan ROEVER ,  Mark ROGERS-EVANS ,  Didier ROMBACH

IPC: C07C235/52 ,  C07C231/02 ,  C07D271/06 ,  C07D277/28 ,  C07D205/04 ,  C07D413/12 ,  C07D305/08 ,  C07D331/04 ,  C07D207/16 ,  C07D413/10 ,  C07D213/61 ,  C07D403/10 ,  C07D231/12 ,  C07D401/10 ,  C07D207/10 ,  C07D413/06

Abstract: The invention relates to a compound of formula (I) wherein R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

公开(公告)号：US09924717B2

公开(公告)日：2018-03-27

申请号：US15408634

申请日：2017-01-18

Applicant: Dow AgroSciences LLC

Inventor： Thomas Barton ,  Xin Gao ,  Jim Hunter ,  Paul R. LePlae, Jr. ,  Lori K. Lawler ,  William C. Lo ,  Jeff Petkus ,  Joshodeep Boruwa ,  Raghuram Tangirala ,  Gerald B. Watson ,  John Herbert

IPC: A01N37/20 ,  A01N37/18 ,  C07D207/06 ,  C07D331/04 ,  C07D213/61 ,  A01N43/40 ,  C07D213/75 ,  A01N43/20 ,  C07C233/65 ,  A01N43/36

CPC classification number: A01N37/20 ,  A01N29/12 ,  A01N31/04 ,  A01N33/04 ,  A01N35/04 ,  A01N37/10 ,  A01N37/18 ,  A01N37/26 ,  A01N43/20 ,  A01N43/36 ,  A01N43/40 ,  A01N53/00 ,  C07C233/65 ,  C07C233/66 ,  C07C233/73 ,  C07C233/78 ,  C07C251/28 ,  C07C251/38 ,  C07C255/46 ,  C07C257/20 ,  C07C259/14 ,  C07C327/48 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/14 ,  C07D207/06 ,  C07D213/61 ,  C07D213/75 ,  C07D331/04

Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).