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公开(公告)号:US3652563A
公开(公告)日:1972-03-28
申请号:US3652563D
申请日:1968-08-08
申请人: BASF AG
IPC分类号: C07C275/16 , C07D233/38 , C07D239/10 , C07D51/18
CPC分类号: C07D239/10 , C07C275/16 , C07D233/38 , C08G2130/00
摘要: UREIDOPROPIONIC ACIDS OF THE FORMULA:
R1-N(-R2)-CO-N(-R3)-CH2-C(-R4)(-R5)-COOH
WHEREIN R1 TO R5 DENOTE IDENTICAL OR DIFFERENT ALIPHATIC, CYCLOALIPHATIC, ARALIPHATIC OR AROMATIC RADICALS, SAID UREIDOPROPIONIC ACIDS BEING PREPARED BY REACTING A UREIDOPROPIONALDEHYDE HAVING THE FORMULA:
R6-N(-R2)-CO-N(-R3)-CH2-C(-R4)(-R5)-CHO
WITH AN OXIDIZING AGENT AT A TEMPERATURE OF FROM 0* TO 100*C., SAID ACIDS BEING USEFUL AS PAPER FINISHING AGENTS AND AS STARTING MATERIALS FOR THE PRODUCTION OF PAPER FINISHING AGENTS AND HERBICIDES.-
公开(公告)号:US2852512A
公开(公告)日:1958-09-16
申请号:US62631156
申请日:1956-12-05
申请人: ROHM & HAAS
发明人: BORTNICK NEWMAN M
IPC分类号: C07D233/30 , C07D233/34 , C07D233/38 , C07D239/10 , C07D241/08 , C07D261/04 , C07D263/18 , C07D263/20 , C07D263/22 , C07D263/24 , C07D265/02 , C07D265/08 , C07D265/10 , C07D265/30 , C07D265/32 , C08K5/3442
CPC分类号: C07D265/30 , C07D233/38 , C07D239/10 , C07D241/08 , C07D261/04 , C07D263/22 , C07D265/02 , C07D265/08 , C07D265/10 , C07D265/32 , C08K5/34 , C08K5/3442 , C10M3/00 , C10M2215/22 , C10M2215/221 , C10M2215/224 , C10M2215/225 , C10M2215/226 , C10M2215/30 , C10M2219/064 , C10M2219/066 , C08L27/06
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公开(公告)号:US2776979A
公开(公告)日:1957-01-08
申请号:US57623656
申请日:1956-04-05
申请人: NORWICH PHARMA CO
发明人: MICHELS JULIAN G
IPC分类号: C07D233/38 , C07D405/12
CPC分类号: C07D405/12 , C07D233/38
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公开(公告)号:US2441935A
公开(公告)日:1948-05-18
申请号:US65450946
申请日:1946-03-14
申请人: HOFFMANN LA ROCHE
发明人: ROBERT DUSCHINSKY
IPC分类号: C07D233/32 , C07D233/38 , C07D233/70 , C07D491/04
CPC分类号: C07D491/04 , C07D233/32 , C07D233/38 , C07D233/70
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公开(公告)号:US20220396581A1
公开(公告)日:2022-12-15
申请号:US17228573
申请日:2021-04-12
发明人: Guangyi WANG , Leonid BEIGELMAN , Anh TRUONG , Carmela NAPOLITANO , Daniele ANDREOTTI , Haiying HE
IPC分类号: C07D495/04 , A61K31/352 , A61K31/4196 , A61K31/4365 , C07C255/66 , C07D233/88 , C07D261/20 , C07D307/40 , C07D307/52 , C07D333/20 , C07D333/58 , A61K31/4025 , A61K31/404 , A61K31/427 , A61K31/4375 , A61K31/4725 , C07D213/50 , C07D233/64 , C07D333/68 , C07D401/12 , C07D409/06 , A61K31/343 , A61K31/382 , A61K31/426 , A61K31/4418 , A61K31/4545 , C07C251/84 , C07D207/335 , C07D215/12 , C07D215/42 , C07D233/61 , C07D401/04 , C07D409/14 , A61K31/277 , A61K31/407 , A61K31/423 , A61K31/4436 , A61K31/4439 , A61K31/496 , A61K31/497 , A61K31/506 , C07C243/34 , C07D209/20 , C07D209/86 , C07D233/38 , C07D233/60 , C07D277/64 , C07D307/81 , C07D405/10 , C07D417/04 , C07D417/12 , A61K31/165 , A61K31/40 , A61K31/4709 , C07C243/18 , C07D277/56 , C07D333/66 , C07D413/04 , C07D471/04 , C07D495/14 , A61K31/4427 , A61K31/5377 , C07D213/42 , C07D213/68 , C07D215/38 , C07D217/24 , C07D307/91 , C07D311/68 , C07D333/16 , C07D333/62 , C07D401/10 , C07D409/12 , A61K31/341 , A61K31/4164 , A61K31/428 , A61K31/444 , A61K31/4704 , A61K31/501 , A61K45/06 , C07C255/34 , C07D209/08 , C07D215/14 , C07D333/54 , C07D335/06 , C07D405/04 , C07D405/12 , C07D409/04 , C07D413/12 , C07D413/14 , A61K31/381 , A61K31/4155 , A61K31/47 , A61K31/538 , C07C251/80 , C07D209/14 , C07D213/65 , C07D333/50 , C07D333/76
摘要: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
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公开(公告)号:US20200247761A1
公开(公告)日:2020-08-06
申请号:US16488517
申请日:2018-01-25
发明人: Syaulan S. YANG , Kuang-Yuan LEE , Meng-Hsien LIU , Ming-Yu HSIAO , Huang-Kai PENG , Chiung-Wen WANG , Edwin SC WU , Peter JS CHIU
IPC分类号: C07D241/04 , C07D211/78 , C07D215/36 , C07C311/21 , C07D231/18 , C07D233/38 , C07D207/48 , C07D211/60 , A61P29/00
摘要: The present invention related to novel sulfonamides or amides as TLR-4 antagonists, and pharmaceutical formulations containing the same and the methods of use thereof. Uses of the present novel sulfonamides or amides include, but are not limited to, the prophylaxis and/or treatment of autoimmune, inflammation, or infection related disorders.
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公开(公告)号:US20180213788A1
公开(公告)日:2018-08-02
申请号:US15747180
申请日:2016-07-15
IPC分类号: A01N47/38 , C07D233/38
摘要: Disclosed are compounds of Formula (1), including all stereoisomers, N-oxides, and salts thereof, (Formula (1)) wherein G, J, Q1, R4, Y2, Q2, R5 and Y1 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (1) and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.
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公开(公告)号:US20180044282A1
公开(公告)日:2018-02-15
申请号:US15688732
申请日:2017-08-28
发明人: Kenneth W. Bair , Nicholas Barczak , Bingsong Han , David R. Lancia, JR. , Cuixian Liu , Matthew W. Martin , Pui Yee Ng , Aleksandra Rudnitskaya , Jennifer R. Thomason , Mary Margaret Zablocki , Xiaozhang Zheng
IPC分类号: C07C259/06 , C07D471/04 , C07D417/04 , C07D241/08 , C07D213/56 , C07D233/68 , C07D235/14 , C07D487/10 , C07D471/10 , C07D295/155 , C07D209/44 , A61K31/5377 , A61K31/4439 , A61K31/495 , A61K31/44 , A61K31/417 , A61K31/4184 , A61K31/397 , C07D495/10 , A61K31/407 , A61K31/435 , A61K31/451 , A61K31/4035 , A61K31/277 , A61K31/438 , C07D221/20 , A61K31/185 , C07D307/68 , C07D213/65 , C07D295/192 , C07D211/58 , C07D211/16 , C07D513/10 , C07D209/46 , C07D209/42 , C07D277/56 , C07D209/08 , C07D498/04 , C07D207/267 , C07D493/08 , C07D207/10 , C07D491/10 , C07D487/08 , C07D487/04 , C07D261/18 , C07D257/04 , C07D249/18 , C07D417/12 , C07D241/12 , C07D409/12 , C07D409/04 , C07D405/12 , C07D239/22 , C07D239/20 , C07D235/30 , C07D401/12 , C07D401/04 , C07D333/70 , C07D233/38 , C07D233/36 , C07D231/18 , C07D231/14 , C07D317/68 , C07D215/12 , C07D213/81 , C07D213/75 , C07D401/14
CPC分类号: C07C259/06 , A61K31/185 , A61K31/277 , A61K31/397 , A61K31/4035 , A61K31/407 , A61K31/417 , A61K31/4184 , A61K31/435 , A61K31/438 , A61K31/44 , A61K31/4439 , A61K31/451 , A61K31/495 , A61K31/5377 , C07D207/10 , C07D207/267 , C07D209/08 , C07D209/42 , C07D209/44 , C07D209/46 , C07D211/16 , C07D211/58 , C07D213/56 , C07D213/65 , C07D213/75 , C07D213/81 , C07D215/12 , C07D221/20 , C07D231/14 , C07D231/18 , C07D233/36 , C07D233/38 , C07D233/68 , C07D235/14 , C07D235/30 , C07D239/20 , C07D239/22 , C07D241/08 , C07D241/12 , C07D249/18 , C07D257/04 , C07D261/18 , C07D277/56 , C07D295/155 , C07D295/192 , C07D307/68 , C07D317/68 , C07D333/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/10 , C07D493/08 , C07D495/10 , C07D498/04 , C07D513/10 , Y02A50/393 , Y02A50/411 , Y02A50/481
摘要: The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.
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公开(公告)号:US20110217654A1
公开(公告)日:2011-09-08
申请号:US13028323
申请日:2011-02-16
IPC分类号: G03F7/004 , C07C69/753 , C07D311/74 , C07C69/63 , C07D307/77 , C07D207/277 , C07C309/82 , C07C69/96 , C07C271/24 , C07D265/30 , C07D233/38 , C08F28/02 , G03F7/20
CPC分类号: C07C69/63 , B33Y70/00 , B33Y80/00 , C07C69/753 , C07C69/96 , C07C271/24 , C07C309/82 , C07D207/277 , C07D233/38 , C07D265/30 , C07D307/77 , C07D311/74 , C08F28/02 , G03F7/004 , G03F7/20
摘要: The invention pertains to a compound generating an acid of the formula I or II, for instance corresponding sulfonium and iodonium salts, as well as corresponding sulfonyloximes wherein X is CH2 or CO; Y is O, NR4, S, O(CO), O(CO)O, O(CO)NR4, OSO2, O(CS), or O(CS)NR4; R1 is for example C1-C18alkyl, C1-C10haloalkyl, C2-C12alkenyl, C4-C30cycloalkenyl, phenyl-C1-C3-alkyl, C3-C30cycloalkyl, C3-C30cycloalkyl-C1-C18alkyl, interrupted C2-C18alkyl, interrupted C3-C30cycloalkyl, interrupted C3-C30cycloalkyl-C1-C18alkyl, interrupted C4-C30cycloalkenyl, phenyl, naphthyl, anthracyl, phenanthryl, biphenylyl, fluorenyl or heteroaryl, all unsubstituted or are substituted; or R1 is NR12R13; R2 and R3 are for example C3-C30cycloalkylene, C3-C30cycloalkyl-C1-C18alkylene, C1-C18alkylene, C1-C10haloalkylene, C2-C12alkenylene, C4-C30cycloalkenylene, phenylene, naphthylene, anthracylene, phenanthrylene, biphenylene or heteroarylene; all unsubstituted or substituted; R4 is for example C3-C30cycloalkyl, C3-C30cycloalkyl-C1-C18alkyl, C1-C18alkyl, C1-C10haloalkyl, C2-C12alkenyl, C4-C30cycloalkenyl, phenyl-C1-C3-alkyl; R12 and R13 are for example C3-C30cycloalkyl, C3-C30cycloalkyl-C1-C18alkyl, C1-C18alkyl, C1-C10haloalkyl, C2-C12alkenyl, C4-C30cycloalkenyl, phenyl-C1-C3-alkyl, Ar, (CO)R15, (CO)OR15 or SO2R15; and Ar is phenyl, biphenylyl, fluorenyl, naphthyl, anthracyl, phenanthryl or heteroaryl, all unsubstituted or substituted.
摘要翻译: 本发明涉及产生式I或II的酸的化合物,例如相应的锍盐和碘鎓盐,以及其中X是CH 2或CO的相应的磺酰肟; Y是O,NR4,S,O(CO),O(CO)O,O(CO)NR4,OSO2,O(CS)或O(CS)NR4; R 1是例如C 1 -C 18烷基,C 1 -C 10卤代烷基,C 2 -C 12烯基,C 4 -C 30环烯基,苯基-C 1 -C 3烷基,C 3 -C 30环烷基,C 3 -C 30环烷基-C 1 -C 18烷基,间断的C 2 -C 18烷基,间断的C 3 -C 30环烷基, 间断的C 3 -C 30环烷基-C 1 -C 18烷基,间断的C 4 -C 30环烯基,苯基,萘基,蒽基,菲基,联苯基,芴基或杂芳基,全部未取代或被取代; 或R1是NR12R13; R2和R3是例如C 3 -C 30亚环烷基,C 3 -C 30环烷基-C 1 -C 18亚烷基,C 1 -C 18亚烷基,C 1 -C 10卤代亚烷基,C 2 -C 12亚烯基,C 4 -C 30亚环烯基,亚苯基,亚萘基,亚蒽基,亚菲基,亚联苯基或亚杂芳基。 全部未取代或取代; R4是例如C 3 -C 30环烷基,C 3 -C 30环烷基-C 1 -C 18烷基,C 1 -C 18烷基,C 1 -C 10卤代烷基,C 2 -C 12链烯基,C 4 -C 30环烯基,苯基-C 1 -C 3烷基; R 12和R 13例如为C 3 -C 30环烷基,C 3 -C 30环烷基-C 1 -C 18烷基,C 1 -C 18烷基,C 1 -C 10卤代烷基,C 2 -C 12烯基,C 4 -C 30环烯基,苯基-C 1 -C 3烷基,Ar,(CO)R 15 CO)OR15或SO2R15; 并且Ar是苯基,联苯基,芴基,萘基,蒽基,菲基或杂芳基,全部是未取代或取代的。
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公开(公告)号:US20050277631A1
公开(公告)日:2005-12-15
申请号:US11195134
申请日:2005-08-01
申请人: Elizabeth Doherty , Jiawang Zhu , Markian Stec , Mark Norman , Hui-Ling Wang , Christopher Fotsch , Ning Chen , Partha Chakrabarti , Celia Dominguez , James Falsey , Christopher Hulme , Jodie Katon , Thomas Nixey , Vassil Ognyanov , Liping Pettus , Robert Rzasa
发明人: Elizabeth Doherty , Jiawang Zhu , Markian Stec , Mark Norman , Hui-Ling Wang , Christopher Fotsch , Ning Chen , Partha Chakrabarti , Celia Dominguez , James Falsey , Christopher Hulme , Jodie Katon , Thomas Nixey , Vassil Ognyanov , Liping Pettus , Robert Rzasa
IPC分类号: A61P29/00 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/64 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/22 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , A61K31/549 , A61K31/501 , C07D417/02 , C07D43/02
CPC分类号: C07D231/40 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/56 , C07D233/38 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
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