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    Detection and signal processing system for particle assays
    144.
    发明授权
    Detection and signal processing system for particle assays 有权

    公开(公告)号：US10060847B2

    公开(公告)日：2018-08-28

    申请号：US15394624

    申请日：2016-12-29

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Yunfeng Ling ,  David P. Stumbo ,  George Carman ,  Denis Pristinski

    IPC: G01N15/14

    CPC classification number: G01N15/1429 ,  G01N15/1404 ,  G01N15/1434 ,  G01N15/1459 ,  G01N2015/1461 ,  G01N2015/1488 ,  G01N2021/4707 ,  G01N2021/4728

    Abstract: Systems and methods for detecting and processing signals from particles. In an exemplary method, particles may be passed through a zone of a channel, while the zone is irradiated with light. Interaction of the light with the particles may deflect light and induce photoluminescence. A deflection signal and a photoluminescence signal may be detected from the zone. Particle waveforms may be identified in the deflection signal. At least a subset of the particle waveforms may be double-peak waveforms including a pair of peaks corresponding to a particle entering and exiting the zone. Amplitudes may be obtained from the photoluminescence signal. The amplitudes may correspond to respective particles and their particle waveforms, and at least a subset of the amplitudes may correspond to the double-peak waveforms. Individual particles may be assigned as positive or as negative for an analyte based on the corresponding amplitudes.

    BOTTLE PRESSURIZATION DELIVERY SYSTEM
    145.
    发明申请
    BOTTLE PRESSURIZATION DELIVERY SYSTEM 审中-公开

    公开(公告)号：US20180238839A1

    公开(公告)日：2018-08-23

    申请号：US15885555

    申请日：2018-01-31

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Nathan Wrench ,  William Mainwaring-Burton ,  Chris Butcher ,  Nick Harrison

    IPC: G01N30/32 ,  B67D7/02 ,  G01N30/22 ,  G01N30/88 ,  G01N30/16

    CPC classification number: G01N30/32 ,  B67D7/0255 ,  G01N30/16 ,  G01N30/22 ,  G01N30/88 ,  G01N2030/8881 ,  Y10T137/9029

    Abstract: A container assembly for use with a high-pressure liquid chromatography (HPLC) instrument is disclosed, in which the container assembly, when coupled to a source of pressurized gas, provides fluid medium to the HPLC instrument at positive pressure. The container assembly has an external exterior container shell, an internal fluid container for holding fluid medium, an interstitial volume between the external exterior container shell and the internal fluid container, a port for fluidly connecting the volume to a pressurized gas source, and a port for fluidly connecting the internal fluid container to the HPLC instrument. As a pressurized gas in the interstitial volume increases, fluid medium flows out of the port connected to the internal fluid bag and container assembly at a positive pressure. A system incorporating the container assembly, and method of use of the same, are also disclosed.

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