公开(公告)号：US20160244479A1

公开(公告)日：2016-08-25

申请号：US14913366

申请日：2014-08-27

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Steven J.D. KARLISH ,  Adriana KATZ ,  Daniel M. TAL

IPC: C07J43/00

CPC classification number: C07J43/003 ,  C07J19/005

Abstract: The present invention relates to digoxin and digitoxin derivatives that are selective inhibitors of the α2 isoform of Na,K-ATPase, and that reduce intra-ocular pressure. The invention further relates to uses of these derivatives for treating disorders associated with elevated intraocular pressure, such as glaucomas, and/or as cardiotonic agents.

Abstract translation: 本发明涉及作为Na，K-ATP酶的α2同种型的选择性抑制剂的地高辛和洋地黄毒苷衍生物，并且降低眼内压。 本发明进一步涉及这些衍生物用于治疗与眼内压升高相关的疾病，例如青光眼，和/或作为强心剂。

公开(公告)号：US09387264B2

公开(公告)日：2016-07-12

申请号：US13856788

申请日：2013-04-04

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD ,  THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV

Inventor： Michal Neeman ,  Raz Zarivach ,  Marina Radoul ,  Batya Cohen ,  Moriel Vandsburger ,  Limor Lewin

IPC: A61K49/14 ,  C07K14/47 ,  C07K14/195

CPC classification number: A61K49/14 ,  C07K14/195 ,  C07K14/47 ,  C07K2319/00 ,  C07K2319/42

Abstract: The invention provides a fusion ferritin protein wherein a ferritin heavy chain polypeptide is fused to a peptide, wherein the peptide is fused to the C-terminal end of the ferritin heavy chain; and the peptide includes at least a portion of a Mms6 protein sequence and at least one heterologous amino acid at its N-terminal end. The invention further provides methods of use of the ferritin fusion protein for Magnetic Resonance Imaging.

Abstract translation: 本发明提供融合铁蛋白，其中铁蛋白重链多肽与肽融合，其中该肽融合到铁蛋白重链的C末端; 并且肽在其N-末端包括至少一部分Mms6蛋白序列和至少一个异源氨基酸。 本发明还提供了用于磁共振成像的铁蛋白融合蛋白的使用方法。

公开(公告)号：US09382293B2

公开(公告)日：2016-07-05

申请号：US14384685

申请日：2013-03-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michal Eisenbach-Schwartz ,  Matityahu Fridkin ,  Michal Cardon-Yaakov

IPC: C07K7/64 ,  C07K7/06 ,  A61K38/00

CPC classification number: C07K7/06 ,  A61K9/0053 ,  A61K38/00 ,  C07K7/64

Abstract: The present application provides synthetic modified peptides of five to seven natural or non-natural amino acids as well as pharmaceutical compositions comprising them, for use in the treatment a disease or disorder presenting behavioral abnormalities associated with impairment of sensory gating function, depression or cognitive impairment, particularly schizophrenia and Alzheimer's disease.

Abstract translation: 本申请提供五至七个天然或非天然氨基酸的合成修饰肽以及包含它们的药物组合物，用于治疗与感觉门控功能障​​碍，抑郁症或认知障碍相关的行为异常的疾病或病症 ，特别是精神分裂症和阿尔茨海默病。

公开(公告)号：US20160186156A1

公开(公告)日：2016-06-30

申请号：US14910001

申请日：2014-08-03

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Edward A. BAYER ,  Yael VAZANA ,  Yoav BARAK ,  Johanna STERN ,  Hadar GILARY ,  Sarah MORAIS

IPC: C12N9/42 ,  C12P19/02 ,  C12N9/96 ,  C12P19/14

CPC classification number: C12N9/2437 ,  C07K2319/20 ,  C07K2319/70 ,  C12N9/16 ,  C12N9/24 ,  C12N9/88 ,  C12N9/96 ,  C12N11/12 ,  C12N11/18 ,  C12N15/62 ,  C12P19/02 ,  C12P19/14 ,  C12Y302/01004 ,  Y02E50/16

Abstract: Multi-enzyme complexes comprising an array of scaffold subunits designed for efficient integration of a plurality of carbohydrate-active enzymes are provided.

Abstract translation: 提供了包含设计用于多个碳水化合物活性酶的有效整合的支架亚基阵列的多酶复合物。

公开(公告)号：US20160175488A1

公开(公告)日：2016-06-23

申请号：US14902574

申请日：2014-07-03

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Jacob KLEIN ,  Ronit GOLDBERG ,  Noa IUSTER ,  Raya SORKIN

IPC: A61L27/52 ,  C08F2/44 ,  C08F2/10 ,  A61L27/44 ,  A61L27/34

CPC classification number: A61L27/52 ,  A61K9/0019 ,  A61K9/0024 ,  A61L27/34 ,  A61L27/44 ,  A61L2300/626 ,  A61L2400/10 ,  A61L2430/06 ,  A61L2430/10 ,  A61L2430/24 ,  A61L2430/38 ,  C08F2/10 ,  C08F2/44 ,  C09D133/066

Abstract: Hydrogels and composite material containing hydrogels and liposomes dispersed therein, which exhibit a reduced friction coefficient compared to neat hydrogels or composites containing hydrogels, processes for preparing the same, and methods for using the same are disclosed.

Abstract translation: 公开了与纯水凝胶或含有水凝胶的复合材料相比，其中分散有水凝胶和脂质体的水凝胶和复合材料以及与其混合的水凝胶和脂质体以及使用该水凝胶和脂质体的方法。

公开(公告)号：US20160152663A1

公开(公告)日：2016-06-02

申请号：US15017049

申请日：2016-02-05

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David MILSTEIN ,  Chidambaram GUNANATHAN ,  Yehoshua BEN-DAVID ,  Ekambaram BALARAMAN ,  Boopathy GNANAPRAKASAM ,  Jing ZHANG

IPC: C07K5/12 ,  C07C231/02 ,  C07C45/00 ,  C07D241/12 ,  C07C51/235 ,  C07C67/28 ,  C07D487/14 ,  C07D295/185

CPC classification number: C07K5/12 ,  C07C29/136 ,  C07C45/002 ,  C07C51/235 ,  C07C67/03 ,  C07C67/28 ,  C07C67/39 ,  C07C209/50 ,  C07C213/00 ,  C07C231/00 ,  C07C231/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D241/12 ,  C07D295/185 ,  C07D307/52 ,  C07D487/14 ,  C07K1/02 ,  C07K1/10 ,  C08L79/02 ,  Y02P20/52 ,  C07C233/05 ,  C07C235/06 ,  C07C235/10 ,  C07C233/36 ,  C07C211/27 ,  C07C215/28 ,  C08L1/00 ,  C07C69/14 ,  C07C69/24 ,  C07C31/04 ,  C07C31/08 ,  C07C31/10 ,  C07C31/12

Abstract: A process for preparing amides by reacting a primary amine and a primary alcohol in the presence of a Ruthenium complex to generate the amide and molecular hydrogen. Primary amines are directly acylated by equimolar amounts of alcohols to produce amides and molecular hydrogen (the only byproduct) in high yields and high turnover numbers. Also disclosed are processes for hydrogenation of amides to alcohols and amines; hydrogenation of organic carbonates to alcohols; hydrogenation of carbamates or urea derivatives to alcohols and amines; amidation of esters; acylation of alcohols using esters; coupling of alcohols with water and a base to form carboxylic acids; dehydrogenation of beta-amino alcohols to form pyrazines and cyclic dipeptides; and dehydrogenation of secondary alcohols to ketones. These reactions are catalyzed by a Ruthenium complex which is based on a dearomatized PNN-type ligand of formula A1 or precursors thereof of formulae A2 or A3.

Abstract translation: 在钌络合物的存在下通过伯胺和伯醇反应制备酰胺以产生酰胺和分子氢的方法。 伯胺通过等摩尔量的醇直接酰化，以高产率和高周转数产生酰胺和分子氢（仅副产物）。 还公开了将酰胺氢化成醇和胺的方法; 将有机碳酸酯氢化成醇; 将氨基甲酸酯或脲衍生物氢化成醇和胺; 酯化酰胺化; 使用酯酰化醇; 醇与水和碱偶联形成羧酸; β-氨基醇的脱氢形成吡嗪和环状二肽; 并将仲醇脱氢成酮。 这些反应由基于式A1的脱芳香族PNN型配体或式A2或A3的前体的钌络合物催化。

公开(公告)号：US09309274B2

公开(公告)日：2016-04-12

申请号：US14488742

申请日：2014-09-17

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Milko E. Van Der Boom ,  Atindra D. Shukla ,  David Rosenblatt ,  Tarkeshwar Gupta

IPC: C07F15/00 ,  G02F1/15 ,  H01G9/22 ,  H01G9/20 ,  H01L51/00 ,  G01N27/30 ,  G01Q80/00 ,  G01N27/327 ,  C07F7/18

CPC classification number: C07F15/0026 ,  C07F7/1804 ,  C07F15/0053 ,  G01N27/30 ,  G01N27/305 ,  G01N27/3275 ,  G01Q80/00 ,  G02F1/15 ,  H01G9/2018 ,  H01G9/2059 ,  H01L51/0002 ,  H01L51/0086 ,  H01L51/0088 ,  Y02E10/542 ,  Y02E10/549 ,  Y10T29/49002

Abstract: A device is presented having reversibly changeable and optically readable optical properties. The device comprises a substrate having an electrically conductive surface and carrying a redox-active layer structure. The redox-active layer structure may be a monolayer or a multi-layer structure and is configured to have at least one predetermined electronic property including at least one of electrodensity and oxidation state. The electronic property of the layer structure defines an optical property of the structure thereby determining an optical response of the structure to certain incident light. This at least one electronic property is changeable by subjecting the redox-active layer structure to an electric field or to a redox-active material. The device thus enables effecting a change in said electronic property that results in a detectable change in the optical response of the layer structure.

Abstract translation: 呈现具有可逆变化和光学可读光学性质的装置。 该器件包括具有导电表面并承载氧化还原活性层结构的衬底。 氧化还原活性层结构可以是单层或多层结构，并且被配置为具有包括电密度和氧化态中的至少一种的至少一种预定的电子性质。 层结构的电子特性限定了该结构的光学特性，从而确定该结构对某些入射光的光响应。 通过使氧化还原活性层结构经受电场或氧化还原活性物质，该至少一种电子性质是可变化的。 因此，该装置能够实现导致层结构的光学响应的​​可检测变化的所述电子特性的变化。

公开(公告)号：US09289433B2

公开(公告)日：2016-03-22

申请号：US13872247

申请日：2013-04-29

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irina Lavelin ,  Varda Rotter ,  Moshe Oren ,  Ami Navon ,  Zvi Kam ,  Benjamin Geiger

IPC: A61K31/555 ,  A61K31/47 ,  A61K31/522 ,  A61K31/60 ,  A61K33/34 ,  C07K14/47 ,  C12N9/64 ,  G01N33/50 ,  A61K31/52

CPC classification number: A61K31/555 ,  A61K31/47 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60 ,  A61K33/34 ,  C07K14/4746 ,  C07K2319/40 ,  C07K2319/60 ,  C12N9/6421 ,  C12Y304/25001 ,  G01N33/5035

Abstract: A method of treating a disease in which inhibiting of a proteasome is advantageous is provided. The method comprises administering to the subject a therapeutically effective amount of a compound which binds to a proteasome of a cell, the compound comprising a copper bound to a ligand, the ligand being configured such that upon binding to the proteasome, the copper interacts with cysteine 31 of a Beta2 subunit of the proteasome and further interacts with cysteine 118 of a Beta3 subunit of the proteasome, thereby treating the disease. Additional novel proteasome inhibitors are also provided as well as methods of identifying proteasome inhibitors.

Abstract translation: 提供了治疗其中抑制蛋白酶体的优点的疾病的方法。 该方法包括向受试者施用治疗有效量的结合细胞蛋白酶体的化合物，所述化合物包含与配体结合的铜，所述配体被配置为使得在结合蛋白酶体时，铜与半胱氨酸相互作用 31的蛋白酶体的β2亚基，并进一步与蛋白酶体的β3亚基的半胱氨酸118相互作用，从而治疗该疾病。 还提供了另外的新型蛋白酶体抑制剂以及鉴定蛋白酶体抑制剂的方法。

公开(公告)号：US20160051629A1

公开(公告)日：2016-02-25

申请号：US14781316

申请日：2014-04-09

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Anthony FUTERMAN ,  Einat VITNER ,  Ran SALOMON

IPC: A61K38/20

CPC classification number: A61K38/2006 ,  A61K45/06

Abstract: The present invention provides compositions and methods for treating lysosomal storage disease characterized by elevation of RIP kinase in a subject in need thereof using at least one RIP kinase inhibitor.

Abstract translation: 本发明提供用于治疗溶酶体贮积病的组合物和方法，其特征在于使用至少一种RIP激酶抑制剂在有需要的受试者中升高RIP激酶。

公开(公告)号：US09242231B2

公开(公告)日：2016-01-26

申请号：US13855258

申请日：2013-04-02

Applicant: Yeda Research and Development Co. Ltd. ,  NDSU Research Foundation

Inventor： Reshef Tenne ,  Yulia Tsverin ,  Uwe Burghaus ,  Mallikharjuna Rao Komarneni

IPC: B01J27/049 ,  B01J27/02 ,  B01J35/00 ,  B01J35/06 ,  C10G45/04 ,  B01D53/86 ,  B01J37/16 ,  B01J37/02

CPC classification number: B01J27/049 ,  B01D53/8687 ,  B01D2255/20776 ,  B01D2255/802 ,  B01D2257/70 ,  B01J27/02 ,  B01J35/0013 ,  B01J35/004 ,  B01J35/006 ,  B01J35/06 ,  B01J37/0217 ,  B01J37/16 ,  C02F2305/08 ,  C02F2305/10 ,  C10G45/04 ,  C10G2300/202 ,  C10G2300/70 ,  C10G2300/703 ,  Y02W10/37

Abstract: This invention relates to a hybrid component comprising at least one nanoparticle of inorganic layered compound (in the form of fullerene-like structure or nanotube), and at least one metal nanoparticle, uses thereof as a catalyst, (e.g. photocatalysis) and processes for its preparation.

Abstract translation: 本发明涉及包含至少一种无机层状化合物纳米颗粒（呈富勒烯结构或纳米管形式）的纳米颗粒和至少一种金属纳米颗粒，其用途作为催化剂（例如光催化剂）及其工艺 制备。