公开(公告)号：US06372247B1

公开(公告)日：2002-04-16

申请号：US09885932

申请日：2001-06-22

申请人： Tadashi Nagashima ,  Satoshi Kuroyanagi ,  Tadanori Yamamura ,  Hideharu Anazawa ,  Yoko Kato ,  Seiji Sugimoto ,  Keiichi Yano

发明人： Tadashi Nagashima ,  Satoshi Kuroyanagi ,  Tadanori Yamamura ,  Hideharu Anazawa ,  Yoko Kato ,  Seiji Sugimoto ,  Keiichi Yano

IPC分类号： A23K1165

CPC分类号： C12N9/16 ,  A23K20/189 ,  Y10S426/807

摘要： Provided is an isolated phytase derived from a microorganism. The microorganism is preferably from the genus Monascus. The phytase has a Michaelis constant of 10 to 110 &mgr;M when phytic acid is used as a substrate. A process for producing the phytase is also provided as is an animal feed comprising the phytase. The phytase is preferably isolated from Monascus anka IFO 30873. The phytase has a Km of 107 &mgr;m when phytic acid is used as a substrate, the optimum pH is 2.5, the optimum temperature is 45° C., the molecular weight of the phytase is 140 kDa when measured by gel filtration, and the isolectric point is 5.2 using chromatofocusing.

摘要翻译： 提供来自微生物的分离的植酸酶。 微生物优选来自红曲霉属。 当植酸作为底物时，植酸酶的米氏常数为10〜110μM。 还提供了用于产生植酸酶的方法，包括植酸酶的动物饲料也是如此。 植酸酶优选与红曲霉IFO 30873分离。当植酸用作底物时，肌醇六磷酸酶的Km为107，最佳pH为2.5，最适温度为45℃，植酸酶的分子量为 当通过凝胶过滤测量时为140kDa，并且使用色谱聚焦的等电点为5.2。

公开(公告)号：US5846810A

公开(公告)日：1998-12-08

申请号：US506340

申请日：1995-07-24

申请人： Keiichi Yano ,  Motoo Yamasaki ,  Keiji Tanaka

发明人： Keiichi Yano ,  Motoo Yamasaki ,  Keiji Tanaka

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K38/46 ,  A61P25/28 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C12N1/21 ,  C12N9/50 ,  C12N9/64 ,  C12N15/09 ,  C12N15/55 ,  C12R1/19 ,  C12N15/12 ,  C12N15/63

CPC分类号： C12N9/6421 ,  A61K38/00

摘要： Provided are P112 protein and P31 protein which proteins are among proteins constituting human 26S proteasome, DNAs encoding the proteins, vectors into which the DNAs are inserted and cells carrying the vectors. The proteins of the present invention are useful not only for elucidating the function of the human 26S proteasome but also for the diagnosis or therapy of various diseases.

摘要翻译： 提供了P112蛋白质和P31蛋白质，其中蛋白质是构成人26S蛋白酶体的蛋白质，编码蛋白质的DNA，插入DNA的载体和携带载体的细胞。 本发明的蛋白质不仅用于阐明人26S蛋白酶体的功能，而且用于诊断或治疗各种疾病。

公开(公告)号：US20080305544A1

公开(公告)日：2008-12-11

申请号：US11571580

申请日：2005-07-06

申请人： Hiroo Iwata ,  Yoshiki Sasai ,  Hironori Yamazoe ,  Masato Kobori ,  Mitsuo Satoh ,  Keiichi Yano

发明人： Hiroo Iwata ,  Yoshiki Sasai ,  Hironori Yamazoe ,  Masato Kobori ,  Mitsuo Satoh ,  Keiichi Yano

IPC分类号： C12N5/06

CPC分类号： C12N5/0619 ,  C12N2500/38 ,  C12N2506/02

摘要： An Object of the present invention is to provide a process for producing a nerve cell by inducing differentiation of an embryonic stem cell, a method for inducing differentiation of the embryonic stem cell into a nerve cell, a medium to be used in the production process or differentiation induction method, or a method for improving purity of the nerve cell obtained by inducing differentiation of the embryonic stem cell. The present invention provides a process for producing a nerve cell which is applicable to treatment of neurodegenerative disease or the like easily, selectively or inexpensively by inducing differentiation induction of an embryonic stem cell using vitamin B12 or a salt thereof and heparin, a substance having heparin-like activity or a salt.

摘要翻译： 本发明的目的是提供一种通过诱导胚胎干细胞的分化来产生神经细胞的方法，用于诱导将胚胎干细胞分化成神经细胞的方法，用于生产过程的培养基或 分化诱导方法或通过诱导胚胎干细胞分化而获得的提高神经细胞的纯度的方法。 本发明提供了通过使用维生素B12或其盐诱导胚胎干细胞的分化诱导和肝素（含有肝素的物质），可以容易地，选择性地或廉价地治疗神经变性疾病等的神经细胞的制造方法 类活动或盐。

公开(公告)号：US20060287088A1

公开(公告)日：2006-12-21

申请号：US11416257

申请日：2006-05-03

申请人： Masahiko Mashimo ,  Shinya Saito ,  Keiichi Yano ,  Norihide Okada

发明人： Masahiko Mashimo ,  Shinya Saito ,  Keiichi Yano ,  Norihide Okada

IPC分类号： A63F13/00

CPC分类号： A63F13/2145 ,  A63F13/10 ,  A63F13/426 ,  A63F13/44 ,  A63F13/814 ,  A63F2300/1075 ,  A63F2300/301 ,  A63F2300/303 ,  A63F2300/638 ,  A63F2300/8047

摘要： A game apparatus includes an LCD, and a game screen is displayed on the LCD. A touch panel is provided on the LCD. The game screen presents a marker image so as to be variable in position in time with performance of music, and also presents a timer circle image for indicating touch timing for the marker image. A player needs to touch a marker image to be touched with precise timing, listening to the music or watching the timer circle image. The player's touch is evaluated on the basis of the touch timing and the touch position. If the touch is evaluated as a failure, the game screen is shaken.

公开(公告)号：US06337085B1

公开(公告)日：2002-01-08

申请号：US09887439

申请日：2001-06-22

申请人： Tadashi Nagashima ,  Satoshi Kuroyanagi ,  Tadanori Yamamura ,  Hideharu Anazawa ,  Yoko Kato ,  Seiji Sugimoto ,  Keiichi Yano

发明人： Tadashi Nagashima ,  Satoshi Kuroyanagi ,  Tadanori Yamamura ,  Hideharu Anazawa ,  Yoko Kato ,  Seiji Sugimoto ,  Keiichi Yano

IPC分类号： A23K1165

CPC分类号： C12N9/16 ,  A23K20/189 ,  Y10S426/807

摘要： The phytase is preferably isolated from Monascus anka IFO 30873. The phytase has a Km of 20 &mgr;m when phytic acid is used as a substrate, the optimum pH is 6.0, the optimum temperature is 50° C., the molecular weight of the phytase is 120 kDa when measured by gel filtration, and the isolectric point is 4.8 using chromatofocusing.

摘要翻译： 植酸酶优选与红曲霉IFO 30873分离。当植酸用作底物时，植酸酶的Km为20m，最适pH为6.0，最适温度为50℃，植酸酶的分子量为 当通过凝胶过滤测量时为120kDa，并且使用色谱聚焦的等电点为4.8。

公开(公告)号：US5858975A

公开(公告)日：1999-01-12

申请号：US836528

申请日：1997-05-02

申请人： Keiichi Yano ,  Motoo Yamasaki ,  Takahiro Moriyama ,  Masaaki Ando

发明人： Keiichi Yano ,  Motoo Yamasaki ,  Takahiro Moriyama ,  Masaaki Ando

IPC分类号： A61K38/00 ,  A61K38/26 ,  C07K14/605 ,  A61K38/23 ,  C07K5/04

CPC分类号： C07K14/605 ,  A61K38/00 ,  Y10S514/866

摘要： An oxyntomodulin peptide has cardiotonic activity and insulin release-promoting activity. The peptide or pharmaceutical salts thereof can be used for prevention or treatment of cardiopathy or diabetes.

摘要翻译： PCT No.PCT / JP95 / 02269 Sec。 371日期：1997年5月2日 102（e）日期1997年5月2日PCT提交1995年11月7日PCT公布。 公开号WO96 / 14336 日期：1996年5月17日，胃泌酸调节肽具有强心活性和胰岛素释放促进活性。 其肽或药用盐可用于预防或治疗心脏病或糖尿病。

公开(公告)号：US5736790A

公开(公告)日：1998-04-07

申请号：US710769

申请日：1996-09-20

申请人： Kiyoshi Iyogi ,  Kaoru Koiwa ,  Keiichi Yano ,  Hironori Asai

发明人： Kiyoshi Iyogi ,  Kaoru Koiwa ,  Keiichi Yano ,  Hironori Asai

IPC分类号： H01L23/485 ,  H05K1/11 ,  H05K3/34 ,  H01L23/48 ,  H01L23/52 ,  H01L29/40

CPC分类号： H01L24/10 ,  H01L24/13 ,  H05K1/111 ,  H05K3/3436 ,  H01L2224/13 ,  H01L2224/13099 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01042 ,  H01L2924/01046 ,  H01L2924/01074 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/014 ,  H01L2924/09701 ,  H01L2924/10253 ,  H01L2924/181 ,  H05K2201/0212 ,  H05K2201/0367 ,  H05K2201/09736 ,  H05K2201/09745 ,  H05K2201/10234 ,  H05K2201/10992 ,  H05K2203/041 ,  Y02P70/611 ,  Y02P70/613

摘要： Disclosed is a bump formed on a pad which is provided on either a semiconductor chip or a package or a wiring substrate for input or output thereof, for making electric connection on the pad. The bump has: a projection projecting from the pad; a ball having conductivity and located above the pad; and a conductive bonding material for bonding the pad for and the ball, wherein creep strength of the ball is larger than strength of the conductive bonding material. With another conductive bonding material provided on the other pad of a wiring substrate or a package, the ball of the bump of the semiconductor chip or the package is placed close to another pad of the wiring substrate or package. The conductive bonding material of the other pad is heated and melted to connect the ball and the other pad of the wiring substrate or package by the conductive bonding material.

摘要翻译： 公开了一种形成在焊盘上的凸块，其设置在半导体芯片或封装或其输入或输出的布线基板上，用于在焊盘上进行电连接。 凸起具有：从该垫突出的突起; 具有导电性并位于垫上方的球; 以及用于接合焊盘和球的导电接合材料，其中球的蠕变强度大于导电接合材料的强度。 通过设置在布线基板或封装的另一个焊盘上的另一个导电接合材料，将半导体芯片或封装的凸块的球放置成靠近布线基板或封装的另一个焊盘。 另一个焊盘的导电接合材料被加热熔化，以通过导电接合材料将接线衬底或封装的球和另一焊盘连接起来。

公开(公告)号：US5703397A

公开(公告)日：1997-12-30

申请号：US745367

申请日：1996-11-08

申请人： Mitsuyoshi Endo ,  Hironori Asai ,  Keiichi Yano ,  Yoshitoshi Sato

发明人： Mitsuyoshi Endo ,  Hironori Asai ,  Keiichi Yano ,  Yoshitoshi Sato

IPC分类号： H01L23/10 ,  H01L23/13 ,  H01L23/15 ,  H01L23/367 ,  H01L23/373 ,  H01L23/498 ,  H01L23/053 ,  H01L23/12

CPC分类号： H01L23/13 ,  H01L23/10 ,  H01L23/15 ,  H01L23/3675 ,  H01L23/3731 ,  H01L23/49822 ,  H01L23/49838 ,  H01L2224/48227 ,  H01L24/48 ,  H01L2924/00014 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/15153 ,  H01L2924/1517 ,  H01L2924/15174 ,  H01L2924/15312 ,  H01L2924/16152 ,  H01L2924/16195 ,  H01L2924/30107 ,  H01L2924/3011 ,  H01L2924/3025

摘要： A semiconductor ceramic multilayer package comprising an aluminum nitride substrate having a semiconductor element mounted on one surface thereof and a wiring pattern electrically connected to the semiconductor element, connecting terminals connected to the wiring pattern and disposed on the other surface of the aluminum nitride substrate, and a sealing member connected to the aluminum nitride substrate with a metallic bonding layer or a glass layer having a thickness of not more than 100 .mu.m in such a manner as to seal the semiconductor element possesses a notably improved heat-radiating property and accomplishes the object of increasing the number of pins and reducing the size of package.

摘要翻译： 一种半导体陶瓷多层封装，包括具有安装在其一个表面上的半导体元件的氮化铝衬底和与半导体元件电连接的布线图案，连接到布线图案并且设置在氮化铝衬底的另一表面上的连接端子，以及 用氮化铝衬底与金属接合层或厚度不大于100μm的玻璃层以密封半导体元件的方式连接的密封构件具有显着提高的散热性能并实现该物体 增加引脚数量并减小封装尺寸。

公开(公告)号：US08945867B2

公开(公告)日：2015-02-03

申请号：US12364049

申请日：2009-02-02

申请人： Tatsuya Ogawa ,  Yoshinobu Konno ,  Naohisa Akashi ,  Hiroshi Takasugi ,  Seiji Sugimoto ,  Keiichi Yano

发明人： Tatsuya Ogawa ,  Yoshinobu Konno ,  Naohisa Akashi ,  Hiroshi Takasugi ,  Seiji Sugimoto ,  Keiichi Yano

IPC分类号： C12P21/08 ,  C12N5/02 ,  C12N5/078 ,  C12N5/10 ,  C12N5/12 ,  C07K16/00

CPC分类号： C07K16/00

摘要： The present invention relates to a process for producing a desired polypeptide using rat cells. Specifically, the present invention relates to a process for producing the polypeptide which comprises culturing rat cells such as YB2/3HL.P2.G11.16Ag.20 (hereinafter referred to as YB2/0), preferably rat cells to which a recombinant DNA comprising DNA encoding a desired polypeptide such as an immunologically functional molecule is introduced, in a medium which does not contain serum (hereinafter referred to as a serum-free medium). Among the desired polypeptides obtained by the process of the present invention, an antibody obtained by using a transformant of YB2/0 has a high antibody-dependent cell-mediated cytotoxic activity (hereinafter sometimes referred to as ADCC activity) and is useful as a pharmaceutical agent.

公开(公告)号：US20120053015A1

公开(公告)日：2012-03-01

申请号：US12872781

申请日：2010-08-31

申请人： Chris Esaki ,  Keiichi Yano

发明人： Chris Esaki ,  Keiichi Yano

IPC分类号： A63B71/00

CPC分类号： A63F13/428 ,  A63B24/0003 ,  A63B69/00 ,  A63B2024/0096 ,  A63B2071/0677 ,  A63B2102/18 ,  A63B2220/806 ,  A63B2220/808 ,  A63B2225/50 ,  A63B2243/007 ,  A63F13/213 ,  A63F13/573 ,  A63F13/67 ,  A63F13/798 ,  A63F13/814 ,  A63F2300/1093 ,  A63F2300/6045 ,  A63F2300/61 ,  A63F2300/8005 ,  A63F2300/8047 ,  G06F3/005 ,  G06F3/011 ,  G06K9/00342

摘要： A system for interacting with an application via a user interface is provided. A user is prompted to perform a looped motion such as an exercise move or dance move depicted by the application. User motion data is received from one or more sensors connected to a computing device executing the application. The user's progress of performing a sequence of a looped motion is determined based on the user motion data. In one embodiment, a user may perform one or more looped motions by choosing from multiple looped motions depicted by the application. In another embodiment, a user may perform looped motions at different skill levels based on a skill level determined for the user. In one embodiment, the looped motions performed by the user are displayed to the user, in an order of the looped motions performed by the user, via the user interface.

摘要翻译： 提供了一种通过用户界面与应用程序进行交互的系统。 提示用户执行循环运动，例如由应用程序描绘的运动移动或跳舞动作。 从连接到执行应用的计算设备的一个或多个传感器接收用户运动数据。 基于用户运动数据确定用户执行循环运动序列的进度。 在一个实施例中，用户可以通过从应用程序描绘的多个循环运动中进行选择来执行一个或多个循环运动。 在另一个实施例中，用户可以基于为用户确定的技能水平来执行不同技能水平的循环运动。 在一个实施例中，由用户执行的循环运动以用户通过用户界面执行的循环运动的顺序被显示给用户。