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公开(公告)号:US20120258313A1
公开(公告)日:2012-10-11
申请号:US13518337
申请日:2010-12-21
申请人: Jie Wen , Kristin Taton , Laurie Lawin , William Knopke , Eric Guire , Patrick Guire
发明人: Jie Wen , Kristin Taton , Laurie Lawin , William Knopke , Eric Guire , Patrick Guire
CPC分类号: C08F8/42 , A61L29/06 , A61L29/085 , A61L29/14 , A61L29/16 , A61L31/022 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/0005 , A61L2300/404 , A61L2300/42 , A61L2400/10 , A61L2420/02 , A61L2420/08 , B05D3/06 , C08F8/28 , C08F8/30 , C08F267/04 , C09D131/00 , C09D135/00 , Y10T428/31507 , Y10T428/31511 , Y10T428/31573 , Y10T428/31598 , Y10T428/31663 , Y10T428/31667 , Y10T428/31721 , Y10T428/3175 , Y10T428/31797 , Y10T428/31855 , Y10T428/31884 , Y10T428/31909 , Y10T428/31913 , Y10T428/31928 , C08F222/06
摘要: The invention describes novel coating agents that include a polymer, one or more latent reactive groups and one or more noncovalent linking groups, the noncovalent linking groups selected to interact with a substrate to which the coating agent is applied. The coating agents are useful for providing a coating that can be further functionalized (for example, by application of additional coating layers), or for providing desirable properties to a surface.
摘要翻译: 本发明描述了新颖的涂层剂,其包括聚合物,一个或多个潜在反应性基团和一个或多个非共价连接基团,所选择的非共价连接基团与施加涂覆剂的基底相互作用。 涂层剂可用于提供可以进一步官能化的涂层(例如,通过施加额外的涂层),或用于为表面提供所需的性质。
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公开(公告)号:US20060147847A1
公开(公告)日:2006-07-06
申请号:US11027036
申请日:2004-12-30
申请人: Patrick Guire , Kristin Taton , Jie Wen
发明人: Patrick Guire , Kristin Taton , Jie Wen
IPC分类号: G03C5/00
CPC分类号: A61L15/46 , A01N59/00 , A61L2300/106 , A61L2300/404 , A61L2300/606
摘要: The invention provides polymeric reagents of a formula: Xa—Y-Zb wherein X is a latent reactive group, Y is a polymeric backbone, and Z is a melamine group. In some aspects of the above formula, a is in the range of 0.5 to 90 mole percent, and b is in the range of 10 to 99.5 mole percent. The latent reactive group can be a photoreactive group or a thermally-reactive group. Monomeric units for preparing the polymeric reagents are also described. Methods of using the polymeric reagents to provide modified surfaces are also described, as well as methods of providing biocidal surfaces and methods of treating habitats for halogen-sensitive microorganisms.
摘要翻译: 本发明提供下式的聚合物试剂:<?in-line-formula description =“In-line Formulas”end =“lead”?> X a-a Z b <?in-line-formula description =“In-line Formulas”end =“tail”?>其中X是潜在的反应性基团,Y是聚合物主链,Z是三聚氰胺基团。 在上式的某些方面,a为0.5〜90摩尔%,b为10〜99.5摩尔%。 潜在反应性基团可以是光反应性基团或热反应性基团。 还描述了用于制备聚合物试剂的单体单元。 还描述了使用聚合物试剂提供改性表面的方法,以及提供杀生物表面的方法和处理卤敏感微生物栖息地的方法。
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公开(公告)号:US20130171331A1
公开(公告)日:2013-07-04
申请号:US13710390
申请日:2012-12-10
申请人: Tahmina Naqvi , Jie Wen , Patrick Guire
发明人: Tahmina Naqvi , Jie Wen , Patrick Guire
IPC分类号: G01N33/48
CPC分类号: C12N5/0068 , A61L27/16 , A61L27/34 , A61L27/50 , A61L27/54 , A61L29/041 , A61L29/085 , A61L29/14 , A61L29/16 , A61L31/048 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/00 , A61L2400/12 , C12M23/08 , C12M23/20 , C12M25/14 , C12N2533/30 , C12N2537/10 , C12N2539/00 , D01D5/0007 , D01F1/10 , D01F6/22 , D01F6/26 , D01F6/625 , D06M15/285 , D06M2400/01 , G01N33/48 , C08L33/26
摘要: A stimuli responsive nanofiber that includes a stimuli responsive polymer, such as a thermally responsive polymer, and a cross-linking agent having at least two latent reactive activatable groups. The nanofiber may also include a biologically active material or a functional polymer. The stimuli responsive nanofiber can be used to modify the surface of a substrate. When the nanofiber includes a thermally responsive polymer, the physical properties of the surface can be controlled by controlling the temperature of the system, thus controlling the ability of the surface to bind to a biologically active material of interest.
摘要翻译: 刺激响应性纳米纤维,其包括刺激响应聚合物,例如热响应性聚合物,以及具有至少两个潜在反应性可活化基团的交联剂。 纳米纤维还可以包括生物活性材料或功能性聚合物。 刺激性响应性纳米纤维可用于改性基材的表面。 当纳米纤维包含热响应性聚合物时,可以通过控制体系的温度来控制表面的物理性能,从而控制表面结合生物活性物质的能力。
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公开(公告)号:US20100255581A1
公开(公告)日:2010-10-07
申请号:US12666168
申请日:2008-06-20
申请人: Tahmina Naqvi , Jie Wen , Patrick Guire
发明人: Tahmina Naqvi , Jie Wen , Patrick Guire
IPC分类号: C12N5/07
CPC分类号: C12N5/0068 , A61L27/16 , A61L27/34 , A61L27/50 , A61L27/54 , A61L29/041 , A61L29/085 , A61L29/14 , A61L29/16 , A61L31/048 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/00 , A61L2400/12 , C12M23/08 , C12M23/20 , C12M25/14 , C12N2533/30 , C12N2537/10 , C12N2539/00 , D01D5/0007 , D01F1/10 , D01F6/22 , D01F6/26 , D01F6/625 , D06M15/285 , D06M2400/01 , G01N33/48 , C08L33/26
摘要: A stimuli responsive nanofiber that includes a stimuli responsive polymer, such as a thermally responsive polymer, and a cross-linking agent having at least two latent reactive activatable groups. The nanofiber may also include a biologically active material or a functional polymer. The stimuli responsive nanofiber can be used to modify the surface of a substrate. When the nanofiber includes a thermally responsive polymer, the physical properties of the surface can be controlled by controlling the temperature of the system, thus controlling the ability of the surface to bind to a biologically active material of interest.
摘要翻译: 刺激响应性纳米纤维,其包括刺激响应聚合物,例如热响应性聚合物,以及具有至少两个潜在反应性可活化基团的交联剂。 纳米纤维还可以包括生物活性材料或功能性聚合物。 刺激性响应性纳米纤维可用于改性基材的表面。 当纳米纤维包含热响应性聚合物时,可以通过控制体系的温度来控制表面的物理性能,从而控制表面结合生物活性物质的能力。
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公开(公告)号:US20110020917A1
公开(公告)日:2011-01-27
申请号:US12666173
申请日:2008-06-20
申请人: Jie Wen , Patrick Guire
发明人: Jie Wen , Patrick Guire
CPC分类号: D01D5/003 , A61L27/50 , A61L29/14 , A61L31/14 , A61L2400/12 , B05D3/067 , B29C35/08 , C12M23/20 , D01D5/0007 , D01F1/10 , D01F6/625 , D06M15/263 , D06M15/273 , D06M15/285 , D06M2400/01
摘要: A nanofiber is formed by combining one or more natural or synthetic polymeric materials and one or more than one cross-linking agents having at least two latent reactive activatable groups. The latent reactive activatable nanofiber may be used to modify the surface of a substrate by activating at least one of the latent reactive activatable groups to bond the nanofiber to the surface by the formation of a covalent bond between the surface of the substrate and the latent reactive activatable group. Some of the remaining latent reactive activatable group(s) are left accessible on the surface of the substrate, and may be used for further surface modification of the substrate. Biologically active materials may be immobilized on the nanofiber modified surface by reacting with the latent reactive groups that are accessible on the surface of the substrate.
摘要翻译: 通过组合一种或多种天然或合成聚合物材料和具有至少两个潜在反应性可活化基团的一种或多种交联剂形成纳米纤维。 潜在的可反应活化的纳米纤维可用于通过活化至少一个潜在的反应性可活化基团来修饰底物的表面,以通过在基材的表面和潜在的反应性之间形成共价键将纳米纤维结合到表面 可激活组。 剩余的潜在反应性可活化基团中的一些在基材的表面上是可接近的,并且可以用于基材的进一步的表面改性。 生物活性物质可以通过与底物表面上可触及的潜在反应性基团反应而固定在纳米纤维改性表面上。
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公开(公告)号:US20100274012A1
公开(公告)日:2010-10-28
申请号:US12831673
申请日:2010-07-07
申请人: Patrick Guire , Kristin Taton , Jie Wen
发明人: Patrick Guire , Kristin Taton , Jie Wen
IPC分类号: C07D251/06
CPC分类号: C07D251/30 , C07C275/10 , C07D251/34 , C09D139/08
摘要: The invention describes novel crosslinking compounds that include photoactivatable moieties. Several families of compounds are disclosed that can include one or more hydrophilic moieties that help to solubilize the compounds in aqueous environments.
摘要翻译: 本发明描述了包含可光活化部分的新型交联化合物。 公开了几种化合物家族,其可以包括一种或多种有助于将化合物溶解在水性环境中的亲水部分。
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公开(公告)号:US20070104757A1
公开(公告)日:2007-05-10
申请号:US11539328
申请日:2006-10-06
申请人: Patrick Guire , Aron Anderson , Richard Amos , Terrence Everson , Peter Duquette
发明人: Patrick Guire , Aron Anderson , Richard Amos , Terrence Everson , Peter Duquette
IPC分类号: A61F2/02
CPC分类号: A61K31/12 , A61K31/74 , A61K47/6957 , A61L27/227 , A61L27/34 , A61L27/507 , A61L29/048 , A61L29/085 , A61L31/047 , A61L31/10 , A61L33/0011 , A61L33/0029 , A61L33/0082
摘要: A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
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公开(公告)号:US20060052460A1
公开(公告)日:2006-03-09
申请号:US11212930
申请日:2005-08-26
申请人: Patrick Guire , Aron Anderson , Richard Amos , Terrence Everson , Peter Duquette
发明人: Patrick Guire , Aron Anderson , Richard Amos , Terrence Everson , Peter Duquette
IPC分类号: A61K31/12
CPC分类号: A61K31/12 , A61K31/74 , A61K47/6957 , A61L27/227 , A61L27/34 , A61L27/507 , A61L29/048 , A61L29/085 , A61L31/047 , A61L31/10 , A61L33/0011 , A61L33/0029 , A61L33/0082
摘要: A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
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公开(公告)号:US5258041A
公开(公告)日:1993-11-02
申请号:US671621
申请日:1991-03-19
申请人: Patrick Guire , Shawn G. Dunkirk
发明人: Patrick Guire , Shawn G. Dunkirk
IPC分类号: A61F2/00 , A61K47/48 , A61L27/34 , A61L27/36 , A61L33/00 , C12N5/00 , C12N11/06 , G01N33/531 , G01N33/543 , A61F2/54
CPC分类号: A61L27/34 , A61F2/0077 , A61K47/48369 , A61L27/36 , A61L33/0011 , A61L33/0029 , C12N11/06 , C12N5/0068 , G01N33/531 , G01N33/543 , C12N2533/30 , C12N2533/54 , C12N2533/70 , C12N2533/78 , C12N2533/80 , Y10S623/901 , Y10S623/92
摘要: A method for attaching a biomolecule to a support having a hydrophobic surface, involving the use of a long chain chemical spacer having a hydrophobic guiding group capable of becoming embedded in the surface, and the biomolecule being covalently bound to the spacer at its opposite end.
摘要翻译: 一种用于将生物分子附着到具有疏水性表面的载体上的方法,涉及使用具有能够嵌入表面的疏水性引导基团的长链化学间隔物,并且生物分子在其相对端共价结合到间隔物。
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公开(公告)号:US20050170427A1
公开(公告)日:2005-08-04
申请号:US11101271
申请日:2005-04-06
申请人: Ralph Chappa , Sheau-Ping Hu , Dale Swan , Melvin Swanson , Patrick Guire
发明人: Ralph Chappa , Sheau-Ping Hu , Dale Swan , Melvin Swanson , Patrick Guire
IPC分类号: G01N33/53 , C07B61/00 , C07C45/63 , C07C235/84 , C07C323/42 , C07H21/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C12Q1/6834 , C40B40/06 , C40B60/14 , G01N1/28 , G01N21/78 , G01N33/566 , G01N37/00 , C07H21/04 , C12M1/34
CPC分类号: B82Y30/00 , B01J2219/00317 , B01J2219/00531 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00716 , B01J2219/00722 , C07B2200/11 , C07C45/63 , C07C235/84 , C07C323/42 , C07H21/00 , C12Q1/6834 , C40B40/06 , C40B60/14 , C07C49/813
摘要: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.
摘要翻译: 用于将目标分子(例如核酸)共价连接到基底表面上的方法和试剂组合物。 试剂组合物包括能够共价结合靶分子的基团。 任选地,组合物可以含有用于将试剂组合物附着到表面上的光反应性基团。 试剂组合物可用于提供用于制备核酸微阵列的活性载玻片。
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