公开(公告)号：US20190059793A1

公开(公告)日：2019-02-28

申请号：US16170901

申请日：2018-10-25

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Rajiv Shah

IPC: A61B5/1495 ,  G01R35/00 ,  A61B5/053 ,  G01N33/96 ,  G01N33/66 ,  G01N33/49 ,  G01N27/416 ,  G01N27/02 ,  A61B5/145 ,  A61M5/172 ,  A61M5/158 ,  A61M5/142 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/1473 ,  A61B5/1459

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20180074010A1

公开(公告)日：2018-03-15

申请号：US15818111

申请日：2017-11-20

Applicant: Medtronic Minimed, Inc.

Inventor： Jenn-Hann Larry Wang ,  Michael E. Miller ,  Raghavendhar Gautham ,  Yiwen Li ,  Rajiv Shah

IPC: G01N27/416 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1486 ,  G01N33/66 ,  G01N27/02 ,  A61M5/172 ,  A61M5/158 ,  A61B5/00 ,  A61B5/1495 ,  A61M5/142 ,  A61B5/053

CPC classification number: A61B5/1495 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US09861746B2

公开(公告)日：2018-01-09

申请号：US13778559

申请日：2013-02-27

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Raghavendhar Gautham ,  Ning Yang ,  Rajiv Shah

IPC: A61B5/05 ,  A61M5/172 ,  G01N27/416 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/00 ,  A61B5/053 ,  A61B5/1495 ,  G01N33/66 ,  A61B5/1459 ,  A61M5/158 ,  A61B5/1486 ,  A61M5/142 ,  G01N27/02 ,  G01N33/96 ,  G01N33/49

CPC classification number: G01N27/4163 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20170181676A1

公开(公告)日：2017-06-29

申请号：US14980205

申请日：2015-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Raghavendhar Gautham ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Jaeho Kim ,  Mike C. Liu ,  Andy Y. Tsai ,  Jeffrey Nishida

IPC: A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/053

CPC classification number: A61B5/14532 ,  A61B5/14865 ,  A61B5/7221 ,  A61B2560/0223 ,  A61B2560/0276

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US09681828B2

公开(公告)日：2017-06-20

申请号：US14267739

申请日：2014-05-01

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Steven C. Jacks ,  Raghavendhar Gautham ,  Bradley C. Liang ,  Megan E. Little ,  Daniel E. Pesantez ,  Rajiv Shah

IPC: C25D5/18 ,  C25D3/50 ,  A61B5/145 ,  G01N27/327 ,  C23C28/00 ,  C25D3/52 ,  C25D3/56 ,  C25D7/00

CPC classification number: G01N27/416 ,  A61B5/1451 ,  A61B5/14532 ,  A61B2562/02 ,  A61B2562/125 ,  C23C28/00 ,  C25D3/52 ,  C25D3/567 ,  C25D5/18 ,  C25D7/00 ,  G01N27/30 ,  G01N27/327

Abstract: A physiological characteristic sensor, a method for forming a physiological characteristic sensor, and a method for forming a platinum deposit having a rough surface are presented here. The method for forming a physiological characteristic sensor includes immersing a sensor electrode in a platinum electrolytic bath. Further, the method includes performing an electrodeposition process by sequentially applying a pulsed signal to the sensor electrode and applying a non-pulsed continuous signal to the sensor electrode to form a platinum deposit on the sensor electrode.

公开(公告)号：US09493807B2

公开(公告)日：2016-11-15

申请号：US13779271

申请日：2013-02-27

Applicant: Medtronic MiniMed, Inc.

Inventor： Megan E. Little ,  Katherine T. Wolfe ,  Raghavendhar Gautham ,  Bradley Chi Liang ,  Rajiv Shah

IPC: G01N27/327 ,  C12Q1/00 ,  A61B5/1486

CPC classification number: A61B5/14532 ,  A61B5/14865 ,  A61B2562/125 ,  A61B2562/166 ,  A61B2562/222 ,  C12Q1/001 ,  C12Q1/006 ,  G01N27/3272 ,  Y10T29/49204

Abstract: The invention disclosed herein includes sensors having three dimensional configurations that allow expansive “360°” sensing (i.e. sensing analyte from multiple directions) in the environments in which such sensors are disposed. Embodiments of the invention provide analyte sensors having foldable substrates adapted to produce optimized configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

Abstract translation: 本文公开的本发明包括具有三维结构的传感器，其在这些传感器被布置的环境中允许宽广的“360°”感测（即感测来自多个方向的分析物）。 本发明的实施例提供了分析物传感器，其具有适于产生电极元件的优化配置的可折叠基底以及用于制造和使用这种传感器的方法。 本发明的典型实施方案包括用于治疗糖尿病的葡萄糖传感器。

公开(公告)号：US09179870B2

公开(公告)日：2015-11-10

申请号：US14470167

申请日：2014-08-27

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rajiv Shah ,  Rebecca K. Gottlieb

IPC: A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  C12Q1/00 ,  C23C14/20 ,  C23C14/34

CPC classification number: A61B5/14865 ,  A61B5/0004 ,  A61B5/0017 ,  A61B5/14532 ,  A61B5/6848 ,  A61B5/6849 ,  C12Q1/006 ,  C23C14/20 ,  C23C14/3414 ,  G01N27/307 ,  G01N27/3273 ,  G01N27/4166 ,  Y10T29/49002 ,  Y10T29/49005 ,  Y10T29/49007 ,  Y10T29/49117 ,  Y10T29/49155

Abstract: A thin film sensor, such as a glucose sensor, is provided for transcutaneous placement at a selected site within the body of a patient. The sensor includes several sensor layers that include conductive layers and includes a proximal segment defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment with sensor electrodes for transcutaneous placement. The sensor electrode layers are disposed generally above each other, for example with the reference electrode above the working electrode and the working electrode above the counter electrode. The electrode layers are separated by dielectric layer.

Abstract translation: 提供薄膜传感器，例如葡萄糖传感器，用于经皮放置在患者体内的选定部位。 传感器包括几个传感器层，其包括导电层，并且包括限定适于与合适的监视器电连接的导电触点的近端段，以及具有用于经皮放置的传感器电极的远端段。 传感器电极层大致彼此上下设置，例如，在工作电极上方的参考电极和对置电极上方的工作电极。 电极层由电介质层分离。

公开(公告)号：US20150300969A1

公开(公告)日：2015-10-22

申请号：US14256229

申请日：2014-04-18

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Benyamin Grosman ,  Desmond Barry Keenan ,  John J. Mastrototaro ,  Rajiv Shah ,  Andrea Varsavsky ,  Ning Yang

IPC: G01N27/02

CPC classification number: G01N27/026

Abstract: A method of measuring blood glucose of a patient is presented here. In accordance with certain embodiments, the method applies a constant voltage potential to a glucose sensor and obtains a constant potential sensor current from the glucose sensor, wherein the constant potential sensor current is generated in response to applying the constant voltage potential to the glucose sensor. The method continues by performing an electrochemical impedance spectroscopy (EIS) procedure for the glucose sensor to obtain EIS output measurements. The method also performs a nonlinear mapping operation on the constant potential sensor current and the EIS output measurements to generate a blood glucose value.

Abstract translation: 这里给出了测量患者血糖的方法。 根据某些实施例，该方法向葡萄糖传感器施加恒定电压电位，并从葡萄糖传感器获得恒定的电位传感器电流，其中响应于向葡萄糖传感器施加恒定电压电位而产生恒定电位传感器电流。 该方法通过对葡萄糖传感器执行电化学阻抗谱（EIS）程序来获得EIS输出测量结果。 该方法还对恒定电位传感器电流和EIS输出测量执行非线性映射操作以产生血糖值。

公开(公告)号：US20150297822A1

公开(公告)日：2015-10-22

申请号：US14788668

申请日：2015-06-30

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Eric Allan Larson ,  Rajiv Shah

IPC: A61M5/00 ,  B65D77/26 ,  A61B5/145 ,  A61L2/08 ,  B65B55/02 ,  B65B5/04 ,  B65B7/28 ,  B65D65/38 ,  A61B5/1486

CPC classification number: A61B50/3001 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B2050/0065 ,  A61B2560/063 ,  A61B2562/12 ,  A61B2562/125 ,  A61B2562/242 ,  A61L2/08 ,  A61L2/087 ,  A61M5/003 ,  B65B5/04 ,  B65B7/16 ,  B65B7/2842 ,  B65B55/02 ,  B65B55/16 ,  B65D65/38 ,  B65D75/326 ,  B65D77/26

Abstract: A glucose sensor product maintains the sterility of the glucose sensor while allowing gaseous manufacturing by-products to be vented from the inside of the glucose sensor package. An exemplary glucose sensor product includes a plastic package tray and a glucose sensor assembly in the plastic package tray. The glucose sensor assembly includes an electrochemical sensor with glucose oxidase enzyme, a sensor base formed at least in part from plastic, a sensor mounting pedestal formed at least in part from plastic, and a sensor introducer formed at least in part from plastic. The glucose sensor product also includes a microbial barrier material coupled to the plastic package tray to seal the glucose sensor assembly in the plastic package tray. The microbial barrier material maintains sterility of the glucose sensor assembly while venting substances outgassed from the plastic package tray, the sensor base, the sensor mounting pedestal, and the sensor introducer.

Abstract translation: 葡萄糖传感器产品保持葡萄糖传感器的无菌性，同时允许气体制造副产物从葡萄糖传感器封装的内部排出。 示例性的葡萄糖传感器产品包括在塑料包装托盘中的塑料包装托盘和葡萄糖传感器组件。 葡萄糖传感器组件包括具有葡萄糖氧化酶的电化学传感器，至少部分由塑料形成的传感器基座，至少部分地由塑料形成的传感器安装基座，以及至少部分地由塑料形成的传感器引导器。 葡萄糖传感器产品还包括耦合到塑料封装托盘以将葡萄糖传感器组件密封在塑料封装托盘中的微生物屏障材料。 微生物阻挡材料保持葡萄糖传感器组件的无菌性，同时排出从塑料包装托盘，传感器基座，传感器安装基座和传感器引导器中脱气的物质。

公开(公告)号：US20130331676A1

公开(公告)日：2013-12-12

申请号：US13778611

申请日：2013-02-27

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Wayne A. Morgan ,  Paris Chen ,  Rajiv Shah

IPC: A61B5/145

CPC classification number: A61B5/1495 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.