公开(公告)号：US20230251230A1

公开(公告)日：2023-08-10

申请号：US18304470

申请日：2023-04-21

Applicant: Waters Technologies Corporation

Inventor： Theodore A. Dourdeville

IPC: G01N30/60 ,  B23K20/02 ,  B23K20/233 ,  B23K20/24 ,  G01N30/20

CPC classification number: G01N30/606 ,  B23K20/023 ,  B23K20/233 ,  B23K20/24 ,  G01N30/20 ,  B23K2101/14

Abstract: A liquid chromatography apparatus includes a diffusion-bonded separation column comprising a lower substrate comprising titanium, an upper substrate comprising titanium, and a titanium patterned foil disposed between the lower substrate and the upper substrate. The lower substrate, titanium patterned foil, and upper substrate are diffusion bonded together to form a fluid path extending from an inlet port to an outlet port, wherein walls defining the fluid path within the diffusion-bonded separation column include a titanium surface coating.

公开(公告)号：US20220252558A1

公开(公告)日：2022-08-11

申请号：US17731318

申请日：2022-04-28

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Theodore A. Dourdeville

IPC: G01N30/38 ,  G01N30/16 ,  G01N30/32 ,  G01N30/60

Abstract: The present disclosure relates to methodologies, systems, and apparatus for controlling fluid flow within a chromatography system. The chromatography system includes a mobile phase pump configured to pump a liquid mobile phase through a column and a restrictor positioned downstream of the column and upstream of a detector. The system also includes a valve configured to operate in at least two positions. In a first position, the valve is configured to direct the output of the column to bypass the valve and reach the detector, while in the second position the valve directs the output of the column to waste.

公开(公告)号：US11340198B2

公开(公告)日：2022-05-24

申请号：US16425057

申请日：2019-05-29

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Theodore A. Dourdeville

IPC: G01N30/38 ,  G01N30/16 ,  G01N30/32 ,  G01N30/60

Abstract: The present disclosure relates to methodologies, systems, and apparatus for controlling fluid flow within a chromatography system. The chromatography system includes a mobile phase pump configured to pump a liquid mobile phase through a column and a restrictor positioned downstream of the column and upstream of a detector. The system also includes a valve configured to operate in at least two positions. In a first position, the valve is configured to direct the output of the column to bypass the valve and reach the detector, while in the second position the valve directs the output of the column to waste.

公开(公告)号：US11185795B2

公开(公告)日：2021-11-30

申请号：US15487599

申请日：2017-04-14

Applicant: Waters Technologies Corporation

Inventor： Edouard S. P. Bouvier ,  Joseph A. Jarrell ,  Wade P. Leveille ,  Fabrice Gilles Ernest Gritti ,  Theodore A. Dourdeville ,  Michael O. Fogwill

IPC: B01D15/16 ,  B01D15/20 ,  B01D15/22 ,  G01N30/30 ,  G01N30/60 ,  G01N30/02 ,  G01N30/32

Abstract: Apparatus and methods for performing chromatography may include a chromatography column and a vacuum insulated jacket having an inner wall and an outer wall. A vacuum area may be formed between the inner wall and the outer wall. The inner wall of the vacuum insulated jacket may surround the chromatography column. A gap may be formed between an outer wall of the chromatography column and the inner wall of the vacuum insulated jacket. The vacuum insulated jacket may extend beyond one or more end frits of the column. The gap may be filled with one or more materials so as to form an insulating or thermal barrier.

公开(公告)号：US11169125B2

公开(公告)日：2021-11-09

申请号：US16384272

申请日：2019-04-15

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Michael O. Fogwill ,  Curt Devlin ,  Theodore A. Dourdeville ,  Jacob N. Fairchild ,  Geoff C. Gerhardt ,  Wade P. Leveille ,  Joseph D. Michienzi ,  Jeffrey Musacchio

IPC: G01N30/00 ,  G01N30/72

Abstract: Techniques and apparatus for ion source devices with minimized post-column volumes are described. In one embodiment, for example, an ion source assembly may include a chromatography column in fluid communication with an ion source device, the chromatography column arranged within a minimum distance of the ion source, the minimum distance comprising between about 60 mm and about 150 mm.

公开(公告)号：US20190317062A1

公开(公告)日：2019-10-17

申请号：US16384272

申请日：2019-04-15

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Michael O. Fogwill ,  Curt Devlin ,  Theodore A. Dourdeville ,  Jacob N. Fairchild ,  Geoff C. Gerhardt ,  Wade P. Leveille ,  Joseph D. Michienzi ,  Jeffrey Musacchio

IPC: G01N30/72

Abstract: Techniques and apparatus for ion source devices with minimized post-column volumes are described. In one embodiment, for example, an ion source assembly may include a chromatography column in fluid communication with an ion source device, the chromatography column arranged within a minimum distance of the ion source, the minimum distance comprising between about 60 mm and about 150 mm.

公开(公告)号：US20190086371A1

公开(公告)日：2019-03-21

申请号：US16133089

申请日：2018-09-17

Applicant: Waters Technologies Corporation

Inventor： Matthew A. Lauber ,  Mathew H. DeLano ,  Scott A. McCall ,  Jonathan L. Belanger ,  Theodore A. Dourdeville ,  Kerri M. Smith ,  Paul D. Rainville ,  Dimple D. Shah ,  Stephen J. Shiner ,  Catalin Doneanu ,  Michael Donegan

IPC: G01N30/56 ,  G01N30/60 ,  G01N30/72 ,  C23C14/24 ,  C23C14/12 ,  C23C14/04

Abstract: A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I: R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20—, —(C1-C10)[NH(CO)NH(C1-C10)]1-20-, or —(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.

公开(公告)号：US20180328899A1

公开(公告)日：2018-11-15

申请号：US16035000

申请日：2018-07-13

Applicant: Waters Technologies Corporation

Inventor： Theodore A. Dourdeville

IPC: G01N30/60 ,  B23K20/24 ,  B23K20/02 ,  B23K20/233 ,  G01N30/20 ,  B23K103/14 ,  B23K101/14

CPC classification number: G01N30/606 ,  B23K20/023 ,  B23K20/233 ,  B23K20/24 ,  B23K2101/14 ,  B23K2103/14 ,  G01N30/20 ,  G01N30/6095 ,  G01N2030/201 ,  G01N2030/202

Abstract: An HPLC apparatus includes a heat exchanger formed from diffusion-bonded first and second titanium substrates. At least two conduits for counterflow are defined between the first and second substrates.

公开(公告)号：US20170282096A1

公开(公告)日：2017-10-05

申请号：US15487599

申请日：2017-04-14

Applicant: Waters Technologies Corporation

Inventor： Edouard S.P. Bouvier ,  Joseph A. Jarrell ,  Wade P. Leveille ,  Fabrice Gilles Ernest Gritti ,  Theodore A. Dourdeville ,  Michael O. Fogwill

IPC: B01D15/16 ,  G01N30/60 ,  G01N30/30 ,  G01N30/32 ,  B01D15/22 ,  B01D15/20

CPC classification number: B01D15/161 ,  B01D15/20 ,  B01D15/22 ,  G01N30/30 ,  G01N30/32 ,  G01N30/6052 ,  G01N2030/027 ,  G01N2030/3007

Abstract: Apparatus and methods for performing chromatography may include a chromatography column and a vacuum insulated jacket having an inner wall and an outer wall. A vacuum area may be formed between the inner wall and the outer wall. The inner wall of the vacuum insulated jacket may surround the chromatography column. A gap may be formed between an outer wall of the chromatography column and the inner wall of the vacuum insulated jacket. The vacuum insulated jacket may extend beyond one or more end frits of the column. The gap may be filled with one or more materials so as to form an insulating or thermal barrier.

公开(公告)号：US20170038350A1

公开(公告)日：2017-02-09

申请号：US15231302

申请日：2016-08-08

Applicant: Waters Technologies Corporation

Inventor： Bernard Bunner ,  Theodore A. Dourdeville

IPC: G01N30/72 ,  B23K20/02 ,  B23H9/12 ,  C23F1/14 ,  B23H9/14 ,  B23K26/382 ,  B23B35/00 ,  C23C16/44 ,  G01N30/60 ,  C23C26/00

CPC classification number: G01N30/7266 ,  B01L3/502707 ,  B01L3/502753 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0487 ,  B23B35/00 ,  B23H9/12 ,  B23H9/14 ,  B23K20/023 ,  B23K20/233 ,  B23K26/382 ,  B23K2101/18 ,  B23K2103/14 ,  C23C16/44 ,  C23C26/00 ,  C23F1/14 ,  G01N30/6095 ,  H01J49/0018 ,  H01J49/167

Abstract: A microfluidic device for separating a sample by chromatography includes diffusion bonded metallic sheets joined together to create a hermetically sealed interface between each adjacent metallic sheet without the introduction of a secondary material. Enclosed within the diffusion bonded sheets is a separation channel accessible by at least one of an inlet or an outlet. The separation channel is packed with micrometer-sized particles serving as a stationary phase in a chromatographic separation. Wetted surfaces of the separation channel include a coating of an organic material at least one monolayer thick.

Abstract translation: 用于通过色谱分离样品的微流体装置包括连接在一起的扩散接合的金属片，以在每个相邻的金属片之间形成气密密封的界面，而不引入次级材料。 封隔在扩散接合片内的是可由入口或出口中的至少一个接近的分离通道。 分离通道用色谱分离中用作固定相的微米级颗粒填充。 分离通道的接液表面包括至少一层单层厚的有机材料的涂层。