公开(公告)号：US20140243512A1

公开(公告)日：2014-08-28

申请号：US14343969

申请日：2012-09-17

Applicant: INSTRACTION GMBH

Inventor： Markus Arendt ,  Björn Degel ,  Thomas Schwarz ,  Gerhard Stumm ,  Martin Welter

IPC: B01J20/286

CPC classification number: B01J20/286 ,  A61K31/436 ,  A61K31/4745 ,  A61K31/7032 ,  B01D15/08 ,  B01J20/103 ,  B01J20/262 ,  B01J20/267 ,  B01J20/28088 ,  B01J20/283 ,  B01J20/285 ,  B01J20/287 ,  B01J20/288 ,  B01J20/289 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3221 ,  B01J20/3253 ,  B01J20/3272 ,  B01J20/3282 ,  B01J20/3285 ,  C07C213/10 ,  C07C2601/14 ,  C07D491/22 ,  C07D498/18 ,  C07H17/08 ,  C07C215/44

Abstract: In a first embodiment the present invention relates to a sorbent comprising a porous inorganic solid support material having on its surface a film of a crosslinked polyvinylamine comprising derivatized amine groups and amine groups binding to the surface of the support material via electron donor/acceptor interactions. In a second embodiment the present invention relates to a sorbent comprising a solid support material, the surface of which comprises a residue of a general formula (I), wherein the residue is attached via a covalent single bond to a functional group on the surface of either the bulk solid support material itself or of a polymer film on the surface of the solid support material. Furthermore, the present invention relates to the use of the sorbents according to the invention for the purification of organic molecules, in particular pharmaceutical active compounds, preferably in chromatographic applications.

Abstract translation: 在第一实施方案中，本发明涉及一种吸附剂，其包含多孔无机固体支持材料，其表面上具有包含衍生的胺基团的交联聚乙烯胺的膜和通过电子给体/受体相互作用结合载体材料的表面的胺基。 在第二个实施方案中，本发明涉及包含固体支持材料的吸附剂，其表面包含通式（I）的残基，其中残基通过共价单键连接到表面上的官能团 本体固体支撑材料本身或固体支撑材料表面上的聚合物膜。 此外，本发明涉及根据本发明的吸附剂用于纯化有机分子，特别是药物活性化合物，优选在色谱应用中的用途。

公开(公告)号：US20140183130A1

公开(公告)日：2014-07-03

申请号：US14181097

申请日：2014-02-14

Applicant: GLYCOREX TRANSPLANTATION AB

Inventor： Kurt G.I. Nilsson

IPC: A61K35/16

CPC classification number: A61K35/16 ,  A61M1/3687 ,  B01D15/3804 ,  B01J20/262 ,  B01J20/267 ,  B01J20/28009 ,  B01J20/3212 ,  B01J20/3217 ,  B01J20/3219 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3255 ,  B01J20/3274 ,  B01J2220/58 ,  G01N2400/38

Abstract: A Product is described and which contains at least one type of ligand bound to a separation material and which allows selective binding or cleavage of a biomolecule for example in human blood.

Abstract translation: 描述了一种产品，其含有与分离材料结合的至少一种类型的配体，并且其允许例如人血液中生物分子的选择性结合或切割。

公开(公告)号：US08377306B2

公开(公告)日：2013-02-19

申请号：US12295288

申请日：2007-03-29

Applicant: Andre-Jean Attias ,  Fabrice Charra ,  Ludovic Douillard ,  Celine Fiorini ,  David Kreher ,  Fabrice Mathevet ,  Guillaume Schull

Inventor： Andre-Jean Attias ,  Fabrice Charra ,  Ludovic Douillard ,  Celine Fiorini ,  David Kreher ,  Fabrice Mathevet ,  Guillaume Schull

IPC: B01D15/04 ,  B01D24/00

CPC classification number: B01J20/28035 ,  B01D15/00 ,  B01D15/34 ,  B01J20/22 ,  B01J20/3204 ,  B01J20/3246 ,  B01J20/3253 ,  B01J20/3255

Abstract: The invention concerns a method for treating a fluid. According to the invention, the fluid is contacted with a substrate at the surface of which there is a network of organic molecules, hereafter referred to as “network molecules”. There is a central core and at least one lateral arm, the molecules being adsorbed at the surface of the substrate. The invention also concerns a two-dimensional molecular sieve formed by the substrate at the surface of which a network of network molecules is adsorbed. The invention further concerns a module for treating a fluid including a circulating device for the fluid to be treated, the device containing one or more two-dimensional molecule sieves.

Abstract translation: 本发明涉及一种处理流体的方法。 根据本发明，流体与其表面具有有机分子网络的底物接触，下文称为网络分子。 存在中心核心和至少一个横向臂，分子被吸附在基底的表面。 本发明还涉及由其上吸附有网络分子网络的表面形成的二维分子筛。 本发明还涉及一种用于处理流体的模块，该流体包括用于待处理流体的循环装置，该装置含有一个或多个二维分子筛。

公开(公告)号：US20120211696A1

公开(公告)日：2012-08-23

申请号：US13435163

申请日：2012-03-30

Applicant: Daniel W. Armstrong ,  Jared Anderson

Inventor： Daniel W. Armstrong ,  Jared Anderson

IPC: C09K3/00

CPC classification number: B01J20/292 ,  B01J20/22 ,  B01J20/286 ,  B01J20/29 ,  B01J20/3092 ,  B01J20/3204 ,  B01J20/3246 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3255 ,  B01J20/3276 ,  B01J20/3282 ,  B01J20/3285 ,  B01J20/3287 ,  B01J2220/54 ,  B01J2220/58 ,  B01J2220/64 ,  B01J2220/84 ,  C07D233/54 ,  C07F9/5407 ,  C07F9/5449 ,  C07F9/58 ,  C07F9/6512 ,  Y02P20/542

Abstract: The present invention relates to diionic liquid salts of dicationic or dianionic molecules, as well as solvents comprising such diionic liquids and the use of such diionic liquids as the stationary phase in a gas chromatographic column.

Abstract translation: 本发明涉及双阳离子或二阴离子分子的双离子液体盐，以及包含这种双离子液体的溶剂以及在气相色谱柱中使用这种二元液体作为固定相。

公开(公告)号：US20120152847A1

公开(公告)日：2012-06-21

申请号：US13146190

申请日：2010-01-20

Applicant: Dieter Falkenhagen ,  Viktoria Weber

Inventor： Dieter Falkenhagen ,  Viktoria Weber

IPC: A61M1/36 ,  B01D15/08 ,  B01J20/22

CPC classification number: B01J20/3253 ,  A61M1/3679 ,  B01D15/00 ,  B01D15/08 ,  B01J20/28004 ,  B01J20/28023 ,  B01J20/28085 ,  B01J20/321 ,  B01J20/3255 ,  B01J2220/58

Abstract: The invention relates to a sorption agent for removing endotoxins from a biological fluid, the sorption agent having a water-insoluble, porous carrier and polymyxin, which is immobilized on the carrier, the carrier having a neutral, hydrophobic surface and polymyxin being immobilized on the surface of the carrier via hydrophobic interaction. The sorption agent is used in extracorporeal blood purification, in particular for treating individuals with sepsis.

Abstract translation: 本发明涉及用于从生物流体中除去内毒素的吸附剂，该吸附剂具有固定在载体上的水不溶性多孔载体和多粘菌素，具有中性疏水性表面和多粘菌素的载体固定在载体上 通过疏水相互作用的载体表面。 吸附剂用于体外血液净化，特别是用于治疗败血症的个体。

公开(公告)号：US20120107959A1

公开(公告)日：2012-05-03

申请号：US13379345

申请日：2010-06-21

Applicant: Lance Liotta ,  Virginia Espina ,  Alessandra Luchini ,  Davide Tamburro

Inventor： Lance Liotta ,  Virginia Espina ,  Alessandra Luchini ,  Davide Tamburro

IPC: G01N21/75

CPC classification number: C07D311/82 ,  B01J20/3253 ,  B01J20/3255 ,  C07D251/50 ,  C07D279/20 ,  C07D403/04 ,  C07D471/22

Abstract: This invention describes the identification of novel organic dye chemistries that can be used as affinity baits to capture proteins and other biomolecules useful in the fields of medical diagnostics, environmental science, toxicology, and infectious disease. Incorporation of unique affinity dye compounds within hydrogel capture particles improves analyte yield and preanalytical precision, and stabilizes the analyte against degradation, while increasing measurement sensitivity. The particles in this invention can be used for routine clinical testing as well as for discovery of low abundance disease biomarkers. Example hydrogel particles containing new high affinity bait chemistries were used to identify a new set of human serum biomarkers.

Abstract translation: 本发明描述了可用作捕获蛋白质和其它可用于医学诊断学，环境科学，毒理学和传染病领域的其他生物分子的亲和诱饵的新型有机染料化学物质的鉴定。 在水凝胶捕获颗粒中引入独特的亲和染料化合物可提高分析物的产率和分析前精度，并稳定分析物以防止降解，同时提高测量灵敏度。 本发明中的颗粒可用于常规临床测试以及发现低丰度疾病生物标志物。 使用含有新的高亲和力诱饵化学物质的示例性水凝胶颗粒来鉴定新的一组人血清生物标志物。

公开(公告)号：US08021894B2

公开(公告)日：2011-09-20

申请号：US12541413

申请日：2009-08-14

Applicant: T. William Hutchens ,  Tai-Tung Yip

Inventor： T. William Hutchens ,  Tai-Tung Yip

IPC: G01N33/543

CPC classification number: C40B30/04 ,  B01D15/1878 ,  B01D15/305 ,  B01D15/3809 ,  B01J20/281 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3248 ,  B01J20/3253 ,  B01J20/3265 ,  B01J20/3274 ,  B01J20/3289 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00725 ,  B01J2220/54 ,  C12Q1/00 ,  C40B40/10 ,  G01N30/00 ,  G01N30/02 ,  G01N30/461 ,  G01N30/463 ,  G01N30/466 ,  G01N30/48 ,  G01N30/482 ,  G01N30/90 ,  G01N30/95 ,  G01N33/531 ,  G01N33/538 ,  G01N33/543 ,  G01N33/54306 ,  G01N33/54353 ,  G01N33/54373 ,  G01N33/54393 ,  G01N33/566 ,  G01N33/6803 ,  G01N33/6845 ,  G01N33/6851 ,  G01N2030/008 ,  G01N2030/009 ,  Y02A90/26 ,  Y10S422/906 ,  Y10S435/803 ,  Y10S435/81 ,  Y10S435/814 ,  Y10S435/815 ,  Y10S435/97 ,  Y10S435/973 ,  Y10S435/975 ,  Y10S436/808 ,  Y10S436/809 ,  Y10S436/811 ,  Y10S436/813 ,  Y10S436/824 ,  Y10S436/825 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/2525 ,  Y10T436/25375 ,  Y10T436/255 ,  B01D15/363 ,  B01D15/322 ,  B01D15/327 ,  B01D15/3804 ,  B01D15/362 ,  B01D15/38 ,  B01D15/26

Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.

Abstract translation: 本发明提供了用于分析样品中分析物的滞留层析方法。 所述方法包括在多种不同的选择性条件下将分析物吸附到底物上，并通过解吸光谱法检测保留在底物上的分析物。 这些方法在生物学和医学中是有用的，包括临床诊断和药物发现。

公开(公告)号：US07998960B2

公开(公告)日：2011-08-16

申请号：US11913514

申请日：2006-05-09

Applicant: Jason Richard Betley ,  James Christopher Pearson ,  Claudia Hildegard Kuhn ,  Baldev Singh Baines

Inventor： Jason Richard Betley ,  James Christopher Pearson ,  Claudia Hildegard Kuhn ,  Baldev Singh Baines

IPC: A01N43/66 ,  C07H19/12 ,  C07K16/06 ,  A61K39/395

CPC classification number: B01J20/289 ,  B01J20/286 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3242 ,  B01J20/3244 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3255 ,  B01J2220/54 ,  B01J2220/58 ,  C07D251/48 ,  C07D251/50 ,  C12Q1/56 ,  G01N33/86

Abstract: For the separation, removal, isolation, purification, characterization, identification or quantification of plasminogen or a protein that is a plasminogen analogue, an affinity adsorbent is used that is a compound of formula (II) wherein one X is N and the other is N, C—Cl or C—CN; A is a support matrix, optionally linked to the triazine ring by a spacer; Z is O, S or N—R and R is H, C1-6 alkyl, C1-6 hydroxyalkyl, benzyl or &bgr;-phenylethyl; B is an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; D is H, OH or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidino or amidino group; or B-D is —CHCOOH—(CH2)3-4—NH2; and q is 2 to 6.

Abstract translation: 对于纤溶酶原或纤溶酶原类似物的蛋白质的分离，去除，分离，纯化，表征，鉴定或定量，使用亲和吸附剂，其为一个X为N且另一个为N的式（II）化合物 ，C-Cl或C-CN; A是支持基质，任选地通过间隔基与三嗪环连接; Z是O，S或N-R，R是H，C 1-6烷基，C 1-6羟基烷基，苄基或叔丁基苯乙基; B是含有1至10个碳原子的任选取代的烃键; D是H，OH或伯氨基，仲氨基，叔氨基，季铵，咪唑，胍基或脒基; 或B-D为-CHCOOH-（CH2）3-4-NH2; q为2〜6。

公开(公告)号：US20110168636A1

公开(公告)日：2011-07-14

申请号：US13052477

申请日：2011-03-21

Applicant: Robert A. Yokel ,  Wesley R. Harris ,  Christopher D. Spilling ,  Chang-Guo Zhan

Inventor： Robert A. Yokel ,  Wesley R. Harris ,  Christopher D. Spilling ,  Chang-Guo Zhan

IPC: B01D15/38

CPC classification number: C07C259/06 ,  B01D15/3828 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3251 ,  B01J20/3253 ,  C02F2101/20 ,  C07C217/28 ,  C07C255/13 ,  C07C311/17 ,  C08F8/28 ,  C08F8/30 ,  C08F12/30 ,  C08F212/08 ,  C08F212/36 ,  C08F212/14 ,  C08F8/36

Abstract: Methods are described for removing aluminum from a solution using novel di- and tripodal compounds as chelators.

Abstract translation: 描述了使用新的二 - 和三峰化合物作为螯合剂从溶液中除去铝的方法。

公开(公告)号：US20110166332A1

公开(公告)日：2011-07-07

申请号：US13063221

申请日：2009-08-28

Applicant: Peter S. Gagnon

Inventor： Peter S. Gagnon

IPC: C07K1/18

CPC classification number: C07K1/20 ,  B01D15/363 ,  B01D15/3809 ,  B01D15/3847 ,  B01J20/3212 ,  B01J20/3253 ,  B01J20/3285 ,  B01J41/20 ,  C07K1/165 ,  C07K1/18

Abstract: The invention relates to a method for separating at least one non-aggregated protein from a liquid protein preparation by contacting said preparation with a multimodal anion exchanger in the presence of protein-excluded zwitterions at a concentration of 0.25 to 2.5 M.

Abstract translation: 本发明涉及一种通过在0.25-2.5M浓度的蛋白质排除的两性离子存在下使所述制剂与多峰阴离子交换剂接触来从液体蛋白制剂中分离至少一种非聚集蛋白的方法。