公开(公告)号：US08187553B2

公开(公告)日：2012-05-29

申请号：US12766349

申请日：2010-04-23

Applicant: Seh Kwang Lee

Inventor： Seh Kwang Lee

IPC: B01J8/02 ,  B01J35/02 ,  B01J19/00 ,  B01J8/08 ,  B01J8/00

CPC classification number: B01J8/02 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00905 ,  B01J2219/00909 ,  B01L3/502753 ,  B01L3/502776 ,  B01L2300/0864 ,  B01L2300/088 ,  B01L2400/0409

Abstract: A microreactor may include a reaction channel having at least one curved microchannel, the at least one curved microchannel having an outer and inner curved surfaces and being configured to generate a centrifugal force, an inlet configured to supply at least one reactant into the reaction channel, and an outlet bifurcated into a first sub-outlet in communication with the inner curved surface of the at least one curved microchannel and a second sub-outlet in communication with the outer curved surface of the at least one curved microchannel.

Abstract translation: 微反应器可以包括具有至少一个弯曲微通道的反应通道，所述至少一个弯曲微通道具有外弯曲表面和内弯曲表面，并被配置成产生离心力，入口构造成将至少一种反应物供应到反应通道中， 以及分岔成与所述至少一个弯曲微通道的内弯曲表面连通的第一子出口的出口和与所述至少一个弯曲微通道的外弯曲表面连通的第二子出口。

公开(公告)号：US20110097706A1

公开(公告)日：2011-04-28

申请号：US12912468

申请日：2010-10-26

Applicant: Gerard Anne Nicolaas van Veen ,  Jacobus Peter Johannes Peters ,  Pleun Dona ,  Alan Frank De Jong

Inventor： Gerard Anne Nicolaas van Veen ,  Jacobus Peter Johannes Peters ,  Pleun Dona ,  Alan Frank De Jong

IPC: C12Q1/70 ,  G01N15/00 ,  G01N21/00 ,  C12M1/34 ,  G01N33/53 ,  G01N23/00 ,  G01N21/76 ,  G01N33/554 ,  G01N31/10

CPC classification number: B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00905 ,  B01J2219/0097 ,  B01L3/502761 ,  B01L7/54 ,  B01L2200/0668 ,  B01L2300/0822 ,  B01L2400/0415 ,  B01L2400/0439 ,  B01L2400/0442 ,  B01L2400/0487 ,  G01N2021/058 ,  H01J37/20 ,  H01J37/26 ,  H01J2237/2004 ,  Y10T436/143333

Abstract: The invention relates to a micro-reactor for observing small particles, cells, bacteria, viruses or protein molecules in a fluid. The micro-reactor shows a first channel formed between two layers for containing the fluid, with an inlet and an outlet, the two layers separated by a first distance. A likewise second channel with an inlet and an outlet is placed adjacent to the first channel. A gap connects the first channel and the second channel, at the gap at least one layer showing a window transparent to the method of inspection and at the window the two layers being separated by a very small distance of, for example, 1 μm or less.The micro-reactor may be used with an optical microscope (in which all particles are in focus), inspection with a Scanning Transmission Electron Microscope (in which the range of the electrons is limited), inspection with soft X-rays in the 250-500 eV range (also showing a limited range), etc. A method of using the micro-reactor includes applying a gradient over the gap, thereby causing the particles to cross the gap. The gradient may be static or dynamic, and may be a gradient in concentration, of a chemical or biological material, in pressure, in temperature, in electric potential, or in magnetic field. By detecting a property of the particles upstream in the first channel, e.g. using fluorescent labels on the particles, and then applying a pressure burst over the channels when the property meets certain preset criteria, only selected particles can be placed in the gap.

Abstract translation: 本发明涉及用于观察流体中的小颗粒，细胞，细菌，病毒或蛋白质分子的微反应器。 微反应器示出了在两层之间形成的用于容纳流体的第一通道，具有入口和出口，两层分开第一距离。 具有入口和出口的同样的第二通道被放置成与第一通道相邻。 间隙连接第一通道和第二通道，在间隙处，至少一层显示对于检查方法是透明的窗口，并且在窗口处，两层被隔开非常小的距离，例如1μm或更小 。 微反应器可以与光学显微镜一起使用（其中所有颗粒都在焦点中），用扫描透射电子显微镜（其中电子的范围被限制）进行检查，在250- 500eV范围（也显示有限范围）等。使用微反应器的方法包括在间隙上施加梯度，从而使颗粒穿过间隙。 梯度可以是静态或动态的，并且可以是化学或生物材料在压力，温度，电位或磁场中的浓度梯度。 通过检测第一通道上游的颗粒的性质，例如， 在颗粒上使用荧光标记，然后当性能达到某些预设标准时，在通道上施加压力突发，只有选定的颗粒才能放置在间隙中。

公开(公告)号：US20090250406A1

公开(公告)日：2009-10-08

申请号：US11721734

申请日：2006-04-24

Applicant: Makoto Takahashi ,  Masaya Nakatani

Inventor： Makoto Takahashi ,  Masaya Nakatani

IPC: B01D43/00 ,  B01J19/00

CPC classification number: B01D21/283 ,  B01D43/00 ,  B01J2219/00783 ,  B01J2219/00905 ,  B01L3/502753 ,  B01L3/502761 ,  B01L3/502769 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0439 ,  C02F1/36 ,  G01N1/40 ,  G01N2001/4094

Abstract: A component separating device includes a substrate, a fluid channel provided at the substrate, an actuator and a groove provided at a surrounding of the actuator, the fluid channel contains a fluid including a liquid component and a solid component, and the actuator generates a standing wave at inside of the fluid channel. By such a constitution, a vibration loss is reduced by reflecting a vibration by the groove to be transmitted to a side of the fluid channel, the standing wave having a strong intensity is generated at inside of the fluid channel, and the small-sized highly accurate component separating device is provided.

Abstract translation: 部件分离装置包括基板，设置在基板处的流体通道，致动器和设置在致动器周围的凹槽，流体通道包含包括液体部件和固体部件的流体，并且致动器产生站立 波在流体通道的内部。 通过这样的结构，通过反射通过沟槽的流动通道的侧面的振动来减小振动损失，在流体通道的内部产生强烈的驻波，并且小的高度 提供了精确的元件分离装置。

公开(公告)号：US20090145860A1

公开(公告)日：2009-06-11

申请号：US10585549

申请日：2005-01-17

Applicant: Raymond William Kenneth Allen ,  Jordan MacLeod Macinnes ,  Geoffrey Hugh Priestman

Inventor： Raymond William Kenneth Allen ,  Jordan MacLeod Macinnes ,  Geoffrey Hugh Priestman

IPC: B01D17/00 ,  B01J19/00 ,  B01D3/08 ,  B01F13/00 ,  B01D17/02 ,  B23P11/00

CPC classification number: B01D3/30 ,  B01D3/08 ,  B01D3/22 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01L3/5027 ,  Y10T29/49826

Abstract: A fluid-contactor includes a rotatable platform arranged to rotate about a predetermined axis. The platform has a channel extending generally in a spiral about the axis. The channel has at least a first aperture for the output of a first fluid, and at least a second aperture distant from the axis for the output of a second, more dense, fluid. The platform is arranged to rotate at an angular velocity sufficient to move second fluid within the channel towards the second aperture.

Abstract translation: 流体接触器包括布置成围绕预定轴线旋转的可旋转平台。 平台具有通常围绕轴线以螺旋形延伸的通道。 通道具有用于输出第一流体的至少第一孔，以及至少一个远离轴线的第二孔，用于输出第二，更致密的流体。 平台被布置成以足以将通道内的第二流体朝向第二孔移动的角速度旋转。

公开(公告)号：US20080069739A1

公开(公告)日：2008-03-20

申请号：US11946678

申请日：2007-11-28

Applicant: Lester Ludwig

Inventor： Lester Ludwig

IPC: B01J19/00

CPC classification number: B01J19/0093 ,  B01J2219/00835 ,  B01J2219/00871 ,  B01J2219/00873 ,  B01J2219/00905 ,  B01J2219/00986 ,  B01J2219/00997 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/567 ,  B01L9/52 ,  B01L2200/10 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/18 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644 ,  B01L2400/086 ,  G01N35/0092 ,  Y10T436/12

Abstract: Systems and methods for software-reconfigurable chemical process systems useful in a wide range of applications. Embodiments may include software control of internal processes, automated provisions for cleaning internal elements with solvents, provisions for clearing and drying gasses, and multitasking operation. In one family of embodiments, a flexible software-reconfigurable multipurpose reusable “Lab-on-a-Chip” or “embedded chemical processor” is realized that can facilitate a wide range of applications, instruments, and appliances. Through use of a general architecture, a single design can be economically manufactured in large scale and readily adapted to diverse specialized applications. Clearing and cleaning provisions may be used to facilitate reuse of the device, or may be used for decontamination prior to recycling or non-reclaimed disposal. In other embodiments, a flexible software-reconfigurable multipurpose reusable laboratory glassware setup may be realized, sparing talented laboratory staff from repetitive, complex, or low-level tasks occurring in analysis, synthesis, or small-scale chemical manufacturing.

Abstract translation: 用于软件可重构化学过程系统的系统和方法可用于广泛的应用。 实施例可以包括内部过程的软件控制，用溶剂清洁内部元件的自动化设备，用于清除和干燥气体的规定以及多任务操作。 在一个实施例系列中，实现了灵活的软件可重新配置的多用途可复用“片上实验室”或“嵌入式化学处理器”，其可以促进广泛的应用，仪器和设备。 通过使用一般架构，单一设计可以经济地大规模制造，并且易于适应不同的专业应用。 可以使用清洁和清洁规定来促进设备的再利用，或者可以在再循环或未回收处理之前用于净化。 在其他实施例中，可以实现灵活的软件可重新配置的多用途可重复使用的实验室玻璃器皿设置，从而在分析，合成或小规模化学制造中发生重复，复杂或低级任务的有才华的实验室人员。

公开(公告)号：US20060263264A1

公开(公告)日：2006-11-23

申请号：US11486186

申请日：2006-07-13

Applicant: Sebastian Bohm ,  John Gilbert

Inventor： Sebastian Bohm ,  John Gilbert

IPC: B01L3/02

CPC classification number: B01F13/0059 ,  B01D57/02 ,  B01J19/0093 ,  B01J2219/00371 ,  B01J2219/00378 ,  B01J2219/00783 ,  B01J2219/00831 ,  B01J2219/00837 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01L3/0244 ,  B01L3/0268 ,  B01L3/502715 ,  B01L3/502792 ,  B01L2200/027 ,  B01L2200/143 ,  B01L2200/147 ,  B01L2300/089 ,  B01L2400/0421 ,  B01L2400/0439 ,  C12Q1/00 ,  G01N27/447 ,  G01N27/44743 ,  G01N27/44782 ,  G01N27/44791 ,  G01N2035/1037 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/2575

Abstract: A fluid interface port in a microfluidic system and a method of forming the fluid interface port is provided. The fluid interface port comprises an opening formed in the side wall of a microchannel sized and dimensioned to form a virtual wall when the microchannel is filled with a first liquid. The fluid interface port is utilized to fill the microchannel with a first liquid, to introduce a second liquid into the first liquid and to eject fluid from the microchannel.

公开(公告)号：US20040028580A1

公开(公告)日：2004-02-12

申请号：US10615976

申请日：2003-07-10

Applicant: TOSOH CORPORATION

Inventor： Toru Futami ,  Tomohiro Ohkawa ,  Tomoyuki Oikawa ,  Akira Kawai ,  Koji Katayama ,  Keiichiro Nishizawa

IPC: B01J008/00

CPC classification number: B01J19/0093 ,  B01F13/0059 ,  B01F13/0093 ,  B01F2005/0031 ,  B01F2005/0088 ,  B01F2215/0409 ,  B01F2215/0427 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01L2200/0636 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0487 ,  B01L2400/086

Abstract: A fine channel device comprising a fine channel (19) provided with at least two inlet ports (11, 28, 29) for feeding fluid, inlet channels communicated with the inlet ports, a confluent portion (37) communicated with the inlet channels to feed the fluid, a branch portion (4) communicated with the fine channel, from which at least two outlet channels are branched to feed predetermined amounts of fluid, and outlet ports (12, 30, 31) communicated with the outlet channels, wherein the fine channel (19) is provided with a plurality of partition walls (22) along a boundary formed by at least two kinds of fluid (13, 14) fed from the inlet ports so as not to cause mutual contamination of fluid, whereby different kinds of fluid flowing in the fine channel in an adjacent state can form stably the fluid boundary and each kind of fluid can be discharged from a predetermined outlet port separately without causing the mutual contamination of fluid between adjacent flows of the fluid, is provided. By using such fine channel device, a chemical reaction can be accelerated by making two different kinds of fluid contact at the fluid boundary in a flowing direction of fluid in the fine channel of the fine channel device.

Abstract translation: 一种细通道装置，包括设置有用于供给流体的至少两个入口端口（11,28,29）的细通道（19），与入口端口连通的入口通道，与入口通道连通的汇合部分（37） 流体，与细通道连通的分支部分（4），至少两个出口通道从该分支部分分支以供给预定量的流体;以及与出口通道连通的出口端口（12,30,31），其中所述精细 通道（19）沿着由从入口端口供给的至少两种流体（13,14）形成的边界设置有多个分隔壁（22），以便不会导致流体的相互污染，由此不同种类的 在相邻状态下在细通道中流动的流体可以稳定地形成流体边界，并且可以分别从预定出口排出各种流体，而不会导致流体相邻流动之间的流体相互污染。 通过使用这种精细通道装置，可以通过在精细通道装置的精细通道中的流体的流动方向上在流体边界处使两种不同种类的流体接触来加速化学反应。

公开(公告)号：US06666909B1

公开(公告)日：2003-12-23

申请号：US09588871

申请日：2000-06-06

Applicant: Ward E. TeGrotenhuis ,  Robert S. Wegeng ,  Greg A. Whyatt ,  Victoria S. Stenkamp ,  Phillip A. Gauglitz

Inventor： Ward E. TeGrotenhuis ,  Robert S. Wegeng ,  Greg A. Whyatt ,  Victoria S. Stenkamp ,  Phillip A. Gauglitz

IPC: F28D1502

CPC classification number: B01D5/0003 ,  B01B1/005 ,  B01D3/00 ,  B01D19/0031 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00835 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01L3/5027 ,  C01B3/384 ,  C01B2203/0805 ,  C01B2203/0833 ,  F28D9/005 ,  F28F2260/02

Abstract: Laminated, multiphase separators and contactors having wicking structures and gas flow channels are described. Some preferred embodiments are combined with microchannel heat exchange. Integrated systems containing these components are also part of the present invention.

Abstract translation: 描述了具有芯吸结构和气体流动通道的层压的多相分离器和接触器。 一些优选实施例与微通道热交换组合。 包含这些组分的集成系统也是本发明的一部分。

公开(公告)号：US5858192A

公开(公告)日：1999-01-12

申请号：US733508

申请日：1996-10-18

Applicant: Frederick F. Becker ,  Peter R. C. Gascoyne ,  Ying Huang ,  Xiao-Bo Wang

Inventor： Frederick F. Becker ,  Peter R. C. Gascoyne ,  Ying Huang ,  Xiao-Bo Wang

IPC: B01J19/00 ,  B03C5/02 ,  G01N30/00 ,  G01N27/26 ,  C25B11/02

CPC classification number: B03C5/028 ,  B01J19/0093 ,  G01N30/0005 ,  B01J2219/00853 ,  B01J2219/00905 ,  B01J2219/00914 ,  G01N2030/0035 ,  Y10S436/806

Abstract: The present disclosure is directed to a novel apparatus and novel methods for the separation, characterization, and manipulation of matter. In particular, the invention combines the use of frequency-dependent dielectric and conductive properties of particulate matter and solubilized matter with the properties of a suspending medium to discriminate and separate such matter. The apparatus includes a chamber having at least one spiral electrode element. Matter is separated in the chamber by a dielectrophoretic (DEP) force caused by the energized electrode or electrodes.

Abstract translation: 本公开涉及用于分离，表征和操纵物质的新型装置和新颖方法。 特别地，本发明结合了使用频率依赖的电介质和颗粒物质和溶解物质的导电性质与悬浮介质的性质，以区分和分离这种物质。 该装置包括具有至少一个螺旋电极元件的腔室。 物质在室内被通过电极或电极引起的介电电泳（DEP）力分离。

公开(公告)号：US5454472A

公开(公告)日：1995-10-03

申请号：US196093

申请日：1994-02-18

Applicant: Wolfgang Benecke ,  Bernd Wagner ,  Rolf Hagedorn ,  Gunter Fuhr ,  Torsten Muller

Inventor： Wolfgang Benecke ,  Bernd Wagner ,  Rolf Hagedorn ,  Gunter Fuhr ,  Torsten Muller

IPC: B01J19/00 ,  B03C5/00 ,  B03C5/02 ,  G01N27/447 ,  G01N30/00 ,  B03C1/30

CPC classification number: B03C5/028 ,  B01J19/0093 ,  B03C5/005 ,  B03C5/022 ,  B03C5/026 ,  G01N30/0005 ,  B01J2219/00828 ,  B01J2219/00853 ,  B01J2219/00905 ,  B01J2219/0093 ,  G01N2030/0035

Abstract: A method of separating mixtures of microscopic dielectric particles in sunsions in an apparatus for carrying the method. A mixture of particles is forced onto guide paths by dielectrophoretic forces or by a flow of the suspension medium with an additional force, which is provided to compensate the force causing the particles to move along the guide paths for specific particle species causing the specific particle species to be fed out from the mixture of particles. The apparatus may be integrated on surfaces of silicon wafers at low cost and in mass-production numbers, and is suitable for isolating minute particles such as biological cells, cell organelles, bio molecules as well as organic dielectric particles.

Abstract translation: PCT No.PCT / DE92 / 00694 Sec。 371日期1994年2月18日 102（e）1994年2月18日PCT PCT 1992年8月19日PCT公布。 出版物WO93 / 03850 日期1993年3月4日。一种在用于携带该方法的装置中分离悬浮液中的微观电介质颗粒的混合物的方法。 通过介电电泳力或通过附加力的悬浮介质的流动将粒子的混合物强制到引导路径上，附加的力被提供以补偿导致颗粒沿着引导路径移动的力，以产生特定的颗粒物质 从颗粒混合物中送出。 该设备可以以低成本和批量生产数量集成在硅晶片的表面上，并且适用于分离微粒，例如生物细胞，细胞器，生物分子以及有机电介质颗粒。