摘要:
Provided are acedan derivatives having an extended π bond, a method for preparing the acedan derivatives, and a method for two-photon microscopy imaging of amyloid-beta plaque using the acedan derivatives; more particularly, to two-photon absorbing fluorescent compounds having a longer absorption wavelength and emission wavelength than acedan and acedan derivatives which are conventional two-photon absorbing fluorophores. The compounds provided may be usefully used for in vivo imaging studies by imaging cells or tissue using the compounds, and may also be usefully used for diagnosing Alzheimer's disease by imaging amyloid-beta plaque using the compounds.
摘要:
Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2, Pgp, or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering effective amounts of certain compounds to the mammal, for example, a compound of the formula (I): wherein R1, R2, R3, X1, X2, X3, a, and b are as described herein. Uses of these compounds in the preparation of a medicament are also disclosed. Also disclosed are compounds of formula (II), pharmaceutical compositions comprising such compounds and uses thereof.
摘要:
A photochromic polymer comprising at least two photochromic moieties linked by a straight or branched chain polymer selected from the group consisting of poly(C2 to C4 alkylene oxide), poly[C1 to C10 alkoxy substituted (C2 to C4 alkylene oxide)] and poly[C1 to C-15 acyloxy substituted (C2 to C4 alkylene oxide)].
摘要:
The present invention refers primarily to a plant extract obtained from Kielmeyera aureovinosa which has accentuated antibiotic activity. In a second modality, the invention describes a new chemical compound isolated from the same, as well as variations thereof. In other terms, the present invention provides compositions comprising a phytotherapic obtained from said plant extract, as well as veterinary pharmaceutical compositions comprising isolated compounds and variations of the same.Additionally, the present invention provides uses of the plant extract, chemical compounds and compositions comprising the same for the preparation of medicines for the prevention or treatment of bacterial infections, as well as methods of prevention or treatment of the same.
摘要:
Disclosed is an organic light emitting compound represented by Formula I: Also disclosed is an organic light emitting device including the organic light emitting compound. The organic light emitting device can be driven at a low voltage to achieve high power efficiency. In addition, the organic light emitting device has excellent luminescent properties, such as high luminance and high luminous efficiency. Due to these advantages, the organic light emitting device can be utilized as a display device or a lighting device.
摘要:
A naphthopyran compound represented by the formula B1 and B2 are selected independently from the group consisting of a phenyl, naphthyl, or heterocyclic aromatic group, or may combine to form one or more aromatic rings. B1 and B2 may further include one or more substituents. R3, R4, R5, R6, and R10 are selected independently from the group consisting of hydrogen, halogen, —Ra, —OH, —ORa, —O—CO—Ra, —CN, —NO2, —SO2Ra, —SORa, —SH, —SRa, —NH2, —NHRa, —NRaRa, or —NRbRc; or wherein R5 and R6 combine to form a cyclic group. Ra may include an alkyl, polycycloalkyl, alkenyl, polyalkenyl, haloalkyl, perhaloalkyl, alkynyl, polyalkynyl, hydroxyalkynyl, polyhydroxyalkynyl; or (C3-20)cycloalkyl group. Rb and Rc may include hydrogen or alkyl groups, or may combine to form a saturated heterocyclic group, or together with an adjacent phenyl group may form a julolidinyl group. R7 is a mesogenic group. And the naphthopyran, which may be referred to as a dichroic-photochromic compound, may be incorporated into an optical article.
摘要翻译:由式B1和B2表示的萘并吡喃化合物独立地选自苯基,萘基或杂环芳族基团,或者可以结合形成一个或多个芳环。 B1和B2可进一步包括一个或多个取代基。 R3,R4,R5,R6和R10独立地选自氢,卤素,-Ra,-OH,-ORa,-O-CO-Ra,-CN,-NO2,-SO2Ra,-SORa, -SH,-SR a,-NH 2,-NHR a,-NR a R a或-NR b R c; 或其中R 5和R 6结合形成环状基团。 R a可以包括烷基,多环烷基,烯基,聚烯基,卤代烷基,全卤代烷基,炔基,聚炔基,羟基炔基,聚羟基炔基; 或(C 3-20)环烷基。 Rb和Rc可以包括氢或烷基,或者可以结合形成饱和杂环基,或者与相邻的苯基一起可以形成高碘基。 R7是介晶组。 并且可以将称为二色性 - 光致变色化合物的萘并吡喃掺入到光学制品中。
摘要:
Described herein are compounds generally comprising an indeno[2′,3′:3,4]naptho[1,2-b]pyran structure. Such compounds may be useful for their photochromic properties, and be used in certain photochromic compositions. Such compositions may further comprise other photochromic compositions and/or materials. Additionally, such compounds and/or compositions may be suitable for preparing certain photochromic articles.
摘要:
Disclosed are a novel sulfonic acid derivative compound and a novel naphthalic acid derivative compound with high solubility in organic solvents, good photosensitivity, and suitability as a photoacid generator and a polymerization initiator. The sulfonic acid derivative compound is represented by the formula (I) (wherein R01, R04, R05, and R06 represent a hydrogen atom; any one of R02 and R03 represents an alkoxy group having a carbon number of 4 to 18 which may be substituted with an alicyclic hydrocarbon group, a heterocyclic group, or a halogen atom and which may have a branch, or the like; and R07 represents an aliphatic hydrocarbon group having a carbon number of 1 to 18 which may be substituted with a halogen atom and/or an alkylthio group, or the like).
摘要:
The present invention relates to photochromic fused naphthopyrans having a benzene ring which is adjacent to the pyran oxygen and is linked to the para substituent via both meta positions, and to the use thereof in plastics of all types, in particular for ophthalmic purposes.