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    Resonant cavity photodiode array for rapid DNA microarray readout
    11.
    发明申请
    Resonant cavity photodiode array for rapid DNA microarray readout 审中-公开
    谐振腔光电二极管阵列用于快速DNA微阵列读取

    公开(公告)号：US20040101861A1

    公开(公告)日：2004-05-27

    申请号：US10307219

    申请日：2002-11-27

    Inventor： Roger G. Little ,  Kurt J. Linden

    IPC: C12Q001/68 ,  C12M001/34

    CPC classification number: G01N21/6454 ,  G01N2021/6469 ,  G01N2201/0407 ,  G01N2201/0612

    Abstract: The present invention provides a microarray having a plurality of micro-locations for confining selected photophores, for example, biological molecules exhibiting fluorescence spectra. The microarray can further include an array of optoelectronic photodetectors each of which is optically coupled with at least one of the micro-locations to detect radiation, for example, fluorescence radiation, that is emitted from the photophores confined in that micro-location. Each photodetector includes a resonant cavity that is formed of a front reflector and/or a back reflector having distributed Bragg reflector structures and a photo-detecting element disposed in the resonant cavity. The microarray can utilize either external optical excitation sources, such as lasers, LEDs, or can contain its own excitation sources in an integrated structure containing both optical radiation emitters, such as, vertical cavity surface emitting lasers or resonant cavity LEDs, and resonant cavity photodetectors. The integrated emitters and detectors can be either coaxially or adjacently located. Further, the microarray can include either separate sample array and excitation/detector array plates, or a single sample/excitation/detector array plate in which the photophore-containing sample molecules can be deposited directly on the excitation/detector array.

    Abstract translation: 本发明提供一种微阵列，其具有用于限制所选择的光致抗体的多个微位置，例如表现出荧光光谱的生物分子。 微阵列还可以包括光电子检测器阵列，每个光电检测器与至少一个微位置光学耦合，以检测从限制在该微位置的光电子发射的辐射，例如荧光辐射。 每个光电检测器包括谐振腔，其由具有分布式布拉格反射器结构的前反射器和/或背反射器形成，以及设置在谐振腔中的光检测元件。 微阵列可以利用诸如激光器，LED的外部光学激发源，或者可以在包含光辐射发射器（诸如垂直腔表面发射激光器或谐振腔LED）的集成结构中包含其自身的激发源，以及谐振腔光电探测器 。 集成的发射器和检测器可以同轴或相邻地定位。 此外，微阵列可以包括单独的样品阵列和激发/检测器阵列板，或者单个样品/激发/检测器阵列板，其中含光致抗体的样品分子可以直接沉积在激发/检测器阵列上。

    Method of discriminating particle aggregation pattern
    13.
    发明授权
    Method of discriminating particle aggregation pattern 失效
    鉴别粒子聚集图案的方法

    公开(公告)号：US5265169A

    公开(公告)日：1993-11-23

    申请号：US775809

    申请日：1991-10-11

    Applicant: Masato Ohta ,  Yasuhiko Yokomori ,  Toshiyuki Furuta

    Inventor： Masato Ohta ,  Yasuhiko Yokomori ,  Toshiyuki Furuta

    IPC: G01N21/17 ,  G01N21/75 ,  G01N21/82 ,  G01N33/543 ,  G06K9/00

    CPC classification number: G01N21/82 ,  G01N2021/755 ,  G01N2201/0407 ,  G01N2201/0446 ,  G01N2201/127

    Abstract: A method for identifying the presence or absence of an aggregation of particles distributed on a translucent surface includes the steps of providing a light sensing device for sensing light incident thereon and producing an output value which represents the intensity of the incident light, and identifying a first output value which is produced by the light sensing device when there is no light incident thereon. The method also identifies a second output value which is produced by the light sensing means when, with no particles present on the translucent surface, light is directed through the translucent surface onto the light sensing device. With a distribution of particles deposited on the translucent surface, light is directed through the translucent surface and onto the light sensing device, causing the light sensing device to produce a third output value. A final output value is then determined as a function of said first, second and third output values.

    Abstract translation: 用于识别分布在半透明表面上的颗粒的聚集的存在或不存在的方法包括以下步骤：提供用于感测入射在其上的光的光感测装置，并产生表示入射光强度的输出值，并且识别第一 当没有光入射时由光检测装置产生的输出值。 该方法还识别由光感测装置产生的第二输出值，当在半透明表面上没有颗粒存在时，光被引导通过透光表面到光感测装置上。 随着沉积在半透明表面上的颗粒的分布，光被引导通过半透明表面并且到达光感测装置，使光感测装置产生第三输出值。 然后确定最终输出值作为所述第一，第二和第三输出值的函数。

    Photoelectric measuring apparatus for use in automatic analyzer
    14.
    发明授权
    Photoelectric measuring apparatus for use in automatic analyzer 失效
    用于自动分析仪的光电测量仪

    公开(公告)号：US4950077A

    公开(公告)日：1990-08-21

    申请号：US343681

    申请日：1989-04-27

    Applicant: Sugio Manabe

    Inventor： Sugio Manabe

    IPC: G01J3/10 ,  G01J3/18 ,  G01J3/28 ,  G01N21/25 ,  G01N21/27 ,  G01J3/42

    CPC classification number: G01N21/253 ,  G01J3/18 ,  G01J3/2803 ,  G01N2201/0407 ,  G01N2201/0415 ,  G01N2201/0826 ,  G01N2201/0833

    Abstract: A photoelectric measuring apparatus for use in an automatic chemical analyzer in which a plurality of test items are analyzed by using light beams having different wavelengths, including a white light source for emitting a polychromatic light beam, a grating for diffracting the polychromatic light beam into a plurality of light beams having predetermined different wavelengths, a plurality of light guides for guiding the light beams emanating from the grating to a plurality of cuvettes containing test liquids to be analyzed, a plurality of light receiving elements for receiving light beams transmitted through the cuvettes, an additional light guide for guiding a polychromatic light beam emanating from the grating as the zero order light beam to a cuvette via an optical filter having a desired transmission wavelength, and an additional light receiving element for receiving a light beam transmitted through the cuvette.

    Abstract translation: 一种用于自动化学分析仪的光电测量装置，其中通过使用具有不同波长的光束来分析多个测试项目，所述光束包括用于发射多色光束的白色光源，用于将多色光束衍射为 具有预定不同波长的多个光束，用于将从光栅发射的光束引导到包含待分析测试液体的多个比色杯的多个光导;多个用于接收透过比色杯的光束的光接收元件， 用于将通过具有期望的透射波长的滤光器将从光栅发出的多色光束作为零级光束引导到比色杯的附加光导，以及用于接收透射通过比色杯的光束的附加光接收元件。

    Instrument for independently and kinetically measuring light transpassion through a plurality of samples
    15.
    发明授权
    Instrument for independently and kinetically measuring light transpassion through a plurality of samples 失效
    用于通过多个样品独立地和动态地测量光透过的仪器

    公开(公告)号：US4936682A

    公开(公告)日：1990-06-26

    申请号：US084098

    申请日：1987-08-11

    Applicant: Joshua K. Hoyt

    Inventor： Joshua K. Hoyt

    IPC: G01N35/02 ,  G01N21/25 ,  G01N21/27

    CPC classification number: G01N21/253 ,  G01N2201/0407 ,  G01N2201/0415 ,  G01N2201/0476

    Abstract: An analytic instrument for kinetically measuring light absorption characteristics of a plurality of independent samples contained in disposable test tubes arranged in a circular pattern about a single light source. The instrument is designed to be used with a host personal computer and is not specific to any particular type of assay. The instrument obtains and temporarily stores raw data in the form of digitized output signals from the plurality of photodetectors and periodically passes them to the host computer. An incubator has test tube wells arranged in a circular array equidistant from a single incandescent light source. The circular symmetry controls the thermal gradients in the incubator such that all of the samples are disposed on the same isotherm and all of the photodetectors are disposed on the same isotherm. The instrument is designed for use with disposable test tubes, and sources of error arising from optical variation in such test tubes are minimized by providing a separate detector for each tube and by holding the tube fixed with respect to the detector. The light output from the single light source is continuously monitored and is kept constant.

    Microfluidic Devices And Method For Their Use
    18.
    发明申请
    Microfluidic Devices And Method For Their Use 审中-公开
    微流体装置及其使用方法

    公开(公告)号：US20150238919A1

    公开(公告)日：2015-08-27

    申请号：US14610814

    申请日：2015-01-30

    Applicant: APPLIED BIOSYSTEMS, LLC

    Inventor： Mark F. OLDHAM ,  Dar BAHATT ,  Kenneth J. LIVAK ,  Jason E. BABCOKE ,  H. Pin KAO ,  Stephen J. GUNSTREAM ,  Kevin S. BODNER ,  Douglas P. GREINER ,  Nigel P. BEARD

    IPC: B01J19/00 ,  G01N21/17 ,  B01L7/00

    CPC classification number: B01J19/0046 ,  B01L3/502715 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0867 ,  B01L2300/185 ,  B01L2400/0655 ,  G01N21/17 ,  G01N2201/0407

    Abstract: Exemplary embodiments provide microfluidic devices and methods for their use. The microfluidic device can include an array of M×N reaction sites formed by intersecting a first and second plurality of fluid channels of a flow layer. The flow layer can have a matrix design and/or a blind channel design to analyze a large number of samples under a limited number of conditions. The microfluidic device can also include a control layer including a valve system for regulating solution flow through fluid channels. In addition, by aligning the control layer with the fluid channels, the detection of the microfluidic devices, e.g., optical signal collection, can be improved by piping lights to/from the reaction sites. In an exemplary embodiment, guard channels can be included in the microfluidic device for thermal cycling and/or reducing evaporation from the reaction sites.

    Abstract translation: 示例性实施例提供了用于其使用的微流体装置和方法。 微流体装置可以包括通过与流动层的第一和第二多个流体通道相交形成的M×N反应位点的阵列。 流层可以具有矩阵设计和/或盲通道设计，以在有限数量的条件下分析大量样品。 微流体装置还可以包括控制层，其包括用于调节通过流体通道的溶液流动的阀门系统。 此外，通过使控制层与流体通道对准，可以通过向/从反应位置的管道灯来改善微流体装置的检测，例如光学信号收集。 在示例性实施例中，保护通道可以包括在微流体装置中用于热循环和/或减少从反应位置的蒸发。

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