公开(公告)号：US20160046982A1

公开(公告)日：2016-02-18

申请号：US14926461

申请日：2015-10-29

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Xiao-Song Gong ,  Yan Wang

IPC: C12Q1/68

CPC classification number: C12Q1/686 ,  C07K14/195 ,  C12Q1/6844 ,  C12Q2527/127 ,  C12Q2527/125 ,  C12Q2521/307

Abstract: In one aspect, compositions and methods for reducing reverse transcriptase (RT) inhibition in RT-PCR are provided. In some embodiments, the RT inhibition reducer is a phosphorothioate oligodeoxycytosine (SdC), phosphorothioate oligodeoxyadenine (SdA), phosphorothioate oligodeoxythymine (SdT), or phosphorothioate oligodeoxyguanosine (SdG).

Abstract translation: 在一个方面，提供了用于在RT-PCR中减少逆转录酶（RT）抑制的组合物和方法。 在一些实施方案中，RT抑制减少剂是硫代磷酸寡脱氧胞嘧啶（SdC），硫代磷酸寡脱氧腺嘌呤（SdA），硫代磷酸寡脱氧胸腺嘧啶（SdT）或硫代磷酸酯寡脱氧鸟苷（SdG）。

公开(公告)号：US20160006910A1

公开(公告)日：2016-01-07

申请号：US14789717

申请日：2015-07-01

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Yochanan Uri ,  Boaz Ran ,  Itay Barak ,  Steven Swihart ,  Evan Thrush

IPC: H04N5/225

CPC classification number: H04N5/2252 ,  G01N21/76 ,  G01N21/763 ,  G01N2201/0221

Abstract: Provided herein are imaging cassettes for detecting a luminescent and/or radioactive signals. Such cassettes are useful in common biological assays, e.g., immunoassays, nucleotide detection assays, and other affinity assays.

Abstract translation: 本文提供了用于检测发光和/或放射性信号的成像盒。 这样的盒可用于常见的生物测定，例如免疫测定，核苷酸检测测定和其他亲和测定。

公开(公告)号：US20150377869A1

公开(公告)日：2015-12-31

申请号：US14749022

申请日：2015-06-24

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Tom Berkelman ,  Jiali Liao

IPC: G01N33/533 ,  C07K1/34 ,  G01N33/58 ,  C07K16/00

CPC classification number: G01N33/533 ,  A61K47/6929 ,  C07K1/34 ,  C07K16/00 ,  G01N33/54346

Abstract: Methods of purifying antibody-nanoparticle conjugates with size exclusion chromatography are provided.

Abstract translation: 提供了具有尺寸排阻色谱法纯化抗体 - 纳米颗粒缀合物的方法。

公开(公告)号：US09164058B2

公开(公告)日：2015-10-20

申请号：US14203351

申请日：2014-03-10

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Lei Li ,  Xuemei Yang ,  Christopher Belisle

IPC: G01N27/447 ,  C08F2/46 ,  C07K1/26 ,  B65D85/00 ,  B01D57/02 ,  C08K3/00

CPC classification number: G01N27/44747 ,  B01D57/02 ,  B65D85/70 ,  C07K1/26 ,  C08F2/46 ,  C08K3/00 ,  G01N21/6428

Abstract: Hand cast gels, and solutions for their preparation, are described.

Abstract translation: 描述了手铸凝胶及其制备方法。

公开(公告)号：US20150286043A1

公开(公告)日：2015-10-08

申请号：US14674520

申请日：2015-03-31

Applicant: Bio-Rad Laboratories, Inc.

Inventor： NICHOLAS DOE

IPC: G02B21/08 ,  G02B21/36

CPC classification number: G02B21/084 ,  G02B21/14 ,  G02B21/361 ,  G02B21/367

Abstract: The present invention relates in general to microscopy systems and the illumination of target regions of the microscopy system with an annular illumination structure. The annular illumination structure can partially illuminate by quadrant, and can include a plurality of LEDs as light sources located in the annular structure that surround the lens or camera of an optical imaging and capture system.

Abstract translation: 本发明一般涉及显微镜系统和具有环形照明结构的显微镜系统的目标区域的照明。 环形照明结构可以通过象限部分地照亮，并且可以包括多个LED，其定位在围绕光学成像和捕获系统的透镜或照相机的环形结构中的光源。

公开(公告)号：US20150126408A1

公开(公告)日：2015-05-07

申请号：US14598091

申请日：2015-01-15

Applicant: Bio-Rad Laboratories, Inc.

Inventor： William F. Link ,  Renato B. Del Rosario ,  Randy Sweet ,  David L. King

IPC: G01N33/543

CPC classification number: G01N33/54306 ,  G01N33/532

Abstract: An anti-antibody reagent for use in a competitive or sandwich simplex or multiplex assay, said reagent comprising one or more labeled anti-antibodies for the primary antibodies to be determined in the assay, the reagent further comprising a corresponding unlabeled anti-antibody in an excess or near excess concentration with respect to their binding partners.

公开(公告)号：US20150093743A1

公开(公告)日：2015-04-02

申请号：US14479132

申请日：2014-09-05

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Amir M. SADRI ,  Kun GUO ,  Daniel Y. CHU ,  Nenad KIRCANSKI ,  Paul J. PATT ,  Tal ROSENZWEIG

IPC: G01N15/14 ,  B01L3/00 ,  C12Q1/24

CPC classification number: G01N15/1459 ,  B01L3/0265 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/027 ,  B01L2200/0652 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/088 ,  B01L2300/165 ,  B01L2300/18 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/0457 ,  B01L2400/0644 ,  B01L2400/065 ,  B01L2400/0655 ,  B01L2400/0688 ,  B01L2400/082 ,  B01L2400/084 ,  C12Q1/24 ,  G01N15/1404 ,  G01N2015/1413 ,  G01N2015/149 ,  Y10T436/25 ,  Y10T436/25375

Abstract: Systems, including apparatus and methods, for the microfluidic manipulation, dispensing, and/or sorting of particles, such as cells and/or beads.

Abstract translation: 用于微流体操纵，分配和/或分选颗粒例如细胞和/或珠粒的系统，包括装置和方法。

公开(公告)号：US08980200B2

公开(公告)日：2015-03-17

申请号：US13923622

申请日：2013-06-21

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Daniel N. Fox ,  Matthias J. G. Ottenberg ,  Kevin P. Raley ,  Nathan Michael Gaskill-Fox

IPC: B01L99/00 ,  B01L3/00 ,  G01N15/14

CPC classification number: B01L3/56 ,  G01N15/1404 ,  G01N2015/1409 ,  G01N2015/1413 ,  Y10T29/49826

Abstract: Disclosed is a nozzle assembly that is compact in size and that uses plastic tubing as an injection needle. Standard plastic fittings are utilized, which are inexpensive and widely available. The nozzle assembly has a simple construction and can be easily assembled and disassembled in a few minutes by a user. Cleaning and/or replacement of parts is inexpensive. Plastic tubing can be used as an injection needle that has superior qualities over commonly used stainless steel injection needles. Flexure of the injection needle tubing is prevented because of the compact size of the nozzle cavity.

Abstract translation: 公开了一种尺寸紧凑并且使用塑料管作为注射针的喷嘴组件。 使用标准的塑料配件，其便宜且广泛可用。 喷嘴组件具有简单的结构，并且可以在几分钟内由用户容易地组装和拆卸。 清洁和/或更换零件便宜。 塑料管可用作注射针，其具有比常用的不锈钢注射针优异的质量。 由于喷嘴腔的紧凑尺寸，防止注射针管弯曲。

公开(公告)号：US20150038356A1

公开(公告)日：2015-02-05

申请号：US14341677

申请日：2014-07-25

Applicant: Bio-Rad Laboratories, Inc.

Inventor： George Karlin-Neumann ,  Svilen Tzonev

IPC: C12Q1/70 ,  C12Q1/68 ,  C12N15/10

CPC classification number: C12Q1/703 ,  C12N15/102 ,  C12Q1/6827 ,  C12Q1/70 ,  C12Q1/701 ,  C12Q2600/156 ,  G01N33/56983 ,  G01N2458/10 ,  Y02A50/54 ,  Y02A50/58 ,  Y02A50/60 ,  C12Q2531/113 ,  C12Q2537/143 ,  C12Q2537/165 ,  C12Q2563/159

Abstract: Provided herein are methods, compositions, systems, and kits for recombination assays, many of which involve amplification reactions such as PCR or droplet digital PCR.

Abstract translation: 本文提供用于重组测定的方法，组合物，系统和试剂盒，其中许多涉及扩增反应，例如PCR或液滴数字PCR。

公开(公告)号：US20150011432A1

公开(公告)日：2015-01-08

申请号：US14493268

申请日：2014-09-22

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Serge Saxonov

IPC: C12N15/10

CPC classification number: C12N15/1065 ,  C12N15/10 ,  C12N15/1075 ,  C12Q1/6876 ,  C12Q2525/191 ,  C12Q2563/179

Abstract: Provided herein are methods, compositions, and kits for assays, many of which involve amplification reactions such as digital PCR or droplet digital PCR. The assays may be used for such applications as sequencing, copy number variation analysis, and others. In some cases, the assays involve subdividing a sample into multiple partitions (e.g., droplets) and merging the partitions with other partitions that comprise adaptors with barcodes.

Abstract translation: 本文提供了用于测定的方法，组合物和试剂盒，其中许多涉及扩增反应，例如数字PCR或液滴数字PCR。 测定可以用于诸如测序，拷贝数变异分析等的应用。 在一些情况下，测定涉及将样品细分成多个分隔（例如，液滴），并将分区与包括具有条形码的适配器的其它分区合并。