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公开(公告)号：US20070173506A1
公开(公告)日：2007-07-26
申请号：US11652728
申请日：2007-01-11
Applicant: Qingping Zeng , John Allen , Matthew Bourbeau , Celia Dominguez , Christopher Fotsch , Nianhe Han , Fang-Tsao Hong , Xin Huang , Matthew Lee , Aiwen Li , Qingyian Liu , James Rider , Seifu Tadesse , Andrew Tasker , Vellarkad Viswanadhan , Xianghong Wang , Kurt Weiler , George Wohlhieter , Guomin Yao , Chester Yuan
Inventor： Qingping Zeng , John Allen , Matthew Bourbeau , Celia Dominguez , Christopher Fotsch , Nianhe Han , Fang-Tsao Hong , Xin Huang , Matthew Lee , Aiwen Li , Qingyian Liu , James Rider , Seifu Tadesse , Andrew Tasker , Vellarkad Viswanadhan , Xianghong Wang , Kurt Weiler , George Wohlhieter , Guomin Yao , Chester Yuan
IPC: A61K31/502 , A61K31/4745 , A61K31/4709 , A61K31/427 , C07D417/02
CPC classification number: C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
Abstract: The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
Abstract translation: 本发明涉及式I和式II的噻唑化合物及其用于治疗由蛋白激酶B（PKB）介导的疾病的组合物，其中变量具有本文提供的定义。 本发明还涉及这种噻唑化合物及其组合物治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病的治疗用途。
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公开(公告)号：US20060030618A1
公开(公告)日：2006-02-09
申请号：US11100272
申请日：2005-04-05
Applicant: Yunxin Bo , Partha Chakrabarti , Ning Chen , Elizabeth Doherty , Christopher Fotsch , Nianhe Han , Michael Kelly , Qingyian Liu , Mark Norman , Vassil Ognyanov , Xianghong Wang , Jiawang Zhu
Inventor： Yunxin Bo , Partha Chakrabarti , Ning Chen , Elizabeth Doherty , Christopher Fotsch , Nianhe Han , Michael Kelly , Qingyian Liu , Mark Norman , Vassil Ognyanov , Xianghong Wang , Jiawang Zhu
IPC: A61K31/353 , C07D319/08
CPC classification number: C07D471/04 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
Abstract: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
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公开(公告)号：US20050272931A1
公开(公告)日：2005-12-08
申请号：US11099978
申请日：2005-04-05
Applicant: Yunxin Bo , Partha Chakrabarti , Ning Chen , Elizabeth Doherty , Christopher Fotsch , Nianhe Han , Michael Kelly , Qingyian Liu , Mark Norman , Vassil Ognyanov , Xianghong Wang , Jiawang Zhu
Inventor： Yunxin Bo , Partha Chakrabarti , Ning Chen , Elizabeth Doherty , Christopher Fotsch , Nianhe Han , Michael Kelly , Qingyian Liu , Mark Norman , Vassil Ognyanov , Xianghong Wang , Jiawang Zhu
IPC: C07D249/18 , A61K31/17 , A61K31/18 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/37 , A61K31/381 , A61K31/4025 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/444 , A61K31/453 , A61K31/47 , A61K31/4704 , A61K31/4709 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/498 , A61K31/505 , A61K31/517 , A61K31/5375 , A61K31/538 , A61P1/00 , A61P1/04 , A61P1/12 , A61P3/10 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/00 , A61P13/10 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/02 , A61P25/00 , A61P25/06 , A61P27/02 , A61P29/00 , A61P31/12 , A61P37/08 , A61P43/00 , C07C233/11 , C07C233/15 , C07C233/33 , C07C233/44 , C07C311/13 , C07C311/16 , C07C317/40 , C07C323/35 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/64 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/22 , C07D215/227 , C07D215/32 , C07D215/38 , C07D215/40 , C07D215/42 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D235/08 , C07D235/26 , C07D237/20 , C07D239/42 , C07D239/88 , C07D239/90 , C07D241/20 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D311/16 , C07D319/18 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D215/16
CPC classification number: C07D471/04 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
Abstract: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
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公开(公告)号：US07514566B2
公开(公告)日：2009-04-07
申请号：US11652728
申请日：2007-01-11
Applicant: Qingping Zeng , John G. Allen , Matthew P. Bourbeau , Celia Dominguez , Christopher H. Fotsch , Nianhe Han , Fang-Tsao Hong , Xin Huang , Matthew R. Lee , Aiwen Li , Qingyian Liu , James T. Rider , Seifu Tadesse , Andrew S. Tasker , Vellarkad N. Viswanadhan , Xianghong Wang , Kurt E. Weiler , George E. Wohlhieter , Guomin Yao , Chester Chenguang Yuan
Inventor： Qingping Zeng , John G. Allen , Matthew P. Bourbeau , Celia Dominguez , Christopher H. Fotsch , Nianhe Han , Fang-Tsao Hong , Xin Huang , Matthew R. Lee , Aiwen Li , Qingyian Liu , James T. Rider , Seifu Tadesse , Andrew S. Tasker , Vellarkad N. Viswanadhan , Xianghong Wang , Kurt E. Weiler , George E. Wohlhieter , Guomin Yao , Chester Chenguang Yuan
IPC: A61K31/425 , C07D277/00
CPC classification number: C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
Abstract: The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
Abstract translation: 本发明涉及式I和式II的噻唑化合物及其用于治疗由蛋白激酶B（PKB）介导的疾病的组合物，其中变量具有本文提供的定义。 本发明还涉及这种噻唑化合物及其组合物治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病的治疗用途。
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公开(公告)号：US07425631B2
公开(公告)日：2008-09-16
申请号：US10823377
申请日：2004-04-12
Applicant: Robert D. Groneberg , Benny C. Askew, Jr. , Derin C. D'Amico , James Zhan , Andras Toro , Youngboo Kim , David A. Mareska , Nianhe Han , Christopher H. Fotsch , Qingyian Liu , Babak Riahi , Kevin Yang , Aiwen Li , Chester Chenguang Yuan , Kaustav Biswas , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jian Jeffrey Chen , Rana Nomak
Inventor： Robert D. Groneberg , Benny C. Askew, Jr. , Derin C. D'Amico , James Zhan , Andras Toro , Youngboo Kim , David A. Mareska , Nianhe Han , Christopher H. Fotsch , Qingyian Liu , Babak Riahi , Kevin Yang , Aiwen Li , Chester Chenguang Yuan , Kaustav Biswas , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jian Jeffrey Chen , Rana Nomak
IPC: C07D215/04
CPC classification number: C07C311/19 , C07C311/13 , C07C311/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D205/04 , C07D207/12 , C07D207/16 , C07D207/20 , C07D209/14 , C07D209/16 , C07D209/40 , C07D209/52 , C07D211/38 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/70 , C07D213/42 , C07D213/56 , C07D213/64 , C07D215/38 , C07D215/40 , C07D215/42 , C07D217/22 , C07D233/54 , C07D239/74 , C07D271/08 , C07D277/64 , C07D279/02 , C07D285/14 , C07D295/125 , C07D295/13 , C07D295/135 , C07D307/14 , C07D307/28 , C07D307/79 , C07D307/81 , C07D311/68 , C07D317/58 , C07D333/20 , C07D333/24 , C07D333/58 , C07D333/62 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/06 , C07D407/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/08
Abstract: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Abstract translation: 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物，类似物，前药和其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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Patent Agency Ranking
公开(公告)号：US20070197598A1
公开(公告)日：2007-08-23
申请号：US11598238
申请日：2006-11-13
Applicant: Martin Henriksson , Evert Homan , Lars Johansson , Jerk Vallgarda , Meredith Williams , Eric Bercot , Christopher Fotsch , Aiwen Li , Guolin Cai , Randall Hungate , Chester Yuan , Christopher Tegley , David Jean , Nianhe Han , Qi Huang , Qingyian Liu , Michael Bartberger , George Moniz , Matthew Frizzle , Teresa Marshall
Inventor： Martin Henriksson , Evert Homan , Lars Johansson , Jerk Vallgarda , Meredith Williams , Eric Bercot , Christopher Fotsch , Aiwen Li , Guolin Cai , Randall Hungate , Chester Yuan , Christopher Tegley , David Jean , Nianhe Han , Qi Huang , Qingyian Liu , Michael Bartberger , George Moniz , Matthew Frizzle , Teresa Marshall
IPC: A61K31/454 , A61K31/4439 , A61K31/426 , C07D417/02 , C07D277/34
CPC classification number: C07D277/54 , C07D277/60 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14
Abstract: The present invention relates to thiazolinones and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
Abstract translation: 本发明涉及噻唑啉酮以及包含该化合物的药物组合物，以及该化合物用于治疗与人类11-β-羟基类固醇脱氢酶1型酶有关的病症的用途的方法以及用于制备作用于 人类11-β-羟基类固醇脱氢酶1型酶。
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公开(公告)号：US07115607B2
公开(公告)日：2006-10-03
申请号：US10202823
申请日：2002-07-24
Applicant: Christopher H. Fotsch , Premilla Arasasingham , Yunxin Bo , Ning Chen , Martin H. Goldberg , Nianhe Han , Feng-Yin Hsieh , Michael G. Kelly , Qingyian Liu , Mark H. Norman , Duncan M. Smith , Markian Stec , Nuria Tamayo , Ning Xi , Shimin Xu
Inventor： Christopher H. Fotsch , Premilla Arasasingham , Yunxin Bo , Ning Chen , Martin H. Goldberg , Nianhe Han , Feng-Yin Hsieh , Michael G. Kelly , Qingyian Liu , Mark H. Norman , Duncan M. Smith , Markian Stec , Nuria Tamayo , Ning Xi , Shimin Xu
IPC: A61K31/496 , C07D401/12 , C07D403/12
CPC classification number: C07D207/08 , A61K38/00 , C07D205/04 , C07D207/09 , C07D209/14 , C07D209/42 , C07D211/26 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/06 , C07D217/14 , C07D217/26 , C07D233/64 , C07D295/185 , C07D317/60 , C07D317/68 , C07D319/18 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D451/02 , C07K5/06026 , C07K5/06139 , C07K5/06147 , C07K5/06191
Abstract: Selected substituted piperazine compounds of Formula I are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Abstract translation: 式I的选择性取代哌嗪化合物对预防和治疗诸如肥胖症等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗涉及黑皮质素受体活化的疾病和其它疾病或病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US20060142357A1
公开(公告)日：2006-06-29
申请号：US11135662
申请日：2005-05-24
Applicant: Martin Henriksson , Evert Homan , Lars Johansson , Jerk Vallgarda , Meredith Williams , Eric Bercot , Christopher Fotsch , Aiwen Li , Guolin Cai , Randall Hungate , Chester Yuan , Christopher Tegley , David Jean , Nianhe Han , Qi Huang , Qingyian Liu , Michael Bartberger , George Moniz , Matthew Frizzle
Inventor： Martin Henriksson , Evert Homan , Lars Johansson , Jerk Vallgarda , Meredith Williams , Eric Bercot , Christopher Fotsch , Aiwen Li , Guolin Cai , Randall Hungate , Chester Yuan , Christopher Tegley , David Jean , Nianhe Han , Qi Huang , Qingyian Liu , Michael Bartberger , George Moniz , Matthew Frizzle
IPC: A61K31/426 , A61K31/421 , C07D277/04 , C07D263/04
CPC classification number: C07D417/06 , C07D263/34 , C07D263/48 , C07D275/03 , C07D277/42 , C07D277/54 , C07D277/60 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D513/10 , C07F7/1804
Abstract: The present invention relates to compounds with the formula (I), (II), (III) or (IV): wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
Abstract translation: 本发明涉及具有式（I），（II），（III）或（IV）的化合物：其中R 1，R 2，R 2， 3，R 4，R 5，R 6，R 7，X和Z分别为 以及包含该化合物的药物组合物的使用方法，以及该化合物用于治疗与人类11-β-羟基类固醇脱氢酶1型酶相关的病症和用于制备作用于人的药物的方法 11-β-羟基类固醇脱氢酶1型酶。
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公开(公告)号：US20050234044A1
公开(公告)日：2005-10-20
申请号：US10823372
申请日：2004-04-13
Applicant: Robert Groneberg , James Zhan , Benny Askew , Derin D'Amico , Nianhe Han , Christopher Fotsch , Qingyian Liu , Babak Riahi , Jiawang Zhu , Kevin Yang , Jian Chen , Rana Nomak
Inventor： Robert Groneberg , James Zhan , Benny Askew , Derin D'Amico , Nianhe Han , Christopher Fotsch , Qingyian Liu , Babak Riahi , Jiawang Zhu , Kevin Yang , Jian Chen , Rana Nomak
IPC: A61K31/425 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/517 , A61K31/55 , A61P29/00 , C07D207/48 , C07D211/96 , C07D215/58 , C07D217/22 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/02 , C07D413/14 , C07D417/02 , C07D417/12 , C07D417/14 , C07D43/02
CPC classification number: C07D207/48 , C07D211/96 , C07D215/58 , C07D217/22 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Abstract translation: 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物，类似物，前药和其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US20050124654A1
公开(公告)日：2005-06-09
申请号：US10823377
申请日：2004-04-12
Applicant: Robert Groneberg , Bonny Askew , Derin D'Amico , James Zhan , Andras Toro , Youngboo Kim , David Mareska , Nianhe Han , Christopher Fotsch , Qingyian Liu , Babak Riahi , Kevin Yang , Aiwen Li , Chester Yuan , Kaustav Biswas , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jian Chen , Rana Nomak
Inventor： Robert Groneberg , Bonny Askew , Derin D'Amico , James Zhan , Andras Toro , Youngboo Kim , David Mareska , Nianhe Han , Christopher Fotsch , Qingyian Liu , Babak Riahi , Kevin Yang , Aiwen Li , Chester Yuan , Kaustav Biswas , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jian Chen , Rana Nomak
IPC: A61K31/18 , A61K31/277 , A61K31/405 , A61K31/47 , A61P25/04 , A61P29/00 , C07C311/19 , C07C311/29 , C07D205/04 , C07D207/12 , C07D207/16 , C07D207/20 , C07D209/14 , C07D209/16 , C07D209/40 , C07D209/52 , C07D211/38 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/70 , C07D213/42 , C07D213/56 , C07D213/64 , C07D215/38 , C07D215/40 , C07D215/42 , C07D217/22 , C07D233/54 , C07D239/74 , C07D271/08 , C07D277/64 , C07D279/02 , C07D285/14 , C07D295/125 , C07D295/13 , C07D295/135 , C07D307/14 , C07D307/28 , C07D307/79 , C07D307/81 , C07D311/68 , C07D317/58 , C07D333/20 , C07D333/24 , C07D333/58 , C07D333/62 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/06 , C07D407/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/08
CPC classification number: C07C311/19 , C07C311/13 , C07C311/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D205/04 , C07D207/12 , C07D207/16 , C07D207/20 , C07D209/14 , C07D209/16 , C07D209/40 , C07D209/52 , C07D211/38 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/70 , C07D213/42 , C07D213/56 , C07D213/64 , C07D215/38 , C07D215/40 , C07D215/42 , C07D217/22 , C07D233/54 , C07D239/74 , C07D271/08 , C07D277/64 , C07D279/02 , C07D285/14 , C07D295/125 , C07D295/13 , C07D295/135 , C07D307/14 , C07D307/28 , C07D307/79 , C07D307/81 , C07D311/68 , C07D317/58 , C07D333/20 , C07D333/24 , C07D333/58 , C07D333/62 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/06 , C07D407/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/08
Abstract: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Abstract translation: 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物，类似物，前药和其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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