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    BRANCHING THERAPY ELEMENTS AND METHOD OF THEIR INSERTION INTO LIVING TISSUE
    21.
    发明申请
    BRANCHING THERAPY ELEMENTS AND METHOD OF THEIR INSERTION INTO LIVING TISSUE 审中-公开
    分配治疗单元及其入侵组织的方法

    公开(公告)号：US20100010550A1

    公开(公告)日：2010-01-14

    申请号：US12442528

    申请日：2007-09-20

    Applicant: Youri Ponomarev ,  Matthias Merz ,  Remco Henricus Wilhelmus Pijnenburg

    Inventor： Youri Ponomarev ,  Matthias Merz ,  Remco Henricus Wilhelmus Pijnenburg

    IPC: A61N1/05 ,  A61M31/00 ,  A61B19/00

    CPC classification number: A61N1/0529 ,  A61N1/0534

    Abstract: An implantable medical system for electrical recording and or providing therapy to a plurality of tissue sites without damage to surrounding blood vessels is disclosed comprising: an implant body having a plurality of therapy elements, the elements being hingedly attached at one end to the surface of the body and releasably extendable outward from the surface of the body at the other end; a release mechanism for each of the elements; and a coating material covering the body and the elements; wherein upon dissolution of the coating material after implantation, the release mechanism is capable of causing the elements to extend outward at one end from the surface of the body and into a plurality of tissue sites without damage to the surrounding blood vessels. The method of implanting the system into a body is also disclosed.

    Abstract translation: 公开了一种用于对多个组织部位进行电记录和/或对周围血管的损伤提供治疗的可植入医疗系统，包括：具有多个治疗元件的植入体，所述元件在一端铰接附接到 并且在另一端从主体的表面可释放地向外延伸; 用于每个元件的释放机构; 以及覆盖所述主体和所述元件的涂层材料; 其中，在植入后溶解涂层材料时，释放机构能够使元件在一端从身体的表面向外延伸并且进入多个组织部位而不损坏周围的血管。 还公开了将系统植入体内的方法。

    Implantable multi-electrode device
    23.
    发明授权
    Implantable multi-electrode device 有权
    可植入多电极装置

    公开(公告)号：US08798737B2

    公开(公告)日：2014-08-05

    申请号：US12442133

    申请日：2007-09-18

    Applicant: Matthias Merz ,  Youri V. Ponomarev ,  Remco H. W. Pijnenburg

    Inventor： Matthias Merz ,  Youri V. Ponomarev ,  Remco H. W. Pijnenburg

    IPC: A61N1/00

    CPC classification number: A61N1/0529 ,  A61B5/04001 ,  A61L31/148 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0536 ,  A61N1/0539 ,  A61N1/0558 ,  A61N1/36082

    Abstract: The invention provides an implantable multi-electrode device (300) and related methods and apparatuses. In one embodiment, the invention includes an implantable device (300) comprising: an assembly block (320); and a plurality of leads (340 . . . 348) radiating from the assembly block (320), each of the plurality of leads (340 . . . 348) containing at least one electrode (342A), such that the electrodes are distributed within a three-dimensional space, wherein the assembly block (320) includes a barb (350) for anchoring the assembly block (320) within implanted tissue.

    Abstract translation: 本发明提供一种可植入式多电极装置（300）及其相关方法和装置。 在一个实施例中，本发明包括可植入装置（300），包括：组装块（320）; 以及从所述组装块（320）辐射的多个引线（340 ... 348），所述多个引线（340 ... 348）中的每一个包含至少一个电极（342A），使得所述电极分布在 三维空间，其中组装块（320）包括用于将组装块（320）固定在植入的组织内的倒钩（350）。

    ELECTROCHEMICAL POTENTIOMETRIC SENSING WITHOUT REFERENCE ELECTRODE
    24.
    发明申请
    ELECTROCHEMICAL POTENTIOMETRIC SENSING WITHOUT REFERENCE ELECTRODE 有权
    无参考电极的电化学电位感测

    公开(公告)号：US20110208457A1

    公开(公告)日：2011-08-25

    申请号：US13061110

    申请日：2009-08-24

    Applicant: Matthias Merz ,  Youri Victorovitch Ponomarev ,  Gilberto Curatola

    Inventor： Matthias Merz ,  Youri Victorovitch Ponomarev ,  Gilberto Curatola

    IPC: G06F19/00

    CPC classification number: G01N27/4148 ,  G01N27/4145

    Abstract: The invention relates to a method of determining a charged particle concentration in an analyte (100), the method comprising steps of: i) determining at least two measurement points of a surface-potential versus interface-temperature curve (c1, c2, c3, c4), wherein the interface temperature is obtained from a temperature difference between a first interface between a first ion-sensitive dielectric (Fsd) and the analyte (100) and a second interface between a second ion-sensitive dielectric (Ssd) and the analyte (100), and wherein the surface-potential is obtained from a potential difference between a first electrode (Fe) and a second electrode (Se) onto which said first ion-sensitive dielectric (Fsd) and said second ion-sensitive dielectric (Ssd) are respectively provided, And ii) calculating the charged particle concentration from locations of the at least two measurement points of said curve (c1, c2, c3, c4). This method, which still is a potentiometric electrochemical measurement, exploits the temperature dependency of a surface-potential of an ion-sensitive dielectric in an analyte. The invention further provides an electrochemical sensor deny for determining a charged particle concentration in an analyte. The invention also provides various sensors which can be used to determine the charged particle concentration, i.e. EGFET's and EIS capacitors.

    Abstract translation: 本发明涉及一种测定分析物（100）中带电粒子浓度的方法，所述方法包括以下步骤：i）确定表面电位对界面温度曲线（c1，c2，c3，c3）的至少两个测量点， c4），其中所述界面温度是由第一离子敏感电介质（Fsd）和分析物（100）之间的第一界面与第二离子敏感电介质（Ssd）与分析物之间的第二界面 （100），并且其中所述表面电位由所述第一离子敏感电介质（Fsd）和所述第二离子敏感电介质（Ssd）上的第一电极（Fe）和第二电极（Se）之间的电位差获得， ），和ii）从所述曲线（c1，c2，c3，c4）的至少两个测量点的位置计算带电粒子浓度。 这种仍然是电位电化学测量的方法利用分析物中离子敏感电介质的表面电位的温度依赖性。 本发明还提供了一种用于确定分析物中带电粒子浓度的电化学传感器。 本发明还提供可用于确定带电粒子浓度的各种传感器，即EGFET和EIS电容器。

    Electrochemical sensor
    29.
    发明授权
    Electrochemical sensor 有权
    电化学传感器

    公开(公告)号：US08864968B2

    公开(公告)日：2014-10-21

    申请号：US12858353

    申请日：2010-08-17

    Applicant: Matthias Merz ,  Youri Victorovitch Ponomarev

    Inventor： Matthias Merz ,  Youri Victorovitch Ponomarev

    IPC: G01N27/333 ,  G01N27/416 ,  G01N27/414

    CPC classification number: G01N27/4167 ,  G01N27/333 ,  G01N27/414 ,  Y10T29/4913

    Abstract: An electrochemical sensor device including a sensor chip having an integrated electrochemical sensor element; and a substrate having a first surface on which the sensor chip is mounted, the substrate comprising a reference electrode structure for the integrated electrochemical sensor element, the reference electrode structure connected to the sensor chip via an electrical connection on the first surface of the substrate.

    Abstract translation: 一种电化学传感器装置，包括具有集成的电化学传感器元件的传感器芯片; 以及基板，其具有安装有传感器芯片的第一表面，所述基板包括用于所述一体化电化学传感器元件的参考电极结构，所述参考电极结构通过所述基板的第一表面上的电连接连接到所述传感器芯片。

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