公开(公告)号：US20080198653A1

公开(公告)日：2008-08-21

申请号：US12032202

申请日：2008-02-15

申请人： Ralf Brederlow ,  Roland Thewes

发明人： Ralf Brederlow ,  Roland Thewes

IPC分类号： G11C11/34

CPC分类号： G11C16/10 ,  G11C16/22 ,  G11C16/30

摘要： A circuit arrangement includes a nonvolatile memory cell having a continuously variable characteristic that can be read out. A programming unit is coupled to the memory cell and designed to apply an analog signal to the memory cell in order to vary the characteristic, if the characteristic lies within a predetermined range of values, in such a way that the characteristic lies outside the predetermined range of values. A supply voltage unit is provided for providing a supply voltage. A changeover unit is coupled to the supply voltage unit and to the programming unit and designed to trigger the application of the analog signal to the memory cell if the supply voltage is interrupted.

摘要翻译： 电路装置包括具有可读出的连续可变特性的非易失性存储单元。 编程单元耦合到存储器单元并且被设计为将模拟信号施加到存储器单元，以便如果特性位于预定值范围内，则改变特性，使得特性位于预定范围之外 的价值观。 提供电源电压单元以提供电源电压。 转换单元耦合到电源电压单元和编程单元，并且被设计成如果电源电压被中断则触发模拟信号施加到存储单元。

公开(公告)号：US20080197430A1

公开(公告)日：2008-08-21

申请号：US11791963

申请日：2005-11-29

申请人： Robert Aigner ,  Ralf Brederlow ,  Lude Elbrecht ,  Heinrich Heiss ,  Stephan Marksteiner ,  Werner Simburger ,  Roland Thewes ,  Hans-Jorg Timme

发明人： Robert Aigner ,  Ralf Brederlow ,  Lude Elbrecht ,  Heinrich Heiss ,  Stephan Marksteiner ,  Werner Simburger ,  Roland Thewes ,  Hans-Jorg Timme

IPC分类号： H01L27/00 ,  H01L21/00 ,  G01N29/00

CPC分类号： G01N29/036 ,  B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0663 ,  B01L2300/0819 ,  G01N33/02 ,  G01N33/15 ,  G01N33/48707 ,  G01N2291/0256 ,  H01L2224/81801 ,  H01L2924/01068 ,  H01L2924/13091 ,  H01L2924/00

摘要： A biochemical semiconductor chip laboratory is disclosed including a coupled address and control chip for biochemical analyses and a method for producing the same. In at least one embodiment the semiconductor chip laboratory has a semiconductor sensor chip, which provides numerous analytical positions for biochemical samples in a matrix. The sensor chip is located on the address and control chip and the analytical positions are in electric contact with a printed contact structure on the upper face of the address and control chip via low-resistance through-platings through the semiconductor substrate of the semiconductor chip.

摘要翻译： 公开了一种生物化学半导体芯片实验室，其包括用于生化分析的耦合地址和控制芯片及其制造方法。 在至少一个实施例中，半导体芯片实验室具有半导体传感器芯片，其为矩阵中的生物化学样品提供许多分析位置。 传感器芯片位于地址和控制芯片上，并且分析位置通过半导体芯片的半导体衬底的低电阻穿透与地址和控制芯片的上表面上的印刷接触结构电接触。

公开(公告)号：US07379766B2

公开(公告)日：2008-05-27

申请号：US10931482

申请日：2004-09-01

申请人： Reinhard Gabl ,  Tamara Birkenmaier ,  Bjorn-Oliver Eversmann ,  Peter Fromherz ,  Martin Jenkner ,  Matthias Schreiter ,  Roland Thewes ,  Wolfram Wersing

发明人： Reinhard Gabl ,  Tamara Birkenmaier ,  Bjorn-Oliver Eversmann ,  Peter Fromherz ,  Martin Jenkner ,  Matthias Schreiter ,  Roland Thewes ,  Wolfram Wersing

IPC分类号： A61B5/04 ,  H01L21/16

CPC分类号： C12N5/0619 ,  G01N33/4833

摘要： Biochip for capacitive stimulation and/or detection of biological tissues. The biochip has a carrier structure, at least one stimulation and/or sensor device, which is arranged in or at the carrier structure, and at least one dielectric layer, one layer area of which is arranged at the stimulation and/or sensor device and the opposite layer area of which forms a stimulation and/or sensor area for capacitive simulation and/or detection of biological tissues, wherein the dielectric layer comprises TiO2.

摘要翻译： 用于电容刺激和/或检测生物组织的生物芯片。 生物芯片具有载体结构，布置在载体结构中或载体结构中的至少一个刺激和/或传感器装置，以及至少一个电介质层，其一个区域布置在刺激和/或传感器装置处， 其相对层区域形成用于电容模拟和/或检测生物组织的刺激和/或传感器区域，其中该介电层包含TiO 2。

公开(公告)号：US20080036444A1

公开(公告)日：2008-02-14

申请号：US11663078

申请日：2005-09-01

申请人： Christian Paulus ,  Meinrad Schienle ,  Claudio Stagni Degli Esposti ,  Roland Thewes

发明人： Christian Paulus ,  Meinrad Schienle ,  Claudio Stagni Degli Esposti ,  Roland Thewes

IPC分类号： G01R27/26 ,  C12Q1/68

CPC分类号： G01N27/3276

摘要： A sensor arrangement including a control circuit is disclosed. In at least one embodiment, at least one sensor electrode can be charged and/or discharged therewith and a comparator unit for the comparison of a provided voltage for the at least one electrode with a reference voltage. A duration necessary for the charging/discharging of the at least one sensor electrode is determined, whereby, from the determined duration, it is determined whether a sensor event, in the form of a hybridisation between trap molecules and the particles for recording, has occurred.

摘要翻译： 公开了一种包括控制电路的传感器装置。 在至少一个实施例中，可以对至少一个传感器电极进行充电和/或放电，以及用于将所述至少一个电极的提供的电压与参考电压进行比较的比较器单元。 确定至少一个传感器电极的充电/放电所需的持续时间，由此，从所确定的持续时间确定是否发生了陷阱分子和用于记录的颗粒之间的杂交形式的传感器事件 。

公开(公告)号：US07283372B2

公开(公告)日：2007-10-16

申请号：US10857635

申请日：2004-05-28

申请人： Werner Weber ,  Gunter Schmid ,  Richard J. Luyken ,  Roland Thewes ,  Markus Seitz

发明人： Werner Weber ,  Gunter Schmid ,  Richard J. Luyken ,  Roland Thewes ,  Markus Seitz

IPC分类号： H05K7/02 ,  H05K7/06 ,  H05K7/08 ,  H05K7/10

CPC分类号： H01L51/0595 ,  B82Y10/00 ,  G11C13/0009 ,  G11C13/0014 ,  G11C2213/15 ,  G11C2213/72 ,  H01L27/28 ,  H01L51/005 ,  H01L51/0053 ,  H01L51/0062 ,  H01L51/0077

摘要： Circuit element having a first layer composed of an electrically insulating substrate material, a first electrically conductive material which is in the form of at least one discrete area, such that it is embedded in or applied to the substrate material, a second layer having a second electrically conductive material, and a monomolecular layer, which is composed of electrically active molecules which transports charge carriers, arranged between the first layer and the second layer. The monomolecular layer is immobilized and makes electrical contact with the second layer. Each of the electrically active molecules has a first unit, which is used as an electron donor, a second unit, which is used as an electron acceptor, wherein the electron donor and the electron acceptor form a diode, and at least one redox-active unit, by means of which a variable resistance is formed, arranged between the first unit and the second unit.

摘要翻译： 具有由电绝缘衬底材料构成的第一层的电路元件，至少一个离散区域形式的第一导电材料，使得其嵌入衬底材料中或施加到衬底材料上，第二层具有第二层 导电材料和单分子层，其由布置在第一层和第二层之间的电荷载流子的电活性分子组成。 单分子层被固定并与第二层电接触。 每个电活性分子具有用作电子给体的第一单元，用作电子受体的第二单元，其中电子给体和电子受体形成二极管，以及至少一种氧化还原活性 单元，其中形成有可变电阻，布置在第一单元和第二单元之间。

公开(公告)号：US20060289726A1

公开(公告)日：2006-12-28

申请号：US11450276

申请日：2006-06-12

申请人： Christian Paulus ,  Roland Thewes

发明人： Christian Paulus ,  Roland Thewes

IPC分类号： G06M7/00

CPC分类号： G01N27/3275 ,  H01L27/092

摘要： A circuit arrangement is disclosed. The circuit arrangement includes a substrate, at least one sensor array arranged on and/or in the substrate, and at least one operating circuit integrated on and/or in the substrate and serving for driving the at least one sensor array. The operating circuit and the sensor array are arranged in a manner spatially separate from one another.

摘要翻译： 公开了一种电路装置。 电路装置包括衬底，布置在衬底上和/或衬底中的至少一个传感器阵列，以及集成在衬底上和/或衬底中的至少一个操作电路，用于驱动至少一个传感器阵列。 操作电路和传感器阵列以空间上彼此分离的方式排列。

公开(公告)号：US20060226030A1

公开(公告)日：2006-10-12

申请号：US10562040

申请日：2004-05-11

申请人： Hans-Christian Hanke ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

发明人： Hans-Christian Hanke ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

IPC分类号： G01F1/64 ,  G01N33/487

CPC分类号： G01N33/54346 ,  B01L3/5027 ,  C12Q1/6825 ,  C12Q1/6834 ,  G01N27/3276 ,  G01N33/5438

摘要： A sensor element is for detecting DNA single strands which are possibly contained in an analyte. The sensor element includes a substrate and at least two electrodes in and/or on the substrate. In a surface area of the substrate, catcher molecules are immobilized and are adapted to hybridize to DNA single strands that are possibly contained in an analyte. The DNA single strands include a label that has dielectric properties that are different from those of the analyte. The electrodes are coupled to a detection device for detecting a change in the capacitative portion of the impedance between the electrodes due to a label that is present in an area surrounding the electrodes as a result of the hybridization event.

摘要翻译： 传感器元件用于检测可能包含在分析物中的DNA单链。 传感器元件包括衬底和衬底中和/或上的至少两个电极。 在底物的表面区域中，捕获剂分子被固定并适于与可能包含在分析物中的DNA单链杂交。 DNA单链包括具有不同于分析物的介电性质的标记。 电极耦合到检测装置，用于由于杂交事件的结果，由于存在于电极周围的区域中的标签，用于检测电极之间的阻抗的电容部分的变化。

公开(公告)号：US06922081B2

公开(公告)日：2005-07-26

申请号：US10399355

申请日：2001-10-16

申请人： Alexander Frey ,  Christian Paulus ,  Roland Thewes

发明人： Alexander Frey ,  Christian Paulus ,  Roland Thewes

IPC分类号： G01N33/53 ,  G01D3/02 ,  G01N27/02 ,  G01N27/22 ,  G01N27/327 ,  G01N27/333 ,  G01N27/414 ,  G01N27/416 ,  G01N27/49 ,  G01N37/00 ,  H03K19/0175 ,  G01R27/26

CPC分类号： G01D3/02 ,  G01N27/3277

摘要： In a first phase a first sensor signal, essentially comprising the current offset signal of the sensor, is applied to the input of an electronic circuit. The first sensor signal is fed to a first signal path and stored therein. In a second phase a second sensor signal, comprising the current offset signal and a time-dependent measured signal, is applied to the input and the stored first sensor signal is fed to the input by means of the first signal path, such that essentially the time dependent measured signal is fed by means of a second signal path coupled to the input.

摘要翻译： 在第一阶段中，基本上包括传感器的当前偏移信号的第一传感器信号被施加到电子电路的输入。 第一传感器信号被馈送到第一信号路径并存储在其中。 在第二阶段，包括当前偏移信号和时间相关测量信号的第二传感器信号被施加到输入端，并且所存储的第一传感器信号通过第一信号路径馈送到输入端，使得基本上 时间相关测量信号通过耦合到输入的第二信号路径馈送。

公开(公告)号：US20050107893A1

公开(公告)日：2005-05-19

申请号：US10964560

申请日：2004-10-12

申请人： Bjorn-Oliver Eversmann ,  Martin Jenkner ,  Christian Paulus ,  Roland Thewes

发明人： Bjorn-Oliver Eversmann ,  Martin Jenkner ,  Christian Paulus ,  Roland Thewes

IPC分类号： A61B5/04 ,  G05B13/02 ,  G06N3/06

CPC分类号： A61B5/7264 ,  A61B5/04001 ,  A61B5/7203 ,  A61B5/7232 ,  A61B5/7282 ,  A61B2562/0209 ,  A61B2562/046 ,  G06N3/061

摘要： Apparatus for measuring neural network activity with a textured semiconductor substrate. Sensor elements have a respective detection electrode on the substrate surface for detecting neural network signals, and the detected neural signals are a basis for outputting electrical sensor output signals via respective sensor element outputs. Each amplifier element has an input and an output. Each of the sensor elements has associated therewith one of the amplifier elements whose input is connected to the sensor output of the respective sensor element. The amplified sensor output signal is output the amplifier output as an amplifier output signal. An activity evaluator has an input, which is connected to at least one of the amplifier outputs, and an output. The activity evaluation device produces an activity signal, which is a measure of activity of the neural network, based on the amplifier output signal, and outputs the amplifier output signal via the evaluation output.

摘要翻译： 用纹理化半导体衬底测量神经网络活动的装置。 传感器元件在基板表面上具有检测电极，用于检测神经网络信号，检测到的神经信号是经由各个传感器元件输出输出电传感器输出信号的基础。 每个放大器元件都有一个输入和一个输出。 每个传感器元件都具有一个放大器元件，其输入端连接到相应传感器元件的传感器输出端。 放大的传感器输出信号作为放大器输出信号输出放大器输出。 活动评估器具有连接到至少一个放大器输出的输入和输出。 活动评估装置基于放大器输出信号产生作为神经网络的活动度量的活动信号，并通过评估输出输出放大器输出信号。

公开(公告)号：US06856161B2

公开(公告)日：2005-02-15

申请号：US10239438

申请日：2001-03-29

申请人： Roland Thewes

发明人： Roland Thewes

IPC分类号： G01N27/414 ,  G01N27/416 ,  G01R29/12 ,  G01R31/27 ,  G01R31/28 ,  G01R31/317 ,  H01L29/78 ,  G01R31/26

CPC分类号： G01R31/31702 ,  G01N27/4145 ,  G01N27/4148 ,  G01R29/12 ,  G01R31/27 ,  G01R31/2829 ,  H03F3/505 ,  H03F2203/5031

摘要： A sensor array is provided including transistors that are coupled together. The transistors are designed as sensors and wherein the sensor array has switching devices for selecting a transistor and wherein the selected transistor's condition may be detected. The sensor array is set up so that the selected transistor is driven as a source follower and at least some of the transistors are MOS field effect transistors that are configured so that at least some of the transistors are capable of detecting biological material.

摘要翻译： 提供了传感器阵列，其包括耦合在一起的晶体管。 晶体管被设计为传感器，并且其中传感器阵列具有用于选择晶体管的开关装置，并且其中可以检测所选择的晶体管的状态。 设置传感器阵列使得所选择的晶体管被​​驱动为源极跟随器，并且至少一些晶体管是被配置为使得至少一些晶体管能够检测生物材料的MOS场效应晶体管。