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公开(公告)号：US20180154046A1
公开(公告)日：2018-06-07
申请号：US15872667
申请日：2018-01-16
申请人： Scripps Health
CPC分类号： A61L27/44 , A61L27/26 , A61L27/3817 , A61L27/3821 , A61L27/54 , A61L2300/412 , A61L2300/64 , A61L2430/02 , A61L2430/06 , C08L5/08 , C08L89/06
摘要： Provided are tri-component matrices having collagen, hyaluronan, and chondroitin sulfate. Also provided are processes for producing a tri-component matrix. Additionally, provided are processes for providing cells capable of producing cartilage to a bone or cartilage defects.
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22.发明申请公开(公告)号：US20180133369A1
公开(公告)日：2018-05-17
申请号：US15837300
申请日：2017-12-11
申请人： The Board of Trustees of the Leland Stanford Junior University , The United States Gorvermment as represented by the Department of Veterans Affairs
发明人： James Chang , Hung Pham , Colin Woon , Simon Farnebo , Anais Legrand
IPC分类号： A61L27/52 , A61L27/36 , A61K45/06 , A61L27/24 , A61L27/54 , A61K35/16 , A61L27/58 , A61K35/12 , A61K38/28 , A61L27/38 , A61L27/50
CPC分类号： A61L27/52 , A61K35/12 , A61K35/16 , A61K38/28 , A61K45/06 , A61L27/24 , A61L27/3633 , A61L27/3662 , A61L27/3687 , A61L27/3804 , A61L27/3834 , A61L27/386 , A61L27/50 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/402 , A61L2300/406 , A61L2300/412 , A61L2300/414 , A61L2300/45 , A61L2300/64 , A61L2400/06 , A61L2430/10 , A61L2430/40 , A61K2300/00
摘要： The invention provides an injectable composition and method for the minimally invasive, in-situ repair and regeneration of an injured ligament or tendon in a mammalian subject. The composition is also useful for the delivery of growth factors, therapeutic agents and cells into the area of tendon or ligament injury.
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公开(公告)号：US20180126036A1
公开(公告)日：2018-05-10
申请号：US15806122
申请日：2017-11-07
发明人： Ryanne Early
CPC分类号： A61L27/3633 , A61K35/00 , A61K35/50 , A61L27/3604 , A61L27/3683 , A61L27/3687 , A61L27/58 , A61L2300/236 , A61L2300/252 , A61L2300/414 , A61L2300/608 , A61L2300/64 , A61L2430/16 , A61L2430/34 , A61L2430/40 , C12N2533/52 , C12N2533/54 , C12N2533/90
摘要： The present invention includes a growth factor profile, connective tissue matrix constituents, and immunoprivileged status of equine placental tissue extracellular matrix (ECM) and accompanying cutaneous tissue, plus the presence of antimicrobial peptides there, render equine placental tissue an ideal source for biological scaffolds for xenotransplantation, and optionally adding at least one of: one or more block-copolymers, one or more osteogenic agent or one or more osteoinductive agents.
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公开(公告)号：US20180085494A1
公开(公告)日：2018-03-29
申请号：US15717201
申请日：2017-09-27
CPC分类号： A61L27/56 , A61L27/30 , A61L27/34 , A61L27/38 , A61L27/52 , A61L27/54 , A61L2300/412 , A61L2300/414 , A61L2300/62 , A61L2300/64 , A61L2420/04 , A61M31/002
摘要： Embodiments herein relate to cell encapsulation membranes, devices including the same, and related methods. In an embodiment, a cell encapsulation membrane is included. The cell encapsulation membrane can include a mesh substrate. The mesh substrate can include a first series of fibers extending in a first direction and a second series of fibers extending in a second direction, the first series of fibers intersecting with the second series of fibers, the mesh substrate defining a plurality of apertures disposed between adjacent fibers of the first series and the second series. The cell encapsulation membrane can further include a coating disposed on the mesh substrate, the coating partially occluding the plurality of apertures defined by the mesh substrate and forming pores. Other embodiments are also included herein.
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公开(公告)号：US09925302B2
公开(公告)日：2018-03-27
申请号：US14642223
申请日：2015-03-09
发明人： Thomas Q. Dinh
CPC分类号： A61L27/362 , A61K9/0019 , A61K9/0034 , A61L27/54 , A61L31/148 , A61L31/16 , A61L2300/00 , A61L2300/414 , A61L2300/43 , A61L2300/45 , A61L2300/64 , A61L2400/06
摘要： A delivery system is provided that is adapted to treat various urological pelvic disorders, such as prolapse, incontinence, and the like. The delivery system can include at least one biologic loaded or otherwise provided with a bioactive agent. The biologic can comprise any drugs, hormones or steroids, stem cells, growth factors, proteins, and/or other bioactive agents to promote cell or tissue growth for the treatment and strengthening of organ walls or tissue. The biologic is generally adapted to controllably release the agent to the surrounding tissue or organ to provide a local and targeted delivery.
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公开(公告)号：US20180071434A1
公开(公告)日：2018-03-15
申请号：US15266590
申请日：2016-09-15
CPC分类号： A61L27/52 , A61L27/3604 , A61L27/38 , A61L27/56 , A61L2300/62 , A61L2300/64
摘要： The present disclosure relates to scaffolds such as protein hydrogel scaffolds. The present disclosure provides methods and technologies that permit formation of cavities within hydrogel scaffolds; in some embodiments, such technologies permit controlled formation of cavities of particular predetermined shape and/or arrangement. In particular embodiments, the present disclosure provides multiphoton absorption technologies that achieve production of cavity-containing scaffolds.
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公开(公告)号：US09872937B2
公开(公告)日：2018-01-23
申请号：US15148821
申请日：2016-05-06
CPC分类号： A61L27/54 , A61J1/035 , A61J1/06 , A61K9/0019 , A61K9/19 , A61K35/28 , A61L27/3625 , A61L2300/41 , A61L2300/412 , A61L2300/64 , C12N5/00 , C12N5/0653
摘要： The present invention provides novel compositions comprising multipotent cells or microvascular tissue, wherein the cells or tissue has been sterilized and/or treated to inactivated viruses, and related methods of using these compositions to treat or prevent tissue injury or disease in an allogeneic subject.
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公开(公告)号：US09867781B2
公开(公告)日：2018-01-16
申请号：US13400382
申请日：2012-02-20
IPC分类号： A61K9/16 , A61K9/00 , A61K31/573 , A61K45/06 , A61K35/39 , G01N33/50 , A61L27/38 , A61L27/48 , A61L27/52 , A61L27/54 , C12N5/071
CPC分类号： A61K9/1641 , A61K9/0019 , A61K31/573 , A61K35/39 , A61K45/06 , A61L27/3804 , A61L27/48 , A61L27/52 , A61L27/54 , A61L2300/41 , A61L2300/622 , A61L2300/64 , C12N5/0676 , C12N2502/1157 , C12N2533/40 , C12N2533/74 , G01N33/5088 , A61K2300/00 , C08L5/04 , C08L5/08
摘要： A composition containing biocompatible hydrogel encapsulating mammalian cells and anti-inflammatory drugs is disclosed. The encapsulated cells have reduced fibrotic overgrowth after implantation in a subject. The compositions contain a biocompatible hydrogel having encapsulated therein mammalian cells and anti-inflammatory drugs or polymeric particles loaded with anti-inflammatory drugs. The anti-inflammatory drugs are released from the composition after transplantation in an amount effective to inhibit fibrosis of the composition for at least ten days. Methods for identifying and selecting suitable anti-inflammatory drug-loaded particles to prevent fibrosis of encapsulated cells are also described. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.
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29.发明申请公开(公告)号：US20180008747A1
公开(公告)日：2018-01-11
申请号：US15710398
申请日：2017-09-20
发明人： Zou Xuenong , Haisheng Li , Cody Bunger
IPC分类号： A61L27/56 , A61F2/28 , A61L27/22 , A61F2/34 , A61L27/00 , A61L27/38 , A61L27/54 , C12N5/00 , C12N5/0775 , A61L27/36 , A61L27/20 , A61F2/46 , A61F2/30 , A61F2/00 , A61F2/44 , A61F2/38 , A61F2/36 , A61F2/32
CPC分类号： A61L27/56 , A61F2/28 , A61F2/30767 , A61F2/3094 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/38 , A61F2/44 , A61F2/4644 , A61F2002/0086 , A61F2002/2817 , A61F2002/2867 , A61F2002/30199 , A61F2002/30225 , A61F2002/30677 , A61F2002/30678 , A61F2002/3093 , A61F2002/30981 , A61F2002/4648 , A61F2230/0063 , A61F2230/0069 , A61F2310/00161 , A61F2310/00293 , A61F2310/00341 , A61F2310/00491 , A61F2310/00544 , A61F2310/00976 , A61F2310/00982 , A61L27/00 , A61L27/20 , A61L27/22 , A61L27/3608 , A61L27/365 , A61L27/38 , A61L27/54 , A61L2300/222 , A61L2300/252 , A61L2300/606 , A61L2300/64 , A61L2400/18 , A61L2430/00 , C12N5/0068 , C12N5/0662
摘要： Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant growth factors, cytokines and antineoplastic drugs in the presence of a hyaluronan and/or dexamethasone alone or in combination with growth factors or transfected osteogenic genes, to be assembled ex vivo in a tissue incubator for implantation into bone tissue.
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公开(公告)号：US20180000989A1
公开(公告)日：2018-01-04
申请号：US15680581
申请日：2017-08-18
CPC分类号： A61L27/24 , A61L27/52 , A61L27/54 , A61L2300/64 , A61L2400/06 , A61L2430/02 , A61L2430/34 , B01J13/0069 , C08J3/075 , C08J2389/00
摘要： There is provided a method for preparing a dense hydrogel comprising an at least partially gelled hydrogel, placing the at least partially gelled hydrogel in fluid communication with an end of a capillary, and driving the at least partially gelled hydrogel into the capillary to form a dense hydrogel. There is also provided a system for preparing the dense hydrogel comprising a capillary having a bore; and a driver in communication with an end of the capillary for driving an at least partially gelled hydrogel into the bore of the capillary to form a dense hydrogel.
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