公开(公告)号：US20170266231A1

公开(公告)日：2017-09-21

申请号：US15478742

申请日：2017-04-04

申请人： NOVABONE PRODUCTS, LLC

发明人： Chloë GOLDBACH ,  Gregory J. POMRINK ,  Roy Layne HOWELL ,  Meryem DEMIR

IPC分类号： A61K33/42 ,  A61L27/54 ,  A61L27/56 ,  A61K33/08 ,  A61L27/10 ,  C03C3/097 ,  A61K33/22 ,  A61K33/14 ,  C03C4/00 ,  A61L26/00

CPC分类号： A61K33/42 ,  A61K8/25 ,  A61K33/08 ,  A61K33/14 ,  A61K33/22 ,  A61L26/0004 ,  A61L26/0066 ,  A61L26/0085 ,  A61L27/10 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L2400/04 ,  A61L2430/02 ,  A61L2430/34 ,  A61Q11/00 ,  C03B19/12 ,  C03B32/02 ,  C03C1/006 ,  C03C3/097 ,  C03C4/0007 ,  C03C10/0009 ,  A61K2300/00

摘要： Methods for processing and or removing organic residuals and or impurities from a solgel-derived bioactive glass-ceramic and compositions comprising solgel-derived bioactive glass-ceramics processed using these methods, are described.

公开(公告)号：US20170258556A1

公开(公告)日：2017-09-14

申请号：US15450192

申请日：2017-03-06

申请人： Masaki WATANABE ,  Yoichi SAKURAI ,  Takuya SAITO ,  Tatsuya NIIMI

发明人： Masaki WATANABE ,  Yoichi SAKURAI ,  Takuya SAITO ,  Tatsuya NIIMI

IPC分类号： A61C8/00 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y80/00 ,  A61C13/00 ,  A61C5/35 ,  A61C5/77 ,  A61C8/02 ,  A61C13/01 ,  A61C13/083 ,  B28B1/00 ,  B29C67/00

CPC分类号： A61C8/0015 ,  A61C5/35 ,  A61C5/77 ,  A61C8/0006 ,  A61C8/0012 ,  A61C13/0013 ,  A61C13/0019 ,  A61C13/01 ,  A61C13/083 ,  A61C2008/0046 ,  A61K6/0008 ,  A61K6/0017 ,  A61K6/0067 ,  A61K6/024 ,  A61K6/0273 ,  A61L27/10 ,  A61L27/54 ,  A61L27/56 ,  A61L2430/12 ,  B28B1/001 ,  B29C64/165 ,  B29K2105/16 ,  B29K2509/02 ,  B29L2031/753 ,  B32B18/00 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  B33Y80/00 ,  C04B35/111 ,  C04B35/16 ,  C04B35/486 ,  C04B35/6264 ,  C04B35/6269 ,  C04B35/63416 ,  C04B35/63424 ,  C04B2235/3203 ,  C04B2235/5445 ,  C04B2235/5454 ,  C04B2235/6026 ,  C04B2235/775 ,  C04B2235/963 ,  A61K6/0023 ,  C08L33/08

摘要： Provided is a medical device including a porous portion and a dense portion, wherein an arithmetic average roughness of a surface of the porous portion is 2.0 μm or greater but 20 μm or less, and wherein an arithmetic average roughness of a surface of the dense portion is less than 2.0 μm.

公开(公告)号：US09724274B2

公开(公告)日：2017-08-08

申请号：US14124542

申请日：2012-06-22

申请人： Simon Berner

发明人： Simon Berner

IPC分类号： A61K6/02 ,  A61L27/10 ,  A61L27/30 ,  A61L27/42 ,  A61L27/50 ,  C04B41/85 ,  C04B41/00 ,  C04B41/45 ,  A61C8/00 ,  C04B111/00

CPC分类号： A61K6/024 ,  A61C8/0012 ,  A61L27/10 ,  A61L27/306 ,  A61L27/427 ,  A61L27/50 ,  A61L2400/18 ,  A61L2430/12 ,  C04B41/009 ,  C04B41/4539 ,  C04B41/85 ,  C04B2111/00836 ,  Y10T428/24355 ,  Y10T428/31 ,  C04B35/00 ,  C04B35/48 ,  C04B41/0072 ,  C04B2103/0012

摘要： Body made of a ceramic material, the body having as an integral part thereof a surface region reaching from the surface of the body down to a predetermined depth. According to the invention, the surface region is enriched with a magnesium component thereby forming a hydrophilic surface area.

公开(公告)号：US09687325B2

公开(公告)日：2017-06-27

申请号：US14375826

申请日：2013-07-19

申请人： DMAX CO., LTD.

发明人： Tae-Seok Park ,  In-Kon Chun

IPC分类号： A61C5/00 ,  A61C13/08 ,  A61L27/10 ,  A61C13/083 ,  A61C13/00 ,  A61C13/09

CPC分类号： A61C13/081 ,  A61C13/0022 ,  A61C13/083 ,  A61C13/09 ,  A61L27/10

摘要： There is provided a method of manufacturing a zirconia block for an artificial tooth having a color gradient. The method includes: preparing colored zirconia-based powder and white zirconia-based powder; preparing a plurality of raw materials in which the colored zirconia-based powder and the white zirconia-based powder are mixed in different weight ratios by mixing the colored zirconia-based powder and the white zirconia-based powder while changing a mixing ratio in order to express a desired color gradient; sequentially injecting the plurality of raw materials into a compression mold or a mold frame to mold in increasing or decreasing order of content of the colored zirconia-based powder of the raw material; and calcining a molding result. According to the present invention, it is possible to express aesthetics of a natural tooth by implementing a color gradient of the natural tooth in the zirconia block itself without using porcelain powder or a liquid color set.

公开(公告)号：US09662215B2

公开(公告)日：2017-05-30

申请号：US14778910

申请日：2014-02-12

申请人： Bundesrepublik Deutschland, vertreten durch das Bundesministerium fuer Wirtschaft und

发明人： Georg Berger ,  Andrea Spitzer ,  Dagmar Nicolaides ,  Jens Guenster ,  Heidi Marx

IPC分类号： C04B35/22 ,  A61F2/30 ,  A61L27/10 ,  A61L27/12 ,  C03C3/112 ,  C03C10/00 ,  C03C10/16 ,  C04B35/447 ,  C04B35/468 ,  C04B35/626 ,  C04B35/653 ,  C09K3/14 ,  B24C11/00 ,  B82Y30/00 ,  B24C1/06 ,  B24C1/08 ,  A61L31/02 ,  C03C4/00 ,  A61F2/28 ,  C04B35/14 ,  C04B35/64

CPC分类号： A61F2/30771 ,  A61F2/28 ,  A61F2002/2835 ,  A61F2002/30906 ,  A61L27/10 ,  A61L27/12 ,  A61L31/026 ,  A61L31/028 ,  B24C1/06 ,  B24C1/08 ,  B24C11/00 ,  B82Y30/00 ,  C03C3/112 ,  C03C4/0007 ,  C03C10/00 ,  C03C10/16 ,  C04B35/14 ,  C04B35/22 ,  C04B35/447 ,  C04B35/468 ,  C04B35/6262 ,  C04B35/64 ,  C04B35/653 ,  C04B2235/3212 ,  C04B2235/3236 ,  C04B2235/3454 ,  C04B2235/36 ,  C04B2235/445 ,  C04B2235/5427 ,  C04B2235/5436 ,  C04B2235/5445 ,  C04B2235/5454 ,  C04B2235/6567 ,  C04B2235/661 ,  C04B2235/668 ,  C04B2235/80 ,  C04B2235/94 ,  C04B2235/96 ,  C09K3/1427

摘要： A sinterable and/or fusible ceramic mass is disclosed, having a long-term stable compound of crystalline phases of apatite, wollastonite, titanite and optionally cristobalite, which is stabilized by a glass phase, and a production process therefor. The ceramic mass can be obtained by sintering a mixture comprising at least the constituents SiO2, CaO, P2O5, MgO, CaF2 and TiO2, on their own or in combination with at least one alkali oxide, the alkali oxide being chosen from NaO2 and K2O. The invention further relates to uses of the sintered material in the form of shaped articles for strengthening, cleaning, roughening or polishing surfaces of medical implants or as a final prosthesis.

公开(公告)号：US09642942B2

公开(公告)日：2017-05-09

申请号：US14800770

申请日：2015-07-16

申请人： Mohamad Elazizi ,  Peter Murray ,  H. Thomas Temple

发明人： Mohamad Elazizi ,  Peter Murray ,  H. Thomas Temple

IPC分类号： A61F5/00 ,  A61P19/00 ,  A61P29/00 ,  A61L27/54 ,  A61L27/18 ,  A61L27/26 ,  A61L27/24 ,  A61L27/22 ,  A61L27/10 ,  A61L27/36 ,  A61L27/12 ,  A61F2/28 ,  A61L27/56 ,  A61L27/58

CPC分类号： A61L27/54 ,  A61F2/2846 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61L27/10 ,  A61L27/12 ,  A61L27/18 ,  A61L27/225 ,  A61L27/24 ,  A61L27/26 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/56 ,  A61L27/58 ,  A61L2430/02 ,  C08L67/04 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/414

摘要： The implantable scaffold matrix composition for osteogenic regeneration has a biodegradable polymer material selected from the group consisting of one or more of polylactic acid, polyglycolic acid, or polycaprolactone, or any combination thereof to provide a time release delivery of an osteogenic effect and further has a pharmaceutical composition selected from the group consisting of one or more of ibuprofen, non-steroidal anti-inflammatory drugs (NSAIDS), acetaminophen, or naproxen sodium or any combination thereof and wherein the implantable composition has a primary and a secondary time release. The primary time release being one of the polymer compositions; each time release extending occurring between 0 days and 19 days, both not being at 0 days. In a preferred composition, the scaffold has an organic material for inhibiting osteoclast selected from a group consisting of one or more of Galardin, Decorin, Actinonin, Marimastat, Batimastat, and phosphodiesterase type 4 or any combination of osteoclast inhibitors.

公开(公告)号：US09604184B2

公开(公告)日：2017-03-28

申请号：US14190484

申请日：2014-02-26

申请人： Orthovita, Inc.

发明人： John A. Gettings ,  Matthew B. Havener ,  Stephen E. McIlhenny

IPC分类号： B01F5/06 ,  B01F13/00

CPC分类号： B01F13/0023 ,  A61L27/10 ,  A61L27/12 ,  A61L27/222 ,  A61L27/24 ,  A61L27/3821 ,  A61L27/54 ,  A61L2300/112 ,  A61L2430/02 ,  B01F5/0685 ,  B01F15/0258 ,  B01F2215/0029 ,  B01F2215/0032 ,  Y10T137/0318 ,  Y10T137/8766

摘要： A mixing system is disclosed in which the system comprises a source of bone-graft or bone-graft-substitute material, a liquid source, and a vacuum source, at least one of the source of bone-graft or bone-graft-substitute material and the liquid source being in communication with the vacuum source. A valve assembly also forms part of the system, the valve assembly having a valve movable between a first position in which a first fluid passageway is created between the source of bone-graft or bone-graft-substitute material and the vacuum, and a second position in which a second fluid passageway is created between the source of bone-graft or bone-graft-substitute material and the liquid source, wherein, in the second position, the valve seals off the first fluid passageway, the vacuum source being adapted to generate a negative-pressure environment, relative to atmospheric pressure, within the valve assembly while the valve is in the first position. Methods of utilizing the aforementioned system are also disclosed.

公开(公告)号：US09592206B2

公开(公告)日：2017-03-14

申请号：US14168975

申请日：2014-01-30

申请人： AMxTek LLC

发明人： James A Walls

IPC分类号： A61F2/02 ,  A61K9/70 ,  A61K33/38 ,  A61K33/42 ,  A61L24/00 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  A61L27/42 ,  A61L27/44 ,  A61F2/30 ,  A61F2/46 ,  A61L27/10 ,  A61B17/60 ,  A61B17/86 ,  A61F2/44

CPC分类号： A61L31/086 ,  A61B17/60 ,  A61B17/8625 ,  A61B17/866 ,  A61F2/28 ,  A61F2/32 ,  A61F2/4455 ,  A61F2/4644 ,  A61F2002/30013 ,  A61F2002/30032 ,  A61F2002/30034 ,  A61F2002/30036 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2310/00329 ,  A61F2310/00359 ,  A61F2310/00928 ,  A61K9/70 ,  A61K33/38 ,  A61K33/42 ,  A61L24/0036 ,  A61L24/0042 ,  A61L24/0063 ,  A61L24/0068 ,  A61L24/0084 ,  A61L24/0089 ,  A61L27/10 ,  A61L27/425 ,  A61L27/427 ,  A61L27/446 ,  A61L31/022 ,  A61L31/082 ,  A61L31/123 ,  A61L31/124 ,  A61L31/127 ,  A61L31/128 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2400/18 ,  A61L2420/04 ,  A61L2430/02 ,  A61L2430/10 ,  A61L2430/34

摘要： A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.

摘要翻译： 通过选择至少一种具有所需粒径和溶解度的水溶性无机材料，并将水溶性无机材料与 至少一种难溶于水或可生物降解的基质材料。 将基质材料与水溶性无机材料混合后，在组织附近放置在患者体内，使得水溶性无机材料以预定的速率溶解，以在基质材料中产生生物上希望的空隙，骨中的骨骼 或其他组织然后可以生长。

公开(公告)号：US20170049922A1

公开(公告)日：2017-02-23

申请号：US15342393

申请日：2016-11-03

申请人： DePuy Synthes Products, Inc.

发明人： Xinyin Liu ,  Mark Fulmer ,  Peter Schaut ,  Kevin Joye

IPC分类号： A61L24/00 ,  C04B28/34 ,  A61L27/12 ,  B05D3/00 ,  A61L27/50 ,  A61L24/02 ,  A61L27/58 ,  B05D1/12 ,  C04B28/14 ,  A61L27/10

CPC分类号： A61L24/0042 ,  A61L24/001 ,  A61L24/02 ,  A61L27/10 ,  A61L27/12 ,  A61L27/32 ,  A61L27/50 ,  A61L27/56 ,  A61L27/58 ,  A61L2400/06 ,  A61L2420/02 ,  A61L2420/08 ,  A61L2430/02 ,  B05D1/12 ,  B05D3/007 ,  C04B28/14 ,  C04B28/344 ,  C04B2111/00836

摘要： The present disclosure is directed to a bioresorbable ceramic composition having a plurality of biocompatible ceramic granules, each of the granules having a coating of a plurality of calcium containing particles, where at least a portion of the particles are bound to at least a portion of an outer surface of each of the granules, and further where the composition is flowable in a dry state. The present disclosure is also directed to a three dimensional scaffold for bone repair that includes the bioresorbable composition, which upon implantation to a locus of repair defines an interconnected pore network between outer walls of the coated granules of the composition. Finally, the present disclosure is directed to methods of forming both the bioresorbable ceramic composition and the three-dimensional ceramic scaffold.

摘要翻译： 本公开涉及具有多个生物相容性陶瓷颗粒的生物可吸收陶瓷组合物，每个颗粒具有多个含钙颗粒的涂层，其中至少一部分颗粒与至少一部分 每个颗粒的外表面，并且其中组合物在干燥状态下可流动。 本公开还涉及用于骨修复的三维支架，其包括生物可再吸收组合物，其在植入修复位点时限定组合物的包衣颗粒的外壁之间的互连孔网络。 最后，本公开涉及形成生物可吸收陶瓷组合物和三维陶瓷支架的方法。

公开(公告)号：US20170035933A1

公开(公告)日：2017-02-09

申请号：US15035010

申请日：2014-11-06

申请人： BS SUPPORT CO., LTD.

发明人： Seung Woo BAEK

IPC分类号： A61L27/30 ,  A61L27/10 ,  A61L27/16 ,  A61L27/44 ,  A61L27/06 ,  A61L27/12

CPC分类号： A61L27/306 ,  A61L27/047 ,  A61L27/06 ,  A61L27/10 ,  A61L27/12 ,  A61L27/16 ,  A61L27/446 ,  A61L2300/102 ,  A61L2300/404 ,  A61L2420/02 ,  A61L2430/24 ,  C08L75/04 ,  C08L83/04

摘要： An artificial biomaterial comprises: a biocompatible matrix suitable for insertion into the human body; and either a coating layer comprising the copper-based compound, formed on the surface of the matrix, or the copper-based compound dispersed in the matrix to form a bulk material, wherein the copper-based compound has a chemical structure of CuxMy, wherein M is any one selected from among elements belonging to groups 15 to 17 of the periodic table, and x/y=0.8-1.5.

摘要翻译： 人造生物材料包括：适于插入人体的生物相容性基质; 以及包含在基体表面上形成的铜基化合物的涂层或分散在基体中的铜基化合物以形成本体材料，其中所述铜基化合物具有CuxMy的化学结构，其中 M是选自属于元素周期表第15〜17族的元素，x / y = 0.8〜1.5。