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公开(公告)号：US20170240633A1
公开(公告)日：2017-08-24
申请号：US15521685
申请日：2015-10-27
Applicant: Agency for Science, Technology and Research
Inventor： Cheng-i Wang , Hsueh Ling Janice Oh , Siok Ping Yeo , Yun Pei Sharon Goh
CPC classification number: C07K16/2803 , C07K16/2809 , C07K16/3061 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/92
Abstract: Anti-TIM-3 antibodies are disclosed, as well as pharmaceutical compositions comprising such antibodies, and uses and methods using the same, such as in the treatment of cancer, infectious diseases, or T-cell dysfunctional disorders. Bispecific antibodies against TIM-3 and other targets are also disclosed, with preferred embodiment of a bispecific antibody against TIM-3 and CD3.
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公开(公告)号：US20170238547A1
公开(公告)日：2017-08-24
申请号：US15519534
申请日：2015-10-14
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Yi Yan YANG , Zhi Xiang VOO
CPC classification number: A01N47/06 , A01N25/08 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2300/404 , C08G64/183 , C08G64/30 , C08G64/40 , C08G65/48 , C08J7/047 , C08J2383/04 , C08J2469/00 , C08J2471/02 , C08J2485/00 , C08L87/005 , C09D5/14 , C09D169/00
Abstract: The present disclosure provides a copolymer comprising monomer units represented by formulas (I) and/or (II) as disclosed and defined herein which are useful in antibacterial and/or antifouling coatings. The present disclosure further provides methods of synthesizing said copolymers.
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公开(公告)号：US20170222030A1
公开(公告)日：2017-08-03
申请号：US15479022
申请日：2017-04-04
Applicant: Agency for Science, Technology and Research
Inventor： Lakshmi Kanta Bera , Surani Bin Dolmanan , Manippady Krishna Kumar , Rasanayagam Sivasayan Kajen , Sudhiranjan Tripathy
IPC: H01L29/778 , H01L29/66 , H01L21/283 , H01L21/324 , H01L21/311 , H01L21/308 , H01L29/45 , H01L21/02
CPC classification number: H01L29/7783 , H01L21/02458 , H01L21/02502 , H01L21/0254 , H01L21/283 , H01L21/3085 , H01L21/31133 , H01L21/324 , H01L29/2003 , H01L29/41766 , H01L29/452 , H01L29/66462 , H01L29/66522 , H01L29/66553 , H01L29/7786 , H01L29/78
Abstract: There is provided a method for fabricating a semiconductor device having the following structure, and comprising the steps of growing a first and a second nucleation layer on a substrate; depositing a binary layer over these nucleation layers; and annealing the binary layer to form a first contact area and a second contact area on the substrate, wherein the annealed binary layer comprises a group 14 element selected from Si, Ge and their combination thereof, and the annealed binary layer in the first and second contact areas are capable of providing a lower contact resistance for a current to flow in the device. This method serves to provide an intermediate layer which enables the fabrication process to become CMOS compatible.
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公开(公告)号：US20170217125A1
公开(公告)日：2017-08-03
申请号：US15510681
申请日：2015-09-10
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Xu LI , Suxi WANG , Chaobin HE , Xikui ZHANG
CPC classification number: B32B5/028 , B32B5/02 , B32B5/24 , B32B25/04 , B32B25/10 , B32B25/14 , B32B25/20 , B32B2260/021 , B32B2260/048 , B32B2262/106 , B32B2264/105 , B32B2270/00 , B32B2307/202 , B32B2307/51 , B32B2307/546 , B32B2437/00 , B32B2457/00 , B32B2457/20 , B32B2535/00 , B82Y30/00 , D01D5/0007 , D01F9/14 , D01F9/17 , D06N3/0015 , D06N3/128 , D06N2201/087 , D06N2203/022 , D06N2203/066 , H01B1/04
Abstract: A conductive carbonaceous fiber is provided, comprising a carbonaceous material obtained from carbonizing an electrospun fiber wherein said fiber comprises at least one conductive metal precursor. The electrospun fibers can be formed into fibrous mats during spinning, stabilization and carbonization that are conductive materials which can be used to make stretchable conductors for flexible electronic devices. The invention relates also to the process for making the fibers, corresponding elastomeric fibrous mesh/polymer composites as well as use of these composites for making stretchable electrical conductors. The obtainable elastomeric composite films (with a thickness in the range of 0.8 to 1.5 mm) exhibit good electrical conductivity and excellent electromechanical stability under mechanical deformations (e.g. elongating, twisting and bending). The scalable fabrication process and low-cost precursors make the elastic electrospun carbon fibers/polymer composite conductors promising materials for applications in flexible electronic devices, displays, sensors, wearable conducting clothes, implantable medical devices, etc.
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公开(公告)号：US09717797B2
公开(公告)日：2017-08-01
申请号：US14097488
申请日：2013-12-05
Applicant: International Business Machines Corporation , Agency For Science, Technology and Research , Universidad del Pais Vasco/Euskal Herriko Unibertsitatea
Inventor： Julian M. W. Chan , Amanda C. Engler , James L. Hedrick , Xiyu Ke , Victor W. L. Ng , Haritz Sardon , Jeremy P. K. Tan , Yi Yan Yang
IPC: A61K9/00 , A61K47/34 , A61K31/704 , A61K31/713 , A61K9/51 , C08G64/02 , C08G64/18 , A61K38/16 , A61K38/00
CPC classification number: A61K47/34 , A61K9/5146 , A61K31/704 , A61K31/713 , A61K38/00 , A61K38/16 , C08G64/0241 , C08G64/183 , C08L69/00
Abstract: Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.
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Patent Agency Ranking
296.发明申请公开(公告)号：US20170214392A1
公开(公告)日：2017-07-27
申请号：US15329558
申请日：2015-09-07
Applicant: Agency for Science, Technology and Research
Inventor： Junghyup Lee , Minkyu Je
IPC: H03K3/012 , H03K3/0231
CPC classification number: H03K3/012 , H03K3/0231
Abstract: According to various embodiments, there is provided a method for generating a reference clock signal, the method including discharging a capacitive element to a discharged state, when a reset signal has a predetermined reset state; charging the capacitive element from the discharged state to a first voltage, when a charge signal has a predetermined charge state; comparing the first voltage to a zero voltage, when a compare signal has a predetermined compare state; generating a second voltage based on the comparing of the first voltage to the zero voltage; generating a clock signal based on the second voltage, using an oscillator; and generating each of the reset signal, the charge signal and the compare signal, based on the clock signal.
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公开(公告)号：US20170192351A1
公开(公告)日：2017-07-06
申请号：US15304848
申请日：2015-04-14
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Joel Kwang Wei YANG , Xiao Ming GOH , Di ZHU , Shawn TAN , Ying Min WANG , Zhaogang DONG
Abstract: A process for plasmonic-based high resolution color printing is provided. The process includes a) providing a nanostructured substrate surface having a reverse structure geometry comprised of nanopits and nanoposts on a support, and b) forming a conformal continuous metal coating over the nanostructured substrate surface to generate a continuous metal film, the continuous metal film defining nanostructures for the plasmonic-based high resolution color printing, wherein a periodicity of the nanostructures is equal to or less than a diffraction limit of visible light. A nanostructured metal film or metal-film coated support obtained by the process and a method for generating a color image are also provided.
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公开(公告)号：US20170189449A1
公开(公告)日：2017-07-06
申请号：US15404774
申请日：2017-01-12
Inventor： Sai Kiang LIM
CPC classification number: A61K35/28 , A61K9/0019 , A61K9/10 , A61K35/12 , A61K47/24 , A61K47/28 , A61L2300/30 , C12N5/0663
Abstract: We describe a particle secreted by a mesenchymal stem cell and comprising at least one biological property of a mesenchymal stem cell. The biological property may comprise a biological activity of a mesenchymal stem cell conditioned medium (MSC-CM) such as cardioprotection or reduction of infarct size. The particle may comprise a vesicle or an exosome.
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299.发明申请公开(公告)号：US20170181915A1
公开(公告)日：2017-06-29
申请号：US15328010
申请日：2015-07-23
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Kai Keng ANG , Cuntai GUAN , Kok Soon PHUA , Longjiang ZHOU , Chuan Chu WANG
IPC: A61H1/02 , A61B5/22 , A61B5/0476 , G09B5/06 , A61B5/11
CPC classification number: A61H1/0274 , A61B5/0476 , A61B5/0482 , A61B5/1121 , A61B5/1126 , A61B5/225 , A61B5/7475 , A61B2560/0223 , A61H1/02 , A61H1/0285 , A61H1/0288 , A61H2001/0203 , A61H2201/1635 , A61H2201/1671 , A61H2201/5043 , A61H2201/5048 , A61H2201/5061 , A61H2201/5064 , A61H2230/105 , G06F3/014 , G06F3/015 , G06F3/016 , G09B5/06
Abstract: A method for calibrating and executing a rehabilitation exercise for a stroke-affected limb of a stroke patient is disclosed, the method comprising the steps of providing a haptic device for an able limb of the stroke patient to manipulate to perform a calibration action to result in a first position of the haptic device, and providing the haptic device for the stroke-affected limb to manipulate to perform the calibration action to result in a second position of the haptic device. The method further comprises the steps of moving the haptic device coupled with the stroke-affected limb from the second position towards the first position until a predetermined counterforce is detected, indicating an extreme position for the stroke-affected limb using the haptic device, and calibrating the haptic device with the extreme position such that during the rehabilitation exercise, the haptic device is prevented from moving beyond the extreme position.
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公开(公告)号：US20170173550A1
公开(公告)日：2017-06-22
申请号：US15327577
申请日：2015-07-21
Applicant: Agency for Science, Technology and Research
Inventor： Thammanoon Sreethawong , Kwok Wei Shah , Shuhua Liu , Shuang-Yuan Zhang , Suo Hon Lim , Kian Seng Ang , Li Sirh Tan , Ming-yong Han
CPC classification number: B01J13/18 , B82B3/0042 , B82Y40/00 , C01B33/12 , C01P2004/04 , C01P2004/64 , C01P2004/84
Abstract: This invention relates to a method for synthesizing a SiO2-coated nanoparticle, the method comprising the step of reacting a hydroxyl-functionalised silane with a nanoparticle in a substantially aqueous phase under conditions to induce silanization of the nanoparticle. The method enables silanization of the nanoparticle in aqueous phase that is substantially free of organic solvents.
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