公开(公告)号：US20150343390A1

公开(公告)日：2015-12-03

申请号：US14654768

申请日：2013-12-23

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Kambiz Ansari ,  Shilin Chen ,  Christina Yuan Ling Tan ,  Isabel Rodriguez

IPC: B01D71/02 ,  B01D53/22 ,  B01D61/14 ,  B01D67/00 ,  B01D61/02

CPC classification number: B01D71/022 ,  B01D53/228 ,  B01D61/025 ,  B01D61/145 ,  B01D67/0053 ,  B01D67/0062 ,  B01D67/0069 ,  B01D69/02 ,  B01D69/06 ,  B01D69/10 ,  B01D69/105 ,  B01D2325/021 ,  C25D1/08 ,  C25D3/12 ,  C25D5/003 ,  C25D5/022 ,  C25D7/123

Abstract: The present disclosure relates to a method of forming a metallic layer having pores extending therethrough, the method comprising the steps of: (a) contacting a cathode substrate with an electrolyte solution comprising at least one cation; reducing the cation to deposit the metallic layer on a surface of the cathode substrate; and (c) generating a plurality of non-conductive regions on the cathode substrate surface during reducing step (b); wherein the deposition of the metallic layer is substantially prevented on the non-conductive regions on the cathode substrate surface to thereby form pores extending through the deposited metallic layer. The present disclosure further provides a metallic porous membrane fabricated by the disclosed process.

Abstract translation: 本发明涉及一种形成具有延伸穿过其中的孔的金属层的方法，所述方法包括以下步骤：（a）使阴极基底与包含至少一种阳离子的电解质溶液接触; 减少阳极以将金属层沉积在阴极衬底的表面上; 和（c）在还原步骤（b）期间在阴极衬底表面上产生多个非导电区域; 其中基本上防止在阴极衬底表面上的非导电区域上金属层的沉积，从而形成延伸穿过沉积的金属层的孔。 本公开还提供了通过所公开的方法制造的金属多孔膜。

公开(公告)号：US20150339816A1

公开(公告)日：2015-11-26

申请号：US14759924

申请日：2013-01-08

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Hanry YU ,  Shuoyu XU

IPC: G06T7/00 ,  G06K9/62 ,  G06K9/52 ,  G01N33/483 ,  G06K9/46

CPC classification number: G06T7/0012 ,  A61B5/0062 ,  A61B5/4244 ,  A61B2576/00 ,  G01N33/4833 ,  G01N33/576 ,  G01N2333/78 ,  G06K9/00147 ,  G06K9/4604 ,  G06K9/52 ,  G06K9/6256 ,  G06K9/6267 ,  G06T7/10 ,  G06T7/143 ,  G06T7/62 ,  G06T2207/10056 ,  G06T2207/20112 ,  G06T2207/30008 ,  G06T2207/30024 ,  G06T2207/30056

Abstract: A method for assessing fibrosis in a tissue is proposed. The method uses a test image which is an image of the tissue and comprises identifying, from the test image, a portal collagen area, a septal collagen area and a fibrillar collagen area respectively comprising pixels representing portal collagen, septal collagen and fibrillar collagen of the tissue, obtaining quantitative values of one or more features for each identified area based on characteristics of the identified area in the test image and assessing fibrosis using the quantitative values obtained for all the identified areas.

Abstract translation: 提出了一种评估组织纤维化的方法。 该方法使用作为组织的图像的测试图像，并且包括从测试图像识别门静脉胶原区域，间隔胶原区域和纤维胶原区域，其分别包括表示门静脉胶原，间隔胶原和纤维胶原的像素 组织，基于测试图像中识别的区域的特征获得每个识别区域的一个或多个特征的定量值，并使用为所有识别的区域获得的定量值来评估纤维化。

公开(公告)号：US20150329821A1

公开(公告)日：2015-11-19

申请号：US14437147

申请日：2013-10-21

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Lay Teng ANG ,  Kyle M. LOH ,  Bing LIM

IPC: C12N5/0735 ,  C12N5/074

CPC classification number: C12N5/0606 ,  C12N5/0603 ,  C12N5/0672 ,  C12N5/0678 ,  C12N5/0696 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/16 ,  C12N2501/385 ,  C12N2501/41 ,  C12N2501/415 ,  C12N2501/727 ,  C12N2501/998 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2533/52 ,  C12N2533/90

Abstract: The present disclosure provides an understanding of the regulation of the developmental phases of stem cells and their induction into relevant cell lineages, such as primitive streak, endoderm, mesoderm, or subterrotories of endoderm's. In particular, the present disclosure provides methods, culture medium and kits for the maintenance and differentiation of stem cells into relevant cell lineages.

Abstract translation: 本公开提供了对干细胞的发育阶段的调节及其对相关细胞谱系的诱导的理解，所述相关细胞系如内胚层的原始条纹，内胚层，中胚层或亚维管。 特别地，本公开提供了用于维持和分化干细胞到相关细胞谱系中的方法，培养基和试剂盒。

公开(公告)号：US20150313869A1

公开(公告)日：2015-11-05

申请号：US14697565

申请日：2015-04-27

Applicant: Agency for Science, Technology and Research

Inventor： Motoichi Kurisawa ,  Fan Lee ,  Joo Eun Chung ,  Pui Yik Peggy Chan

IPC: A61K31/353 ,  C12P17/06 ,  A61K31/738

CPC classification number: A61K31/353 ,  A61K9/0024 ,  A61K31/015 ,  A61K31/05 ,  A61K31/738 ,  A61K47/61 ,  A61K47/6903 ,  A61L27/54 ,  C08J3/075 ,  C08J2397/00 ,  C12P17/06 ,  C12P19/26

Abstract: There is provided methods for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid including a method for producing a hydrogel that is capable of adhesion of cells and which comprises enzymatically cross-linked conjugates of a hydrogel forming agent and a flavonoid. There is also provided a method for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid without the addition of an exogenous peroxide or peroxidase or without the addition of an exogenous peroxide. Hydrogels produced by such methods and methods of using the hydrogels are also described herein.

Abstract translation: 提供了包含水凝胶形成剂和类黄酮的缀合物的水凝胶的方法，包括能够粘附细胞的水凝胶的制造方法，其包含水凝胶形成剂和类黄酮的酶交联的缀合物。 还提供了一种制备水凝胶的方法，其包括水凝胶形成剂和类黄酮的缀合物，而不加入外源性过氧化物酶或过氧化物酶或不加入外源过氧化物。 本文还描述了通过这些使用水凝胶的方法和方法生产的水凝胶。

公开(公告)号：US20150299311A1

公开(公告)日：2015-10-22

申请号：US14755106

申请日：2015-06-30

Applicant: Agency For Science, Technology And Research (A*Star)

Inventor： Bruno REVERSADE

IPC: C07K16/26 ,  G01N33/74

CPC classification number: C07K14/575 ,  A61K38/00 ,  C07K7/00 ,  C07K14/46 ,  C07K16/26 ,  C07K2317/30 ,  C07K2317/34 ,  C12N15/113 ,  C12N2310/14 ,  G01N33/74 ,  G01N2333/575

Abstract: We describe an ELABELA polypeptide comprising a sequence CXXXRCXXXHSRVPFP (SEQ ID NO: 1), in which X signifies an amino acid residue, such as a sequence selected from the group consisting of: SEQ ID NO: 2 to SEQ ID NO: 18, preferably CLQRRCMPLHSRVPFP (SEQ ID NO: 2), or a fragment, homologue, variant or derivative thereof, which polypeptide is capable of maintaining self-renewal and/or pluripotency of a stem cell.

Abstract translation: 我们描述了包含序列CXXXRCXXXHSRVPFP（SEQ ID NO：1）的ELABELA多肽，其中X表示氨基酸残基，例如选自SEQ ID NO：2至SEQ ID NO：18的序列，优选 CLQRRCMPLHSRVPFP（SEQ ID NO：2）或其片段，同系物，变体或衍生物，其能够维持干细胞的自我更新和/或多能性。

公开(公告)号：US09157861B2

公开(公告)日：2015-10-13

申请号：US13665033

申请日：2012-10-31

Applicant: Agency for Science, Technology and Research

Inventor： Ping Bai ,  Xiaodong Zhou ,  Lin Wu

IPC: H01J40/14 ,  G01N21/64 ,  G01N21/62

CPC classification number: G01N21/648 ,  G01N21/62

Abstract: A sensor and a method of detecting a target analyte are provided. The sensor includes a substrate; a layer comprising a plurality of through holes, wherein the layer is disposed above the substrate; a first element configured to detect a target analyte; a second element that can produce a detectable signal; wherein the first element and the second element are configured to couple the target analyte between the first element and the second element.

Abstract translation: 提供了一种传感器和检测目标分析物的方法。 传感器包括基板; 包括多个通孔的层，其中所述层设置在所述衬底上方; 构造成检测目标分析物的第一元件; 可产生可检测信号的第二个元件; 其中所述第一元件和所述第二元件被配置为在所述第一元件和所述第二元件之间耦合所述目标分析物。

公开(公告)号：US20150276711A1

公开(公告)日：2015-10-01

申请号：US14432041

申请日：2013-09-30

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Hanry Yu ,  Yi-Chin Toh ,  Jiangwa Xing

IPC: G01N33/50

CPC classification number: G01N33/5014 ,  G01N33/5026 ,  G01N33/5044 ,  G01N33/5073

Abstract: A method and system of in vitro developmental toxicity testing comprising the steps of micropatterning an extracellular matrix; growing embryonic stem cells on the micropatterned extracellular matrix in the presence of mesoendermal induction and testing for change of the geometrical mesoendoderm structure in the presence or absence of a test compound wherein (1) a decrease in mesoendodermal differentiation and/or (2) a change in morphology of the geometrical mesoendoderm structure in the presence of the test compound compared to cells in the absence of the test compound indicates that the test compound is a developmental toxic agent.

Abstract translation: 一种体外发育毒性试验的方法和系统，包括微细胞外基质的步骤; 在存在或不存在测试化合物的情况下，在介孔介导诱导的存在下，在微图案化的细胞外基质上培养胚胎干细胞并测试几何中胚层结构的变化，其中（1）中胚层内分化的减少和/或（2）变化 在与受试化合物不存在的情况下，在试验化合物存在下，几何中内胚层结构的形态表明试验化合物是发育毒性剂。

公开(公告)号：US09136672B2

公开(公告)日：2015-09-15

申请号：US14090543

申请日：2013-11-26

Applicant: Agency for Science, Technology and Research

Inventor： Xianshu Luo ,  Junfeng Song ,  Haifeng Zhou ,  Tsung-Yang Liow ,  Mingbin Yu ,  Patrick Guo-Qiang Lo

IPC: H01S5/00 ,  H01S5/10 ,  H01S5/02 ,  B82Y20/00 ,  H01S5/343 ,  H01S5/065 ,  H01S5/125

CPC classification number: H01S5/1032 ,  B82Y20/00 ,  H01S5/021 ,  H01S5/0657 ,  H01S5/1014 ,  H01S5/125 ,  H01S5/343

Abstract: An optical light source is provided. The optical light source includes a waveguide including two reflectors arranged spaced apart from each other to define an optical cavity therebetween, an optical gain medium, and a coupling structure arranged to couple light between the optical cavity and the optical gain medium.

Abstract translation: 提供光学光源。 光学光源包括波导，其包括彼此间隔布置以在其间限定光腔的两个反射器，光学增益介质和布置成在光学腔和光学增益介质之间耦合光的耦合结构。

公开(公告)号：US20150255547A1

公开(公告)日：2015-09-10

申请号：US14389043

申请日：2013-03-28

Applicant: Agency for Science, Technology and Research

Inventor： Li Yuan ,  Patrick Guo Qiang Lo ,  Haifeng Sun ,  Kean Boon Lee ,  Weizhu Wang ,  Susai Lawrence Selvaraj

IPC: H01L29/205 ,  H01L29/201 ,  H01L29/872 ,  H01L29/06 ,  H01L29/40 ,  H01L29/20 ,  H01L29/778

CPC classification number: H01L29/872 ,  H01L27/0605 ,  H01L27/0629 ,  H01L29/0646 ,  H01L29/0657 ,  H01L29/1066 ,  H01L29/2003 ,  H01L29/207 ,  H01L29/402 ,  H01L29/41766 ,  H01L29/42316 ,  H01L29/4236 ,  H01L29/42376 ,  H01L29/4238 ,  H01L29/517 ,  H01L29/66219 ,  H01L29/66462 ,  H01L29/7786 ,  H01L29/7788 ,  H01L29/861

Abstract: Structures for III-nitride GaN high electron mobility transistors (HEMT), method for fabricating for GaN devices and integrated chip-level power systems using the GaN devices are provided. The GaN HEMT structure includes a substrate, an AlGaN/GaN heterostructure grown on the substrate, and a normally-off GaN device fabricated on the AlGaN/GaN heterostructure. The AlGaN/GaN heterostructure includes a GaN buffer layer and an AlGaN barrier layer. The integrated chip-level power system includes a substrate, an AlGaN/GaN heterostructure layer grown on the substrate and a plurality of GaN devices. The AlGaN/GaN heterostructure layer includes a GaN buffer layer and an AlGaN barrier layer and is formed into mesa areas and valley areas. Each of the plurality of GaN devices are fabricated on a separate one of the mesa areas.

Abstract translation: 提供了III族氮化物GaN高电子迁移率晶体管（HEMT）的结构，GaN器件的制造方法和使用GaN器件的集成芯片级电力系统。 GaN HEMT结构包括衬底，在衬底上生长的AlGaN / GaN异质结构和在AlGaN / GaN异质结构上制造的常关GaN器件。 AlGaN / GaN异质结构包括GaN缓冲层和AlGaN势垒层。 集成芯片级电力系统包括衬底，在衬底上生长的AlGaN / GaN异质结构层和多个GaN器件。 AlGaN / GaN异质结构层包括GaN缓冲层和AlGaN阻挡层，并且形成在台面区域和谷区域中。 多个GaN器件中的每一个被制造在独立的台面区域之一上。

公开(公告)号：US09123884B2

公开(公告)日：2015-09-01

申请号：US13623741

申请日：2012-09-20

Applicant: Agency for Science, Technology and Research

Inventor： Yuanhong Luo ,  Rachid Sbiaa ,  Yan Hwee Sunny Lua

IPC: G11C11/00 ,  H01L43/08

CPC classification number: G11C11/1675 ,  G11C11/161 ,  H01L43/08

Abstract: According to embodiments of the present invention, a magnetoresistive device is provided. The magnetoresistive device includes at least two ferromagnetic soft layers, wherein the at least two ferromagnetic soft layers have different ranges of magnetization switching frequencies. Further embodiments provide a magnetoresistive device including at least two oscillating ferromagnetic structures, wherein ranges of operating current amplitudes at which oscillations are induced for the at least two oscillating ferromagnetic structures are different. According to further embodiments of the present invention, writing methods for the magnetoresistive devices are provided.

Abstract translation: 根据本发明的实施例，提供了一种磁阻器件。 磁阻器件包括至少两个铁磁软层，其中至少两个铁磁软层具有不同的磁化开关频率范围。 另外的实施例提供包括至少两个振荡铁磁结构的磁阻器件，其中为至少两个振荡铁磁结构引起振荡的工作电流幅度的范围是不同的。 根据本发明的另外的实施例，提供了用于磁阻器件的写入方法。