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41 条记录 (耗时 0.035 秒)

    Micromachined fluidic coupler
    32.
    发明授权
    Micromachined fluidic coupler 失效
    微加工流体耦合器

    公开(公告)号：US5890745A

    公开(公告)日：1999-04-06

    申请号：US790101

    申请日：1997-01-29

    申请人： Gregory T. A. Kovacs

    发明人： Gregory T. A. Kovacs

    IPC分类号： B01L3/00 ,  F15C5/00 ,  F16L35/00

    CPC分类号： F15C5/00 ,  B01L3/565 ,  B01L2200/027 ,  Y10S285/911 ,  Y10S285/915 ,  Y10T29/49002 ,  Y10T29/49865 ,  Y10T428/2457

    摘要： A method for producing a microfluidic coupler includes the step of producing a first mask on a top surface of a wafer. The first mask defines an insertion channel pattern selected to correspond to the cross sectional shape of a capillary. The wafer is etched through the first mask to form an insertion channel. A second mask is produced on a bottom surface of the wafer. The second mask defines a subchannel pattern selected to match the diameter of the bore of the capillary. The wafer is etched through the second mask to form a subchannel connected to the insertion channel. The capillary is inserted into the insertion channel such that the capillary is in fluid communication with the subchannel. In one embodiment, a capillary guide is secured to the wafer to facilitate insertion of the capillary into the insertion channel. The capillary guide has a tapered guide channel aligned with the insertion channel for guiding the capillary into the insertion channel.

    摘要翻译： 微流体耦合器的制造方法包括在晶片的顶面上制作第一掩模的工序。 第一掩模限定了被选择为对应于毛细管的横截面形状的插入通道图案。 通过第一掩模蚀刻晶片以形成插入通道。 在晶片的底表面上产生第二掩模。 第二个掩模定义了选择以匹配毛细管的孔的直径的子通道图案。 通过第二掩模蚀刻晶片以形成连接到插入通道的子通道。 毛细管插入到插入通道中，使得毛细管与子通道流体连通。 在一个实施例中，毛细管引导件被固定到晶片以便于将毛细管插入到插入通道中。 毛细管引导件具有与插入通道对准的锥形引导通道，用于将毛细管引导到插入通道中。

    Method for separating an analyte from a sample
    34.
    发明授权
    Method for separating an analyte from a sample 有权
    从样品中分离分析物的方法

    公开(公告)号：US08247176B2

    公开(公告)日：2012-08-21

    申请号：US13042203

    申请日：2011-03-07

    申请人： Kurt E. Petersen ,  William A. McMillan ,  Lee A. Christel ,  Ronald Chang ,  Farzad Pourahmadi ,  Jesus Ching ,  Gregory T. A. Kovacs ,  M. Allen Northrup

    发明人： Kurt E. Petersen ,  William A. McMillan ,  Lee A. Christel ,  Ronald Chang ,  Farzad Pourahmadi ,  Jesus Ching ,  Gregory T. A. Kovacs ,  M. Allen Northrup

    IPC分类号： C12Q1/68

    CPC分类号： C12N15/1017 ,  B01D15/00 ,  B01L7/52 ,  B01L2400/0622 ,  B01L2400/0644 ,  C12M47/06 ,  G01N1/34 ,  Y10T436/255

    摘要： An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge has a second flow path for eluting the captured analyte from the extraction chamber, the second flow diverging from the first flow path after passing through the extraction chamber. The sample is forced to flow through the extraction chamber and into a waste chamber, thereby capturing the analyte with the solid support as the sample flows through the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber and along the second flow path.

    摘要翻译： 将样品通过将样品引入具有样品端口和从样品端口延伸的第一流路的盒中而将分析物与流体样品分离。 第一流路包括提取室，其包含用于从样品捕获分析物的固体支持物。 所述筒具有用于从所述提取室洗脱所捕获的分析物的第二流动路径，所述第二流在通过所述提取室之后从所述第一流动路径发散。 样品被迫流过提取室并进入废物室，从而当样品流过提取室时用固体支持物捕获分析物。 然后通过迫使洗脱液体流过提取室并沿着第二流动路径，将捕获的分析物从萃取室洗脱。

    Implantable continuous intraocular pressure sensor
    37.
    发明授权
    Implantable continuous intraocular pressure sensor 失效
    植入式连续眼压传感器

    公开(公告)号：US06939299B1

    公开(公告)日：2005-09-06

    申请号：US09733879

    申请日：2000-12-08

    申请人： Kurt Petersen ,  Gregory T. A. Kovacs ,  Terence G. Ryan ,  Leon G. Partamian ,  David A. Lee

    发明人： Kurt Petersen ,  Gregory T. A. Kovacs ,  Terence G. Ryan ,  Leon G. Partamian ,  David A. Lee

    IPC分类号： A61B3/16

    CPC分类号： A61B3/16 ,  A61B2560/0219 ,  A61B2562/0247

    摘要： An implantable miniaturized pressure sensor integrates a capacitor and an inductor in one small chip, forming a resonant LC circuit having a Q value of 10 or greater. The capacitor has an upper capacitor plate and a lower capacitor plate disposed proximate thereof. The upper and lower capacitor plates are connected to one or more spiral inductor coils. The sensor is micromachined from silicon to form a thin and robust membrane disposed on top of the upper capacitor plate. The sensor is hermetically sealed and the membrane is deflected relative to the upper capacitor plate by an external fluid, gas, or mechanical pressure. The resonant frequency of the sensor can be remotely monitored and continuously measured with an external detector pick up coil disposed proximate the sensor. The sensor can be smaller than 2×2×0.5 mm and is particularly useful for intraocular applications.

    摘要翻译： 可植入的小型化压力传感器将电容器和电感器集成在一个小芯片中，形成Q值为10或更大的谐振LC电路。 电容器具有位于其附近的上电容器板和下电容器板。 上下电容器板连接到一个或多个螺旋电感线圈。 该传感器从硅微加工形成薄而坚固的薄膜，设置在上电容器板的顶部。 该传感器被气密密封，并且膜通过外部流体，气体或机械压力相对于上电容器板偏转。 传感器的谐振频率可以远程监控，并使用靠近传感器设置的外部检测器拾取线圈连续测量。 传感器可以小于2x2x0.5 mm，对于眼内应用尤其有用。