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49 条记录 (耗时 0.038 秒)

    Measuring tissue morphology
    34.
    发明授权
    Measuring tissue morphology 失效
    测量组织形态

    公开(公告)号：US6091984A

    公开(公告)日：2000-07-18

    申请号：US948734

    申请日：1997-10-10

    申请人： Lev T. Perelman ,  Vadim Backman ,  Michael S. Feld ,  George Zonios ,  Irving Itzkan ,  Ramasamy Manoharan

    发明人： Lev T. Perelman ,  Vadim Backman ,  Michael S. Feld ,  George Zonios ,  Irving Itzkan ,  Ramasamy Manoharan

    IPC分类号： G01N21/17 ,  A61B5/00 ,  A61B10/00

    CPC分类号： A61B5/0084 ,  A61B5/0075 ,  A61B5/0086

    摘要： The present invention relates to systems and methods for measuring one or more physical characteristics of material such as tissue using optical radiation. The system can use light that is scattered by a tissue layer to determine, for example, the size of nuclei in the tissue layer to aid in the characterization of the tissue. These methods can include the use of fiber optic devices to deliver and collect light from a tissue region of interest to diagnose, for example, whether the tissue is normal or precancerous.

    摘要翻译： 本发明涉及用于使用光学辐射测量诸如组织的材料的一种或多种物理特性的系统和方法。 该系统可以使用由组织层散射的光来确定例如组织层中的核的大小以帮助表征组织。 这些方法可以包括使用光纤装置来递送和收集来自感兴趣的组织区域的光，以诊断例如组织是正常还是癌前。

    Intrinsic Raman spectroscopy
    36.
    发明授权
    Intrinsic Raman spectroscopy 有权
    内在拉曼光谱

    公开(公告)号：US09103793B2

    公开(公告)日：2015-08-11

    申请号：US11492214

    申请日：2006-07-24

    申请人： Kate Bechtel ,  Wei-Chuan Shih ,  Michael S. Feld

    发明人： Kate Bechtel ,  Wei-Chuan Shih ,  Michael S. Feld

    IPC分类号： A61B5/1455 ,  G01N21/65 ,  A61B5/145

    CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1495 ,  A61B2560/0223 ,  G01N21/65

    摘要： The present invention relates to systems and methods for the measurement of analytes such as glucose. Raman and reflectance spectroscopy are used to measure a volume, of material such as a blood sample or tissue within a subject and determine a concentration of a blood analyte based thereon. The present invention further relates to a calibration method, constrained regularization (CR), and demonstrates its use for analyzing spectra including, for example, the measurement glucose concentrations using transcutaneous Raman spectroscopy.

    摘要翻译： 本发明涉及用于测量诸如葡萄糖的分析物的系统和方法。 使用拉曼和反射光谱来测量受试者内的材料，例如血液样本或组织的体积，并且基于此测定血液分析物的浓度。 本发明还涉及校准方法，约束正则化（CR），并证明其用于分析光谱的用途，包括例如使用经皮拉曼光谱测量葡萄糖浓度。

    Systems and methods for spectroscopy of biological tissue
    37.
    发明授权
    Systems and methods for spectroscopy of biological tissue 有权
    生物组织光谱系统和方法

    公开(公告)号：US07647092B2

    公开(公告)日：2010-01-12

    申请号：US10178062

    申请日：2002-06-21

    申请人： Jason T. Motz ,  Luis H. Galindo ,  Martin Hunter ,  Ramachandra Dasari ,  Michael S. Feld

    发明人： Jason T. Motz ,  Luis H. Galindo ,  Martin Hunter ,  Ramachandra Dasari ,  Michael S. Feld

    IPC分类号： A61B6/06

    CPC分类号： A61B5/02007 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/0091 ,  A61B5/415 ,  A61B5/4312 ,  A61B5/4519 ,  A61B5/7232 ,  G01N21/474 ,  G01N21/65 ,  G01N2021/4745 ,  G01N2021/4759 ,  G01N2021/656

    摘要： The system and method of the present invention relates to using spectroscopy, for example, Raman spectroscopic methods for diagnosis of tissue conditions such as vascular disease or cancer. In accordance with a preferred embodiment of the present invention, a system for measuring tissue includes a fiber optic probe having a proximal end, a distal end, and a diameter of 2 mm or less. This small diameter allows the system to be used for the diagnosis of coronary artery disease or other small lumens or soft tissue with minimal trauma. A delivery optical fiber is included in the probe coupled at the proximal end to a light source. A filter for the delivery fibers is included at the distal end. The system includes a collection optical fiber (or fibers) in the probe that collects Raman scattered radiation from tissue, the collection optical fiber is coupled at the proximal end to a detector. A second filter is disposed at the distal end of the collection fibers. An optical lens system is disposed at the distal end of the probe including a delivery waveguide coupled to the delivery fiber, a collection waveguide coupled to the collection fiber and a lens.

    摘要翻译： 本发明的系统和方法涉及使用光谱学，例如用于诊断诸如血管疾病或癌症的组织条件的拉曼光谱方法。 根据本发明的优选实施例，用于测量组织的系统包括具有近端，远端和2mm或更小直径的光纤探针。 这种小直径允许系统用于诊断冠状动脉疾病或其他小腔或软组织，具有最小的创伤。 输送光纤包括在近端耦合到光源的探针中。 用于输送纤维的过滤器包括在远端。 该系统包括在探针中收集来自组织的拉曼散射辐射的收集光纤（或纤维），收集光纤在近端耦合到检测器。 第二过滤器设置在收集纤维的远端。 光学透镜系统设置在探头的远端，包括耦合到输送纤维的输送波导，耦合到收集光纤的收集波导和透镜。

    Systems and methods for phase measurements
    38.
    发明授权
    Systems and methods for phase measurements 有权
    相位测量的系统和方法

    公开(公告)号：US07557929B2

    公开(公告)日：2009-07-07

    申请号：US10871610

    申请日：2004-06-18

    申请人： Christopher M. Fang-Yen ,  Gabriel Popescu ,  Changhuei Yang ,  Adam Wax ,  Ramachandra R. Dasari ,  Michael S. Feld

    发明人： Christopher M. Fang-Yen ,  Gabriel Popescu ,  Changhuei Yang ,  Adam Wax ,  Ramachandra R. Dasari ,  Michael S. Feld

    IPC分类号： G01B9/02 ,  G01B11/02

    CPC分类号： G01B9/02091 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/7232 ,  G01B9/02002 ,  G01B9/02007 ,  G01B9/02011 ,  G01B9/02057 ,  G01B9/02063 ,  G01B9/02067 ,  G01B9/02069 ,  G01B9/02071 ,  G01B9/02072 ,  G01B9/02078 ,  G01B9/02083 ,  G01B9/0209 ,  G01B2290/45 ,  G01B2290/60 ,  G01B2290/70 ,  G01J9/04 ,  G01N21/45

    摘要： Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention.

    摘要翻译： 本发明的优选实施例涉及用于相位测量的系统，其使用多种策略的组合来解决相位噪声问题，包括但不限于公共路径干涉测量，相位参考，主动稳定和差分测量。 实施例涉及用于用光成像小生物物体的光学装置。 这些实施方案可以应用于例如细胞生理学和神经科学领域。 这些优选实施例基于相位测量和成像技术的原理。 使用相位测量和成像技术的科学动机源于例如亚微米级别的细胞生物学，其可以包括但不限于成像发育异常起源，细胞通讯，神经元传播和遗传密码的实现。 亚细胞组分的结构和动力学目前不能使用现有的方法和技术（例如x射线和中子散射）在其天然状态下研究。 相比之下，具有纳米分辨率的基于光的技术使得能够以其天然状态研究细胞机械。 因此，本发明的优选实施例包括基于干涉测量和/或相位测量的原理的系统，并且用于研究细胞生理学。 这些系统包括使用光学干涉仪来测量相位的低相干干涉测量（LCI）原理，或使用其中使用细胞部件本身内部的干扰的光散射光谱（LSS），或者替代地，LCI和LSS的原理可以组合以产生 在本发明的系统中。