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公开(公告)号:US20240076619A1
公开(公告)日:2024-03-07
申请号:US18361584
申请日:2023-07-28
Applicant: Agilent Technologies, Inc.
Inventor: Xiaoyu Zhang , Yama A. Abassi , Nan Li , Xiaobo Wang
CPC classification number: C12N5/0657 , C12N5/0018 , C12N5/0696 , C12N13/00 , G01N27/028 , C12N2506/45 , C12N2529/00
Abstract: A method of characterizing an effect of a compound on cardiomyocyte beating, including providing a system configured to culture, electrically pace, and monitor heating of beating cells: culturing two populations of immature cardiomyocytes in the system; adding a compound suspected of having an effect on cardiomyocyte maturation to one of the populations of immature cardiomyocytes; electrically pacing the two populations of immature cardiomyocytes according to a pulse profile that functionally matures immature cardiomyocytes until at least one of the two populations of cardiomyocytes is functionally mature; and Characterizing the compound as further driving maturation if the population with compound addition functionally matures before the other cardiomyocyte population.
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公开(公告)号:US11921093B2
公开(公告)日:2024-03-05
申请号:US17584250
申请日:2022-01-25
Applicant: Agilent Technologies, Inc.
Inventor: Daniela Loraing , Lena Höninger , Uwe Effelsberg , Andreas Otto , Ansgar Waldbaur , Armin Steinke , Thomas Ortmann , Michael Lang
IPC: G01N30/60
CPC classification number: G01N30/6047
Abstract: A mounting device for mounting a sample separation unit configured for separating, preferably chromatographically separating, compounds in a fluidic sample includes a first fluid connector configured for being mechanically and fluidically coupled with a first fluid interface of the sample separation unit, a second fluid connector configured for being mechanically and fluidically coupled with a second fluid interface of the sample separation unit, and a swivel mechanism configured for swivelling the first fluid connector between a mounting orientation for mounting the first fluid interface of the sample separation unit at the first fluid connector and an alignment orientation for aligning the second fluid interface of the mounted sample separation unit with the second fluid connector for subsequently coupling the second fluid interface with the second fluid connector.
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公开(公告)号:US20240038520A1
公开(公告)日:2024-02-01
申请号:US18345744
申请日:2023-06-30
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor: Kenneth R. NEWTON , Tong CHEN , Stephen ZANON
CPC classification number: H01J49/066 , H01J49/0481
Abstract: In some examples, an ion funnel-based collision cell may include an ion funnel entrance section formed by a plurality of adjacently disposed entrance members. Each entrance member of at least one pair of the adjacently disposed entrance members may include a successively larger opening to form a tapered or profiled entrance for ions entering the ion funnel-based collision cell. An insulation material may be disposed adjacent to or in contact with each entrance member of the at least one pair of the adjacently disposed entrance members to prevent, outside of each successively larger opening, flow of gas between each entrance member of the at least one pair of the adjacently disposed entrance members.
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公开(公告)号:US20240033658A1
公开(公告)日:2024-02-01
申请号:US18227107
申请日:2023-07-27
Applicant: Agilent Technologies, Inc.
Inventor: Manfred Berndt , Konstantin Shoykhet
CPC classification number: B01D19/0031 , B01D15/166
Abstract: A degasser for degassing a mobile phase includes a degasser chamber with a degasser volume for receiving a degassing membrane, a delimiting unit for delimiting a first space of the degasser volume with respect to a second space of the degasser volume while maintaining a fluid connection between the first space and the second space. The first space in an operation in an environment of the degassing membrane includes a higher partial pressure of vapor of the mobile phase than the second space with a lower partial pressure of vapor of the mobile phase. The degasser further includes a suction unit for sucking a gas that passed through the degassing membrane from the second space, and/or an associated gas supply unit for supplying an associated gas in the second space or in a fluid conduit that is connected to the second space.
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公开(公告)号:US20240033656A1
公开(公告)日:2024-02-01
申请号:US18021371
申请日:2021-08-17
Applicant: Agilent Technologies, Inc.
Inventor: Armin Steinke , Christian Daniel Ruf
CPC classification number: B01D15/18 , B01D15/166 , B01L3/502715 , B01L2200/0689 , B01L2300/123 , B01L2200/027 , B01L2200/025
Abstract: A fluidic coupling is positioned between a first fluidic structure and a second fluidic structure. The first fluidic structure has a first channel configured for conducting fluid and opening at a first opening at a first surface of the first fluidic structure. The second fluidic structure has a second channel configured for conducting fluid and opening at a second opening at a second surface of the second fluidic structure. The fluidic coupling includes a sealing element and an elastic structure. The elastic structure may be elastically deformed by the sealing element, thus allowing a fluidic communication between the first channel and the second channel.
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公开(公告)号:US11885676B2
公开(公告)日:2024-01-30
申请号:US17290561
申请日:2019-10-15
Applicant: Agilent Technologies, Inc.
Inventor: Anders Knudtzen , Steve Lever
CPC classification number: G01J3/0202 , G01J3/0291 , G02B7/003 , G02B7/20
Abstract: The invention provides an optical coupling, comprising: a first coupling portion and a second coupling portion, the first and second coupling portions configured to mate in kinematic constraint via a first mounting interface and at least two further mounting interfaces, wherein: the first coupling portion comprises a first mounting element and the second coupling portion comprises a socket, and the first mounting element is receivable in the socket at the first mounting interface such that the first mounting interface constrains lateral displacements of the first coupling portion relative to the second coupling portion when mated; and at least one optical channel for transmitting abeam of light along an optical axis through the optical coupling, the optical channel comprising complementary light-transmitting ports in the first and second coupling portions, wherein the optical axis is not laterally removed from the first mounting interface by more than half the distance between the first mounting interface and the nearest of the further mounting interfaces.
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公开(公告)号:US20240018510A1
公开(公告)日:2024-01-18
申请号:US18256877
申请日:2020-12-10
Applicant: Agilent Technologies, Inc.
Inventor: David Taussig , Israel Steinfeld , Nicholas M Sampas , Brian Jon Peter
IPC: C12N15/10 , C12Q1/6869
CPC classification number: C12N15/1065 , C12Q1/6869
Abstract: The present invention relates to preparation, sequencing and analysis of a sequencing library of adaptor-tagged fragments, wherein the fragments have different orientations relative to a sequencing adaptor.
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公开(公告)号:US11858961B2
公开(公告)日:2024-01-02
申请号:US17398763
申请日:2021-08-10
Applicant: Agilent Technologies, Inc.
Inventor: Michael J. Kimzey , Francis T. Haxo , Vaishali Sharma
CPC classification number: C07K1/1136 , C07K1/113 , C11D1/62 , C11D17/00
Abstract: Ammonium cation detergents comprising a quaternary or tertiary ammonium cation can be used as detergents to denature proteins and are particularly useful in denaturing glycoproteins or glycopeptides prior to enzymatic deglycosylation. Ammonium cation detergents with sulfate or sulfonate anions are particularly useful.
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公开(公告)号:US20230416733A1
公开(公告)日:2023-12-28
申请号:US18332464
申请日:2023-06-09
Applicant: Agilent Technologies, Inc.
Inventor: Daniel E. RYAN , Douglas J. DELLINGER , Jeffrey R. SAMPSON , Robert KAISER , Joel MYERSON
IPC: C12N15/11 , C12N9/22 , C07H21/02 , C12N15/113 , C12N15/90 , C12Q1/6876
CPC classification number: C12N15/111 , C12N9/22 , C07H21/02 , C12N15/113 , C12N15/907 , C12Q1/6876 , C12N2310/10 , C12N2310/312 , C12N2310/323 , C12N2310/333 , C12N2310/346 , C12N2310/3517 , C12N2320/51 , C12N2320/53 , C12N2330/31 , C12N2310/20 , C12N2310/315 , C12N2310/3231 , C12N2310/335 , C12N2310/531 , C12N2310/321 , C12N2310/322
Abstract: The present invention relates to modified guide RNAs and their use in clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems.
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公开(公告)号:US20230407379A1
公开(公告)日:2023-12-21
申请号:US18246651
申请日:2021-07-30
Applicant: Agilent Technologies, Inc.
Inventor: Adrienne McCampbell , Victor Lim , Sean Nasri , Brian Phillip Smart
IPC: C12Q1/6841 , C12Q1/6806
CPC classification number: C12Q1/6841 , C12Q1/6806
Abstract: The present methods and apparatus apply an electric field to a sample in order to prepare it for analysis. In some embodiments, an electric field is applied for drying, staining and coverslipping of tissue sections, providing improved tissue sections for analysis and storage.
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