公开(公告)号：US20060013743A1

公开(公告)日：2006-01-19

申请号：US11224654

申请日：2005-09-12

申请人： Arne Karlsson ,  Mark Krawczyk ,  Ara Alexanian ,  Duncan Akporiaye ,  Ivar Dahl

发明人： Arne Karlsson ,  Mark Krawczyk ,  Ara Alexanian ,  Duncan Akporiaye ,  Ivar Dahl

IPC分类号： B01L3/02

CPC分类号： G01N1/26 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00391 ,  B01J2219/00394 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00698 ,  B01J2219/00707 ,  B01J2219/00745 ,  B01J2219/00747 ,  C40B30/08 ,  C40B40/18 ,  C40B60/14 ,  G01N31/10 ,  G01N35/08 ,  G01N2030/025 ,  G01N2035/00188 ,  Y10T436/25 ,  Y10T436/2575

摘要： An apparatus and a method for rapidly generating a plurality of isolated effluents have been developed. A specific embodiment involves screening a plurality of solids through simultaneously contacting the members of the plurality with a fluid, sampling the resulting fluids, and processing the resulting fluids to, for example, determine changes as compared to the feed fluid or as compared to other resulting fluids.

摘要翻译： 已经开发了用于快速产生多个隔离流出物的装置和方法。 具体实施例涉及通过同时使多个部件的成员接触流体，对所得到的流体进行取样并且将所得到的流体进行处理以例如与进料流体相比确定变化或与其它结果相比较来筛选多个固体 流体。

公开(公告)号：US06869799B1

公开(公告)日：2005-03-22

申请号：US09607535

申请日：2000-06-29

申请人： Shenheng Guan ,  Lynn Van Erden ,  Robert C. Haushalter ,  Xiao Ping Zhou ,  Xuejun Jason Wang ,  Ravi Srinivasan

发明人： Shenheng Guan ,  Lynn Van Erden ,  Robert C. Haushalter ,  Xiao Ping Zhou ,  Xuejun Jason Wang ,  Ravi Srinivasan

IPC分类号： G01N37/00 ,  B01J4/00 ,  B01J19/00 ,  C40B30/00 ,  C40B30/08 ,  C40B40/18 ,  C40B60/12 ,  G01N30/24 ,  G01N31/10 ,  G01N35/10 ,  C02N31/10

CPC分类号： G01N31/10 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00306 ,  B01J2219/00313 ,  B01J2219/00319 ,  B01J2219/00353 ,  B01J2219/00391 ,  B01J2219/00394 ,  B01J2219/00409 ,  B01J2219/00423 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00745 ,  B01J2219/00747 ,  C40B30/08 ,  C40B40/18 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

摘要： The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of vessels for containing individual library members and a fluid handling system that apportions a test fluid about equally between each of the vessels. This allows for simultaneous screening of library members by detecting changes in test fluid following contact with individual library members. Fluid flow through each of the vessels is controlled using passive flow restrictors or active flow controllers to ensure that each library member contacts approximately the same amount of test fluid per unit time. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.

摘要翻译： 本发明公开了一种用于快速分析组合图书馆成员的装置和方法。 该装置包括用于容纳单个文件库构件的多个容器和在每个容器之间均匀分配测试流体的流体处理系统。 这允许通过检测与单个库成员接触后测试流体的变化来同时筛选库成员。 通过每个容器的流体流动使用被动流量限制器或主动流量控制器来控制，以确保每个库构件每单位时间接触大约相同量的测试流体。 基于它们催化流体反应物转化的能力，所公开的装置对于筛选文库成员特别有用。

公开(公告)号：US06168914A

公开(公告)日：2001-01-02

申请号：US09216093

申请日：1998-12-18

申请人： David A. Campbell ,  Valery V. Antonenko ,  Harold E. Selick ,  Robert M. Gavin ,  Satoru Ida ,  Arthur H. Muir

发明人： David A. Campbell ,  Valery V. Antonenko ,  Harold E. Selick ,  Robert M. Gavin ,  Satoru Ida ,  Arthur H. Muir

IPC分类号： C12O100

CPC分类号： B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00319 ,  B01J2219/00353 ,  B01J2219/00391 ,  B01J2219/00423 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00664 ,  B01J2219/00689 ,  C40B60/14 ,  Y10T436/25

摘要： The invention provides a system and method for synthesizing chemicals onto supports in a parallel manner to produce a combinatorial collection of compounds. The system includes a plurality of middle plates, with each middle plate defining a plurality of reaction zones arranged in a two dimensional array. The reaction zones are adapted to receive a solid support, such as a sheet of membrane, and the middle plates are stackable on each other to form a three dimensional array of reaction zones. The system also includes a pair of end plates, where the middle plates are located between the end plates, and where the end plates include an array of fluid guides corresponding to the array of reaction zones, to allow for selective routing of reagents through the reaction zones.

摘要翻译： 本发明提供了一种用于以平行方式将化学物质合成到载体上以产生化合物组合收集的系统和方法。 该系统包括多个中间板，每个中间板限定以二维阵列排列的多个反应区。 反应区适于接收诸如膜片的固体支持物，并且中间板彼此堆叠以形成反应区域的三维阵列。 该系统还包括一对端板，其中中间板位于端板之间，并且其中端板包括对应于反应区阵列的流体引导阵列，以允许试剂选择性地穿过反应 区域。

公开(公告)号：US5655560A

公开(公告)日：1997-08-12

申请号：US357512

申请日：1994-12-16

申请人： Haim Kedar ,  Donald T. Roth

发明人： Haim Kedar ,  Donald T. Roth

IPC分类号： B01J4/02 ,  B01J19/00 ,  C40B60/14 ,  F16K11/22 ,  B08B9/00 ,  B08B9/06

CPC分类号： B01J4/02 ,  B01J19/0046 ,  F16K11/22 ,  B01J2219/00389 ,  B01J2219/00391 ,  B01J2219/00409 ,  C40B60/14 ,  Y10T137/0402 ,  Y10T137/0491 ,  Y10T137/4245 ,  Y10T137/4336 ,  Y10T137/87249 ,  Y10T137/87322

摘要： In an exemplary aspect, the invention provides a fluid distribution system including a first fluid path, and a second fluid path that is laterally spaced-apart from the first fluid path. A third fluid path connects the first and the second fluid paths. A valve is provided that is axially translatable through a third fluid path between a first position and a second position. In a first position, the valve is removed from the third fluid path, and in the second position, the valve substantially fills the third fluid path.

摘要翻译： 在示例性方面，本发明提供了一种流体分配系统，其包括第一流体路径和与第一流体路径横向间隔开的第二流体路径。 第三流体路径连接第一和第二流体路径。 提供一个阀，其可在第一位置和第二位置之间通过第三流体路径轴向平移。 在第一位置，阀从第三流体路径移除，并且在第二位置，阀基本上填充第三流体路径。

公开(公告)号：US5175209A

公开(公告)日：1992-12-29

申请号：US648808

申请日：1991-01-31

申请人： Kenneth L. Beattie ,  James D. Frost, III

发明人： Kenneth L. Beattie ,  James D. Frost, III

IPC分类号： B01J19/00 ,  C07H21/00 ,  C40B40/06 ,  C40B50/14 ,  C40B60/14

CPC分类号： C07H21/00 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00322 ,  B01J2219/00391 ,  B01J2219/00423 ,  B01J2219/00454 ,  B01J2219/00461 ,  B01J2219/005 ,  B01J2219/00502 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00722 ,  C40B40/06 ,  C40B50/14 ,  C40B60/14

摘要： A wafer for synthesizing biopolymers which includes a solid phase support material, a reaction chamber which receives and retains the support material and at least one inert porous material which allows flow through the wafer. Also included is a segmented wafer synthesis device comprising at least one, and preferably numerous, wafers for the simultaneous synthesis of multiple defined-sequenced biopolymers. Further there are process steps for synthesizing a variety of biopolymers. Synthetic polynucleotides have played a key role in studies of genetic organization through their use as primers for DNA sequencing and as hybridization probes, linkers and adapters in the cloning of genes.

摘要翻译： 用于合成生物聚合物的晶片，其包括固相支持材料，接收并保持载体材料的反应室和允许流过晶片的至少一种惰性多孔材料。 还包括分段晶片合成装置，其包括用于同时合成多个定义顺序的生物聚合物的至少一个，优选多个晶片。 此外，还有用于合成各种生物聚合物的方法步骤。 合成多核苷酸在遗传组织的研究中起着关键的作用，它们用作DNA测序的引物，以及作为克隆基因的杂交探针，接头和衔接子。

公开(公告)号：US20130273662A1

公开(公告)日：2013-10-17

申请号：US13880821

申请日：2011-10-17

申请人： Armin Lange De Oliveira ,  Michael Dejmek ,  Oliver Koechel ,  Juergen Bechtel

发明人： Armin Lange De Oliveira ,  Michael Dejmek ,  Oliver Koechel ,  Juergen Bechtel

IPC分类号： G01N31/10

CPC分类号： G01N31/10 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00389 ,  B01J2219/00391 ,  B01J2219/00423 ,  B01J2219/00477 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00689 ,  B01J2219/00707 ,  B01J2219/00747 ,  B01J2219/00792 ,  B01J2219/00835 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/00963 ,  B01J2219/00986

摘要： The present invention relates to a catalysis apparatus for testing catalysts with variable process pressure adjustment over a pressure range from 0.01 millibar to 300 bar. The apparatus preferably has a plurality of reaction chambers (101, 102, . . . ) arranged in parallel, the reaction chamber outlet-side lines (211, 212, . . . ) of which are divided into two groups of sub-lines. One group of main lines (411, 412, . . . ) is operatively connected to a regulating valve (61), which is common to all of the main lines, and to an exhaust-air line (62), and the second group of secondary lines (311, 312, 313, . . . ) and switching valves (321, 322, . . . ) is operatively connected to an analysis unit (34). It is preferable for reaction chamber outlet-side lines (201, 202, . . . ) to be equipped in each case with a separate line for regulating fluid supply (211, 212, . . . ). In a preferred embodiment, the connecting points of the reaction chamber outlet-side lines (201, 202, . . . ) to the respective main lines (411, 412, . . . ) and secondary lines (311, 312, . . . ) have in each case one mixing vessel (301, 302, . . . ).

摘要翻译： 本发明涉及一种用于在0.01毫巴至300巴的压力范围内测试具有可变过程压力调节的催化剂的催化装置。 该装置优选地具有并排布置的多个反应室（101,102 ...），反应室出口侧管线（211,212 ...）被分成两组子管线。 一组主线路（411,412 ...）可操作地连接到所有主线路和排气管线（62）共同的调节阀（61），并且第二组 的二次管线（311,312,313 ......）和切换阀（321,322 ...）可操作地连接到分析单元（34）。 反应室出口侧管线（201,202 ...）最好在各种情况下配备一条用于调节流体供应（211,212 ...）的单独管线。 在一个优选实施例中，反应室出口侧线（201,202 ...）到相应主线（411,412 ...）和次级线（311,312 ...）的连接点。 ）在每种情况下都具有一个混合容器（301,302 ......）。

公开(公告)号：US07997297B2

公开(公告)日：2011-08-16

申请号：US11910493

申请日：2005-04-04

申请人： Martin Smit ,  Gerardus Johannes Maria Gruter

发明人： Martin Smit ,  Gerardus Johannes Maria Gruter

IPC分类号： B01J19/00 ,  F16K7/04

CPC分类号： B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00391 ,  B01J2219/004 ,  B01J2219/00477 ,  B01J2219/00585 ,  B01J2219/00601 ,  B01J2219/00707 ,  B01J2219/00747 ,  Y10T137/7358 ,  Y10T137/7374 ,  Y10T137/7771 ,  Y10T137/7781 ,  Y10T137/7836

摘要： The invention relates to a system for performing parallel chemical experiments. The system comprises an array of parallel flow through reactors each comprising a reaction chamber, a reactor inlet and a reactor outlet connected to the reactor chamber. Downstream of each reactor a corresponding active pressure regulating arrangement is provided for actively regulating the reactor pressure. The pressure regulating arrangement comprises a passage for reactor effluent with an inlet connected to the reactor outlet and an outlet for discharging reactor effluent at a reduced pressure with respect to the reactor pressure.

摘要翻译： 本发明涉及一种用于进行平行化学实验的系统。 该系统包括平行流通反应器的阵列，每个反应器包括反应室，反应器入口和连接到反应器室的反应器出口。 每个反应器的下游提供相应的主动压力调节装置，用于主动调节反应器压力。 压力调节装置包括用于反应器流出物的通道，其具有连接到反应器出口的入口和用于相对于反应器压力在减压下排放反应器流出物的出口。

公开(公告)号：US07867458B2

公开(公告)日：2011-01-11

申请号：US12424744

申请日：2009-04-16

申请人： Alfred Haas ,  Wolfgang Strehlau ,  Armin Brenner ,  Oliver Koechel ,  Markus Friess ,  Torsten Zech

发明人： Alfred Haas ,  Wolfgang Strehlau ,  Armin Brenner ,  Oliver Koechel ,  Markus Friess ,  Torsten Zech

IPC分类号： B01J19/00 ,  G01N25/08 ,  G05D7/00 ,  G05B21/00

CPC分类号： B01J19/0006 ,  B01J19/0046 ,  B01J2219/00038 ,  B01J2219/00162 ,  B01J2219/00164 ,  B01J2219/00286 ,  B01J2219/00389 ,  B01J2219/00391 ,  B01J2219/00423 ,  B01J2219/00477 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00689 ,  B01J2219/00707 ,  B01J2219/0072 ,  B01J2219/00745 ,  B01J2219/00747 ,  C40B30/08 ,  C40B40/18 ,  C40B60/14 ,  Y10T436/21

摘要： The present invention relates to a method and a device for the parallel study of chemical reactions in at least two spatially separated reaction spaces. In particular, the invention is suitable for reactions which are not constant volume reactions and/or for reactions in which fluid flows through at least two spatially separated reaction spaces are intended to be controlled together for all the reaction spaces, or for related subsets of them, in the most straightforward way possible.According to one embodiment, the device according to the invention for the parallel study of chemical reactions comprises at least the following components: (a) at least two spatially separated reaction spaces; (b) on the reaction space input side, at least one common educt feed for the reaction spaces according to (a); (d) on the reaction space output side, at least one connection per reaction space to at least one holding gas feed common to all the reaction spaces, or subsets of them; (e) on the reaction space output side, and downstream of the connection to the holding gas feed according to (d) in the product flow direction, at least one restrictor per reaction space.

摘要翻译： 本发明涉及在至少两个空间分离的反应空间中并行研究化学反应的方法和装置。 特别地，本发明适用于不是恒定的体积反应和/或其中流体流过至少两个空间分离的反应空间的反应旨在一起控制所有反应空间或其相关子集的反应 ，以最直接的方式可能。 根据一个实施方案，根据本发明的用于平行研究化学反应的装置至少包括以下组分：（a）至少两个空间分离的反应空间; （b）在反应空间输入侧，根据（a）的反应空间的至少一种普通的喷射进料; （d）在反应空间输出侧，每个反应空间至少一个连接到所有反应空间或它们的子集共同的至少一个保持气体进料; （e）在反应空间输出侧和根据（d）在产品流动方向上与保持气体进料的连接的下游，每个反应空间至少有一个限制器。

公开(公告)号：US20090280029A1

公开(公告)日：2009-11-12

申请号：US11914216

申请日：2006-05-10

申请人： Youshu Kang ,  Guilin Wang ,  Wenge Wang ,  Wenhui Wang ,  Youqi Wang ,  Guangping Xie ,  Sibiao Xu ,  Xiaowen Zhu ,  Xianzhong Zhao

发明人： Youshu Kang ,  Guilin Wang ,  Wenge Wang ,  Wenhui Wang ,  Youqi Wang ,  Guangping Xie ,  Sibiao Xu ,  Xiaowen Zhu ,  Xianzhong Zhao

IPC分类号： G01N33/00

CPC分类号： B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00313 ,  B01J2219/00389 ,  B01J2219/00391 ,  B01J2219/00479 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00601 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00738 ,  B01J2219/00756 ,  B01L9/52 ,  B01L13/02 ,  C40B60/08 ,  G01N1/18

摘要： The present invention discloses a materials-processing system, which comprises an inputting subsystem, a processing apparatus coupled to the inputting subsystem and a collecting subsystem coupled to the processing apparatus. The inputting subsystem comprises three or more sample vessels, which can be connected to the processing apparatus. Since the processing system includes multiple sample vessels, which can be grouped into different groups so that each group contains two or more of the multiple sample vessels. High throughput materials transport can be realized by sequentially connecting different groups of sample vessels to the processing apparatus, thereby overcoming a limitation of the prior art that cannot continuously perform multiple batches of materials processing and improving material processing efficiency.

摘要翻译： 本发明公开了一种材料处理系统，其包括输入子系统，耦合到输入子系统的处理装置和耦合到处理装置的收集子系统。 输入子系统包括三个或更多个可连接到处理装置的样品容器。 由于处理系统包括多个样品容器，其可以分组成不同的组，使得每组包含多个样品容器中的两个或更多个。 可以通过将不同组的样品容器顺序地连接到处理装置来实现高通量材料输送，从而克服了现有技术的不能连续地进行多批次材料处理并提高材料处理效率的限制。

公开(公告)号：US20060177370A1

公开(公告)日：2006-08-10

申请号：US10567029

申请日：2004-07-30

申请人： Hartmut Hibst ,  Frieder Borgmeier ,  Martin Dieterle

发明人： Hartmut Hibst ,  Frieder Borgmeier ,  Martin Dieterle

IPC分类号： C01B19/00

CPC分类号： B01J19/2415 ,  B01J19/0046 ,  B01J19/10 ,  B01J19/18 ,  B01J23/002 ,  B01J27/0576 ,  B01J2219/00033 ,  B01J2219/0004 ,  B01J2219/00126 ,  B01J2219/00128 ,  B01J2219/00286 ,  B01J2219/00353 ,  B01J2219/00391 ,  B01J2219/00479 ,  B01J2219/00486 ,  B01J2219/00495 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01J2219/00689 ,  B01J2219/00707 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2523/00 ,  C40B30/08 ,  C40B40/18 ,  C40B50/08 ,  C40B60/14 ,  B01J2523/55 ,  B01J2523/56 ,  B01J2523/64 ,  B01J2523/68

摘要： The sequential production of a library of N different solids, in particular heterogeneous catalysts, where N within a day is an integer of at least 2, is performed by a) producing at least two different sprayable solutions, emulsions and/or dispersions of elements and/or element compounds of the chemical elements present in the catalyst and optionally of dispersions of inorganic support materials, b) continuously metering the at least two different solutions, emulsions and/or dispersions in a predefined ratio into a mixing apparatus in which the solutions, emulsions and/or dispersions are homogeneously mixed, c) continuously drying the mixture removed from the mixing apparatus and recovering the dried mixture, d) changing the ratios in step b) and repeating steps b), c) and d) (N-1) times until N different dried mixtures are obtained, e) optionally shaping and optionally calcining the mixtures to give the solids.

摘要翻译： 通过a）产生N种不同固体，特别是非均相催化剂的文库，其中N在一天内是至少2的整数，其通过a）产生至少两种不同的可喷雾溶液，元素的乳液和/或分散体，以及 存在于催化剂中的化学元素的元素化合物和任选的无机载体材料的分散体，b）将预定比例的至少两种不同溶液，乳液和/或分散体连续计量成混合设备，其中溶液， 乳液和/或分散体均匀混合，c）连续干燥从混合装置中除去的混合物并回收干燥的混合物，d）改变步骤b）中的比例并重复步骤b），c）和d）（N-1 ），直到获得N种不同的干燥混合物，e）任选地成型和任选地煅烧混合物以得到固体。