-
公开(公告)号：US09342721B2
公开(公告)日：2016-05-17
申请号：US14328410
申请日：2014-07-10
Applicant: EMD Millipore Corporation
Inventor： Aaron Burke
CPC classification number: G06K7/10366 , A61L2/26 , G06K19/0717 , G06K19/0723
Abstract: A system and method for verifying the occurrence of an environmental condition is disclosed. Rather than store information concerning the occurrence and/or success of the sterilization process, the present invention modifies the wireless transmission characteristics of the device. In some embodiments, the bandwidth of the wireless transceiver is altered as a result of undergoing sterilization. In other embodiments, the resonance frequency of the circuit is affected. In other embodiments, one or more of these parameters are affected based on other environmental conditions, such as shock or vibration.
Abstract translation: 公开了一种用于验证环境条件的发生的系统和方法。 本发明不是存储关于灭菌处理的发生和/或成功的信息，而是修改设备的无线传输特性。 在一些实施例中，作为进行灭菌的结果，无线收发器的带宽被改变。 在其他实施例中，电路的谐振频率受到影响。 在其他实施例中，这些参数中的一个或多个基于其他环境条件（例如冲击或振动）而受到影响。
-
452.发明申请METHODS OF INCREASING PROTEIN PURITY USING PROTEIN A BASED CHROMATOGRAPHY 审中-公开使用基于蛋白质的色谱法增加蛋白质纯度的方法公开(公告)号：US20160122385A1
公开(公告)日：2016-05-05
申请号：US14768254
申请日：2014-03-07
Applicant: EMD MILLIPORE CORPORATION
Inventor： Nanying Bian , Melissa Holstein
Abstract: The present invention provides methods for increasing purity of an Fc-containing protein by removing protein aggregates during the Protein A chromatography step used during the purification of the Fc-containing protein.
Abstract translation: 本发明提供了在纯化含Fc蛋白质期间使用的蛋白A色谱步骤期间通过除去蛋白质聚集体来提高含Fc蛋白质的纯度的方法。
-
公开(公告)号：US20160114272A1
公开(公告)日：2016-04-28
申请号：US14890774
申请日：2014-09-02
Applicant: EMD MILLIPORE CORPORATION
Inventor： Maybelle Woo , David Yavorksy , John Amara , Nripen Singh
CPC classification number: B01D39/1623 , B01D29/66 , B01D39/163 , B01D2239/0407 , B01D2239/0654 , B01D2239/086
Abstract: A depth filtration device for the clarification of biological fluids including a composite depth filter media having a nonwoven first layer integral with a second layer containing a polyaeryionitrile (PAN) fibers, a filter aid, and a wet-strength resin. The depth filter media exhibits increased creased binding capacity for soluble impurities such as DNA and host cells proteins from biological/cell culture feed-streams during secondary clarification and low-level impurity clearance of harvested cell culture fluids, such as those used for the manufacture of monoclonal antibodies. The depth filter media additionally exhibits significantly lower flushing requirements, resulting in lower levels of organic, inorganic and bioburden extractables released, high dirt holding capacities and good chemical and/or radiation resistance.
Abstract translation: 一种用于澄清生物流体的深度过滤装置，包括具有与包含聚噻吩（PAN）纤维的第二层成一体的非织造第一层的复合深度过滤介质，助滤剂和湿强度树脂。 深度过滤介质在二次澄清过程中生物/细胞培养物料流中的可溶性杂质如DNA和宿主细胞蛋白质的增加的结合能力增加，并且收集的细胞培养液的低含量杂质清除，例如用于制造 单克隆抗体。 深度过滤介质还显示出显着降低的冲洗要求，导致释放的有机，无机和生物负载提取物水平较低，高污垢保持能力以及良好的化学和/或耐辐射性。
-
公开(公告)号：US20160103045A1
公开(公告)日：2016-04-14
申请号：US14974334
申请日：2015-12-18
Applicant: EMD Millipore Corporation
Inventor： Christopher A. Scott , Timothy K. Nadler , Kurt Greenizen , Louis Bonhomme , Sara D. Gutierrez , Masaharu Mabuchi , David Briggs , Phillip Clark , Ralph T. Scaduto
CPC classification number: G01N1/34 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2315/02 , B01L3/5021 , B01L3/5085 , B01L2300/0618 , B01L2300/0681 , C07K1/16 , C07K1/22 , G01N1/405 , G01N1/4077 , G01N2001/4088 , Y10T436/25375
Abstract: Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed.
-
公开(公告)号：US20160067703A1
公开(公告)日：2016-03-10
申请号：US14940864
申请日：2015-11-13
Applicant: EMD Millipore Corporation
Inventor： Jad Jaber , Wilson Moya , James Hamzik , Arezki Boudif , Yu Zhang , Neil Soice , John Charkoudian , Nripen Singh
CPC classification number: B01J41/14 , B01J41/13 , C07K1/30 , C07K1/32 , C07K16/00 , C07K2317/10 , C08F8/00 , C08F8/02 , C08F126/02 , C08F26/02
Abstract: The present invention provides novel and improved stimulus responsive polymers and methods of using the same for the purification of biomolecules.
Abstract translation: 本发明提供了新的和改进的刺激响应聚合物以及使用其进行生物分子纯化的方法。
-
Patent Agency Ranking
公开(公告)号：US09279100B2
公开(公告)日：2016-03-08
申请号：US14012103
申请日：2013-08-28
Applicant: EMD Millipore Corporation
Inventor： Pierre Guedon
CPC classification number: C12M33/07 , B01L3/567 , G01N1/10 , G01N35/1097 , G01N2001/022
Abstract: The device for the transfer of a medium comprises a magazine having two main faces (17) of which one is adapted to cooperate with a container and a lateral face (18) extending between said main faces (17) as well as at least one sliding valve (3) housed in a cavity of said magazine (2) and in which there is formed a transfer duct (59) for said medium which issues on said face (17) adapted to cooperate with said container, said valve (3) having a closed position in which it sealingly isolates said duct (59) from said container and an open position in which said duct (59) is placed in communication with said container; said valve (3) comprising a valve member (40), an isolation sleeve (41) surrounding at least partially said valve member (40) as well as spring means (58) adapted to be compressed by said valve member (40) when said valve (3) is in its open position.
-
公开(公告)号：US09272840B2
公开(公告)日：2016-03-01
申请号：US14745770
申请日：2015-06-22
Applicant: EMD Millipore Corporation
Inventor： James Hobson , James Austin , Boris Pesakovich , Elias G. Noukas , Thomas Janko , Shaun McMahon
CPC classification number: A61J1/10 , B65B69/0091 , B65D88/20 , B65D90/046 , B65D2203/10 , B65D2303/00 , B65F1/06 , Y10T29/49826
Abstract: The present invention is an alignment device for a bag containing one or more ports. The alignment device is attached to either the one or more ports or to the bag adjacent the one or more ports. The plate has an indicator or a unique outer edge shape that is designed to fit into a corresponding unique opening in a holder to ensure proper alignment of the bag and its port(s) in the holder. The plate is has a series of holes equal to and in alignment with the one or more ports of the bag and the port(s) extend through the holes of the plate.
-
公开(公告)号：US20160051943A1
公开(公告)日：2016-02-25
申请号：US14878030
申请日：2015-10-08
Applicant: EMD Millipore Corporation
Inventor： Mikhail Kozlov , Kevin Rautio
CPC classification number: B01D71/56 , B01D67/0006 , B01D67/009 , B01D69/125 , B01D2323/30 , B01D2323/34 , B01D2325/14 , B01D2325/30 , C07K1/24 , C07K1/34
Abstract: A negatively charged microporous filtration medium having a high charge density comprising a porous substrate and a polymerized cross-linked polymeric coating located on the inner and outer surfaces of the substrate. The coating may be formed from a reactant solution comprising negatively charged cross-linkable polymerizeable acrylamidoalkyl monomers and acrylamido cross-linking agents which are polymerized in situ on the substrate. The negatively charged microporous filtration medium are suitable for use as prefiltration membranes for selectively removing protein aggregates from a protein solution.
-
公开(公告)号：US09259687B2
公开(公告)日：2016-02-16
申请号：US13889616
申请日：2013-05-08
Applicant: EMD Millipore Corporation
Inventor： Jean-Louis Weissenbach , Sebastien Cirou
CPC classification number: B01D63/00 , B01D61/20 , B01D2313/105 , B01D2313/125 , B01D2313/13 , B01D2313/18 , B01D2313/58 , B01D2313/90 , B01D2315/10 , Y10T137/6851 , Y10T137/8593
Abstract: The invention concerns a bag comprising a first conduit (13C) which extends longitudinally between a flow pump connector (11C) emerging on a first side (68) and a tangential filter connector (11M) emerging on a second side (69); a second conduit (13B) which extends longitudinally from a first side of said conduit (13C) between a supply container connector (11B) emerging on said first side (68), and another tangential flow connector (11N) emerging on said second side (69); a third conduit (13H) which extends from a second side of said conduit (13C), starting at a collecting container connector (11J), until it enters said first conduit (13C); and a fourth conduit (13A) which extends from the first side of said conduit (13C), starting at a transfer pump connector (11A), until it enters said second conduit (13B).
-
公开(公告)号：US09227994B2
公开(公告)日：2016-01-05
申请号：US13955024
申请日：2013-07-31
Applicant: EMD Millipore Corporation
Inventor： Wilson Moya , Jad Jaber
Abstract: The present invention relates to a selectively soluble polymer capable of binding to a desired molecules in an unclarified mixture containing various biological materials and the methods of using such a polymer to purify a molecule from such a mixture. The polymer is soluble in the mixture under a certain set of process conditions such as pH or temperature and/or salt concentration and is rendered insoluble and precipitates out of solution upon a change in the process conditions. The polymer is capable of binding to the desired molecule (protein, polypeptide, etc) and remains capable of binding to that molecule even after the polymer is precipitated out of solution. The precipitate can then be filtered out from the remainder of the stream and the desired biomolecule is recovered such as by elution and further processed.
-
-
-
-
-
-
-
-
-
Search Results
492
records
(took 0.022 seconds)
