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41.发明申请Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds 审中-公开蜂窝状蛋白酶抑制剂化合物的膦酸酯类似物的细胞积累公开(公告)号：US20070010489A1
公开(公告)日：2007-01-11
申请号：US10511998
申请日：2003-04-25
申请人： Murty Arimilli , Mark Becker , Clifford Bryant , James Chen , Xiaowu Chen , Azar Dastgah , Maria Fardis , Gong-Xin He , Haolun Jin , Choung Kim , William Lee , Christopher Lee , Kuei-Ying Lin , Hongtao Liu , Richard Mackman , Michael Mitchell , Peter Nelson , Hyung-Jung Pyun , Tanisha Rowe , Mark Sparacino , Sundaramoorthi Swaminathan , James Tario , Jianying Wang , Matthew Wiliams , Lianhong Xu , Zheng-Yu Yang , Richard Yu , Jiancun Zhang , Lijun Zhang
发明人： Murty Arimilli , Mark Becker , Clifford Bryant , James Chen , Xiaowu Chen , Azar Dastgah , Maria Fardis , Gong-Xin He , Haolun Jin , Choung Kim , William Lee , Christopher Lee , Kuei-Ying Lin , Hongtao Liu , Richard Mackman , Michael Mitchell , Peter Nelson , Hyung-Jung Pyun , Tanisha Rowe , Mark Sparacino , Sundaramoorthi Swaminathan , James Tario , Jianying Wang , Matthew Wiliams , Lianhong Xu , Zheng-Yu Yang , Richard Yu , Jiancun Zhang , Lijun Zhang
IPC分类号： A61K31/663 , C07F9/6515 , C07F9/6512
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/58 , C07F9/645 , C07F9/6506 , C07F9/650905 , C07F9/650947 , C07F9/6512 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit 5 HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
摘要翻译： 公开了具有用作治疗剂和其它工业目的的具有HIV蛋白酶抑制性质的膦酸酯取代的化合物。 该组合物抑制5种HIV蛋白酶活性和/或用于治疗AIDS和其它抗病毒感染以及用于检测HIV蛋白酶的测定。
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42.发明申请公开(公告)号：US20050239054A1
公开(公告)日：2005-10-27
申请号：US10740694
申请日：2003-12-22
申请人： Murty Arimilli , Mark Becker , Gabriel Birkus , Clifford Bryant , James Chen , Xiaowu Chen , Tomas Cihlar , Azar Dastgah , Eugene Eisenberg , Maria Fardis , Marcos Hatada , Gong-Xin He , Haolun Jin , Choung Kim , William Lee , Christopher Lee , Kuei-Ying Lin , Hongtao Liu , Richard MacKman , Martin McDermott , Michael Mitchell , Peter Nelson , Hyung-Jung Pyun , Tanisha Rowe , Mark Sparacino , Sundaramoorthi Swaminathan , James Tario , Jianying Wang , Matthew Williams , Lianhong Xu , Zheng-Yu Yang , Richard Yu , Jiancun Zhang , Lijun Zhang
发明人： Murty Arimilli , Mark Becker , Gabriel Birkus , Clifford Bryant , James Chen , Xiaowu Chen , Tomas Cihlar , Azar Dastgah , Eugene Eisenberg , Maria Fardis , Marcos Hatada , Gong-Xin He , Haolun Jin , Choung Kim , William Lee , Christopher Lee , Kuei-Ying Lin , Hongtao Liu , Richard MacKman , Martin McDermott , Michael Mitchell , Peter Nelson , Hyung-Jung Pyun , Tanisha Rowe , Mark Sparacino , Sundaramoorthi Swaminathan , James Tario , Jianying Wang , Matthew Williams , Lianhong Xu , Zheng-Yu Yang , Richard Yu , Jiancun Zhang , Lijun Zhang
IPC分类号： C12N9/99 , A61K31/4155 , A61K31/66 , A61K31/665 , A61K31/675 , A61P31/18 , A61P43/00 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/48 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F20060101 , C07F9/02 , C07F9/38 , C07F9/40 , C07F9/44 , C07F9/58 , C07F9/62 , C07F9/645 , C07F9/6506 , C07F9/6509 , C07F9/6512 , C07F9/653 , C07F9/6533 , C07F9/655 , C07F9/6558 , C07F9/6561 , C07F9/6584 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C12Q1/70 , G01N33/04 , G01N33/50
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/58 , C07F9/645 , C07F9/6506 , C07F9/650905 , C07F9/650947 , C07F9/6512 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04 , G01N2500/20
摘要： Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
摘要翻译： 提供了用于鉴定被羧基酯或膦酸酯基取代的抗HIV治疗化合物的方法。 可以使用新型GS-7340酯水解酶来筛选这些化合物的文库。 还提供了与GS-7340酯水解酶有关的组合物和方法。
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公开(公告)号：US20050197320A1
公开(公告)日：2005-09-08
申请号：US10424130
申请日：2003-04-25
申请人： James Chen , Xiaowu Chen , Choung Kim , William Lee , Christopher Lee , Peter Nelson , James Tario , Lianhong Xu
发明人： James Chen , Xiaowu Chen , Choung Kim , William Lee , Christopher Lee , Peter Nelson , James Tario , Lianhong Xu
IPC分类号： C12N9/99 , A61K31/4155 , A61K31/66 , A61K31/665 , A61K31/675 , A61P31/18 , A61P43/00 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/48 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F20060101 , C07F9/02 , C07F9/38 , C07F9/40 , C07F9/44 , C07F9/58 , C07F9/62 , C07F9/645 , C07F9/6506 , C07F9/6509 , C07F9/6512 , C07F9/653 , C07F9/6533 , C07F9/655 , C07F9/6558 , C07F9/6561 , C07F9/6584 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C12Q1/70 , G01N33/04 , G01N33/50
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/58 , C07F9/645 , C07F9/6506 , C07F9/650905 , C07F9/650947 , C07F9/6512 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： Phosphorus-substituted imidazole compounds with anti-HIV properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit reverse transcriptase activity and are useful therapeutically for the inhibition of such enzymes, as well as in assays for the detection of such enzymes.
摘要翻译： 公开了具有用作治疗剂和其它工业目的的具有抗HIV性质的磷取代的咪唑化合物。 组合物抑制逆转录酶活性，并且可用于抑制这些酶以及用于检测这些酶的测定中。
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公开(公告)号：US06294573B1
公开(公告)日：2001-09-25
申请号：US09492567
申请日：2000-01-27
申请人： Michael L. Curtin , Yujia Dai , Steven K. Davidsen , Joseph F. Dellaria, Jr. , Alan S. Florjancic , Jianchun Gong , Yan Guo , Howard R. Heyman , James H. Holms , Michael R. Michaelides , Jamie R. Stacey , Douglas H. Steinman , Carol K. Wada , Lianhong Xu
发明人： Michael L. Curtin , Yujia Dai , Steven K. Davidsen , Joseph F. Dellaria, Jr. , Alan S. Florjancic , Jianchun Gong , Yan Guo , Howard R. Heyman , James H. Holms , Michael R. Michaelides , Jamie R. Stacey , Douglas H. Steinman , Carol K. Wada , Lianhong Xu
IPC分类号： C07C25537
CPC分类号： C07D263/04 , C07D207/09 , C07D207/48 , C07D307/14 , C07D317/28
摘要： Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：US09575080B2
公开(公告)日：2017-02-21
申请号：US12528185
申请日：2008-02-22
申请人： Manoj C. Desai , Hongtao Liu , Lianhong Xu
发明人： Manoj C. Desai , Hongtao Liu , Lianhong Xu
IPC分类号： C07D277/28 , C07D277/30 , C07D417/14 , A61K31/5377 , A61K31/496 , A61K31/427 , G01N33/94 , A61K45/06 , G01N33/58
摘要： The present application provides for a compound of Formula IV, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
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公开(公告)号：US09102614B2
公开(公告)日：2015-08-11
申请号：US13806067
申请日：2011-07-01
申请人： Kerim Babaoglu , Elizabeth Bacon , Kyla Bjornson , Hongyan Guo , Randall L. Halcomb , Paul Hrvatin , John O. Link , Hongtao Liu , Ryan Mcfadden , Michael L. Mitchell , Paul Roethle , James Taylor , James D. Trenkle , Randall W. Vivian , Lianhong Xu
发明人： Kerim Babaoglu , Elizabeth Bacon , Kyla Bjornson , Hongyan Guo , Randall L. Halcomb , Paul Hrvatin , John O. Link , Hongtao Liu , Ryan Mcfadden , Michael L. Mitchell , Paul Roethle , James Taylor , James D. Trenkle , Randall W. Vivian , Lianhong Xu
IPC分类号： C07D295/073 , C07D295/155 , C07D493/04 , C07D311/20 , C07D311/58 , C07D239/34 , C07D239/36 , C07D231/12 , C07D213/64 , C07D213/73 , C07D213/65 , C07D205/04 , C07D215/14 , C07C59/64 , C07D211/48 , C07D215/04 , C07D233/58 , C07D241/12 , C07D309/10 , C07D491/06 , C07C229/34 , C07C233/47 , C07C255/57 , C07C271/22 , C07C311/16 , C07D239/26 , C07D239/42 , C07D487/04
CPC分类号： C07C59/64 , C07C229/34 , C07C233/47 , C07C255/57 , C07C271/22 , C07C311/16 , C07D205/04 , C07D211/48 , C07D213/64 , C07D213/65 , C07D213/73 , C07D215/04 , C07D215/14 , C07D231/12 , C07D233/58 , C07D239/26 , C07D239/34 , C07D239/36 , C07D239/42 , C07D241/12 , C07D295/073 , C07D295/155 , C07D309/10 , C07D311/20 , C07D311/58 , C07D487/04 , C07D491/06 , C07D493/04
摘要： The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula (I).
摘要翻译： 本发明提供了本文所述的式（I）化合物或其盐。 本发明还提供了包含式I化合物的药物组合物，制备式（I）化合物的方法，用于制备式I化合物的中间体和治疗HIV病毒增殖的治疗方法，治疗AIDS或延迟 使用式（I）化合物的哺乳动物中的AIDS或ARC症状。
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公开(公告)号：US20140249074A1
公开(公告)日：2014-09-04
申请号：US14280478
申请日：2014-05-16
申请人： Elizabeth M. Bacon , Eda Canales , Aesop Cho , Jeromy J. Cottell , Manoj C. Desai , Michael Graupe , Hongyan Guo , Randall L. Halcomb , Darryl Kato , Choung U. Kim , Thorsten A. Kirschberg , Evan S. Krygowski , Scott E. Lazerwith , John O. Link , Hongtao Liu , Qi Liu , Richard L. Mackman , Michael L. Mitchell , Jay P. Parrish , Hyung-Jung Pyun , Joseph H. Saugier , Scott D. Schroeder , Jianyu Sun , James G. Taylor , James D. Trenkle , Winston C. Tse , Randall W. Vivian , William J. Watkins , Lianhong Xu
发明人： Elizabeth M. Bacon , Eda Canales , Aesop Cho , Jeromy J. Cottell , Manoj C. Desai , Michael Graupe , Hongyan Guo , Randall L. Halcomb , Darryl Kato , Choung U. Kim , Thorsten A. Kirschberg , Evan S. Krygowski , Scott E. Lazerwith , John O. Link , Hongtao Liu , Qi Liu , Richard L. Mackman , Michael L. Mitchell , Jay P. Parrish , Hyung-Jung Pyun , Joseph H. Saugier , Scott D. Schroeder , Jianyu Sun , James G. Taylor , James D. Trenkle , Winston C. Tse , Randall W. Vivian , William J. Watkins , Lianhong Xu
IPC分类号： A61K31/4184 , A61K45/06
CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US20140045818A1
公开(公告)日：2014-02-13
申请号：US14112473
申请日：2012-04-20
申请人： Michael L. Mitchell , Paul A. Roethle , Lianhong Xu , Hong Yang , Ryan McFadden , Kerim Babaoglu
发明人： Michael L. Mitchell , Paul A. Roethle , Lianhong Xu , Hong Yang , Ryan McFadden , Kerim Babaoglu
IPC分类号： C07D491/052 , A61K45/06 , C07D277/82 , A61K31/4741 , C07D277/64 , A61K31/428
CPC分类号： C07D491/06 , A61K9/0019 , A61K9/12 , A61K9/20 , A61K9/48 , A61K31/428 , A61K31/4741 , A61K45/06 , C07D277/62 , C07D277/64 , C07D277/82 , C07D417/04 , C07D417/10 , C07D491/052
摘要： The invention provides compounds of formula I: or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula I.
摘要翻译： 本发明提供了本文所述的式I化合物或其盐。 本发明还提供了包含式I化合物的药物组合物，制备式I化合物的方法，可用于制备式I化合物的中间体和用于治疗HIV病毒增殖，治疗AIDS或延迟AIDS发作的治疗方法或 哺乳动物使用式I化合物的ARC症状。
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公开(公告)号：US20140039021A1
公开(公告)日：2014-02-06
申请号：US14045717
申请日：2013-10-03
申请人： Elizabeth Bacon , Eda Canales , Aesop Cho , Jeromy Cottell , Mano Desai , Michael Graupe , Hongyan Guo , Randall Halcomb , Darryl Kato , Choung U. Kim , Thorsten A. Kirschberg , Evan Krygowski , Scott Lazerwith , John Link , Hongtao Liu , Qi Liu , Richard Mackman , Michael Mitchell , Jay Parrish , Hyung-Jung Pyun , Joseph Saugier , Scott Schroeder , Jianyu Sun , James Taylor , James Trenkle , Winston Tse , Randall Vivian , William Watkins , Lianhong Xu
发明人： Elizabeth Bacon , Eda Canales , Aesop Cho , Jeromy Cottell , Mano Desai , Michael Graupe , Hongyan Guo , Randall Halcomb , Darryl Kato , Choung U. Kim , Thorsten A. Kirschberg , Evan Krygowski , Scott Lazerwith , John Link , Hongtao Liu , Qi Liu , Richard Mackman , Michael Mitchell , Jay Parrish , Hyung-Jung Pyun , Joseph Saugier , Scott Schroeder , Jianyu Sun , James Taylor , James Trenkle , Winston Tse , Randall Vivian , William Watkins , Lianhong Xu
IPC分类号： C07D403/14
CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及抗病毒化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US08354421B2
公开(公告)日：2013-01-15
申请号：US12215264
申请日：2008-06-26
申请人： Gong-Xin He , Choung U. Kim , Michael L. Mitchell , Lianhong Xu
发明人： Gong-Xin He , Choung U. Kim , Michael L. Mitchell , Lianhong Xu
IPC分类号： A61K31/505 , C07F9/09 , C07D239/08
CPC分类号： C07D239/54
摘要： The invention is related to compounds of Formula (I): or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，酯和/或膦酸盐，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法。
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