公开(公告)号：US20090117196A1

公开(公告)日：2009-05-07

申请号：US12348867

申请日：2009-01-05

Applicant: Egisto Boschetti

Inventor： Egisto Boschetti

IPC: A61K9/14

CPC classification number: A61K9/1635 ,  A61K47/6927

Abstract: The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present invention relates to a process for producing the polyvinylalcohol microspheres.

Abstract translation: 本发明涉及包含聚乙烯醇的栓塞用微球。 本发明还涉及适用于栓塞的可注射悬浮液，其包含聚乙烯醇微球和合适的液体载体。 本发明还涉及一种用于预防或治疗性栓塞的方法，其包括向哺乳动物施用含有聚乙烯醇微球和适合的液体载体的可注射悬浮液。 最后，本发明涉及聚乙烯醇微球的制造方法。

公开(公告)号：US20070151910A1

公开(公告)日：2007-07-05

申请号：US10583509

申请日：2005-01-14

Applicant: Egisto Boschetti ,  Pierre Girot

Inventor： Egisto Boschetti ,  Pierre Girot

IPC: B01D15/08

CPC classification number: B01J39/26 ,  B01D15/327 ,  B01D15/361 ,  B01D15/362 ,  B01J20/289 ,  B01J20/3242 ,  B01J20/3285 ,  B01J41/20 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00702 ,  B01J2219/0074 ,  B01J2220/54 ,  C07K1/16 ,  C07K1/18 ,  G01N30/02 ,  G01N33/54353 ,  G01N2035/00158 ,  Y10S435/803

Abstract: Ion exchange and hydrophobic interaction chromatographic materials are constructed by tethering a terminal binding functionality to a solid support via a hydrophobic linker. The backbone of the linker typically comprises sulfur-containing moieties. Suitable terminal binding functionalities are tertiary amines, quaternary ammonium salts, or hydrophobic groups. These chromatographic materials possess both hydrophobic and ionic character under the conditions prescribed for their use. The separation of proteins from crude mixtures at physiological ionic strength can be accomplished with a chromatographic material of this type by applying pH or ionic strength gradients, thereby effecting protein adsorption and desorption.

Abstract translation: 离子交换和疏水相互作用层析材料是通过一个疏水性接头将末端结合官能团连接到固体支持物构成的。 接头的骨架通常包含含硫部分。 合适的末端结合官能团是叔胺，季铵盐或疏水基团。 这些色谱材料在规定的条件下具有疏水性和离子性。 通过施加pH或离子强度梯度，可以用这种类型的色谱材料在生理离子强度下从粗混合物中分离蛋白质，从而进行蛋白质吸附和解吸。

公开(公告)号：US20070142629A1

公开(公告)日：2007-06-21

申请号：US10558649

申请日：2005-06-16

Applicant: Luc Guerrier ,  Egisto Boschetti ,  Frederic Fortis

Inventor： Luc Guerrier ,  Egisto Boschetti ,  Frederic Fortis

IPC: C07K1/12

CPC classification number: G01N33/6803 ,  B01D15/1871 ,  B01D15/327 ,  B01D15/361 ,  B01D15/3804 ,  B01D15/3809 ,  B01D15/3847 ,  B01J20/28052 ,  B01J20/3242 ,  B01J2220/54 ,  B01J2220/603 ,  C07K1/16 ,  C07K1/36 ,  G01N27/44773 ,  G01N33/6842 ,  G01N2030/027

Abstract: Methods, apparatuses, and kits for fractionating complex mixtures of biological molecules are provided. In one aspect the methods provided include providing a series of different sorbents, introducing the complex mixture to the series of sorbents, contacting serially the complex mixture with each of the sorbents, and capturing biomolecular components from the complex mixture on the sorbents so that each of the sorbents captures a substantially unique subset of said plurality of biomolecular components.

Abstract translation: 提供了用于分离生物分子的复杂混合物的方法，装置和试剂盒。 在一个方面，提供的方法包括提供一系列不同的吸附剂，将复杂混合物引入到一系列吸附剂中，将复合混合物与每种吸附剂连续地接触，并从吸附剂上的复合物混合物捕获生物分子组分， 吸附剂捕获所述多个生物分子组分的基本独特的子集。

公开(公告)号：US20070059776A1

公开(公告)日：2007-03-15

申请号：US11499898

申请日：2006-08-03

Applicant: Egisto Boschetti ,  Lisa Bradbury ,  Huw Davies ,  Lee Lomas ,  Thang Pham ,  Vanitha Thulasiraman ,  Tai-Tung Yip

Inventor： Egisto Boschetti ,  Lisa Bradbury ,  Huw Davies ,  Lee Lomas ,  Thang Pham ,  Vanitha Thulasiraman ,  Tai-Tung Yip

IPC: G01N33/567 ,  G01N33/53

CPC classification number: G01N33/6842 ,  C07K1/16 ,  C07K1/18 ,  C07K1/20 ,  C07K1/22 ,  G01N33/6803 ,  G01N2030/8411 ,  H01J49/00 ,  H01J49/0418 ,  G01N30/7233

Abstract: The invention provides methods of monitoring the production of a target polypeptide by generating surface enhanced laser desorption/ionization mass spectral profiles of samples taken from multiple cell culture batches or of samples taken at different times from a given batch. The invention additionally provides methods for monitoring the purification of a target polypeptide from a mixture by generating surface enhanced laser desorption/ionization mass spectral profiles of samples taken at various times during a purification process. In addition, the invention relates to methods of identifying conditions that can be used in increasing the scale of a given purification process.

Abstract translation: 本发明提供了通过产生从多个细胞培养物批次或从给定批次的不同时间采集的样品获取的样品的表面增强的激光解吸/电离质谱图来监测目标多肽的产生的方法。 本发明另外提供了通过产生在纯化过程中的不同时间采集的样品的表面增强的激光解吸/电离质谱图来监测来自混合物的目标多肽的纯化的方法。 此外，本发明涉及鉴定可用于增加给定纯化方法的规模的条件的方法。

公开(公告)号：US07060298B2

公开(公告)日：2006-06-13

申请号：US10029294

申请日：2001-12-28

Applicant: Jean Marie Vogel ,  Richard Thomas ,  Egisto Boschetti

Inventor： Jean Marie Vogel ,  Richard Thomas ,  Egisto Boschetti

IPC: A61K9/14 ,  A61K9/16 ,  A61K9/00

CPC classification number: A61K9/0034 ,  A61K9/1635 ,  A61K9/1641 ,  A61K47/62 ,  A61K47/6927 ,  A61K49/0442 ,  A61K49/048

Abstract: The invention encompasses the treatment of urinary incontinence, gastroesophageal reflux disease and the amelioration of skin wrinkles using biocompatible hydrophilic cationic microparticles and a cell adhesion promoter.

Abstract translation: 本发明包括使用生物相容的亲水性阳离子微粒和细胞粘附促进剂治疗尿失禁，胃食管反流疾病和改善皮肤皱纹。

公开(公告)号：US20050214815A1

公开(公告)日：2005-09-29

申请号：US11014225

申请日：2004-12-17

Applicant: Egisto Boschetti ,  Luc Bourgeois

Inventor： Egisto Boschetti ,  Luc Bourgeois

IPC: B01D15/36 ,  B01J20/32 ,  B01J39/26 ,  B01J41/20 ,  B01J47/00 ,  C12Q1/68

CPC classification number: B01J39/26 ,  B01D15/361 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3217 ,  B01J20/3219 ,  B01J20/3221 ,  B01J20/3257 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3289 ,  B01J41/20 ,  B01J47/016 ,  B01J2220/54 ,  G01N33/54393 ,  G01N33/6851

Abstract: In relation to a chromatographic chip, for protein separation, a polymer surface is provided that has a first polymer layer, attached to a support surface, which can be anionic or cationic. To the first layer is attached a second polymer layer, characterized by an opposite charge.

Abstract translation: 关于色谱芯片，对于蛋白质分离，提供聚合物表面，其具有连接到支撑表面的第一聚合物层，其可以是阴离子或阳离子的。 第一层附着有第二聚合物层，其特征在于相反的电荷。

公开(公告)号：US6045697A

公开(公告)日：2000-04-04

申请号：US200884

申请日：1998-11-30

Applicant: Pierre Girot ,  Egisto Boschetti

Inventor： Pierre Girot ,  Egisto Boschetti

IPC: B01D15/08 ,  B01J20/32

CPC classification number: B01D15/08 ,  B01D15/20 ,  B01J20/28004 ,  B01J20/28057 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/288 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/327 ,  B01J20/3282 ,  B01J20/3289 ,  B01J39/26 ,  B01J41/20 ,  B01J2220/54 ,  B01J2220/58

Abstract: This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous supports are disclosed which are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by use of a passivation mixture comprising a main monomer, a passivating agent comprising polyethyleneimine, and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction with biomolecules.

Abstract translation: 本发明一般涉及改性多孔固体载体及其制备和使用方法。 特别地，公开了钝化多孔载体，其特征在于基本上不伴随生物分子的非特异性吸附或相互作用的可逆高吸附能力。 通过使用包含主单体，包含聚乙烯亚胺的钝化剂和交联剂的钝化混合物来实现钝化，该聚合物上的该混合物导致基本上消除了与生物分子的不期望的非特异性相互作用。

公开(公告)号：US5648100A

公开(公告)日：1997-07-15

申请号：US471303

申请日：1995-06-06

Applicant: Egisto Boschetti ,  Michel Brouard ,  Ludovic Drouet ,  Pierre Girot ,  Alexandre Laurent ,  Michel Wassef

Inventor： Egisto Boschetti ,  Michel Brouard ,  Ludovic Drouet ,  Pierre Girot ,  Alexandre Laurent ,  Michel Wassef

IPC: A61K9/50 ,  A61K9/16 ,  A61K31/715 ,  A61K31/726 ,  A61K31/78 ,  A61K38/00 ,  A61K38/16 ,  A61K38/17 ,  A61K49/00 ,  A61L24/06 ,  A61P9/00 ,  A61K9/14

CPC classification number: A61L24/06 ,  A61K9/1676 ,  A61L2400/06 ,  A61L2430/36

Abstract: The present invention concerns the use of microspheres for therapeutic embolization consisting of a hydrophilic acrylic copolymer coated with a cell adhesion promoter.

Abstract translation: 本发明涉及微球用于治疗栓塞的用途，其由涂覆有细胞粘附促进剂的亲水丙烯酸共聚物组成。

公开(公告)号：US5445732A

公开(公告)日：1995-08-29

申请号：US254625

申请日：1994-06-06

Applicant: Pierre Girot ,  Egisto Boschetti

Inventor： Pierre Girot ,  Egisto Boschetti

IPC: B01D15/08 ,  B01J20/32 ,  B01J39/16

CPC classification number: B01D15/20 ,  B01J20/28004 ,  B01J20/28057 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/288 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/327 ,  B01J20/3282 ,  B01J20/3289 ,  B01J39/165 ,  B01D15/3804 ,  B01J2220/54 ,  B01J2220/58

Abstract: This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous polymeric supports are disclosed which are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by use of a passivation mixture comprising a main monomer, a passivating monomer that is different from the main monomer, and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction with biomolecules.

Abstract translation: 本发明一般涉及改性多孔固体载体及其制备和使用方法。 特别地，公开了钝化的多孔聚合物载体，其特征在于基本上不伴随生物分子的非特异性吸附或相互作用的可逆的高吸附能力。 通过使用包含主单体，不同于主单体的钝化单体和交联剂的钝化混合物实现钝化，该聚合物上的该混合物导致基本上消除了与生物分子的不期望的非特异性相互作用。

公开(公告)号：US5075371A

公开(公告)日：1991-12-24

申请号：US619822

申请日：1990-11-29

Applicant: Egisto Boschetti ,  Pierre Girot

Inventor： Egisto Boschetti ,  Pierre Girot

IPC: B01J20/281 ,  B01D15/08 ,  B01J20/26 ,  B01J20/285 ,  B01J41/08 ,  C08F2/44 ,  C08K3/36 ,  C08L33/00 ,  C08L33/04 ,  G01N30/88

CPC classification number: C08K3/36 ,  B01D15/08 ,  B01J20/26 ,  C08F2/44 ,  Y10S524/903

Abstract: A homogeneous composite polymer containing, in an interpenetrated form, 20% to 80% by weight of silica and 80% to 20% by weight of a three-dimensional crosslinked acrylic, vinyl and/or allyl copolymer comprising, in a copolymerized form, 98% to 70% by weight of at least one monofunctional acrylic, vinyl or allyl monomer and 2% to 30% by weight of a difunctional acrylic or allyl crosslinking monomer is useful in liquid chromatography.