公开(公告)号：US10080374B2

公开(公告)日：2018-09-25

申请号：US14126540

申请日：2012-06-14

Applicant: Terhi Aaltonen ,  Päivi Myllärinen ,  Ilkka Huumonen ,  Emmi Martikainen

Inventor： Terhi Aaltonen ,  Päivi Myllärinen ,  Ilkka Huumonen ,  Emmi Martikainen

IPC: A23C9/12 ,  A23C19/00 ,  A23C19/068 ,  A23C19/032 ,  A23C19/05

CPC classification number: A23C19/068 ,  A23C19/0328 ,  A23C19/05 ,  A23C2210/202 ,  A23C2210/252 ,  C12Y203/02013

Abstract: The present invention relates to a process for producing cheese, comprising the steps of: providing a first raw material liquid; providing a second raw material liquid; treating the first raw material liquid with a protein crosslinking enzyme to provide an enzyme-treated raw material liquid; mixing the enzyme-treated raw material liquid with the second raw material liquid to provide cheese milk; processing the cheese milk into cheese. The process produces cheese in improved yields while retaining the organoleptic properties of cheese unchanged. The invention further relates to cheese treated with a protein crosslinking enzyme, having the moisture on a fat-free basis of 67% or less and a protein profile of cheese has proteins of molecular weight of less than 66 kDa.

公开(公告)号：US20180199585A1

公开(公告)日：2018-07-19

申请号：US15817109

申请日：2017-11-17

Applicant: Karsten Bruun QVIST ,  Jeppe Wegner TAMS ,  Merete FAERGEMAND ,  Christel GARRIGUES ,  Per Munk NIELSEN

Inventor： Karsten Bruun QVIST ,  Jeppe Wegner TAMS ,  Merete FAERGEMAND ,  Christel GARRIGUES ,  Per Munk NIELSEN

IPC: A23C9/127 ,  A23C9/12 ,  A23C9/13

CPC classification number: A23C9/1275 ,  A23C9/1209 ,  A23C9/1216 ,  A23C9/1322 ,  A23Y2220/00 ,  C12Y203/02013

Abstract: The present invention relates to a method for producing an acidified milk product using an enzyme having transglutaminase activity.

公开(公告)号：US20180169297A1

公开(公告)日：2018-06-21

申请号：US15735270

申请日：2016-06-10

Applicant: Laboratoire Français du Fractionnement et des Biotechnologies

Inventor： Abdessatar Chtourou ,  Jean-Luc Plantier ,  Philippe Mondon

IPC: A61L27/20 ,  A61K8/73 ,  A61L27/22 ,  A61K8/66 ,  A61K8/64 ,  A61K8/42 ,  A61Q19/08

CPC classification number: A61L27/20 ,  A61K8/42 ,  A61K8/64 ,  A61K8/66 ,  A61K8/735 ,  A61K9/0019 ,  A61K31/167 ,  A61K38/363 ,  A61K38/45 ,  A61K38/4846 ,  A61K47/36 ,  A61K2800/91 ,  A61L27/225 ,  A61L27/227 ,  A61L2300/402 ,  A61Q19/08 ,  C12Y203/02013 ,  C12Y304/21021 ,  A61K2300/00

Abstract: The present invention concerns an injectable composition comprising FVII and a filler, and its use for preventing or treating body and skin defects, especially folds, wrinkles, skin depressions and scars, while diminishing, decreasing or avoiding skin reactions due to injection, specially redness, ecchymosis, bruising, bleeding, erythema, oedema, necrosis, ulceration, swelling and/or inflammation.

公开(公告)号：US20180011093A1

公开(公告)日：2018-01-11

申请号：US15710334

申请日：2017-09-20

Applicant: Bio-Rad Laboratories, Inc.

Inventor： David King ,  William F. Link ,  Renato del Rosario ,  Michael Leos

IPC: G01N33/569 ,  C12N9/10 ,  C12N11/14 ,  G01N33/543

CPC classification number: G01N33/543 ,  C12N9/1044 ,  C12N11/14 ,  C12Y203/02013 ,  G01N33/54393 ,  G01N33/56988

Abstract: The present disclosure provides compositions and methods that are useful for normalizing the amount of signal detected in an assay, such as an immunoassay. The compositions and methods are useful for improving the accuracy of immunoassays, such as immunoassays that detect whether a subject is infected with a retrovirus such as HIV.

公开(公告)号：US20170354637A1

公开(公告)日：2017-12-14

申请号：US15180552

申请日：2016-06-13

Applicant: Orthopeutics, LP

Inventor： Matthew E. Brown ,  Thomas P. Hedman

IPC: A61K31/352 ,  A61K47/34 ,  A61K9/70 ,  A61K47/02 ,  A61K31/121 ,  A61K38/45 ,  A61K31/353 ,  A61K31/15 ,  A61K9/00

CPC classification number: A61K31/352 ,  A61K9/0019 ,  A61K9/006 ,  A61K31/121 ,  A61K31/15 ,  A61K31/353 ,  A61K31/538 ,  A61K31/7004 ,  A61K38/45 ,  A61K47/02 ,  A61K47/34 ,  C12Y203/02013

Abstract: The present invention relates to administration or application of a crosslink inducing agent to a subject following a stiffening procedure to the respiratory system. The present invention has identified that such application or administration of a crosslinking reagent to fibrotic tissue allows for improved stability and strength of the tissue.

公开(公告)号：US20170319746A1

公开(公告)日：2017-11-09

申请号：US15535322

申请日：2014-12-12

Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)

Inventor： Matthias Lutolf ,  Andrea Negro

IPC: A61L27/38 ,  C12P19/04 ,  B33Y70/00 ,  B33Y80/00 ,  B29C64/40 ,  A61L27/26 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  C08J3/075 ,  C09D105/04 ,  C09D171/02 ,  C12N9/10 ,  C12N5/077 ,  C12N5/00 ,  C12M1/00 ,  C12M3/06 ,  C12M3/00 ,  B33Y10/00 ,  B29K71/00 ,  B29C64/112 ,  B29K105/00

CPC classification number: A61L27/3804 ,  A61L27/18 ,  A61L27/20 ,  A61L27/26 ,  A61L27/38 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L27/60 ,  A61L2300/414 ,  A61L2400/18 ,  A61L2430/00 ,  B29C64/112 ,  B29C64/40 ,  B29K2071/02 ,  B29K2105/0061 ,  B29K2995/0056 ,  B32B2556/00 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00 ,  C08J3/075 ,  C08J2305/04 ,  C08J2371/02 ,  C09D11/102 ,  C09D11/14 ,  C09D105/04 ,  C09D171/02 ,  C12M21/08 ,  C12M23/16 ,  C12M23/30 ,  C12M25/14 ,  C12M29/10 ,  C12M33/00 ,  C12N5/0062 ,  C12N5/0656 ,  C12N9/1044 ,  C12N2513/00 ,  C12N2533/74 ,  C12N2537/10 ,  C12P19/04 ,  C12Y203/02013 ,  C12Y402/02003 ,  C08L71/02 ,  C08L5/04

Abstract: A composition comprising a first material and a second material, wherein said first material is cross-linkable by a first cross-linking reaction and said second material is cross-linkable by a second cross-linking reaction, wherein said first cross-linking reaction and said second cross-linking reaction are inducible by a common activator.

公开(公告)号：US09730458B2

公开(公告)日：2017-08-15

申请号：US12312240

申请日：2007-10-29

Applicant: Mauro Rossi ,  Carmela Gianfrani ,  Rosa Anna Siciliano

Inventor： Mauro Rossi ,  Carmela Gianfrani ,  Rosa Anna Siciliano

IPC: A21D6/00 ,  A21D2/26 ,  A23J3/34 ,  A23L5/20 ,  A23L7/104 ,  A23L33/18 ,  A21D2/00

CPC classification number: A21D2/268 ,  A21D2/265 ,  A21D6/00 ,  A23J3/346 ,  A23L5/25 ,  A23L7/107 ,  A23L33/18 ,  C12Y203/02013

Abstract: The present invention relates to the use of an enzymatic method for treating flour, semolina and protein extracts derived from cereals known to stimulate a pathological immune response in patients affected by Celiac Disease (CD). Said treatment drastically reduces or completely eliminates the toxicity of gluten or similar products derived from other cereals. The method uses the catalytic activity of microbial transglutaminase and, in particular, its ability to bind proteins in cereal flour or semolina to an alkylated (C1-C4) derivative of lysine. After the treatment said proteins extracted from flour show a substantially lowered immuno-stimulatory activity in celiac patients T lymphocytes.

公开(公告)号：US20160160186A1

公开(公告)日：2016-06-09

申请号：US14605320

申请日：2015-01-26

Applicant: SynPhaGen LLC.

Inventor： Todd Bernard PARSLEY ,  Christian Furlan FREGUIA

IPC: C12N7/00 ,  C02F3/34 ,  C12N15/63 ,  A01N63/00 ,  C12N15/113

CPC classification number: C02F3/34 ,  A01N63/02 ,  A61K38/2066 ,  A61K38/45 ,  A61K38/482 ,  A61K48/005 ,  C12N7/00 ,  C12N15/111 ,  C12N15/113 ,  C12N15/70 ,  C12N15/86 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/32 ,  C12N2330/50 ,  C12N2795/00021 ,  C12N2795/00031 ,  C12N2795/00032 ,  C12N2795/00043 ,  C12N2795/14143 ,  C12N2820/55 ,  C12Y201/02001 ,  C12Y203/02013

Abstract: Compositions for a phage particle are disclosed. The phage particle is non-replicating and includes at least one heterologous nucleic acid sequence that is capable of being expressed in a target bacteria. The expressed heterologous nucleic acid sequence is non-lethal to the target bacteria.

Abstract translation: 公开了噬菌体颗粒的组合物。 噬菌体颗粒是非复制型的，并且包括能够在靶细菌中表达的至少一种异源核酸序列。 表达的异源核酸序列对靶细菌是非致死的。

公开(公告)号：US09260680B2

公开(公告)日：2016-02-16

申请号：US11666718

申请日：2005-11-10

Applicant: Ralf Pasternack ,  Stefan Marx ,  Dominik Jordan

Inventor： Ralf Pasternack ,  Stefan Marx ,  Dominik Jordan

IPC: A23L2/84 ,  C12C5/00 ,  A23L1/015 ,  A23L1/30 ,  C12C12/00

CPC classification number: C12C5/004 ,  A23L2/84 ,  A23L5/25 ,  A23L33/135 ,  C12C12/00 ,  C12Y101/03005 ,  C12Y110/03002 ,  C12Y111/01007 ,  C12Y114/18001 ,  C12Y203/02013 ,  C12Y503/04001

Abstract: A process for the preparation of a beverage, a beverage base, a beverage concentrate or a beverage additive having a reduced prolamin content from prolamin-containing raw materials, comprising the following steps: a) contacting the beverage or a precursor of the beverage with cross-linking enzymes to obtain modified prolamin; b) removing the modified prolamin at least partially.

Abstract translation: 一种用于制备饮酒，饮料基料，饮料浓缩物或具有从含醇溶蛋白原料中降低的醇溶蛋白含量的饮料添加剂的方法，包括以下步骤：a）使饮料或饮料的前体与十字 连接酶获得改性醇溶蛋白; b）至少部分地去除改性的醇溶醇。

公开(公告)号：US20160040141A1

公开(公告)日：2016-02-11

申请号：US14923749

申请日：2015-10-27

Applicant: Amano Enzyme Inc.

Inventor： Masamichi Okada ,  Yoshiaki Kurono ,  Hitoshi Amano ,  Shotaro Yamaguchi

IPC: C12N9/10

CPC classification number: C12N9/1044 ,  C12N9/96 ,  C12Y203/02013

Abstract: Disclosed is a transglutaminase having excellent stability. Also disclosed is a process for producing the transglutaminase. Specifically disclosed is a stabilized transglutaminase, which has such a structure in which a pro-sequence peptide of transglutaminase is bound to a mature transglutaminase. Also specifically disclosed is a process for producing stabilized transglutaminase, which includes the steps of culturing a microorganism capable of producing transglutaminase under the conditions where transglutaminase can be produced; and separating and collecting matured transglutaminase having a pro-sequence peptide bound thereto from a culture medium.

Abstract translation: 公开了具有优异稳定性的转谷氨酰胺酶。 还公开了用于生产转谷氨酰胺酶的方法。 具体公开了一种稳定的转谷氨酰胺酶，其具有转谷氨酰胺酶的前序肽与成熟转谷氨酰胺酶结合的结构。 还具体公开了一种稳定的转谷氨酰胺酶的制造方法，其特征在于，在能够生产转谷氨酰胺酶的条件下培养能够生产转谷氨酰胺酶的微生物的步骤; 并从培养基中分离并收集与其结合的前序肽的成熟转谷氨酰胺酶。