公开(公告)号：US11913872B2

公开(公告)日：2024-02-27

申请号：US17167847

申请日：2021-02-04

Applicant: President and Fellows of Harvard College ,  Children's Medical Center Corporation

Inventor： Darren Yang ,  Andrew Ward ,  Wesley Philip Wong ,  Kenneth Anders Halvorsen

IPC: G01N21/07 ,  G01N33/53 ,  C12Q1/68 ,  C12Q1/6816 ,  G01N33/543 ,  G01N15/14 ,  G01N33/557 ,  G01N15/00 ,  G01N15/10 ,  B82Y15/00 ,  B04B13/00 ,  B04B15/02

CPC classification number: G01N21/07 ,  B82Y15/00 ,  C12Q1/68 ,  C12Q1/6816 ,  G01N15/1434 ,  G01N33/53 ,  G01N33/543 ,  G01N33/557 ,  B04B13/00 ,  B04B15/02 ,  G01N2015/0038 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2201/021 ,  G01N2201/0423 ,  G01N2201/0693 ,  G01N2203/0089 ,  C12Q1/68 ,  C12Q2523/303 ,  C12Q2525/30

Abstract: An apparatus for measuring a characteristic of a sample using a centrifuge and optical components is disclosed. The centrifuge may be a standard benchtop centrifuge. The optical components may be sized and dimensioned to fit, along with the sample, inside the centrifuge.

公开(公告)号：US20230160832A1

公开(公告)日：2023-05-25

申请号：US17997152

申请日：2021-05-20

Applicant: BSD ROBOTICS PTY LTD

Inventor： Andrew Stewart

IPC: G01N21/88 ,  G01N21/01 ,  G01N33/48 ,  G01N35/00

CPC classification number: G01N21/88 ,  G01N21/01 ,  G01N33/48 ,  G01N35/00732 ,  G01N2201/10 ,  G01N2035/00752 ,  G01N2201/0636 ,  G01N2201/121 ,  G01N2201/0693

Abstract: The present invention relates to a biological sample quality apparatus for determining the quality of a biological sample. The apparatus includes a sample receiver for receiving the biological sample. One or more light sources are provided for supplying light to the sample. An image sensor is provided for capturing an image of the lit sample. The apparatus also includes an image processor for image processing the captured image to determine the quality of the sample. Advantageously, image processing may be used to determine the quality of a sample for use in collection sites and screening laboratories so that acceptability can be determined prior to analyzing the sample. Determination that the sample is of sufficient quality (e.g. sufficient biomaterial) prior to analyzing saves wastage of laboratory time and expense of materials and chemicals. The apparatus may be in the form of desktop or hand-held portable variations.

公开(公告)号：US20170082593A1

公开(公告)日：2017-03-23

申请号：US15214608

申请日：2016-07-20

Applicant: Timothy J. Nedwed ,  Changyong Zhang ,  David A. Palandro

Inventor： Timothy J. Nedwed ,  Changyong Zhang ,  David A. Palandro

IPC: G01N33/28 ,  G01N21/31 ,  G01N21/59

CPC classification number: G01N33/2823 ,  G01N21/31 ,  G01N21/59 ,  G01N21/94 ,  G01N29/032 ,  G01N2021/0118 ,  G01N2201/0212 ,  G01N2201/0214 ,  G01N2201/0218 ,  G01N2201/0693 ,  G01N2201/0696 ,  G01N2291/0226 ,  G01N2291/048 ,  G01N2291/102 ,  G01V8/02

Abstract: Methods and systems for detecting oil proximate to a body of ice is disclosed herein. An example system includes an energy emitter disposed proximate to a first surface of a body of ice. An energy detector is disposed proximate to a second surface of the body of ice. The energy detector is used to map a distribution of oil proximate to the body of ice based, at least in part, on differences in energy transmitted through the body of ice.

公开(公告)号：US20150123000A1

公开(公告)日：2015-05-07

申请号：US14362944

申请日：2012-12-05

Applicant: GasSecure AS

Inventor： Håkon Sagberg ,  Britta Grennberg Fismen ,  Kari Anne Hestnes Bakke ,  Jon Tschudi ,  Ib-Rune Johansen ,  Knut Baeroe Sandven

IPC: G01N21/3504 ,  G01R27/26 ,  G01N21/31

CPC classification number: G01N21/3504 ,  G01N21/314 ,  G01N2021/317 ,  G01N2021/3513 ,  G01N2201/061 ,  G01N2201/0693 ,  G01N2201/0696 ,  G01N2201/128 ,  G01R27/2605

Abstract: A gas sensor for measuring concentration of a predetermined gas comprises a light source arranged to emit pulses of light, a measurement volume, a detector arranged to receive light that has passed through the measurement volume, and an adaptable filter disposed between the light source and the detector. The gas sensor has a measurement state in which it passes at least one wavelength band which is absorbed by the gas and a reference state in which said wavelength band is attenuated relative to the measurement state. The adaptable filter is arranged to change between one of said measurement state and said reference state to the other at least once during each pulse.

Abstract translation: 用于测量预定气体浓度的气体传感器包括布置成发射脉冲的光源，测量体积，被布置成接收已经通过测量体积的光的检测器，以及设置在光源和 探测器。 气体传感器具有测量状态，其中它通过被气体吸收的至少一个波长带和相对于测量状态使所述波长带衰减的参考状态。 适应滤波器被布置成在每个脉冲期间至少一次地在所述测量状态和所述参考状态中的一个之间改变另一个。

公开(公告)号：US08933384B2

公开(公告)日：2015-01-13

申请号：US13430316

申请日：2012-03-26

Applicant: Cagri A. Savran ,  Khalid M. Arif

Inventor： Cagri A. Savran ,  Khalid M. Arif

IPC: G02B27/00 ,  G02B7/00 ,  H01L27/00 ,  G01N21/55 ,  G02B21/00 ,  G02B21/18 ,  G02B21/36 ,  G01N21/47 ,  G01N21/64 ,  G01N21/65

CPC classification number: G01N21/55 ,  G01N21/4788 ,  G01N21/553 ,  G01N21/554 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/479 ,  G01N2021/558 ,  G01N2201/0221 ,  G01N2201/0693 ,  G02B21/0008 ,  G02B21/18 ,  G02B21/36

Abstract: A system for and method of performing multi-technique imaging. Such multi-technique imaging system includes a surface for supporting a specimen and at least two illumination sources for producing light radiation. The system also includes a plurality of reflective and refractive devices arranged to direct at least part of the light radiation from each of the at least two illumination sources to the surface such that at least part of the light radiation from each of the at least two illumination sources illuminates substantially the same area on the surface. The system also includes a sensor configured to receive light radiation from the at least two illumination sources reflected by the specimen and/or that pass by the specimen. The system also includes a power source configured to power the at least two illumination sources and the sensor.

Abstract translation: 一种执行多技术成像的系统和方法。 这种多技术成像系统包括用于支撑样本的表面和用于产生光辐射的至少两个照明源。 该系统还包括多个反射和折射装置，其布置成将来自至少两个照明源中的每一个的光辐射的至少一部分引导到表面，使得来自至少两个照射中的每一个的至少部分光辐射 光源基本上照射在表面上相同的区域。 该系统还包括被配置为接收来自由样本反射的至少两个照明源的光辐射和/或由样本通过的传感器。 该系统还包括被配置为对至少两个照明源和传感器供电的电源。

公开(公告)号：US08822929B2

公开(公告)日：2014-09-02

申请号：US13492415

申请日：2012-06-08

Applicant: Guillaume Nesa ,  Pierre Combet

Inventor： Guillaume Nesa ,  Pierre Combet

IPC: G01N33/497 ,  G01J5/02 ,  A61B5/00 ,  A61B5/08

CPC classification number: G01N33/497 ,  A61B5/082 ,  A61B5/097 ,  A61B5/4845 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/3504 ,  G01N33/4972 ,  G01N2021/0382 ,  G01N2021/158 ,  G01N2201/0221 ,  G01N2201/06186 ,  G01N2201/0693 ,  G01N2201/0696

Abstract: A portable breath analyzing device to measure the rate of partial gas that is exhaled in the breath fluid. The device includes a rechargeable power supply unit, a device to emit pulsated infrared radiation, an infrared receiver, and a measuring vessel. The emission device includes a heating element; the measuring vessel includes a metallic tube whose interior surface is polished and coated with a deposit that reflects at least the infrared radiation of wavelengths that are between (9 μm, 10 μm) and at each end of the tube, a nozzle comprising a cone-shaped section meant to be placed in the tube axis. The infrared emission device is placed on the longitudinal axis of the tube, at the level of one of the nozzles, and the receiver is placed on the longitudinal axis, at the level of the other nozzle.

Abstract translation: 便携式呼吸分析装置，用于测量在呼吸液中呼出的部分气体的速率。 该装置包括可再充电电源单元，发射脉动红外辐射的装置，红外接收器和测量容器。 发光装置包括加热元件; 测量容器包括金属管，其内表面被抛光并涂覆有至少反映在（9μm，10μm）之间的波长的红外辐射并且在每个端部处的红外辐射的沉积物， 意在放置在管轴上。 红外发射装置放置在管的纵向轴线上，在其中一个喷嘴的水平处，并且接收器放置在另一个喷嘴的水平面上的纵向轴线上。

公开(公告)号：US20130074577A1

公开(公告)日：2013-03-28

申请号：US13492415

申请日：2012-06-08

Applicant: Guillaume Nesa ,  Pierre Combet

Inventor： Guillaume Nesa ,  Pierre Combet

IPC: G01N33/497

CPC classification number: G01N33/497 ,  A61B5/082 ,  A61B5/097 ,  A61B5/4845 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/3504 ,  G01N33/4972 ,  G01N2021/0382 ,  G01N2021/158 ,  G01N2201/0221 ,  G01N2201/06186 ,  G01N2201/0693 ,  G01N2201/0696

Abstract: A portable breath analyzing device to measure the rate of partial gas that is exhaled in the breath fluid. The device includes a rechargeable power supply unit, a device to emit pulsated infrared radiation, an infrared receiver, and a measuring vessel. The emission device includes a heating element; the measuring vessel includes a metallic tube whose interior surface is polished and coated with a deposit that reflects at least the infrared radiation of wavelengths that are between (9 μm, 10 μm) and at each end of the tube, a nozzle comprising a cone-shaped section meant to be placed in the tube axis. The infrared emission device is placed on the longitudinal axis of the tube, at the level of one of the nozzles, and the receiver is placed on the longitudinal axis, at the level of the other nozzle.

Abstract translation: 便携式呼吸分析装置，用于测量在呼吸液中呼出的部分气体的速率。 该装置包括可再充电电源单元，发射脉动红外辐射的装置，红外接收器和测量容器。 发光装置包括加热元件; 测量容器包括金属管，其内表面被抛光并涂覆有至少反映在（9μm，10μm）之间的波长的红外辐射并且在每个端部处的红外辐射的沉积物， 意在放置在管轴上。 红外发射装置放置在管的纵向轴线上，在其中一个喷嘴的水平处，并且接收器放置在另一个喷嘴的水平面上的纵向轴线上。

公开(公告)号：US08379199B2

公开(公告)日：2013-02-19

申请号：US12513265

申请日：2007-11-01

Applicant: Robert P. Freese ,  Terrell K. Teague ,  David L. Perkins ,  William J. Soltmann

Inventor： Robert P. Freese ,  Terrell K. Teague ,  David L. Perkins ,  William J. Soltmann

IPC: G01J3/40

CPC classification number: G01J3/4338 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/0264 ,  G01N21/255 ,  G01N21/31 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/4738 ,  G01N2021/1793 ,  G01N2201/0691 ,  G01N2201/0693 ,  G01N2201/1293

Abstract: An optical analysis system for measuring compositions of a sample includes a light source radiating a first light. A modulator disposed in a ray path of the light modulates the light to a desired frequency. A spectral element filters the light for a spectral range of interest of the sample. An optical filter receives a first light beam split from the light reflecting from the sample and optically filters data carried by the first light beam into at least one orthogonal component of the first light beam. A first detector measures a property of the orthogonal component. A second detector receives a second light beam split from the light reflecting from the sample for comparison of the property of the orthogonal component to the second light beam. An accelerometer senses when to acquire data from the sample.

Abstract translation: 用于测量样品组成的光学分析系统包括辐射第一光的光源。 设置在光的射线路径中的调制器将光调制到期望的频率。 光谱元素对样品的感兴趣的光谱范围进行滤光。 滤光器接收从从样品反射的光分裂的第一光束，并且将由第一光束承载的数据光学滤波成第一光束的至少一个正交分量。 第一检测器测量正交分量的特性。 第二检测器接收从从样品反射的光分离的第二光束，用于比较正交分量与第二光束的性质。 加速度计检测何时从样品中获取数据。

公开(公告)号：US20110084842A1

公开(公告)日：2011-04-14

申请号：US12577768

申请日：2009-10-13

Applicant: Aviv Tzidon ,  Yehuda Yavets-Chen ,  Dekel Tzidon

Inventor： Aviv Tzidon ,  Yehuda Yavets-Chen ,  Dekel Tzidon

IPC: G08B21/00 ,  G01N21/00

CPC classification number: G01N21/4133 ,  G01N21/0303 ,  G01N21/274 ,  G01N21/29 ,  G01N33/28 ,  G01N33/2847 ,  G01N2021/0392 ,  G01N2021/4153 ,  G01N2201/0221 ,  G01N2201/0693 ,  G01N2201/0696 ,  G01N2201/12707 ,  G01N2201/12738

Abstract: An optical fluid tester device for testing a fluid sample in an ampoule includes an ampoule cradle, a radiation source, a radiation detector and an analyzer. The ampoule cradle supports the ampoule. The ampoule with the fluid sample serves as a lens whose focal properties are dependent on the index of refraction of the fluid sample. The radiation source irradiates the ampoule. The radiation detector is located opposite the radiation source so that the ampoule, when supported by the ampoule cradle, lies between the radiation source and the radiation detector. The detector serves to detect the intensity of the incident radiation. The analyzer verifies the composition of the fluid sample based on the detected intensity, which is dependent on the focal properties of the ampoule and is, therefore, indicative of the composition of the fluid sample.

Abstract translation: 用于在安瓿中测试流体样品的光学流体测试装置包括安瓿座，辐射源，辐射探测器和分析器。 安瓿座支撑安瓿。 具有流体样品的安瓿用作透镜，其焦点特性取决于流体样品的折射率。 辐射源照射安瓿。 放射线检测器位于辐射源的对面，使得当安瓿座支撑时，安瓿位于辐射源和辐射探测器之间。 检测器用于检测入射辐射的强度。 分析仪基于检测到的强度来验证流体样品的组成，其取决于安瓿的焦点特性，因此指示流体样品的组成。

公开(公告)号：US20100227386A1

公开(公告)日：2010-09-09

申请号：US12438725

申请日：2007-08-24

Applicant: Pavel Neuzil ,  Juergen Pipper ,  Lukas Novak

Inventor： Pavel Neuzil ,  Juergen Pipper ,  Lukas Novak

IPC: C12M1/34 ,  G01J1/58

CPC classification number: G01N21/645 ,  B01L3/5088 ,  B01L7/52 ,  B01L2200/147 ,  B01L2300/1827 ,  G01N21/0332 ,  G01N21/6428 ,  G01N21/76 ,  G01N21/763 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/0221 ,  G01N2201/0625 ,  G01N2201/0627 ,  G01N2201/0693

Abstract: A detection system is provided, the detection system comprising a light source that generates excitation light having a wavelength sufficient to excite a fluorophore in a sample; an excitation filter positioned along a first line along a path of the excitation light, the excitation filter transmitting the excitation light from the light source; a beam splitter positioned along the first line, the beam splitter reflecting the excitation light transmitted by the excitation filter along a second line toward a mirror positioned on one side of the beam splitter, and passing emitted light reflected along the second line; the mirror, positioned to reflect the excitation light from the beam splitter to the fluorophore in the sample along a third line, normal to both the first and second lines, wherein the mirror further reflects emitted light emitted along the third line, along the second line toward the beam splitter; an emission filter positioned along the second line, on a second side of the beam splitter; and a detector that detects the emitted light transmitted by the emission filter.

Abstract translation: 提供一种检测系统，所述检测系统包括产生具有足以激发样品中的荧光团的波长的激发光的光源; 激励滤光器，其沿着激励光的路径沿着第一线定位，所述激发滤光器透射来自所述光源的激发光; 分束器，沿着第一线定位，分束器将由激励滤光器透射的激发光沿着第二线反射到位于分束器一侧的反射镜，并且使沿着第二线反射的发射光反射; 所述反射镜被定位成将来自分束器的激发光沿着与第一和第二线垂直的第三线反射到样品中的荧光团，其中反射镜还沿着第二条线反射沿着第三条线发射的发射光 朝向分束器; 沿着所述第二线定位在所述分束器的第二侧上的发射滤光器; 以及检测由发射滤波器发射的发射光的检测器。