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185 条记录 (耗时 0.074 秒)

    Process for the preparation of a hot-melt extruded laminate
    51.
    发明授权
    Process for the preparation of a hot-melt extruded laminate 有权
    制备热熔挤出层压板的方法

    公开(公告)号：US08465759B2

    公开(公告)日：2013-06-18

    申请号：US12294372

    申请日：2007-03-22

    申请人： Michael M. Crowley ,  Justin M. Keen ,  John J. Koleng ,  Feng Zhang

    发明人： Michael M. Crowley ,  Justin M. Keen ,  John J. Koleng ,  Feng Zhang

    IPC分类号： A61F13/00 ,  A61K47/00 ,  A61L15/00 ,  B29C47/06 ,  B32B37/00

    CPC分类号： A61K9/7007 ,  A61K9/006 ,  A61K9/7069 ,  B29C47/0019 ,  B29C47/0021 ,  B29C47/065 ,  B29C47/0816 ,  B29C47/145 ,  B29C47/16 ,  B29K2105/0097 ,  B29K2995/0092 ,  B29K2995/0093

    摘要： A process for the preparation of a bioadhesive laminate comprising a hot-melt extruded reservoir layer and a hot-melt extruded backing layer is provided. The reservoir layer comprises a thermoplastic bioadhesive composition containing an active agent. An active agent-containing thermoplastic bioadhesive hydrophilic composition is hot-melt coextruded with a hydrophobic composition to form at least a bi-layered laminate. The hydrophilic composition and the hydrophobic composition have at least one polymer in common. In addition, the melt flow index of the hydrophobic composition is within 50% of the melt flow index of the hydrophilic composition. As a result, the laminate has a uniform transverse cross-section and/or a uniform longitudinal cross-section throughout a major of the length of the laminate. Moreover, when the laminate is divided into unit doses of approximately the same size, they have a high degree of content uniformity with respect to the active agent(s) present therein.

    摘要翻译： 提供了一种用于制备包含热熔挤压储存层和热熔挤出背衬层的生物粘合层压材料的方法。 储层包含含有活性剂的热塑性生物粘合剂组合物。 将含活性剂的热塑性生物粘附性亲水性组合物与疏水组合物热熔共挤出以形成至少双层层压体。 亲水组合物和疏水组合物具有至少一种共聚物。 此外，疏水性组合物的熔体流动指数在亲水性组合物的熔体流动指数的50％以内。 结果，层压体在层压体的整个长度上具有均匀的横截面和/或均匀的纵向横截面。 此外，当将层压体分成大致相同尺寸的单位剂量时，它们相对于其中存在的活性剂具有高度的均匀度。

    SCF Extract Containing Cardiac Glycoside
    55.
    发明申请
    SCF Extract Containing Cardiac Glycoside 有权
    含有心脏糖苷的SCF提取物

    公开(公告)号：US20120219620A1

    公开(公告)日：2012-08-30

    申请号：US13417686

    申请日：2012-03-12

    申请人： O.Cradell Addington ,  Feng Zhang ,  John J. Koleng

    发明人： O.Cradell Addington ,  Feng Zhang ,  John J. Koleng

    IPC分类号： A61K36/24 ,  A61P31/12 ,  A61P35/00 ,  A61K9/48 ,  A61K31/704

    CPC分类号： A61K36/24

    摘要： A supercritical fluid (SCF) extract of a cardiac glycoside-containing plant mass is provided. The extract can be included in a pharmaceutical composition containing an extract-solubilizing amount of solubilizer. Oleandrin is included within the extract when a cardiac glycoside-containing plant, such as Nerium oleander, is extracted by SCF extraction. The extract can also contain one or more other SCF extractable pharmacologically active agents. The composition can be used to treat a wide range of disorders that are therapeutically responsive to a cardiac glycoside.

    摘要翻译： 提供了含有强心苷的植物体的超临界流体（SCF）提取物。 提取物可以包含在含有提取物增溶量的增溶剂的药物组合物中。 当通过SCF提取提取含有含有强心苷的植物，例如夹心夹心素时，包含在提取物中。 提取物还可以含有一种或多种其它SCF可提取的药理学活性剂。 该组合物可用于治疗对心脏糖苷治疗响应的各种各样的疾病。

    Circuit board
    56.
    发明授权
    Circuit board 失效
    电路板

    公开(公告)号：US08237055B2

    公开(公告)日：2012-08-07

    申请号：US12564734

    申请日：2009-09-22

    申请人： Wang-Jia Chen ,  Wei Zhou ,  Yu-Hsu Lin ,  Feng Zhang

    发明人： Wang-Jia Chen ,  Wei Zhou ,  Yu-Hsu Lin ,  Feng Zhang

    IPC分类号： H05K1/00

    CPC分类号： H05K1/025 ,  H05K1/0245 ,  H05K2201/09236 ,  H05K2201/09318 ,  H05K2201/09345 ,  H05K2201/09727

    摘要： A circuit board includes an insulation layer, a signal layer disposed on one side of the insulation layer, and a ground plane and a power plane disposed on the insulation layer at a side opposite to the signal layer. The insulation layer forms a separating area arranged between the ground plane and the power plane. At least two signal traces parallel to each other are arranged on the signal layer at one side corresponding to one of the ground plane and the power plane. A width of the signal trace close to the separating area is wider than that of the signal trace away from the separating area.

    摘要翻译： 电路板包括绝缘层，设置在绝缘层的一侧的信号层，以及设置在与信号层相对的一侧的绝缘层上的接地面和电源面。 绝缘层形成布置在接地平面和电源平面之间的分离区域。 彼此平行的至少两条信号迹线在对应于接地平面和电源平面之一的一侧上布置在信号层上。 靠近分离区域的信号迹线的宽度比远离分离区域的信号迹线宽。

    SYSTEMS, METHODS AND COMPOSITIONS FOR OPTICAL STIMULATION OF TARGET CELLS
    58.
    发明申请
    SYSTEMS, METHODS AND COMPOSITIONS FOR OPTICAL STIMULATION OF TARGET CELLS 有权
    用于目标细胞光刺激的系统，方法和组合物

    公开(公告)号：US20110301529A1

    公开(公告)日：2011-12-08

    申请号：US13208419

    申请日：2011-08-12

    申请人： Feng Zhang ,  Karl Deisseroth ,  Viviana Gradinaru

    发明人： Feng Zhang ,  Karl Deisseroth ,  Viviana Gradinaru

    IPC分类号： A61M37/00 ,  C12N13/00

    CPC分类号： A61N5/062 ,  A01K67/0333 ,  A01K2217/052 ,  A01K2227/703 ,  A01K2267/0356 ,  A61K38/00 ,  A61K48/005 ,  A61K48/0058 ,  A61K48/0083 ,  A61N5/0613 ,  A61N5/0622 ,  C07K14/00 ,  C07K14/195 ,  C07K14/215 ,  C12N13/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/16643 ,  C12N2740/16043 ,  C12N2740/16071 ,  C12N2750/14143 ,  C12N2830/002

    摘要： Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated NpHR-based molecule comprising a nucleic acid sequence that codes for light-activated NpHR-based molecule and a promoter. Either a high expression of the molecule manifests a toxicity level that is less than about 75%, or the light-activated NpHR-based proteins are expressed using at least two NpHR-based molecular variants. Each of the variants characterized in being useful for expressing a light-activated NpHR-based molecule that responds to light by producing an inhibitory current to dissuade depolarization of the neuron. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion pumps or for controlling inhibitory currents in a cell (e.g., in in vivo and in vitro environments).

    摘要翻译： 使用光，例如体内或体外，使用各种方法和装置来实施靶细胞的刺激。 一个实例涉及用于递送光激活的基于NpHR的分子的载体，其包含编码基于光激活的基于NpHR的分子和启动子的核酸序列。 分子的高表达表现出小于约75％的毒性水平，或者使用至少两种基于NpHR的分子变体表达光激活的NpHR基蛋白。 每个变体的特征在于可用于表达基于光激活的基于NpHR的分子，其通过产生抑制电流来抑制神经元的去极化来响应光。 其他方面和实施方案涉及用于离子泵的物质和分子的组合物，或用于控制细胞中的抑制性电流（例如在体内和体外环境中）的系统，方法，试剂盒，组合物。

    Three-dimensional, position-sensitive radiation detection
    60.
    发明授权
    Three-dimensional, position-sensitive radiation detection 有权
    三维，位置敏感的辐射检测

    公开(公告)号：US07692155B2

    公开(公告)日：2010-04-06

    申请号：US12190385

    申请日：2008-08-12

    申请人： Zhong He ,  Feng Zhang

    发明人： Zhong He ,  Feng Zhang

    IPC分类号： G01T1/24

    CPC分类号： G01T1/247 ,  G01T7/005

    摘要： Disclosed herein is a method of determining a characteristic of radiation detected by a radiation detector via a multiple-pixel event having a plurality of radiation interactions. The method includes determining a cathode-to-anode signal ratio for a selected interaction of the plurality of radiation interactions based on electron drift time data for the selected interaction, and determining the radiation characteristic for the multiple-pixel event based on both the cathode-to-anode signal ratio and the electron drift time data. In some embodiments, the method further includes determining a correction factor for the radiation characteristic based on an interaction depth of the plurality of radiation interactions, a lateral distance between the selected interaction and a further interaction of the plurality of radiation interactions, and the lateral positioning of the plurality of radiation interactions.

    摘要翻译： 本文公开了一种通过具有多个辐射相互作用的多像素事件来确定由辐射检测器检测的辐射的特性的方法。 该方法包括基于所选择的相互作用的电子漂移时间数据确定多个辐射相互作用的选定相互作用的阴极至阳极信号比，以及基于阴极 - 阴极两者确定多像素事件的辐射特性， 阳极信号比和电子漂移时间数据。 在一些实施例中，该方法还包括基于多个辐射相互作用的相互作用深度，所选择的相互作用与多个辐射相互作用的进一步相互作用之间的横向距离以及横向定位 的多个辐射相互作用。