公开(公告)号：US20170038361A1

公开(公告)日：2017-02-09

申请号：US15173809

申请日：2016-06-06

Applicant: Axion BioSystems, Inc.

Inventor： Isaac Perry Clements ,  Amanda Jervis Preyer ,  Swaminathan Rajaraman ,  Daniel Christopher Millard ,  James David Ross

IPC: G01N33/483 ,  G01N21/01 ,  B01L3/00

CPC classification number: G01N33/4836 ,  B01L3/50853 ,  B01L2300/046 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/01 ,  G01N21/75 ,  G01N2021/015 ,  G01N2021/0346 ,  G01N2201/0446 ,  G01N2201/062

Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.

Abstract translation: 公开了一种电光刺激和记录系统，包括衬底和耦合到衬底的多个阱。 所述系统还包括邻近所述多个孔中的相应一个孔设置的至少一个电极组，其中所述电极组包括至少一个电极，所述至少一个电极被配置为收集与相应的阱的至少一部分相关联的电信号。 该系统还包括对应于相应的一个孔的发光元件组，并且被配置为将光学刺激传送到相应孔的至少一部分。

公开(公告)号：US20160282268A1

公开(公告)日：2016-09-29

申请号：US14778120

申请日：2014-02-19

Applicant: Sony Corporation

Inventor： Naoki Morimoto ,  Shinichi Kai

IPC: G01N21/64 ,  G01N21/27 ,  G01N21/01

CPC classification number: G01N21/6428 ,  G01N21/01 ,  G01N21/27 ,  G01N21/274 ,  G01N21/6452 ,  G01N2021/0175 ,  G01N2021/1753 ,  G01N2021/178 ,  G01N2021/1789 ,  G01N2021/6419 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2201/0446 ,  G01N2201/0453 ,  G01N2201/0484

Abstract: There is provided a data processing apparatus including: a data determination portion that specifies, in each of first and second light intensity distribution data, an analysis range corresponding to a storage area for storing a detection target, the first and second light intensity distribution data being acquired on the basis of light emitted from first and light sources to a detection area; and a mode selection portion that selects an operation mode of the data determination portion. The mode selection portion selects one of a first mode in which the data determination portion specifies the analysis range in each of the first light intensity distribution data and the second light intensity distribution data, and a second mode in which the data determination portion specifies the analysis range in the second light intensity distribution data on the basis of information on the analysis range of the first light intensity distribution data.

Abstract translation: 提供了一种数据处理装置，包括：数据确定部，其在第一和第二光强分布数据中的每一个中指定与用于存储检测对象的存储区域对应的分析范围，第一和第二光强度分布数据为 基于从第一和光源发射的光到检测区域获取; 以及选择数据确定部分的操作模式的模式选择部分。 模式选择部分选择第一模式，其中数据确定部分指定第一光强分布数据和第二光强分布数据中的每一个中的分析范围，第二模式中数据确定部分指定分析 基于关于第一光强度分布数据的分析范围的信息，在第二光强分布数据的范围内。

公开(公告)号：US20160041095A1

公开(公告)日：2016-02-11

申请号：US14821686

申请日：2015-08-07

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  Ali Kabiri ,  Jason W. Sickler ,  Brett J. Gyarfas ,  Jeremy Lackey ,  Gerard Schmid ,  Paul E. Glenn ,  Lawrence C. West ,  Benjamin Cipriany ,  Keith G. Fife

IPC: G01N21/64 ,  C12Q1/68

CPC classification number: G01N21/6408 ,  C12Q1/6874 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/648 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2201/0446 ,  G01N2201/062

Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.

Abstract translation: 用于分析单分子和进行核酸测序的装置和方法。 装置可以包括测定芯片，其包括多个像素，其中样品阱被配置为接收样品，当被激发时，样品阱发射发射能量; 用于在特定方向上引导发射能量的至少一个元件; 以及发光能量从样品阱向传感器行进的光路。 该装置还包括与测定芯片接口的仪器。 仪器包括用于激发每个样品井中的样品的激发光源; 多个传感器对应于样品孔。 每个传感器可以检测来自相应样品阱中的样品的发射能量。 仪器包括至少一个光学元件，其将来自每个样品的发射能量引向多个传感器中的相应传感器。

公开(公告)号：US09134296B2

公开(公告)日：2015-09-15

申请号：US14356487

申请日：2012-10-23

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Norikazu Sugiyama ,  Takuji Kataoka ,  Ikuo Arata

IPC: G01N21/01 ,  G01N33/50 ,  G02B21/08 ,  G01N21/49 ,  G01N21/59 ,  G02B21/36

CPC classification number: G01N21/47 ,  G01N21/49 ,  G01N21/59 ,  G01N33/4833 ,  G01N33/5005 ,  G01N2201/0446 ,  G01N2201/062 ,  G02B21/088 ,  G02B21/36

Abstract: A method for observing stem cells by an observation device 1 comprises, placing stem cells C in a petri dish 11, mounting the petri dish 11 on a waveguide 21 via water 13, emitting illumination light L1 into the waveguide 21 and emitting the illumination light L1 to the stem cells C in the petri dish 11 via the water 13, and detecting scattered light L2, the scattered light L2 being the illumination light L1 emitted to the stem cells C that is scattered by the stem cells C and has passed through the waveguide 21. Then, in the light image detected by means of the scattered light L2, a region that is markedly darker than other regions is identified as being in the state tending toward differentiation.

Abstract translation: 通过观察装置1观察干细胞的方法包括：将干细胞C放置在培养皿11中，通过水13将培养皿11安装在波导21上，将照明光L1发射到波导21中并发射照明光L1 通过水13向陪替氏培养皿11中的干细胞C，并且检测散射光L2，散射光L2是发射到干细胞C的干细胞C的照射光L1，其被干细胞C散射并已经通过波导 然后，在通过散射光L2检测到的光图像中，比其他区域明显更暗的区域被识别为处于朝向微分的状态。

公开(公告)号：US08988677B2

公开(公告)日：2015-03-24

申请号：US13265969

申请日：2010-04-23

Applicant: Simon Webster

Inventor： Simon Webster

IPC: G01N1/10 ,  G01N21/03

CPC classification number: G01N21/03 ,  G01N21/0332 ,  G01N2021/0346 ,  G01N2201/0446

Abstract: A unit is provided comprising an array (2) of sample containers (1), said containers, being connected together and arranged in a planar configuration, each container having multiple optically transparent windows arranged such that the sample contained therein can be interrogated using simultaneous multiple optical analytical techniques, the array of containers being configured so as to allow optical access to the windows of each container in the array. Also provided is an apparatus comprising such a unit, a system comprising a combination of such an apparatus and unit and a method of analyzing multiple samples by introducing each individual sample into an individual container of such an apparatus, illuminating the samples and detecting and analyzing light emerging therefrom.

Abstract translation: 提供了包括样品容器（1）的阵列（2），所述容器连接在一起并布置成平面构造的单元，每个容器具有多个光学透明窗口，其布置使得其中容纳的样品可以使用同时多个 光学分析技术，容器阵列被配置为允许光学访问阵列中每个容器的窗口。 还提供了一种包括这种单元的装置，包括这种装置和单元的组合的系统以及通过将每个单独的样品引入这种装置的单独容器中来分析多个样品的方法，照亮样品并检测和分析光 从中出现。

公开(公告)号：US08874273B2

公开(公告)日：2014-10-28

申请号：US13022856

申请日：2011-02-08

Applicant: Gang Sun ,  Greg Harris ,  Andy May ,  Kyle Self ,  Kevin Farrell ,  Paul Wyatt

Inventor： Gang Sun ,  Greg Harris ,  Andy May ,  Kyle Self ,  Kevin Farrell ,  Paul Wyatt

IPC: G05B21/00 ,  G01N35/00 ,  G01N15/14 ,  B01L3/00

CPC classification number: G01N35/00029 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/06 ,  B01L2300/0654 ,  B01L2300/0829 ,  C12Q1/686 ,  G01N15/1475 ,  G01N21/6428 ,  G01N35/00732 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/1065 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00752 ,  G01N2035/0091 ,  G01N2035/1034 ,  G01N2201/025 ,  G01N2201/0446 ,  Y10S901/01 ,  Y10T436/11

Abstract: Systems for managing workflows to perform chemical or biological reactions using microfluidic devices.

Abstract translation: 用于管理使用微流体装置进行化学或生物反应的工作流的系统。

公开(公告)号：US20120182556A1

公开(公告)日：2012-07-19

申请号：US13383986

申请日：2010-07-16

Applicant: Peter Van Praet

Inventor： Peter Van Praet

IPC: G01N21/59

CPC classification number: G01N21/00 ,  G01N21/253 ,  G01N2201/0446 ,  G01N2201/0453 ,  G01N2201/0627 ,  G01N2201/10

Abstract: Light emitting diodes (LEDs) are mounted in an array to an upper structure overlying a lower structure with a plurality of light detectors thereon. Each LED is configured to overlie a separate detector. Each LED emits light at a frequency relevant for measuring optical density of a specimen. LEDs having different frequencies are included within the LED array. A corresponding array of detectors is also provided, mounted to the lower structure. Spacing between adjacent LEDs and between adjacent detectors match a spacing between wells in a microtiter plate. Spacing between the lower structure and the upper structure supporting the LEDs is sufficient for the microtiter plate to fit between. Circuitry sequentially fires individual LEDs and gathers optical density data through the detectors for specimens in the wells of the microtiter plate. The structures are then moved to a next adjacent well position on the microtiter plate and the process repeated.

Abstract translation: 发光二极管（LED）以阵列的形式安装在覆盖下部结构的上部结构上，其上具有多个光检测器。 每个LED被配置为覆盖单独的检测器。 每个LED以与测量样品的光密度相关的频率发光。 具有不同频率的LED包括在LED阵列内。 还提供了相应的检测器阵列，安装到下部结构。 相邻LED之间和相邻检测器之间的间距与微量滴定板中的孔之间的间距相匹配。 支撑LED的下部结构和上部结构之间的间距足以使微量滴定板相适应。 电路依次点火各个LED，并通过微量滴定板孔中的标本的检测器收集光密度数据。 然后将结构移动到微量滴定板上的下一个相邻的孔位置，并重复该过程。

公开(公告)号：US20110160073A1

公开(公告)日：2011-06-30

申请号：US12827521

申请日：2010-06-30

Applicant: Igor Kordunsky ,  Jeffrey A. Goldman ,  Michael J. Finney

Inventor： Igor Kordunsky ,  Jeffrey A. Goldman ,  Michael J. Finney

IPC: C40B30/04 ,  C40B60/12

CPC classification number: C12Q1/686 ,  B01L7/52 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1822 ,  G01N21/276 ,  G01N21/6452 ,  G01N2201/0446

Abstract: A fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler and methods of use are provided. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module includes one or more channels, each having an excitation light generator and an emission light detector both disposed within the detection module. When the support structure is attached to the thermal cycler and the detection module is mounted on the support structure, the detection module is movable so as to be positioned in optical communication with different ones of the plurality of wells. The detection module is removable from the support structure to allow easy replacement.

Abstract translation: 提供了用于分析位于热循环仪中的多个孔中的样品的荧光检测装置和使用方法。 在一个实施例中，该装置包括可附接到热循环仪的支撑结构和可移动地安装在支撑结构上的检测模块。 检测模块包括一个或多个通道，每个通道具有设置在检测模块内的激发光发生器和发射光检测器。 当支撑结构附接到热循环仪并且检测模块安装在支撑结构上时，检测模块可移动以便定位成与多个井中的不同井的光通信。 检测模块可从支撑结构移除，以方便更换。

公开(公告)号：US20100315644A1

公开(公告)日：2010-12-16

申请号：US12756157

申请日：2010-04-07

Applicant: Richard Egan ,  Graham Lidgard ,  David Booker

Inventor： Richard Egan ,  Graham Lidgard ,  David Booker

IPC: G01N21/55

CPC classification number: G01N21/01 ,  G01N21/84 ,  G01N21/8483 ,  G01N33/487 ,  G01N2201/0446 ,  G01N2201/126 ,  G16H10/40 ,  Y02A90/26

Abstract: A diagnostic assay system including a test device and a scanning device are described. In one implementation, the scanning device includes a source of electromagnetic radiation, an optics assembly, a detector, and a microprocessor disposed within a chassis. The test device and scanning device may be configured to be movable relative to each other during operation of the scanning device.

Abstract translation: 描述了包括测试装置和扫描装置的诊断测定系统。 在一个实施方式中，扫描装置包括电磁辐射源，光学组件，检测器和布置在底盘内的微处理器。 测试装置和扫描装置可以被配置为在扫描装置的操作期间可相对于彼此移动。

公开(公告)号：US20100123088A1

公开(公告)日：2010-05-20

申请号：US12692758

申请日：2010-01-25

Applicant: Petri KIVELÄ

Inventor： Petri KIVELÄ

IPC: G01J1/58

CPC classification number: G01N21/253 ,  G01N21/13 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/76 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6471 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0446 ,  G01N2201/0453 ,  G01N2201/0826 ,  G01N2201/103

Abstract: The present invention relates generally to the field of biochemical laboratory instrumentation for different applications of measuring properties of samples on e.g. microtitration plates and corresponding sample supports. The object of the invention is achieved by providing an optical measurement instrumentation wherein a sample (281-285) is activated (212AS, 218AS) and the emission is detected (291, 292), wherein between the activation and detection phases of measuring the sample, a shift is made in the relative position between the sample and means (218) directing the activation radiation to the sample as well as in the relative position between the sample and the means (293) receiving the emission radiation from the sample. This can be implemented e.g. by moving (299) the sample assay plate and/or a measuring head between the activation and emission phases of a sample. The invention allows a simultaneous activation of a first sample and detecting emission from a second sample thus enhancing efficiency of the measurement.

Abstract translation: 本发明一般涉及生物化学实验室仪器领域，用于不同应用样品的测量性质。 微量滴定板和相应的样品支架。 本发明的目的是通过提供一种光学测量仪器实现的，其中样品（281-285）被激活（212AS，218AS）并且检测到发射（291,292），其中在测量样品的激活和检测阶段之间 在样品和将激活辐射指向样品的装置（218）之间的相对位置以及样品和接收来自样品的发射辐射的装置（293）之间的相对位置进行位移。 这可以被实现。 通过在样品的活化和发射阶段之间移动（299）样品测定板和/或测量头。 本发明允许同时激活第一样品并检测来自第二样品的发射，从而提高测量的效率。