公开(公告)号：US20240019454A1

公开(公告)日：2024-01-18

申请号：US18254636

申请日：2021-12-21

申请人： BECKMAN COULTER, INC.

发明人： Richard L. Situ ,  Lewis M. Mindeman ,  Michael J. Calabrese ,  Colin L. Granger ,  Kyle Suico

IPC分类号： G01N35/04 ,  G01N33/49

CPC分类号： G01N35/04 ,  G01N33/491 ,  G01N2035/00495

摘要： The presently claimed and described technology provides integrated automated instruments (100, 100A, 100B, 100C) and methods (800) for automatically processing a whole blood sample (50) in a single sample tube (80). These include: mixing the sample in the tube; analyzing a portion (50P) of the mixed sample (50M); centrifuging the sample in the tube thereby separating plasma (60); and analyzing a portion (60P) of the plasma. A pretreatment module (200) may mix, centrifuge, transport, and store the sample. The integrated instrument may include multiple detector components and does not require external sample handling.

公开(公告)号：US11872035B2

公开(公告)日：2024-01-16

申请号：US17394290

申请日：2021-08-04

申请人： Ascensia Diabetes Care Holdings AG

发明人： Huan-Ping Wu ,  Mark D. Cerutti

IPC分类号： A61B5/145 ,  A61B5/00 ,  G16H40/67 ,  A61B5/1486 ,  G01N33/487 ,  G01N33/49 ,  G16H50/30 ,  G16H50/70 ,  G16H40/40 ,  A61B5/1495

CPC分类号： A61B5/14532 ,  A61B5/0002 ,  A61B5/1451 ,  A61B5/1486 ,  A61B5/6801 ,  A61B5/72 ,  A61B5/7228 ,  G01N33/48707 ,  G01N33/49 ,  G16H40/67 ,  A61B5/1495 ,  A61B5/14865 ,  A61B2560/0223 ,  G16H40/40 ,  G16H50/30 ,  G16H50/70

摘要： A method of determining glucose values during continuous glucose monitoring (CGM) measurements includes providing a CGM device including a sensor, a memory, and a processor; applying a constant voltage potential to the sensor; measuring a primary current signal resulting from the constant voltage potential and storing the measured primary current signal in the memory; applying a probing potential modulation sequence to the sensor; measuring probing potential modulation current signals resulting from the probing potential modulation sequence and storing measured probing potential modulation current signals in the memory; determining an initial glucose concentration based on a conversion function value and the primary current signal; determining a connection function based on the primary current signal and a plurality of the probing potential modulation current signals; and determining a final glucose concentration based on the initial glucose concentration and the connection function value. Other aspects are provided.

公开(公告)号：US11867613B2

公开(公告)日：2024-01-09

申请号：US17659702

申请日：2022-04-19

申请人： COR HEALTH, INC.

发明人： Robert G. Messerschmidt

IPC分类号： G01N21/25 ,  A61B5/151 ,  G01N33/49

CPC分类号： G01N21/255 ,  A61B5/151 ,  G01N33/49 ,  G01N2201/0221 ,  G01N2201/0636

摘要： A blood sample collector can be used to collect a blood sample from a subject. The blood sample collector can be placed in a receptacle of a spectrometer to measure spectral data from the blood sample while the blood sample separates. The container may comprise a window to allow light such as infrared light to pass through the container, with the blood sample at least partially separating within the container between spectral measurements, which can provide improved accuracy of the measurements and additional information regarding the sample. The container may comprise an elongate axis and the container configured for placement in the spectrometer receptacle with the elongate axis extending toward a vertical direction in order to improve gravimetric separation of the blood sample. The spectrometer can be configured to measure the blood sample at a plurality of heights along the sample as the sample separates.

公开(公告)号：US20240003867A1

公开(公告)日：2024-01-04

申请号：US18469239

申请日：2023-09-18

申请人： Northwestern University

发明人： William E. Funk ,  Thomas McDade

IPC分类号： G01N33/49 ,  A61B5/15 ,  A61B5/145 ,  G01N33/84 ,  A61B5/151

CPC分类号： G01N33/49 ,  A61B5/150755 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150358 ,  G01N33/84 ,  A61B5/150305 ,  A61B5/15142 ,  A61B2562/0295 ,  A61B2562/242

摘要： The present invention provides methods, compositions, kits, and devices for detecting heavy metals in dried blood (e.g., dried blood spots). For example, the present invention provides: 1) dried blood spot paper that is detectably free of heavy metals and methods of preparing such paper using organic acid; 2) dried blood extraction solutions optimized for heavy metal detection (e.g., extraction solutions containing acetic acid and/or gold); 3) methods for estimating venous blood volume from dried blood mass; and 4) kits and kit components optimized for heavy metal detection in dried blood (e.g., kits with paper detectably free of heavy metals, heavy metal free skin wipes, metal free collection case, etc.).

公开(公告)号：US11860154B2

公开(公告)日：2024-01-02

申请号：US17331893

申请日：2021-05-27

申请人： Leuko Labs, Inc.

发明人： Carlos Castro Gonzalez ,  Ian Butterworth ,  Aurelien Bourquard ,  Alvaro Sanchez Ferro

IPC分类号： G01N33/49 ,  G06T7/00 ,  G06T7/11 ,  G06T7/38 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20 ,  G16H50/70 ,  G01N21/31 ,  G06V20/69 ,  G06F18/214 ,  G06V10/764 ,  G06V10/82 ,  G06V10/56 ,  G01N15/14 ,  G01N15/00 ,  G01N15/10

CPC分类号： G01N33/49 ,  G01N15/147 ,  G01N15/1429 ,  G01N15/1475 ,  G01N21/31 ,  G06F18/2148 ,  G06T7/0016 ,  G06T7/11 ,  G06T7/38 ,  G06V10/56 ,  G06V10/764 ,  G06V10/82 ,  G06V20/695 ,  G06V20/698 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20 ,  G16H50/70 ,  G01N2015/008 ,  G01N2015/0073 ,  G01N2015/1006 ,  G01N2015/1443 ,  G01N2015/1486 ,  G06T2207/10016 ,  G06T2207/10056 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30101 ,  G06T2207/30242 ,  G06V2201/03

摘要： In one aspect, a method to detect white blood cells and/or white blood cell subtypes from non-invasive capillary videos is featured. The method includes acquiring a first plurality of images of a region of interest including one or more capillaries of a predetermined area of a human subject from non-invasive capillary videos captured with an optical device, processing the first plurality of images to determine one or more optical absorption gaps located in said capillary, and annotating the first plurality of images with an indication of any optical absorption gap detected in the first plurality of images. The method also includes acquiring a second plurality of images of the same region of interest of the same capillary with an advanced optical device capable of resolving cellular structure of white blood cells and white blood cell subtypes and spatiotemporally annotating the second plurality of images with an indication of any white blood cell detected and/or a subtype of any white blood cell detected in the second plurality of images. The method also includes inputting the first plurality of images and annotated information from the first plurality of images and annotated information from the spatiotemporally annotated second plurality of images into a machine learning subsystem configured to determine a presence of white blood cells and/or the subtype of any white blood cells present in the one or more optical absorption gaps in the first plurality of images.

公开(公告)号：US11852640B2

公开(公告)日：2023-12-26

申请号：US16170389

申请日：2018-10-25

申请人： Beckman Coulter, Inc.

发明人： Carlos Ramirez ,  Nery Ortiz ,  Milton Swaby

IPC分类号： G01N35/00 ,  G01N15/10 ,  G01N15/14 ,  G01N15/02 ,  G01N33/49 ,  G01N15/00 ,  G16H40/40 ,  G16H10/40 ,  G16H40/60 ,  G16H50/20

CPC分类号： G01N35/00623 ,  G01N15/0205 ,  G01N15/1012 ,  G01N15/1031 ,  G01N15/1459 ,  G01N33/4915 ,  G01N35/00693 ,  G16H10/40 ,  G16H40/40 ,  G16H40/60 ,  G16H50/20 ,  G01N2015/008 ,  G01N2015/0069 ,  G01N2015/0073 ,  G01N2015/0084 ,  G01N2015/1006 ,  G01N2015/1087 ,  G01N2015/1402 ,  G01N2015/1493

摘要： Instances of the present technology may include a method for operating a hematology analyzer. The method may include passing a control material through a hematology analyzer. The control material may include a first cell population and a second cell population. The method may also include determining a first cell population volume measurement and a second cell population volume measurement. A first value of a first cell population distribution width and a second value of a second cell population distribution width may be calculated. The method may include comparing the first value to a first reference range. The method may also include comparing the second value to a second reference range. Furthermore, the method may include classifying an operational status of the hematology analyzer based on the comparison of the first value to the first reference range and based on the comparison of the second value to the second reference range.

公开(公告)号：US11852639B2

公开(公告)日：2023-12-26

申请号：US17590944

申请日：2022-02-02

申请人： Perosphere Technologies Inc.

发明人： Sasha Bakhru ,  Bryan Laulicht ,  Stefan Zappe ,  Solomon Steiner

IPC分类号： G01N33/86 ,  G01N33/49 ,  B01L3/00 ,  B01L9/00

CPC分类号： G01N33/86 ,  B01L3/502715 ,  B01L9/527 ,  G01N33/4905 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/1827

摘要： A microfluidic, chip-based assay device has been developed for measuring physical properties of an analyte (particularly, whole blood or whole blood derivatives). The technologies can be applied to measure clotting times of whole blood or blood derivatives, determine the effects of anticoagulant drugs on the kinetics of clotting/coagulation, as well as evaluate the effect of anticoagulant reversal agents. These technologies can additionally be used to optimize the dosage of anticoagulation drugs and/or their reversal agents. The assay is independent of the presence of anticoagulant; clotting is activated by exposure of the blood sample in the device to a glass (or other negatively charged material such as oxidized silicon) surface, which activates the intrinsic pathway and can be further hastened by the application of shear flow across the activating materials surface. The absence of chemical activating agents and highly controlled and reproducible micro-environment yields a point of care universal clotting assay.

公开(公告)号：US20230408381A1

公开(公告)日：2023-12-21

申请号：US18333256

申请日：2023-06-12

申请人： Sysmex Corporation

发明人： Daiki Kawakami ,  Seiya Shinabe ,  Tomoyuki Asahara

IPC分类号： G01N1/28 ,  G01N33/49 ,  G01N1/30 ,  G06T7/00

CPC分类号： G01N1/2813 ,  G01N33/49 ,  G01N1/30 ,  G06T7/0002

摘要： Disclosed is a control method for a test system including a smear imaging unit configured to image a smear of a specimen, the control method including: preparing a plurality of the smears; sequentially storing, in a storing container capable of storing therein a plurality of the smears, the smears having been prepared; and transporting, when information about a standby situation for imaging processing by the smear imaging unit satisfies a predetermined condition, the storing container that stores therein the smears to the smear imaging unit regardless of the number of the smears stored in the storing container.

公开(公告)号：US11840720B2

公开(公告)日：2023-12-12

申请号：US16725914

申请日：2019-12-23

申请人： Metabolomic Technologies Inc.

发明人： Lu Deng ,  David Chang

IPC分类号： G01N33/48 ,  C12Q1/6886 ,  G01N33/493 ,  G01N33/49 ,  A61K45/06 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  G01N33/492 ,  G01N33/493 ,  A61K45/06 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/57419 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/7028

摘要： The invention relates to methods and compositions for detecting colorectal cancer and colorectal polyps by measurement of metabolites in bodily fluids such as urine, including diacetylspermine and kynurenine.

公开(公告)号：US20230393039A1

公开(公告)日：2023-12-07

申请号：US18364392

申请日：2023-08-02

申请人： NOUL CO., LTD.

发明人： Dong Young Lee ,  Chan Yang Lim ,  Kyung Hwan Kim

IPC分类号： G01N1/31 ,  G01N1/30 ,  C12Q1/6844 ,  C12Q1/6848 ,  G01N33/50 ,  G01N21/77 ,  B01L3/00 ,  G01N15/06 ,  G01N33/52 ,  G01N33/574 ,  G01N33/558 ,  G01N15/14 ,  G01N33/49 ,  G01N33/60 ,  C12Q1/686 ,  C07K16/30 ,  C12Q1/70 ,  G01N33/483 ,  G06T7/00 ,  G01N33/53 ,  G01N33/533

CPC分类号： G01N1/312 ,  G01N1/30 ,  C12Q1/6844 ,  C12Q1/6848 ,  G01N33/5082 ,  G01N21/77 ,  B01L3/00 ,  G01N15/06 ,  G01N33/52 ,  G01N33/574 ,  G01N33/558 ,  G01N15/14 ,  G01N33/49 ,  G01N33/60 ,  C12Q1/686 ,  C07K16/3061 ,  G01N1/31 ,  C12Q1/701 ,  G01N33/4833 ,  G06T7/0014 ,  G01N33/5304 ,  G01N33/533 ,  G06T7/0012 ,  G01N2015/0693 ,  G01N2021/7786 ,  B01L7/52

摘要： The present disclosure relates to a tissue diagnosis device including a plate supporter configured to support a plate on which a reaction region is placed and a sample is placed in the reaction region, a patch controller configured to support the patch which contains a labeling substance that specifically labels the target substance, and control a position of the patch relative to the reaction region so that the patch provides the labeling substance to the reaction region, and a target substance detector configured to detect the labeling substance and detect the target substance included in the tissue sample.