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    Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
    62.
    发明授权
    Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products 有权
    输血注册网络提供用户和遗传特征的血液制品提供者之间的实时交互

    公开(公告)号：US07363170B2

    公开(公告)日：2008-04-22

    申请号：US11092420

    申请日：2005-03-29

    Applicant: Michael Seul ,  Robert James Danegy

    Inventor： Michael Seul ,  Robert James Danegy

    IPC: G06F17/00 ,  C12Q1/68

    CPC classification number: G06F19/322 ,  G06F19/00 ,  G06F19/18 ,  G06F19/24 ,  G06F19/28 ,  G06F19/3481 ,  G06Q10/10 ,  G06Q50/22 ,  G06Q50/24 ,  G16H10/60 ,  G16H40/20 ,  Y02A90/22 ,  Y02A90/26

    Abstract: Disclosed is a registry system, including member institutions, in which transfusion donors and recipients are registered following genotyping, which would typically take place in a member institution, or a member institution would have access to the genotyping information, if performed outside. The registry database can be accessed and searched by members seeking samples of particular type(s). Systems are disclosed for maintaining economic viability of genotyping in connection with transfusions, by maximizing the number of units placed with the minimal number of candidate donors typed. Genotyping of potential donors, and product supply, is matched to forecasted demand. Genotyping can also be limited to the more clinically relevant markers. The registry system can also be integrated with one format of assay which generates an image for analysis, whereby the imaged results can be analyzed and redacted by experts in a central location, and then transmitted back to the patient or their representative.

    Abstract translation: 披露了一个注册系统，包括成员机构，其中输血捐赠者和接受者在基因分型之后注册，通常在成员机构中进行注册，或者成员机构如果在外部执行，则可以访问基因分型信息。 可以通过搜索特定类型的样本的成员访问和搜索注册表数据库。 公开了系统，用于通过最大限度地利用输入的候选捐赠者的数量最大化来维持与输血相关的基因分型的经济可行性。 潜在捐赠者的基因分型和产品供应与预测需求相匹配。 基因分型也可以限于更临床相关的标记物。 注册系统也可以与生成用于分析的图像的一种形式的测定结合，由此可以在中心位置的专家分析和编辑成像结果，然后传送回患者或其代表。

    Real-time monitoring of nucleic acid target-identifying signals
    64.
    发明授权
    Real-time monitoring of nucleic acid target-identifying signals 有权
    实时监测核酸靶标识别信号

    公开(公告)号：US07344841B2

    公开(公告)日：2008-03-18

    申请号：US11438161

    申请日：2006-05-22

    Applicant: Ghazala Hashmi ,  Michael Seul ,  Joachim Messing

    Inventor： Ghazala Hashmi ,  Michael Seul ,  Joachim Messing

    IPC: C12Q1/68 ,  C07H21/02 ,  C07H21/04

    CPC classification number: C12Q1/6827 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y20/00 ,  C12Q1/6837 ,  C12Q2565/102 ,  C12Q2563/149 ,  C12Q2537/143

    Abstract: This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.

    Abstract translation: 本发明提供了用于生物体的遗传测试的组合物和方法，并且用于将遗传测试的结果与明确识别生物体的唯一标记相关联。 标记可以是内部标记，例如单核苷酸多态性（SNP），短串联重复序列（STR）或基因组基因座内的其他位点。 或者，标记可以是外部的，使得它们在测试之前分开地添加到遗传样品中。

    Method of nucleic acid typing for selecting registered donors for cross-matching to transfusion recipients
    68.
    发明申请
    Method of nucleic acid typing for selecting registered donors for cross-matching to transfusion recipients 有权
    用于选择注册捐献者的核酸分型方法用于对输血接受者的交叉匹配

    公开(公告)号：US20060105370A1

    公开(公告)日：2006-05-18

    申请号：US11257285

    申请日：2005-10-24

    Applicant: Ghazala Hashmi ,  Michael Seul ,  Marion Reid ,  Michael Pierce

    Inventor： Ghazala Hashmi ,  Michael Seul ,  Marion Reid ,  Michael Pierce

    IPC: C12Q1/68 ,  C12P19/34

    CPC classification number: C12Q1/6881 ,  C12Q2600/156 ,  C12Q2600/16

    Abstract: Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes—and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others.

    Abstract translation: 公开了基于接受者和供体基因型的比较以及等位基因和单体型的潜在组合的遗传交叉匹配的方法和算法。 本发明的方法而不是侧重于表型预测，而是依赖于在接受者和可用供体中鉴定的遗传变异体的比较，其信息优选地将在广泛可用的供体登记册中编译，以最大化分子相容性。 可以基于供体和受体之间的基因型差异的加权临床意义来匹配基因型，使得某些错配比其他错配更可接受。

    Number coding for identification of subtypes of coded types of solid phase carriers
    69.
    发明申请
    Number coding for identification of subtypes of coded types of solid phase carriers 有权
    用于识别编码类型的固相载体亚型的编号

    公开(公告)号：US20050288870A1

    公开(公告)日：2005-12-29

    申请号：US10943760

    申请日：2004-09-17

    Applicant: Michael Seul ,  Enqing Tan ,  Chiu Chau

    Inventor： Michael Seul ,  Enqing Tan ,  Chiu Chau

    IPC: C12Q1/68 ,  G01N33/48 ,  G01N33/50 ,  G01N33/543 ,  G01N33/68 ,  H03M20060101 ,  G06F19/00

    CPC classification number: G01N33/6845 ,  G01N33/543 ,  G01N33/54313 ,  G01N33/564

    Abstract: Disclosed is number coding of pairs (“doublets”) or small sets (“multiplets”) of solid phase carriers provides distinguishable subtypes of a given type of such carriers, where each carrier type is distinguishable on the basis of a C-code. Such number coding is useful for augmenting a coding system, such as a color code, and thereby effectively multiplying the number of “colors” (distinguishable sub-types). It can be applied, for example, in multiplexed nucleic acid or protein analysis.

    Abstract translation: 公开了固相载波的对（“双”）或小集（“多重”）的数字编码提供了给定类型的这种载波的可区分的子类型，其中每个载波类型基于C码可区分。 这种数字编码对于增加诸如颜色代码的编码系统是有用的，从而有效地乘以“颜色”的数量（可区分的子类型）。 它可以应用于例如多重核酸或蛋白质分析中。

    Array cytometry
    70.
    发明授权
    Array cytometry 失效
    阵列细胞计数

    公开(公告)号：US06958245B2

    公开(公告)日：2005-10-25

    申请号：US09995894

    申请日：2001-11-28

    Applicant: Michael Seul ,  Alice X. Li

    Inventor： Michael Seul ,  Alice X. Li

    IPC: B01J19/00 ,  B01L3/00 ,  C07B61/00 ,  C12Q1/68 ,  G01N15/14 ,  G01N33/543 ,  G02B3/00 ,  G21K1/00 ,  H05H3/04 ,  G01N33/546

    CPC classification number: G02B3/0056 ,  B01J19/0046 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00713 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2300/089 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0454 ,  C12Q1/6825 ,  C12Q1/6837 ,  C40B40/00 ,  G01N15/1463 ,  G01N33/54313 ,  G01N2015/149 ,  G02B3/0012 ,  H05H3/04 ,  Y10T436/25125 ,  C12Q2565/501 ,  C12Q2563/155 ,  C12Q2565/607

    Abstract: A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled elektrokinetic assembly of particles near surfaces relies on the combination of three functional elements, the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. This invention is also for a method and apparatus to direct the lateral motion and induce the assembly into planar arrays of cells on semiconductor surfaces in response to temporally and spatially varying electric fields and to projected patterns of illumination.

    Abstract translation: 一种用于在诸如氧化硅的绝缘电极和电解质溶液之间的界面处操作胶体颗粒和生物分子的方法和装置。 表面附近颗粒的光控电动组装取决于三个功能元素的组合，即AC电场引起的平面聚集体的组装; 电解质/氧化硅/硅界面的图案化以在组装过程上施加空间控制; 并通过外部照明实现对装配过程的实时控制。 本发明提供一组基本操作，使得能够对几种类型的颗粒和生物分子的平面阵列的创建和放置以及阵列形状和尺寸的操纵进行交互式控制。 本发明使得能够以阵列格式进行诊断测定和生化分析的样品制备和处理以及这些操作的功能整合。 此外，本发明提供了用于产生具有所需性质的材料表面和用于制造表面安装光学部件的步骤。 本发明还涉及一种方法和装置，以响应于时间和空间上变化的电场以及投射的照明模式，引导横向运动并将组件引导到半导体表面上的平面阵列阵列。

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