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61.发明申请Droplet Actuator Devices, Configurations, and Methods for Improving Absorbance Detection 有权液滴致动器装置，配置和改进吸光度检测的方法公开(公告)号：US20100118307A1
公开(公告)日：2010-05-13
申请号：US12529025
申请日：2008-03-13
IPC分类号： G01N21/00
CPC分类号： G01N21/0303 , G01N21/031 , G01N2021/035 , G01N2021/036 , G01N2201/08
摘要： Devices, configurations and methods for improving absorbance detection are provided. For example, methods and devices are provided for determining the absorbance of a droplet, e.g., a droplet on a droplet actuator, by providing an elongated light path through the droplet.
摘要翻译： 提供了用于改善吸光度检测的装置，配置和方法。 例如，提供了通过提供穿过液滴的细长光路来确定液滴的吸光度的方法和装置，例如液滴致动器上的液滴。
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公开(公告)号：US20090304944A1
公开(公告)日：2009-12-10
申请号：US12523776
申请日：2008-01-22
CPC分类号： B01L3/0241 , B01F13/0071 , B01F13/0076 , B01L3/502792 , B01L2300/0819 , B01L2300/089 , B01L2300/165 , B01L2400/0415 , B01L2400/0427
摘要： The present invention relates to surface assisted fluid loading and droplet dispensing on a droplet micro actuator. A droplet actuator is provided and includes one or more electrodes configured for conducting one or more droplet operations on a droplet operations surface of the substrate. The droplet actuator further includes a wettable surface defining a path from a fluid reservoir into a locus which is sufficiently near to one or more of the electrodes that activation of the one or more electrodes results in a droplet operation. Methods and systems are also provided.
摘要翻译： 本发明涉及液滴微型致动器上的表面辅助流体加载和液滴分配。 提供液滴致动器并且包括一个或多个电极，其被配置用于在基板的液滴操作表面上进行一个或多个液滴操作。 液滴致动器还包括可润湿表面，其限定从流体储存器到足以接近一个或多个电极的轨迹的路径，所述一个或多个电极的激活导致液滴操作。 还提供了方法和系统。
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公开(公告)号：US20090263834A1
公开(公告)日：2009-10-22
申请号：US12393534
申请日：2009-02-26
IPC分类号： G01N33/542
CPC分类号： G01N33/54333
摘要： Droplet actuator devices and methods for immunoassays and washing are provided. According to one embodiment, a method of providing a droplet in contact with a surface of a super paramagnetic bead with a reduced concentration of a substance is provided and includes: (a) providing a super paramagnetic bead in contact with a droplet comprising a starting concentration and starting quantity of the substance and having a starting volume; (b) conducting one or more droplet operations to merge a wash droplet with the droplet provided in step (a) to yield a combined droplet; and (c) conducting one or more droplet operations to divide the combined droplet to yield a set of droplets. The set of droplets includes: (i) a droplet in contact with the super paramagnetic bead having a decreased concentration of the substance relative to the starting concentration; and (ii) a droplet which is separated from the super paramagnetic bead.
摘要翻译： 提供液滴致动器装置和免疫测定和洗涤方法。 根据一个实施方案，提供了一种提供与物质浓度降低的超顺磁珠的表面接触的液滴的方法，包括：（a）提供与包含起始浓度的液滴接触的超顺磁珠 并开始物质的起始体积; （b）进行一个或多个液滴操作以将洗涤液滴与步骤（a）中提供的液滴合并以产生组合液滴; 和（c）进行一个或多个液滴操作以分开组合液滴以产生一组液滴。 一组液滴包括：（i）与超顺磁珠接触的液滴，其物质相对于起始浓度降低; 和（ii）从超顺磁珠分离的液滴。
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公开(公告)号：US20080281471A1
公开(公告)日：2008-11-13
申请号：US11838450
申请日：2007-08-14
申请人： Gregory F. Smith , Ryan A. Sturmer , Philip Y. Paik , Vijay Srinivasan , Michael G. Pollack , Vamsee K. Pamula , Keith R. Brafford , Richard M. West
发明人： Gregory F. Smith , Ryan A. Sturmer , Philip Y. Paik , Vijay Srinivasan , Michael G. Pollack , Vamsee K. Pamula , Keith R. Brafford , Richard M. West
CPC分类号： B01F13/0071 , B01F13/0076 , B01L3/502715 , B01L3/502792 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/0668 , B01L2200/148 , B01L2200/16 , B01L2300/024 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/043 , B01L2400/0436 , B01L2400/0442 , B01L2400/0448 , B01L2400/0683 , G01N33/49
摘要： A droplet actuator with cartridge is provided. According to one embodiment, a sample analyzer is provided and includes an analyzer unit comprising electronic or optical receiving means, a cartridge comprising self-contained droplet handling capabilities, and a wherein the cartridge is coupled to the analyzer unit by a means which aligns electronic and/or optical outputs from the cartridge with electronic or optical receiving means on the analyzer unit. According to another embodiment, a sample analyzer is provided and includes a sample analyzer comprising a cartridge coupled thereto and a means of electrical interface and/or optical interface between the cartridge and the analyzer, whereby electrical signals and/or optical signals may be transmitted from the cartridge to the analyzer.
摘要翻译： 提供带墨盒的液滴致动器。 根据一个实施例，提供了样本分析器，并且包括分析器单元，其包括电子或光学接收装置，包括独立液滴处理能力的盒，以及其中所述盒通过使电子和 /或来自带有分析仪单元上的电子或光学接收装置的盒的光学输出。 根据另一个实施例，提供了一个样本分析器，它包括一个样本分析器，该样本分析器包括与其相连接的盒，以及盒和分析器之间的电接口和/或光学接口的装置，由此电信号和/或光信号可以从 墨盒进入分析仪。
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公开(公告)号：US07439014B2
公开(公告)日：2008-10-21
申请号：US11639736
申请日：2006-12-15
IPC分类号： C12Q1/00
CPC分类号： G01N27/26 , B01F13/0071 , B01F13/0076 , B01L3/0268 , B01L3/502715 , B01L3/502723 , B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/0668 , B01L2200/0673 , B01L2200/0684 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/0424 , B01L2400/0427 , B01L2400/043 , B01L2400/0436 , B01L2400/0442 , B01L2400/0448 , C12Q1/686 , C12Q1/6869 , G01N27/3271 , G01N27/416 , G01N27/447 , G01N35/00029 , G01N2035/00158 , G01N2035/00237
摘要： The present invention relates to droplet-based surface modification and washing. According to one embodiment, a method of providing a droplet in contact with a surface with a reduced concentration of a substance is provided, wherein the method includes: (a) providing a droplet microactuator comprising a surface in contact with a droplet comprising a starting concentration and starting quantity of the substance and having a starting volume; (b) conducting one or more droplet operations to merge a wash droplet with the droplet provided in step (a) to yield a combined droplet; and (c) conducting one or more droplet operations to divide the combined droplet to yield a set of droplets comprising: (i) a droplet in contact with the surface having a decreased concentration of the substance relative to the starting concentration; and (ii) a droplet which is separated from the surface.
摘要翻译： 本发明涉及液滴表面改性和洗涤。 根据一个实施例，提供了一种提供与物质浓度降低的表面接触的液滴的方法，其中所述方法包括：（a）提供液滴微致动器，其包括与包含起始浓度的液滴的表面 并开始物质的起始体积; （b）进行一个或多个液滴操作以将洗涤液滴与步骤（a）中提供的液滴合并以产生组合液滴; 和（c）进行一个或多个液滴操作以分开组合的液滴以产生一组液滴，其包括：（i）与所述表面接触的液滴相对于起始浓度具有降低的物质浓度; 和（ii）与表面分离的液滴。
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公开(公告)号：US20070242111A1
公开(公告)日：2007-10-18
申请号：US11639664
申请日：2006-12-15
IPC分类号： B41J2/125
CPC分类号： B41J2/125 , B01L3/502792 , B01L2200/143 , B01L2200/147 , B01L2300/0645 , B01L2300/0654 , B01L2400/0424 , B01L2400/0427 , B01L2400/043 , B01L2400/0487 , B41J2/17509 , G01N15/1484 , G01N2015/1006
摘要： The present invention relates to droplet-based diagnostics. According to one embodiment, a droplet microactuator system is provided and includes: (a) a droplet microactuator configured to conduct droplet operations; and (b) a sensor configured in a sensing relationship with the droplet microactuator, such that the sensor is capable of sensing a signal from and/or a property of one or more droplets on the droplet microactuator.
摘要翻译： 本发明涉及基于液滴的诊断。 根据一个实施例，提供了液滴微致动器系统，其包括：（a）构造成进行液滴操作的液滴微致动器; 和（b）配置成与液滴微致动器的感测关系的传感器，使得传感器能够感测来自液滴微致动器上的一个或多个液滴的信号和/或特性。
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公开(公告)号：US20070241068A1
公开(公告)日：2007-10-18
申请号：US11639531
申请日：2006-12-15
IPC分类号： B01D57/00
CPC分类号： B01L3/502784 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01L3/502715 , B01L3/502761 , B01L3/502792 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/0421 , B01L2400/0424 , B01L2400/0427 , B01L2400/043 , B01L2400/0436 , B01L2400/0442 , Y10T436/11 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： The present invention relates to droplet-based washing. According to one embodiment, a method of providing a droplet in contact with a surface with a reduced concentration of a substance is provided, wherein the method includes: (a) providing a surface in contact with a droplet comprising a starting concentration and starting quantity of the substance and having a starting volume; (b) conducting one or more droplet operations to merge a wash droplet with the droplet provided in step (a) to yield a combined droplet; and (c) conducting one or more droplet operations to divide the combined droplet to yield a set of droplets comprising: (i) a droplet in contact with the surface having a decreased concentration of the substance relative to the starting concentration; and (ii) a droplet which is separated from the surface.
摘要翻译： 本发明涉及液滴洗涤。 根据一个实施方案，提供了一种提供与具有降低的物质浓度的表面接触的液滴的方法，其中所述方法包括：（a）提供与包含起始浓度和起始浓度的液滴接触的表面 该物质并具有起始体积; （b）进行一个或多个液滴操作以将洗涤液滴与步骤（a）中提供的液滴合并以产生组合液滴; 和（c）进行一个或多个液滴操作以分开组合的液滴以产生一组液滴，其包括：（i）与所述表面接触的液滴相对于起始浓度具有降低的物质浓度; 和（ii）与表面分离的液滴。
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公开(公告)号：US08524506B2
公开(公告)日：2013-09-03
申请号：US11936289
申请日：2007-11-07
IPC分类号： G01N1/10
CPC分类号： B01F13/0071 , B01F13/0076 , B01F13/0084 , B01J2219/00479 , B01J2219/00653 , B01L3/502792 , B01L2300/089 , B01L2300/165 , B01L2400/0415 , B01L2400/0427 , C40B60/14 , G01N15/14 , G01N2035/1046 , G02B26/005 , Y10T436/11 , Y10T436/113332 , Y10T436/117497 , Y10T436/118339 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： Methods for sampling a liquid flow are provided. The method includes supplying a continuous liquid flow from a continuous flow fluid input source to a surface along a first flow path. The method additionally includes sampling the continuous liquid flow by performing an electric field-based technique to split off a sample droplet from a portion of the liquid flow, whereby the sample droplet is distinct from the liquid flow and controllable independently of the liquid flow, wherein the electric field-based technique is performed by providing a set of electrodes on the surface and selectively biasing the set of electrodes, whereby the sample droplet is formed on one of the set of electrodes.
摘要翻译： 提供了液体取样方法。 该方法包括将连续的液体流从连续流体流体输入源提供到沿着第一流动路径的表面。 该方法另外包括通过执行基于电场的技术对液体流的一部分分离样品液滴来对连续液体流进行采样，由此样品液滴与液体流不同，并且可独立于液体流动而控制，其中 通过在表面上设置一组电极并选择性地偏置该组电极来执行基于电场的技术，由此在一组电极中形成样品液滴。
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公开(公告)号：US20130146455A1
公开(公告)日：2013-06-13
申请号：US13759416
申请日：2013-02-05
IPC分类号： C25B9/00
CPC分类号： B01L3/50273 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01F13/0084 , B01L3/00 , B01L3/5027 , B01L3/502784 , B01L3/502792 , B01L2200/06 , B01L2200/0605 , B01L2200/10 , B01L2300/089 , B01L2300/161 , B01L2300/165 , B01L2400/0415 , B01L2400/0427 , B41J2002/14395 , C25B9/00 , G01N27/44791 , G02B26/005
摘要： Methods are provided for manipulating droplets. The methods include providing the droplet on a surface comprising an array of electrodes and a substantially co-planer array of reference elements, wherein the droplet is disposed on a first one of the electrodes, and the droplet at least partially overlaps a second one of the electrodes and an intervening one of the reference elements disposed between the first and second electrodes. The methods further include activating the first and second electrodes to spread at least a portion of the droplet across the second electrode and deactivating the first electrode to move the droplet from the first electrode to the second electrode.
摘要翻译： 提供了用于操纵液滴的方法。 所述方法包括在包括电极阵列和基本上共平面的参考元件阵列的表面上提供液滴，其中液滴设置在电极的第一个上，并且液滴至少部分地与第二个 电极和设置在第一和第二电极之间的参考元件中的插入件之一。 所述方法还包括激活第一和第二电极以将液滴的至少一部分扩散穿过第二电极，并且去激活第一电极以使液滴从第一电极移动到第二电极。
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公开(公告)号：US08048628B2
公开(公告)日：2011-11-01
申请号：US11753318
申请日：2007-05-24
CPC分类号： G01N27/44769 , B01F13/0071 , B01F13/0076 , B01L3/502707 , B01L3/502792 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2200/12 , B01L2300/0645 , B01L2300/0663 , B01L2300/0819 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2300/089 , B01L2300/12 , B01L2300/1827 , B01L2400/0415 , B01L2400/0424 , B81B3/0021 , B81B2201/058 , B81C1/00119 , C12Q1/6846 , G01N27/447 , G01N27/44791 , G05D7/0694 , H01L21/6715 , Y10T436/2575
摘要： Methods for amplifying nucleic acid, such as DNA or RNA, on a printed circuit board (PCB) substrate are disclosed. The amplification can be achieved through a variety of methods such as thermocycling or isothermally. The printed circuit board substrate can comprise an array of electrodes for transporting droplets and can be part of a sandwich structure including a top plate parallel to the printed circuit board substrate.
摘要翻译： 公开了在印刷电路板（PCB）衬底上放大核酸如DNA或RNA的方法。 扩增可以通过各种方法如热循环或等温进行。 印刷电路板基板可以包括用于输送液滴的电极阵列，并且可以是包括平行于印刷电路板基板的顶板的夹层结构的一部分。
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