公开(公告)号：US08489164B2

公开(公告)日：2013-07-16

申请号：US12913096

申请日：2010-10-27

Applicant: Jonathan L. Kuhn

Inventor： Jonathan L. Kuhn

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/0031 ,  A61B5/14535 ,  A61B5/14551 ,  A61B5/7239

Abstract: A medical device system and associated method monitor tissue hemoglobin concentration. Light attenuation is measured in a volume of tissue in a patient. A value of a tissue scattering coefficient corresponding to the tissue volume in the patient is established in response to the attenuation measurement. A second derivative of the light attenuation measurement is determined. An artifact correction term is computed in response to the established tissue scattering coefficient, and a tissue hemoglobin concentration is computed using the artifact correction term and the second derivative.

Abstract translation: 医疗器械系统及相关方法监测组织血红蛋白浓度。 在患者的组织体积中测量光衰减。 响应于衰减测量建立与患者组织体积相对应的组织散射系数的值。 确定光衰减测量的二阶导数。 根据建立的组织散射系数计算人工制品校正项，并使用伪影校正项和二次导数计算组织血红蛋白浓度。

公开(公告)号：US20130172698A1

公开(公告)日：2013-07-04

申请号：US13566886

申请日：2012-08-03

Applicant: Paul D. Reynolds ,  Raul Escutia ,  John F. Larkin ,  Charles Hu ,  Michael F. Tomasco ,  Daniel R. Bloom ,  Joseph A. Vivolo ,  Richard M. Wiard

Inventor： Paul D. Reynolds ,  Raul Escutia ,  John F. Larkin ,  Charles Hu ,  Michael F. Tomasco ,  Daniel R. Bloom ,  Joseph A. Vivolo ,  Richard M. Wiard

IPC: A61B5/157 ,  A61B5/00 ,  A61B5/151 ,  A61B5/15 ,  A61B5/145 ,  A61B5/1455

CPC classification number: A61B5/157 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150114 ,  A61B5/150183 ,  A61B5/150305 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150419 ,  A61B5/150519 ,  A61B5/150572 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150809 ,  A61B5/150816 ,  A61B5/150824 ,  A61B5/150984 ,  A61B5/15109 ,  A61B5/15111 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15151 ,  A61B5/15161 ,  A61B5/15163 ,  A61B5/15176 ,  A61B5/15182 ,  A61B5/742 ,  A61B2562/0295 ,  G01N15/0612 ,  G01N21/03 ,  G01N21/78 ,  G01N33/487

Abstract: Described here are meters and methods for sampling, transporting, and/or analyzing a fluid sample. The meters may include a meter housing and a cartridge. In some instances, the meter may include a tower which may engage one or more portions of a cartridge. The meter housing may include an imaging system, which may or may not be included in the tower. The cartridge may include one or more sampling arrangements, which may be configured to collect a fluid sample from a sampling site. A sampling arrangement may include a skin-penetration member, a hub, and a quantification member.

Abstract translation: 这里描述了用于采样，运输和/或分析流体样品的仪表和方法。 仪表可以包括仪表外壳和墨盒。 在一些情况下，仪表可以包括可以与盒的一个或多个部分接合的塔。 仪表外壳可以包括成像系统，其可以包括或不包括在塔中。 盒可以包括一个或多个采样装置，其可以被配置为从采样点收集流体样品。 采样装置可以包括皮肤穿透构件，轮毂和定量构件。

公开(公告)号：US08473019B2

公开(公告)日：2013-06-25

申请号：US12507934

申请日：2009-07-23

Applicant: Joseph P. Ortner ,  Bryan J. Scheele

Inventor： Joseph P. Ortner ,  Bryan J. Scheele

IPC: A61B5/1455

CPC classification number: A61B5/6833 ,  A61B5/026 ,  A61B5/14535 ,  A61B5/14552 ,  A61B5/4519 ,  A61B5/6824 ,  A61B5/6826 ,  A61B5/6838 ,  A61B2562/164

Abstract: A patient interface and method of locating the patient interface for use particularly in spectroscopy applications. The patient interface includes a concave region and first and second convex regions. A wing extends from the concave region to help locate the patient interface properly. The convex regions provide additional adhesion support, particularly when used on the thenar eminence. The patient interface may be placed in a number of locations on a patient to determine an optimum location for measurement prior to affixing the interface to the patient.

公开(公告)号：US20130150687A1

公开(公告)日：2013-06-13

申请号：US13688715

申请日：2012-11-29

Applicant: Toshinori KATO

Inventor： Toshinori KATO

IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/145

CPC classification number: A61B5/14552 ,  A61B5/0042 ,  A61B5/0205 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/14551 ,  A61B5/4064 ,  A61B5/4519 ,  A61B5/7225 ,  A61B5/7278 ,  A61B5/743 ,  A61B10/0045 ,  G01N21/359 ,  G01N2021/3144 ,  G06F19/00

Abstract: An apparatus and a program are provided which are capable of simultaneously measuring, evaluating, imaging and displaying the biological function of sites with different biological functions, such as the brain and the muscle, different parts of the brain or different muscle locations, using near-infrared spectroscopy. In an apparatus for evaluating biological function K, physiological indices, including parameters derived from changes in deoxyhemoglobin concentration and changes in oxyhemoglobin concentration, are calculated by a calculating part of a controller. To measure simultaneously, evaluate, image and display the biological functions of sites with different biological function, such as the brain and the muscle, different parts of the brain or different muscle locations, these physiological indices from different sites of the living body are adjusted in such a way that they can be compared with each other by the calculating part and displayed by a display part.

Abstract translation: 提供了一种能够同时测量，评估，成像和显示具有不同生物学功能的位点（如脑和肌肉，大脑不同部位或不同肌肉位置）的生物功能的装置和程序， 红外光谱。 在用于评价生物功能K的装置中，通过控制器的计算部分来计算包括由脱氧血红蛋白浓度的变化和氧合血红蛋白浓度的变化导出的参数的生理指标。 为了同时测量，评估，显示和显示具有不同生物学功能的位点（如脑和肌肉，脑部不同部位或不同肌肉位置）的生物学功能，这些来自生命体不同部位的生理指标被调整 这种方式使得它们可以通过计算部分彼此比较并由显示部分显示。

公开(公告)号：US08449524B2

公开(公告)日：2013-05-28

申请号：US13174610

申请日：2011-06-30

Applicant: James R. Braig ,  Richard Keenan ,  Peter Rule ,  Gil Rivas ,  Mahesh Seetharaman

Inventor： James R. Braig ,  Richard Keenan ,  Peter Rule ,  Gil Rivas ,  Mahesh Seetharaman

IPC: A61M5/168

CPC classification number: A61B5/4839 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/412 ,  A61B5/7475 ,  A61M5/16827 ,  A61M5/1723 ,  A61M2005/1404 ,  A61M2005/14208 ,  A61M2005/1726 ,  A61M2205/12 ,  A61M2205/3303 ,  A61M2209/084 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468

Abstract: Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g., insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.

Abstract translation: 公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。 本文公开的系统和方法还可以包括注射或注射治疗药物（例如胰岛素或葡萄糖）并提供血糖控制的治疗剂量系统。 治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。

公开(公告)号：US08444576B2

公开(公告)日：2013-05-21

申请号：US13237157

申请日：2011-09-20

Applicant: Masaki Fujiwara ,  Yoshinori Amano

Inventor： Masaki Fujiwara ,  Yoshinori Amano

IPC: A61B5/00 ,  A61B5/151 ,  A61B5/157

CPC classification number: A61B5/157 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/15019 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150519 ,  A61B5/15087 ,  A61B5/15117 ,  A61B5/1513 ,  A61B5/1519 ,  A61B2562/0295

Abstract: A blood test apparatus has a housing, a blood sensor, and a plurality of connectors. The blood sensor has a plurality of connection terminals that are electrically connected with each electrode of the electrode system; and a reference terminal that serves as a reference. The plurality of connectors are configured to connect to the plurality of connection terminals and the reference terminal of the blood sensor attached at a predetermined position in the blood test apparatus, respectively. And also, relations between the reference terminal and each of the plurality of connection terminals are measured to identify the reference terminal automatically.

Abstract translation: 血液检查装置具有壳体，血液传感器和多个连接器。 血液传感器具有与电极系统的每个电极电连接的多个连接端子; 以及作为参考的参考端子。 多个连接器被配置为分别连接到血液检查装置中的预定位置处的多个连接端子和血液传感器的参考端子。 并且，还测量参考终端与多个连接终端中的每一个之间的关系以自动识别参考终端。

公开(公告)号：US08417311B2

公开(公告)日：2013-04-09

申请号：US12559328

申请日：2009-09-14

Applicant: Peter Rule

Inventor： Peter Rule

IPC: A61B5/05

CPC classification number: A61M5/1723 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150305 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150862 ,  A61B5/155 ,  A61B5/157 ,  A61B5/412 ,  A61B5/4839 ,  A61B5/7475 ,  A61M5/1415 ,  A61M5/142 ,  A61M5/16827 ,  A61M2005/1404 ,  A61M2005/14208 ,  A61M2005/1726 ,  A61M2205/12 ,  A61M2205/18 ,  A61M2205/3313 ,  A61M2205/3569 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468

Abstract: Disclosed are methods and apparatuses for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment dose (e.g. insulin, dextrose, etc.) and provide glycemic control. The dose of the treatment drug may be based on the patient's calculated sensitivity to treatment dosing, for example. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte. Delivery of the treatment drug can be cut off if the determined analyte concentration indicates that continued delivery would be harmful to the patient.

Abstract translation: 公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。 本文公开的系统和方法还可以包括注射或注射治疗剂量（例如胰岛素，葡萄糖等）并提供血糖控制的治疗剂量系统。 治疗药物的剂量可以基于例如患者对治疗剂量的计算灵敏度。 治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。 如果确定的分析物浓度表明持续传递对患者有害，则可以切断治疗药物的递送。

公开(公告)号：US08340739B2

公开(公告)日：2012-12-25

申请号：US12524028

申请日：2008-01-25

Applicant: Motoaki Murakami ,  Yoshihiko Izumichi

Inventor： Motoaki Murakami ,  Yoshihiko Izumichi

IPC: A61B5/00 ,  A61M37/00 ,  C12M1/34 ,  C12M3/00

CPC classification number: A61B5/1459 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/4839 ,  A61B2560/0223 ,  A61F2/022 ,  A61M1/14 ,  A61M1/3609 ,  A61M5/1723 ,  A61M2205/3303 ,  A61M2205/3306 ,  A61M2230/201

Abstract: This invention provides a monitor device capable of detecting possible abnormalities in body fluid withdrawal by a body fluid sampler and variations in the dilution when a withdrawn body fluid is diluted, and a living organism-measuring device with this monitor device. The former device includes a first optical sensor disposed on a diluent channel through which a diluent is introduced into a body fluid sampler for withdrawing a body fluid; a second optical sensor disposed on a diluted body fluid channel through which the diluted body fluid is transferred to a living organism-measuring sensor, and close to the first optical sensor; and a controlling unit for judging whether variations in a dilution to which the body fluid is diluted are within predetermined limits, from data outputted by the first optical sensor and data outputted by the second optical sensor. The latter device has the monitor device incorporated thereto.

Abstract translation: 本发明提供了一种监测装置，其能够检测体液取样器体液抽出的可能异常和稀释时的稀释变化，以及具有该监视装置的生物体测定装置。 前一种装置包括设置在稀释剂通道上的第一光学传感器，通过该稀释剂通道将稀释剂引入体液取样器中以便抽出体液; 设置在稀释的体液通道上的第二光学传感器，稀释的体液通过该第二光学传感器传递到生物体测量传感器，并且靠近第一光学传感器; 以及控制单元，用于根据由第一光学传感器输出的数据和由第二光学传感器输出的数据判断体液稀释的稀释度的变化是否在预定限度内。 后一种装置具有并入其中的监视器装置。

公开(公告)号：US20120277655A1

公开(公告)日：2012-11-01

申请号：US13424454

申请日：2012-03-20

Applicant: Martin Gerber ,  John Burnes ,  SuPing Lyu ,  VenKalesh R. Manda ,  Bryant Pudil

Inventor： Martin Gerber ,  John Burnes ,  SuPing Lyu ,  VenKalesh R. Manda ,  Bryant Pudil

IPC: A61M1/16 ,  A61M1/14

CPC classification number: A61M1/1603 ,  A61B5/0031 ,  A61B5/026 ,  A61B5/0295 ,  A61B5/053 ,  A61B5/0537 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14535 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/4836 ,  A61B5/4848 ,  A61B5/4875 ,  A61B5/6866 ,  A61B5/7282 ,  A61B2560/0223 ,  A61M1/00 ,  A61M1/14 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1605 ,  A61M1/1607 ,  A61M1/1613 ,  A61M1/28 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/342 ,  A61M1/3607 ,  A61M1/3609 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3672 ,  A61M2202/0498 ,  A61M2205/04 ,  A61M2205/18 ,  A61M2205/33 ,  A61M2205/3303 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3375 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/60 ,  A61M2205/70 ,  A61M2230/00 ,  A61M2230/005 ,  A61M2230/06 ,  A61M2230/20 ,  A61M2230/207 ,  A61M2230/208 ,  A61M2230/65 ,  B01D61/00 ,  B01D61/32 ,  B01D65/02 ,  B01D2321/12 ,  B01D2321/40 ,  G06F19/00

Abstract: A method includes initiating a blood fluid removal session of a patient; monitoring an indicator of tissue fluid volume of the patient, or a portion thereof, during the blood fluid removal session; monitoring an indicator of blood fluid volume of the patient during the blood fluid removal session; determining whether a ratio of the indicator of tissue fluid volume to indicator of blood fluid volume is outside of a predetermined range; and altering the rate of fluid removal during the blood fluid removal session if the ratio is determined to be outside of the predetermined range. A blood fluid removal system may be configured to carry out the method.

Abstract translation: 一种方法包括启动患者的血液流体清除会话; 在血液清除会话期间监测患者或其部分的组织液体体积的指标; 在血液清除期间监测患者的血液体积的指标; 确定组织液体体积指标与血液体积指标之间的比率是否超出预定范围; 以及如果所述比例被确定为在所述预定范围之外，则改变在所述血液流体清除会话期间的流体去除速率。 血液清除系统可以被配置为执行该方法。

公开(公告)号：US20120277551A1

公开(公告)日：2012-11-01

申请号：US13424429

申请日：2012-03-20

Applicant: Martin Gerber ,  SyPing Lyu ,  Bryant Pudil

Inventor： Martin Gerber ,  SyPing Lyu ,  Bryant Pudil

IPC: A61M1/14 ,  A61B5/145 ,  A61B5/021 ,  A61B5/024 ,  A61B5/00 ,  A61B5/0205

CPC classification number: A61M1/1603 ,  A61B5/0031 ,  A61B5/026 ,  A61B5/0295 ,  A61B5/053 ,  A61B5/0537 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14535 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/4836 ,  A61B5/4848 ,  A61B5/4875 ,  A61B5/6866 ,  A61B5/7282 ,  A61B2560/0223 ,  A61M1/00 ,  A61M1/14 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1605 ,  A61M1/1607 ,  A61M1/1613 ,  A61M1/28 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/342 ,  A61M1/3607 ,  A61M1/3609 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3672 ,  A61M2202/0498 ,  A61M2205/04 ,  A61M2205/18 ,  A61M2205/33 ,  A61M2205/3303 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3375 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/60 ,  A61M2205/70 ,  A61M2230/00 ,  A61M2230/005 ,  A61M2230/06 ,  A61M2230/20 ,  A61M2230/207 ,  A61M2230/208 ,  A61M2230/65 ,  B01D61/00 ,  B01D61/32 ,  B01D65/02 ,  B01D2321/12 ,  B01D2321/40 ,  G06F19/00

Abstract: Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patent parameters. By comparing the patient's current parameters to past parameters in response to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.

Abstract translation: 用于监测患者参数和血液流体清除系统参数的方法包括识别导致改善的患者参数或恶化的专利参数的那些系统参数。 通过根据系统参数或系统参数的变化将患者的当前参数与过去的参数进行比较，血液流体清除系统可能能够避免将来使用可能损害患者的参数，并且可能能够了解哪些参数可能 在血液清除术中治疗患者最有效。